Characterization of a flocculation-like phenotype in Cryptococcus neoformans and its effects on pathogenesis

Cellular Microbiology

Volumn 8, Issue 11, 2006, Pages 1730-1739

  Li, Li ^a   Zaragoza, Oscar ^a   Casadevall, Arturo ^a   Fries, Bettina C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE K;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIRULENCE; CELL ADHESION; CELL AGGREGATION; CONTROLLED STUDY; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; CULTURE MEDIUM; FEMALE; FUNGAL STRAIN; FUNGUS CULTURE; FUNGUS IMMUNITY; FUNGUS ISOLATION; HOST PATHOGEN INTERACTION; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; LUNG MYCOSIS; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONTENT; STATISTICAL SIGNIFICANCE; SURVIVAL RATE;

ANIMALS; BACTERIAL ADHESION; CARBOHYDRATES; CELLS, CULTURED; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; CULTURE MEDIA; ENDOPEPTIDASE K; FEMALE; GENOTYPE; MICE; MICROSCOPY, PHASE-CONTRAST; MUTATION; PHAGOCYTOSIS; PHENOTYPE; SALTS; SURVIVAL RATE;

FILOBASIDIELLA NEOFORMANS; MURINAE;

EID: 33749564710     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2006.00742.x     Document Type: Article

References (45)

1. Chang, Y.C., and Kwon-Chung, K.J. (1994) Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol Cell Biol 14: 4912-4919.
2. Chen, S.C., Muller, M., Zhou, J.Z., Wright, L.C., and Sorrell, T.C. (1997) Phospholipase activity in Cryptococcus neoformans: A new virulence factor? J Infect Dis 175: 414-420.
3. Cormack, B.P., Ghori, N., and Falkow, S. (1999) An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 285: 578-582.
4. Cox, G.M., McDade, H.C., Chen, S.C., Tucker, S.C., Gottfredsson, M., Wright, L.C., et al. (2001) Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. Mol Microbiol 39: 166-175.
5. De Las Penas, A., Pan, S.J., Castano, I., Alder, J., Cregg, R., and Cormack, B.P. (2003) Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing. Genes Dev 17: 2245-2258.
6. Del Poeta, M. (2004) Role of phagocytosis in the virulence of Cryptococcus neoformans. Eukaryot Cell 3: 1067-1075.
7. Dong, Z.M., and Murphy, J.W. (1997) Cryptococcal polysaccharides bind to CD18 on human neutrophils. Infect Immun 65: 557-563.
8. Feldmesser, M., Mukherjee, J., and Casadevall, A. (1996) Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro. J Antimicrob Chemother 37: 617-622.
9. Franzot, S.P., Mukherjee, J., Cherniak, R., Chen, L.C., Hamdan, J.S., and Casadevall, A. (1998) Microevolution of a standard strain of Cryptococcus neoformans resulting in differences in virulence and other phenotypes. Infect Immun 66: 89-97.
10. Fries, B.C., Goldman, D.L., Cherniak, R., Ju, R., and Casadevall, A. (1999) Phenotypic switching in Cryptococcus neoformans results in changes in cellular morphology and glucuronoxylomannan structure. Infect Immun 67: 6076-6083.
11. Fries, B.C., Taborda, C.P., Serfass, E., and Casadevall, A. (2001) Phenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection. J Clin Invest 108: 1639-1648.
12. Fujita, A., Kikuchi, Y., Kuhara, S., Misumi, Y., Matsumoto, S., and Kobayashi, H. (1989) Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or yeast heat-shock transcription factor. Gene 85: 321-328.
13. Garcia-Hermoso, D., Dromer, F., and Janbon, G. (2004) Cryptococcus neoformans capsule structure evolution in vitro and during murine infection. Infect Immun 72: 3359-3365.
14. Gates, M.A., Thorkildson, P., and Kozel, T.R. (2004) Molecular architecture of the Cryptococcus neoformans capsule. Mol Microbiol 52: 13-24.
15. Gaur, N.K., Klotz, S.A., and Henderson, R.L. (1999) Overexpression of the Candida albicans ALA1 gene in Saccharomyces cerevisiae results in aggregation following attachment of yeast cells to extracellular matrix proteins, adherence properties similar to those of Candida albicans. Infect Immun 67: 6040-6047.
16. Goldman, D.L., Fries, B.C., Franzot, S.P., Montella, L., and Casadevall, A. (1998) Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents. Proc Natl Acad Sci USA 95: 14967-14972.
17. Guo, B., Styles, C.A., Feng, Q., and Fink, G.R. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci USA 97: 12158-12163.
18. Halme, A., Bumgarner, S., Styles, C., and Fink, G.R. (2004) Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast. Cell 116: 405-415.
19. Hazen, B.W., and Hazen, K.C. (1988) Modification and application of a simple, surface hydrophobicity detection method to immune cells. J Immunol Methods 107: 157-163.
20. Hoyer, L.L. (2001) The ALS gene family of Candida albicans. Trends Microbiol 9: 176-180.
21. Ibrahim, A.S., Filler, S.G., Alcouloumre, M.S., Kozel, T.R., Edwards, J.E., Jr, and Ghannoum, M.A. (1995) Adherence to and damage of endothelial cells by Cryptococcus neoformans in vitro: Role of the capsule. Infect Immun 63: 4368-4374.
22. Iraqui, I., Garcia-Sanchez, S., Aubert, S., Dromer, F., Ghigo, J.M., d'Enfert, C., and Janbon, G. (2005) The Yak1p kinase controls expression of adhesins and biofilm formation in Candida glabrata in a Sir4p-dependent pathway. Mol Microbiol 55: 1259-1271.
23. Jacobson, E.S., and Emery, H.S. (1991) Temperature regulation of the cryptococcal phenoloxidase. J Med Vet Mycol 29: 121-124.
24. Kozel, T.R. (1993) Opsonization and phagocytosis of Cryptococcus neoformans. Arch Med Res 24: 211-218.
25. Kozel, T.R. (1996) Activation of the complement system by pathogenic fungi. Clin Microbiol Rev 9: 34-46.
26. Levitz, S.M., and Tabuni, A. (1991) Binding of Cryptococcus neoformans by human cultured macrophages. Requirements for multiple complement receptors and actin. J Clin Invest 87: 528-535.
27. Lindell, D.M., Moore, T.A., McDonald, R.A., Toews, G.B., and Huffnagle, G.B. (2005) Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection. J Immunol 174: 7920-7928.
28. Lortholary, O., Improvisi, L., Fitting, C., Cavaillon, J.M., and Dromer, F. (2002) Influence of gender and age on course of infection and cytokine responses in mice with disseminated Cryptococcus neoformans infection. Clin Microbiol Infect 8: 31-37.
29. Maitta, R.W., Datta, K., Chang, Q., Luo, R.X., Witover, B., Subramaniam, K., and Pirofski, L.A. (2004) Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles. Infect Immun 72: 4810-4818.
30. Mansour, M.K., and Levitz, S.M. (2002) Interactions of fungi with phagocytes. Curr Opin Microbiol 5: 359-365.
31. Merkel, G.J., and Scofield, B.A. (1997) The in vitro interaction of Cryptococcus neoformans with human lung epithelial cells. FEMS Immunol Med Microbiol 19: 203-213.
32. Miki, B.L., Poon, N.H., James, A.P., and Seligy, V.L. (1982) Possible mechanism for flocculation interactions governed by gene FLO1 in Saccharomyces cerevisiae. J Bacteriol 150: 878-889.
33. Powderly, W.G. (1993) Cryptococcal meningitis and AIDS. Clin Infect Dis 17: 837-842.
34. Ralph, P., and Nakoinz, I. (1975) Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line. Nature 257: 393-394.
35. Reynolds, T.B., and Fink, G.R. (2001) Bakers' yeast, a model for fungal biofilm formation. Science 291: 878-881.
36. Rhodes, J.C., Polacheck, I., and Kwon-Chung, K.J. (1982) Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans. Infect Immun 36: 1175-1184.
37. Salas, S.D., Bennett, J.E., Kwon-Chung, K.J., Perfect, J.R., and Williamson, P.R. (1996) Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. J Exp Med 184: 377-386.
38. Soares, E.V., and Vroman, A. (2003) Effect of different starvation conditions on the flocculation of Saccharomyces cerevisiae. J Appl Microbiol 95: 325-330.
39. Stratford, M. (1989) Evidence for two mechanisms of flocculation in Saccharomyces cerevisiae. Yeast. 5: S441-445.
40. Suzzi, G., Romano, P., Westall, F., and Vannini, L. (1996) The flocculation of wine yeasts: Biochemical and morphological characteristics in Kloeckera apiculata. Antonie Van Leeuwenhoek 69: 273-277.
41. Taborda, C.P., and Casadevall, A. (2002) CR3 (CD11b/CD18) and CR4 (CD11c/ CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans. Immunity 16: 791-802.
42. Verstrepen, K.J., Derdelinckx, G., Verachtert, H., and Delvaux, F.R. (2003) Yeast flocculation: What brewers should know. Appl Microbiol Biotechnol 61: 197-205.
43. Wiederrecht, G., Seto, D., and Parker, C.S. (1988) Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell 54: 841-853.
44. Wormley, F.L., Jr, Heinrich, G., Miller, J.L., Perfect, J.R., and Cox, G.M. (2005) Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. Infect Immun 73: 5022-5030.
45. Zaragoza, O., Taborda, C.P., and Casadevall, A. (2003) The efficacy of complement-mediated phagocytosis of Cryptococcus neoformans is dependent on the location of C3 in the polysaccharide capsule and involves both direct and indirect C3-mediated interactions. Eur J Immunol 33: 1957-1967.