Mercury abolishes neurotrophic factor-stimulated Jak-STAT signaling in nerve cells by oxidative stress

Toxicological Sciences

Volumn 94, Issue 1, 2006, Pages 129-138

  Monroe, Richard K ^a   Halvorsen, Stanley W ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Ciliary neurotrophic factor; Cytokine; gp130; Interferon ; Neurotoxicity; Signal transduction; Transition metals; Tyrosine kinase

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; DICHLOROFLUORESCEIN; FIBROBLAST GROWTH FACTOR RECEPTOR TYROSINE KINASE; GAMMA INTERFERON RECEPTOR; GLUTATHIONE; HYDROGEN PEROXIDE; JANUS KINASE; MERCURY CHLORIDE; NEUROPROTECTIVE AGENT; NEUROTOXIN; PROTEIN TYROSINE KINASE; RECOMBINANT CILIARY NEUROTROPHIC FACTOR; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MATURATION; CELL STRAIN HEPG2; CELL SURVIVAL; CHICK EMBRYO; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEVELOPMENTAL DISORDER; EMBRYO; ENVIRONMENTAL FACTOR; HUMAN; HUMAN CELL; MERCURIALISM; MYOTUBE; NERVE CELL CULTURE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INJURY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RETINA NERVE CELL; RISK FACTOR; SIGNAL TRANSDUCTION;

ASCORBIC ACID; CELL LINE, TUMOR; CELL SURVIVAL; CILIARY NEUROTROPHIC FACTOR; COPPER SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTORS; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKIN-6; JANUS KINASES; MERCURIC CHLORIDE; MICROSCOPY, FLUORESCENCE; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; ZINC SULFATE;

EID: 33749592409     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl073     Document Type: Article

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