Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-κB-dependent signaling pathways

American Journal of Respiratory Cell and Molecular Biology

Volumn 25, Issue 2, 2001, Pages 141-149

  Conron, M ^a   Bondeson, J ^a   Pantelidis, P ^a   Beynon, H L C ^a   Feldmann, M ^a   DuBois, R M ^a   Foxwell, B M J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; BETA GALACTOSIDASE; CYTOKINE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC REGULATION; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; MACROPHAGE; MEMBRANE ANTIGEN; TRANSGENE; VIRUS INFECTION; VIRUS VECTOR;

EID: 0034869228     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.25.2.4327     Document Type: Article

References (50)

1. Description of sarcoidosis: Report of the Subcommittee on Classification and Definition
2. Pulmonary sarcoidosis: A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity
3. T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1
4. Interleukin-2 receptor gene expression by bronchoalveolar lavage lymphocytes in pulmonary sarcoidosis
5. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
6. Bias toward use of a specific T cell receptor beta-chain variable region in a subgroup of individuals with sarcoidosis
7. Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis
8. Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis
9. Release of interleukin-1 by alveolar macrophages of patients with active pulmonary sarcoidosis
10. Lung-restricted activation of the alveolar macrophage/monocyte system in pulmonary sarcoidosis
11. Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
12. Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes
13. Macrophage inflammatory protein-1 alpha expression in interstitial lung disease
14. Sarcoidosis: TNF-alpha release from alveolar macrophages and serum level of sIL-2R are prognostic markers
15. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: Analysis of local and regional cytokine and chemokine networks
16. Selective regulation of cytokine induction by adenoviral gene transfer of IkappaB alpha into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent
17. Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent
18. CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent
19. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter
20. Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site
21. The essential role of the UA-rich sequence in endotoxin-induced cachectin/TNF synthesis
22. The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription
23. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
24. Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines
25. Defining therapeutic targets by using adenovirus: Blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
26. Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor
27. Human adenovirus-host cell interactions: Comparative study with members of subgroups B and C
28. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
29. Targeted adenovirus-mediated gene delivery to T cells via CD3
30. Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery
31. Bronchoalveolar lavage constituents in healthy individuals, idiopathic pulmonary fibrosis, and selected comparison groups
32. Methods for construction of adenovirus vectors
33. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ
34. Identification of novel factors that bind to the PRD I region of the human beta-interferon promoter
35. Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells
36. Antibodies against interferons: Characterization of interferons and immunoassays
37. Stability of Th1 and Th2 populations
38. Evaluation of measurement of human TNF in plasma by ELISA
39. T-lymphocytes that accumulate in the lung in sarcoidosis have evidence of recent stimulation of the T-cell antigen receptor
40. Alveolar macrophages in idiopathic pulmonary fibrosis display a more monocyte-like immunophenotype and an increased release of free oxygen radicals
41. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis
42. Increased secretion of tumor necrosis factor-alpha, interleukin-1-beta, and interleukin-6 by alveolar macrophages from patients with sarcoidosis
43. Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B
44. NF-kappa B is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment
45. Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome
46. Nuclear localization of RelB is associated with effective antigen-presenting cell function
47. The T-cell transcription factor NFAT is a substrate for calcineurin and interacts with Fos and Jun
48. Inhibition of NF-AT-dependent transcription by NF-kappa B: Implications for differential gene expression in T helper cell subsets
49. A common factor regulates both Th1- and Th2-specific cytokine gene expression
50. Activation of the interleukin-4 gene is controlled by the unique calcineurin-dependent transcriptional factor NF(P)