Enantioselective synthesis of protected L-4-[sulfonamido(difluoromethyl)] phenylalanine and L-4-[sulfonamido(methyl)]phenylalanine and an examination of hexa- and tripeptide platforms for evaluating pTyr mimics for PTP1B inhibition

Journal of Organic Chemistry

Volumn 71, Issue 21, 2006, Pages 8190-8197

  Hill, Bryan ^a   Ahmed, Vanessa ^a   Bates, Daniel ^a   Taylor, Scott D ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVE SYNTHESIS; PEPTIDE SYNTHESES; PHENYLALANINE;

AMINO ACIDS; OXIDATION; POLYPEPTIDES; PROTEINS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

4 [SULFONAMIDO(DIFLUOROMETHYL)]PHENYLALANINE; 4 [SULFONAMIDO(METHYL)]PHENYLALANINE; ALANINE DERIVATIVE; AMINE; AMINO ACID; ASPARTIC ACID DERIVATIVE; BENZILIC ACID; GLUTAMIC ACID DERIVATIVE; HEXAPEPTIDE; LEUCINE; METHIONINE DERIVATIVE; PHENYLALANINE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B; SULFONAMIDE; TRIPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHLORINATION; ENANTIOSELECTIVITY; ENZYME INHIBITION; OXIDATION; PEPTIDE SYNTHESIS; PROTEIN ANALYSIS; REACTION ANALYSIS;

PHENYLALANINE;

EID: 33749988707     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo061496r     Document Type: Article

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