Effect of recombinant human interferon α B/D (rHu-IFN-α B/D) in combination with acyclovir in experimental HSV-1 encephalitis

Antiviral Research

Volumn 44, Issue 1, 1999, Pages 75-78

  Wintergerst, U ^a   Gangemi, J D ^b   Whitley, R J ^c   Chatterjee, S ^d   Kern, E R ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b CLEMSON UNIVERSITY   (United States)

^c University of Alabama at Birmingham   (United States)

^d JCR Biopharmaceuticals Inc   (United States)

Author keywords

Acyclovir; Encephalitis; HSV 1; Interferon

Indexed keywords

ACICLOVIR; RECOMBINANT ALPHA INTERFERON A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; HERPES SIMPLEX VIRUS 1; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS ENCEPHALITIS;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ENCEPHALITIS, HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON TYPE I, RECOMBINANT; MICE;

ANIMALIA; DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1; MURINAE;

EID: 0032699703     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(99)00055-8     Document Type: Article

References (18)

1. Catalano L.W., London W.T., Rice J.M., Sever J.L. Prophylactic and therapeutic use of Poly(I) Poly (C) (Poly-D-lysine) against Herpes virus encephalitis in mice. Proc. Soc. Exp. Biol. Med. 140:1972;67-71.
2. Cerruti R.L., Connell E.V., Trown P.W., Sim S. Synergistic interaction between interferon-α and acyclovir in the treatment of Herpes simplex virus type 1 infection in mice. Antiviral Res. S1:1985;217-223.
3. Chatterjee S., Hunter E., Whitley R.J. Effect of cloned human interferons on protein synthesis and morphogenesis of herpes simplex virus. J. Virol. 56:1985;419-425.
4. Chatterjee S., Burns P. Expression of herpes simplex virus type 1 glycoproteins in interferon-treated human neuroblastoma cells. J. Virol. 64:1990;5209-5213.
5. De Clercq E., Luczak M. Intranasal challenge of mice with Herpes simplex virus: an experimental model for evaluation of the efficacy of antiviral drugs. J. Infect. Dis. 133:1976;A226-A236.
6. Fitzwilliam J.F., Griffith J.F. Experimental encephalitis caused by Herpes simplex virus: comparison of treatment with Tilorone Hydrochloride and Phosphonoacetic acid. J. Infect. Dis. 133:1976;A221-A225.
7. Fraser-Smith E.B., Eppstein D.A., Marsh Y.V., Matthews T.R. Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl) guanine in combination with alpha-interferon against Herpes simplex virus type 2 in mice. Antimicrob. Agents Chemother. 26:1984;937-938.
8. Fraser-Smith E.B., Eppstein D.A., Marsh Y.V., Matthews T.R. Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl) guanine in combination with beta-interferon against Herpes simplex virus type 2 in mice. Antimicrob. Agents Chemother. 25:1984;563-565.
9. Gangemi J.D., Lazdins J., Dietrich F.M., Matter A., Poncioni B., Hochkeppel H.-K. Antiviral activity of a novel recombinant human interferon-α B/D hybrid. J. Interferon Res. 9:1989;227-237.
10. Horisberger M.A., De Staritzky K. A recombinant human interferon-α B/D hybrid with a broad host-range. J. Gen. Virol. 68:1987;945-948.
11. Moran D.M., Kern E.R., Overall J.C. Synergism between recombinant human interferon and nucleoside antiviral agents against Herpes simplex virus: Examination with an automated microtiter plate assay. J. Infect. Dis. 151:1985;1116-1122.
12. Sköldenberg B., Forsgren M., Alestig K., Bergström T., Burman L., Dahlquist E., Forkman A., Fryden A., Lövgren K., Norlin K., Norrby R., Olding-Stenkvist E., Stiernstedt G., Uhnoo I., De Vahl K. Acyclovir versus vidarabine in herpes simplex encephalitis. Lancet. i:1984;707-711.
13. Smee D.F., Campbell N.L., Matthews T.R. Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl) guanine, acyclovir, and two 2′-fluoropyrimidine nucleosides. Antiviral Res. 5:1985;259-267.
14. Stanwick T.L., Schinazi R., Campbell D.E., Nahmias A.J. Combined antiviral effect of interferon and acyclovir on herpes simplex virus type 1 and 2. Antimicrob. Agents Chemother. 19:1981;672-674.
15. Whitley R.J. Herpes simplex virus infections of the central nervous system. Am. J. Med. 85(suppl 2a):1988;61-67.
16. Whitley R.J., Alford C.A., Hirsch M.S., Schooley R.T., Luby J.P., Aoki F.Y., Hanley D., Nahmias A.J., Seng-Jaw S. Vidarabine vs. acyclovir therapy in herpes simplex encephalitis. N. Engl. J. Med. 314:1986;144-149.
17. Wintergerst U.and, Belohradsky B.H. Acyclovir versus the combination acyclovir plus beta-interferon in focal viral encephalitis. Infection. 20:1992;207-212.
18. Wintergerst U., Gangemi J.D., Kern E.R., Whitley R.J., Chatterjee S. Differential effect of recombinant human and mouse interferons on replication of herpes simplex virus type 1 in mouse cells. Antiviral Res. 32:1996;27-34.