Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia

Pediatrics

Volumn 116, Issue 5, 2005, Pages 1226-1230

  Merhar, Stephanie L ^a,b   Gilbert, Donald L ^b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Bilirubin; Bilirubin albumin binding; Cerebrospinal fluid; Kernicterus; Neuroimaging

Indexed keywords

BILIRUBIN; NEUROTRANSMITTER; TRIHEXYPHENIDYL; 3 O METHYLDOPA; 3-METHOXYTYROSINE; 5 HYDROXYINDOLEACETIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; DRUG DERIVATIVE; HOMOVANILLIC ACID; TYROSINE;

ANAMNESIS; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID; CLINICAL ASSESSMENT; CLINICAL FEATURE; ELECTROENCEPHALOGRAM; EYE EXAMINATION; FEMALE; GLOBUS PALLIDUS; HUMAN; HYPERBILIRUBINEMIA; KERNICTERUS; LABORATORY TEST; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; PREMATURITY; PRIORITY JOURNAL; RADIODIAGNOSIS; SCHOOL CHILD; STAINING; TRANSFUSION; CHILD; DEVELOPMENTAL DISORDER; FOLLOW UP; PATHOLOGY;

CHILD; DEVELOPMENTAL DISABILITIES; FEMALE; FOLLOW-UP STUDIES; GLOBUS PALLIDUS; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; HYPERBILIRUBINEMIA; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; KERNICTERUS; MAGNETIC RESONANCE IMAGING; NEUROTRANSMITTER AGENTS; TYROSINE;

EID: 33644678198     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2004-2468     Document Type: Article

References (33)

1. Blackmon LR, Fanaroff AA, Raju TN, National Institute of Child Health and Human Development. Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. Pediatrics. 2004;114:229-233
2. Ip S, Chung M, Kulig J, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004;114(1). Available at: www.pediatrics.org/cgi/content/full/114/1/e130
3. Watchko JF, Maisels MJ. Jaundice in low birthweight infants: pathobiology and outcome. Arch Dis Child Fetal Neonatal Ed. 2003;88:F455-F488
4. Graziani LJ, Mitchell DG, Kornhauser M, et al. Neurodevelopment of preterm infants: neonatal neurosonographic and serum bilirubin studies. Pediatrics. 1992;89:229-234
5. O'Shea TM, Dillard RG, Klinepeter KL, Goldstein DJ. Serum bilirubin levels, intracranial hemorrhage, and the risk of developmental problems in very low birth weight neonates. Pediatrics. 1992;90:888-892
6. van de Bor M, Ens-Dokkum M, Schreuder AM, Veen S, Brand R, Verloove-Vanhorick SP. Hyperbilirubinemia in low birth weight infants and outcome at 5 years of age. Pediatrics. 1992;89:359-364
7. Yeo KL, Perlman M, Hao Y, Mullaney P. Outcomes of extremely premature infants related to their peak serum bilirubin concentrations and exposure to phototherapy. Pediatrics. 1998;102:1426-1431
8. Okumura A, Hayakawa F, Kato T, Itomi K, Mimura S, Watanabe K. Preterm infants with athetoid cerebral palsy: kernicterus? Arch Dis Child Fetal Neonatal Ed. 2001;84:F136-F137
9. Govaert P, Lequin M, Swarte R, et al. Changes in globus pallidus with (pre)term kernicterus. Pediatrics. 2003;112:1256-1263
10. Sugama S, Soeda A, Eto Y. Magnetic resonance imaging in three children with kernicterus. Pediatr Neurol. 2001;25:328-331
11. Martich-Kriss V, Kollias SS, Ball WS Jr. MR findings in kernicterus. AJNR. Am J Neuroradiol. 1995;16(4 suppl):819-821
12. Volpe JJ. Bilirubin and Brain Injury. In: Neurology of the Newborn. 4th ed. Philadelphia, PA: Saunders; 2001:521-546
13. Connolly AM, Volpe JJ. Clinical features of bilirubin encephalopathy. Clin Perinatol. 1990;17:371-379
14. Perlman M, Fainmesser P, Sohmer H, Tamari H, Wax Y, Pevsmer B. Auditory nerve-brainstem evoked responses in hyperbilirubinemic neonates. Pediatrics. 1983;72:658-664
15. Nakamura H, Takada S, Shimabuku R, Matsuo M, Matsuo T, Negishi H. Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia. Pediatrics. 1985;75:703-708
16. Stern L, Denton RL. Kernicterus in small premature infants. Pediatrics. 1965;35:483-485
17. Ahdab-Barmada M. Kernicterus in the premature neonate. J Perinatol. 1987;7:149-152
18. Koch CA, Jones DV, Dine MS, Wagner EA. Hyperbilirubinemia in premature infants: a follow-up study. J Pediatr. 1959;55:23-29
19. Watchko JF, Oski FA. Kernicterus in preterm newborns: past, present, and future. Pediatrics. 1992;90:707-715
20. Oh W, Tyson JE, Fanaroff AA, et al. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics. 2003;112:773-779
21. Ho VB, Fitz CR, Chuang SH, Geyer CA. Bilateral basal ganglia lesions: pediatric differential considerations. Radiographics. 1993;13:269-292
22. Gartner LM, Snyder RN, Chabon RS, Bernstein J. Kernicterus: high incidence in premature infants with low serum bilirubin concentrations. Pediatrics. 1970;45:906-917
23. Lucey JF. The unsolved problem of kernicterus in the susceptible low birth weight infant. Pediatrics. 1972;49:646-647
24. Pearlman MA, Gartner LM, Lee K, Morecki R, Horoupian DS. Absence of kernicterus in low-birth weight infants from 1971 through 1976: comparison with findings in 1966 and 1967. Pediatrics. 1978;62: 460-464
25. Ahlfors CE. Bilirubin-albumin binding and free bilirubin. J Perinatol. 2001;21(suppl 1):S40-S42; discussion S59-S62
26. Ahlfors CE. Criteria for exchange transfusion in jaundiced newborns. Pediatrics. 1994;93:488-494
27. Nakamura H, Yonetani M, Uetani Y, Funato M, Lee Y. Determination of serum unbound bilirubin for prediction of kernicterus in low birthweight infants. Acta Paediatr Jpn. 1992;34:642-647
28. Cashore WJ, Oh W. Unbound bilirubin and kernicterus in low-birthweight infants. Pediatrics. 1982;69:481-485
29. Funato M, Tamai H, Shimada S, Nakamura H. Vigintiphobia, unbound bilirubin, and auditory brainstem responses. Pediatrics. 1994;93:50-53
30. Ahdab-Barmada M, Moossy J. The neuropathology of kernicterus in the premature neonate: diagnostic problems. J Neuropathol Exp Neurol. 1984; 43:45-56
31. Burke RE, Fahn S, Marsden CD. Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl. Neurology. 1986;36:160-164
32. Marsden CD, Marion MH, Quinn N. The treatment of severe dystonia in children and adults. J Neurol Neurosurg Psychiatry. 1984;47:1166-1173
33. Maisels MJ, Watchko JF. Treatment of jaundice in low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 2003;88:F459-F463