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Volumn 27, Issue 2, 2006, Pages 71-80

Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited

Author keywords

Autoimmunity; Cytokines; Immunology; Lymphocytes; Schizophrenia

Indexed keywords

CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PENTOXIFYLLINE; TRANSFER FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

EID: 33749531529     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2006.07.006     Document Type: Review
Times cited : (220)

References (106)
  • 1
    • 0142244688 scopus 로고    scopus 로고
    • Schizophrenia
    • Freedman R. Schizophrenia. N Engl J Med 349 (2003) 1738-1749
    • (2003) N Engl J Med , vol.349 , pp. 1738-1749
    • Freedman, R.1
  • 3
    • 0030879160 scopus 로고    scopus 로고
    • A differential role for interleukin-6 and tumor necrosis factor-alpha in schizophrenia?
    • Naudin J., Capo C., Giusano B., Mege J.L., and Azorin J.M. A differential role for interleukin-6 and tumor necrosis factor-alpha in schizophrenia?. Schizophr Res 26 (1997) 227-233
    • (1997) Schizophr Res , vol.26 , pp. 227-233
    • Naudin, J.1    Capo, C.2    Giusano, B.3    Mege, J.L.4    Azorin, J.M.5
  • 4
    • 0026554963 scopus 로고
    • Tumor necrosis factor modulates the inactivation of catecholamine secretion in cultured sympathetic neurons
    • Soliven B., and Albert J. Tumor necrosis factor modulates the inactivation of catecholamine secretion in cultured sympathetic neurons. J Neurochem 58 (1992) 1073-1078
    • (1992) J Neurochem , vol.58 , pp. 1073-1078
    • Soliven, B.1    Albert, J.2
  • 5
    • 0028205758 scopus 로고
    • Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6
    • Zalcman S., Green-Johnson J.M., Murray L., Nance D.M., Dyck D., Anisman H., et al. Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res 643 (1994) 40-49
    • (1994) Brain Res , vol.643 , pp. 40-49
    • Zalcman, S.1    Green-Johnson, J.M.2    Murray, L.3    Nance, D.M.4    Dyck, D.5    Anisman, H.6
  • 6
    • 0035397968 scopus 로고    scopus 로고
    • Neuroleptics normalize increased release of interleukin- 1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia
    • Kowalski J., Blada P., Kucia K., Madej A., and Herman Z.S. Neuroleptics normalize increased release of interleukin- 1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia. Schizophr Res 50 (2001) 169-175
    • (2001) Schizophr Res , vol.50 , pp. 169-175
    • Kowalski, J.1    Blada, P.2    Kucia, K.3    Madej, A.4    Herman, Z.S.5
  • 7
    • 0023190469 scopus 로고
    • The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells
    • Denicoff K.D., Rubinow D.R., Papa M.Z., Simpson C., Seipp C.A., Lotze M.T., et al. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med 107 (1987) 293-300
    • (1987) Ann Intern Med , vol.107 , pp. 293-300
    • Denicoff, K.D.1    Rubinow, D.R.2    Papa, M.Z.3    Simpson, C.4    Seipp, C.A.5    Lotze, M.T.6
  • 8
    • 0027321416 scopus 로고
    • Autoimmunity and schizophrenia: an epiphenomenon or an etiology?
    • Amital H., and Shoenfeld Y. Autoimmunity and schizophrenia: an epiphenomenon or an etiology?. Isr J Med Sci 29 (1993) 593-597
    • (1993) Isr J Med Sci , vol.29 , pp. 593-597
    • Amital, H.1    Shoenfeld, Y.2
  • 10
    • 0034936545 scopus 로고    scopus 로고
    • An abbreviated review of immune abnormalities in schizophrenia
    • Rapaport M.H., and Delrahim K.K. An abbreviated review of immune abnormalities in schizophrenia. CNS Spectr 6 (2001) 392-397
    • (2001) CNS Spectr , vol.6 , pp. 392-397
    • Rapaport, M.H.1    Delrahim, K.K.2
  • 11
    • 0006352181 scopus 로고
    • Schizophrenia: some new aetiological considerations
    • Burch P.R. Schizophrenia: some new aetiological considerations. Br J Psychiatry 110 (1964) 818-824
    • (1964) Br J Psychiatry , vol.110 , pp. 818-824
    • Burch, P.R.1
  • 12
    • 0028796495 scopus 로고
    • Immunoglobulin and albumin content of cerebrospinal fluid in schizophrenic patients: relationship to negative symptomatology
    • Muller N., and Ackenheil M. Immunoglobulin and albumin content of cerebrospinal fluid in schizophrenic patients: relationship to negative symptomatology. Schizophr Res 14 (1995) 223-228
    • (1995) Schizophr Res , vol.14 , pp. 223-228
    • Muller, N.1    Ackenheil, M.2
  • 14
    • 0348226486 scopus 로고    scopus 로고
    • Club Rhumatisme et Inflammation. Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level
    • Gorwood P., Pouchot J., Vinceneux P., Puechal X., Flipo R.M., De Bandt M., et al. Club Rhumatisme et Inflammation. Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level. Schizophr Res 66 (2004) 21-29
    • (2004) Schizophr Res , vol.66 , pp. 21-29
    • Gorwood, P.1    Pouchot, J.2    Vinceneux, P.3    Puechal, X.4    Flipo, R.M.5    De Bandt, M.6
  • 15
    • 0035671855 scopus 로고    scopus 로고
    • The schizophrenia-rheumatoid arthritis connection: infectious, immune, or both?
    • Torrey E.F., and Yolken R.H. The schizophrenia-rheumatoid arthritis connection: infectious, immune, or both?. Brain Behav Immun 15 (2001) 401-410
    • (2001) Brain Behav Immun , vol.15 , pp. 401-410
    • Torrey, E.F.1    Yolken, R.H.2
  • 16
    • 0013823321 scopus 로고
    • Genetic and stress factors affecting the abnormal lymphocyte in schizophrenia
    • Fessel W.J., Hirata-Hibi M., and Shapiro I.M. Genetic and stress factors affecting the abnormal lymphocyte in schizophrenia. J Psychiatr Res 3 (1965) 275-283
    • (1965) J Psychiatr Res , vol.3 , pp. 275-283
    • Fessel, W.J.1    Hirata-Hibi, M.2    Shapiro, I.M.3
  • 18
    • 0032557948 scopus 로고    scopus 로고
    • The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6
    • Lin A., Kenis G., Bignotti S., Tura G.J., De Jong R., Bosmans E., et al. The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6. Schizophr Res 32 (1998) 9-15
    • (1998) Schizophr Res , vol.32 , pp. 9-15
    • Lin, A.1    Kenis, G.2    Bignotti, S.3    Tura, G.J.4    De Jong, R.5    Bosmans, E.6
  • 19
    • 0029079357 scopus 로고
    • Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers
    • Maes M., Bosmans E., Calabrese J., Smith R., and Meltzer H.Y. Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers. J Psychiatr Res 29 (1995) 141-152
    • (1995) J Psychiatr Res , vol.29 , pp. 141-152
    • Maes, M.1    Bosmans, E.2    Calabrese, J.3    Smith, R.4    Meltzer, H.Y.5
  • 20
    • 0028097933 scopus 로고
    • Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illness
    • Ganguli R., Yang Z., Shurin G., Chengappa K.N., Brar J.S., Gubbi A.V., et al. Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illness. Psychiatry Res 51 (1994) 1-10
    • (1994) Psychiatry Res , vol.51 , pp. 1-10
    • Ganguli, R.1    Yang, Z.2    Shurin, G.3    Chengappa, K.N.4    Brar, J.S.5    Gubbi, A.V.6
  • 21
    • 0028866623 scopus 로고
    • Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes
    • Brett F.M., Mizisin A.P., Powell H.C., and Campbell I.L. Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J Neuropathol Exp Neurol 54 (1995) 766-775
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 766-775
    • Brett, F.M.1    Mizisin, A.P.2    Powell, H.C.3    Campbell, I.L.4
  • 23
    • 0028077038 scopus 로고
    • Serum-soluble interleukin-2 receptors in neuroleptic-naïve schizophrenic subjects and in medicated schizophrenic subjects with and without tardive dyskinesia
    • Rapaport M.H., and Lohr J.B. Serum-soluble interleukin-2 receptors in neuroleptic-naïve schizophrenic subjects and in medicated schizophrenic subjects with and without tardive dyskinesia. Acta Psychiatr Scand 90 (1994) 311-315
    • (1994) Acta Psychiatr Scand , vol.90 , pp. 311-315
    • Rapaport, M.H.1    Lohr, J.B.2
  • 25
    • 0342439882 scopus 로고    scopus 로고
    • Increase in expression of adhesion molecule receptors on T helper cells during antipsychotic treatment and relationship to blood-brain barrier permeability in schizophrenia
    • Muller N., Riedel M., Hadjamu M., Schwarz M.J., Ackenheil M., and Gruber R. Increase in expression of adhesion molecule receptors on T helper cells during antipsychotic treatment and relationship to blood-brain barrier permeability in schizophrenia. Am J Psychiatry 156 (1999) 634-636
    • (1999) Am J Psychiatry , vol.156 , pp. 634-636
    • Muller, N.1    Riedel, M.2    Hadjamu, M.3    Schwarz, M.J.4    Ackenheil, M.5    Gruber, R.6
  • 26
    • 0024563415 scopus 로고
    • Aberrant T cell-mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production
    • Villemain F., Chatenoud L., Galinowski A., Homo-Delarche F., Ginestet D., Loo H., et al. Aberrant T cell-mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production. Am J Psychiatry 146 (1989) 609-616
    • (1989) Am J Psychiatry , vol.146 , pp. 609-616
    • Villemain, F.1    Chatenoud, L.2    Galinowski, A.3    Homo-Delarche, F.4    Ginestet, D.5    Loo, H.6
  • 28
    • 4444240323 scopus 로고    scopus 로고
    • Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia
    • Zhang X.Y., Zhou D.F., Cao L.Y., Zhang P.Y., Wu G.Y., and Shen Y.C. Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia. J Clin Psychiatry 65 (2004) 940-947
    • (2004) J Clin Psychiatry , vol.65 , pp. 940-947
    • Zhang, X.Y.1    Zhou, D.F.2    Cao, L.Y.3    Zhang, P.Y.4    Wu, G.Y.5    Shen, Y.C.6
  • 31
    • 0034653179 scopus 로고    scopus 로고
    • Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients
    • Schwarz M.J., Riedel M., Ackenheil M., and Muller N. Decreased levels of soluble intercellular adhesion molecule-1 (sICAM-1) in unmedicated and medicated schizophrenic patients. Biol Psychiatry 47 (2000) 29-33
    • (2000) Biol Psychiatry , vol.47 , pp. 29-33
    • Schwarz, M.J.1    Riedel, M.2    Ackenheil, M.3    Muller, N.4
  • 32
    • 0026655635 scopus 로고
    • Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia
    • Kilidireas K., Latov N., Strauss D.H., Gorig A.D., Hashim G.A., Gorman J.M., et al. Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia. Lancet 340 (1992) 569-572
    • (1992) Lancet , vol.340 , pp. 569-572
    • Kilidireas, K.1    Latov, N.2    Strauss, D.H.3    Gorig, A.D.4    Hashim, G.A.5    Gorman, J.M.6
  • 33
    • 0032968669 scopus 로고    scopus 로고
    • Antibodies to heat shock proteins in schizophrenic patients: implications for the mechanism of the disease
    • Schwarz M.J., Riedel M., Gruber R., Ackenheil M., and Muller N. Antibodies to heat shock proteins in schizophrenic patients: implications for the mechanism of the disease. Am J Psychiatry 156 (1999) 1103-1104
    • (1999) Am J Psychiatry , vol.156 , pp. 1103-1104
    • Schwarz, M.J.1    Riedel, M.2    Gruber, R.3    Ackenheil, M.4    Muller, N.5
  • 34
    • 18844454972 scopus 로고    scopus 로고
    • Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia
    • Avgustin B., Wraber B., and Tavcar R. Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia. Croat Med J 46 (2005) 268-274
    • (2005) Croat Med J , vol.46 , pp. 268-274
    • Avgustin, B.1    Wraber, B.2    Tavcar, R.3
  • 35
    • 33750701761 scopus 로고    scopus 로고
    • Riedel M, Spellmann I, Schwarz MJ, Strassnig M, Sikorski C, Moller HJ, et al. Decreased T cellular immune response in schizophrenic patients. J Psychiatr Res, in press. doi:10.1016/j.jpsychires.2005.11.007.
  • 36
    • 0035671763 scopus 로고    scopus 로고
    • Review of immunological and immunopathological findings in schizophrenia
    • Rothermundt M., Arolt V., and Bayer T.A. Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 15 (2001) 319-339
    • (2001) Brain Behav Immun , vol.15 , pp. 319-339
    • Rothermundt, M.1    Arolt, V.2    Bayer, T.A.3
  • 37
    • 0032821589 scopus 로고    scopus 로고
    • Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective
    • Lieberman J.A. Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol Psychiatry 46 (1999) 729-739
    • (1999) Biol Psychiatry , vol.46 , pp. 729-739
    • Lieberman, J.A.1
  • 38
    • 0033588276 scopus 로고    scopus 로고
    • Evidence for activation of microglia in patients with psychiatric illnesses
    • Bayer T.A., Buslei R., Havas L., and Falkai P. Evidence for activation of microglia in patients with psychiatric illnesses. Neurosci Lett 271 (1999) 126-128
    • (1999) Neurosci Lett , vol.271 , pp. 126-128
    • Bayer, T.A.1    Buslei, R.2    Havas, L.3    Falkai, P.4
  • 39
    • 0033983020 scopus 로고    scopus 로고
    • Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics
    • Radewicz K., Garey L.J., Gentleman S.M., and Reynolds R. Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. J Neuropathol Exp Neurol 59 (2000) 137-150
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 137-150
    • Radewicz, K.1    Garey, L.J.2    Gentleman, S.M.3    Reynolds, R.4
  • 40
  • 41
    • 0019481002 scopus 로고
    • Myelin basic protein antibodies in the serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients
    • Ruutiainen J., Arnadottir T., Molnar G., Salmi A., and Frey H. Myelin basic protein antibodies in the serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients. Acta Neurol Scand 64 (1981) 196-206
    • (1981) Acta Neurol Scand , vol.64 , pp. 196-206
    • Ruutiainen, J.1    Arnadottir, T.2    Molnar, G.3    Salmi, A.4    Frey, H.5
  • 44
    • 33645907194 scopus 로고    scopus 로고
    • Association of schizophrenia and autoimmune diseases: linkage of Danish national registers
    • Eaton W.W., Byrne M., Ewald H., Mors O., Chen C.Y., Agerbo E., and Mortensen P.B. Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. Am J Psychiatry 163 (2006) 521-528
    • (2006) Am J Psychiatry , vol.163 , pp. 521-528
    • Eaton, W.W.1    Byrne, M.2    Ewald, H.3    Mors, O.4    Chen, C.Y.5    Agerbo, E.6    Mortensen, P.B.7
  • 45
    • 0027325457 scopus 로고
    • Infection and autoimmunity as etiologic factors in schizophrenia: a review and reappraisal
    • Kirch D.G. Infection and autoimmunity as etiologic factors in schizophrenia: a review and reappraisal. Schizophr Bull 19 (1993) 355-370
    • (1993) Schizophr Bull , vol.19 , pp. 355-370
    • Kirch, D.G.1
  • 47
    • 32844463928 scopus 로고    scopus 로고
    • The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
    • Ashdown H., Dumont Y., Ng M., Poole S., Boksa P., and Luheshi G.N. The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia. Mol Psychiatry 11 (2006) 47-55
    • (2006) Mol Psychiatry , vol.11 , pp. 47-55
    • Ashdown, H.1    Dumont, Y.2    Ng, M.3    Poole, S.4    Boksa, P.5    Luheshi, G.N.6
  • 48
    • 28244433855 scopus 로고    scopus 로고
    • Maternal-fetal blood incompatibility and the risk of schizophrenia in offspring
    • Insel B.J., Brown A.S., Bresnahan M.A., Schaefer C.A., and Susser E.S. Maternal-fetal blood incompatibility and the risk of schizophrenia in offspring. Schizophr Res 80 (2005) 331-342
    • (2005) Schizophr Res , vol.80 , pp. 331-342
    • Insel, B.J.1    Brown, A.S.2    Bresnahan, M.A.3    Schaefer, C.A.4    Susser, E.S.5
  • 49
    • 33646831799 scopus 로고    scopus 로고
    • Immunological stress at the maternal-foetal interface: a link between neurodevelopment and adult psychopathology
    • Meyer U., Feldon J., Schedlowski M., and Yee B.K. Immunological stress at the maternal-foetal interface: a link between neurodevelopment and adult psychopathology. Brain Behav Immun 20 (2006) 378-388
    • (2006) Brain Behav Immun , vol.20 , pp. 378-388
    • Meyer, U.1    Feldon, J.2    Schedlowski, M.3    Yee, B.K.4
  • 50
    • 33644610741 scopus 로고    scopus 로고
    • Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia
    • Ozawa K., Hashimoto K., Kishimoto T., Shimizu E., Ishikura H., and Iyo M. Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry 59 (2006) 546-554
    • (2006) Biol Psychiatry , vol.59 , pp. 546-554
    • Ozawa, K.1    Hashimoto, K.2    Kishimoto, T.3    Shimizu, E.4    Ishikura, H.5    Iyo, M.6
  • 51
    • 0031558802 scopus 로고    scopus 로고
    • Seasonality of births in schizophrenia and bipolar disorder: a review of the literature
    • Torrey E.F., Miller J., Rawlings R., and Yolken R.H. Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 28 (1997) 1-38
    • (1997) Schizophr Res , vol.28 , pp. 1-38
    • Torrey, E.F.1    Miller, J.2    Rawlings, R.3    Yolken, R.H.4
  • 52
    • 33645217100 scopus 로고    scopus 로고
    • Prenatal infection as a risk factor for schizophrenia
    • Brown A.S. Prenatal infection as a risk factor for schizophrenia. Schizophr Bull 32 (2006) 200-202
    • (2006) Schizophr Bull , vol.32 , pp. 200-202
    • Brown, A.S.1
  • 53
    • 0023409074 scopus 로고
    • Herpes simplex virus antibodies in the cerebrospinal fluid of schizophrenic patients
    • Bartova L., Rajcani J., and Pogady J. Herpes simplex virus antibodies in the cerebrospinal fluid of schizophrenic patients. Acta Virol 31 (1987) 443-446
    • (1987) Acta Virol , vol.31 , pp. 443-446
    • Bartova, L.1    Rajcani, J.2    Pogady, J.3
  • 55
    • 0028047416 scopus 로고
    • Brain structure changes in schizophrenics with high serum titers of antibodies to herpes virus
    • Pandurangi A.K., Pelonero A.L., Nadel L., and Calabrese V.P. Brain structure changes in schizophrenics with high serum titers of antibodies to herpes virus. Schizophr Res 11 (1994) 245-250
    • (1994) Schizophr Res , vol.11 , pp. 245-250
    • Pandurangi, A.K.1    Pelonero, A.L.2    Nadel, L.3    Calabrese, V.P.4
  • 56
    • 0018941678 scopus 로고
    • Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients
    • Albrecht P., Torrey E.F., Boone E., Hicks J.T., and Daniel N. Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients. Lancet 2 (1980) 769-772
    • (1980) Lancet , vol.2 , pp. 769-772
    • Albrecht, P.1    Torrey, E.F.2    Boone, E.3    Hicks, J.T.4    Daniel, N.5
  • 57
    • 0020320411 scopus 로고
    • Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay
    • Torrey E.F., Yolken R.H., and Winfrey C.J. Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay. Science 216 (1982) 892-894
    • (1982) Science , vol.216 , pp. 892-894
    • Torrey, E.F.1    Yolken, R.H.2    Winfrey, C.J.3
  • 58
    • 0022981638 scopus 로고
    • Herpes simplex virus, cytomegalovirus and Epstein-Barr virus antibody titres in sera from schizophrenic patients
    • Delisi L.E., Smith S.B., Hamovit J.R., Maxwell M.E., Goldin L.R., Dingman C.W., et al. Herpes simplex virus, cytomegalovirus and Epstein-Barr virus antibody titres in sera from schizophrenic patients. Psychol Med 16 (1986) 757-763
    • (1986) Psychol Med , vol.16 , pp. 757-763
    • Delisi, L.E.1    Smith, S.B.2    Hamovit, J.R.3    Maxwell, M.E.4    Goldin, L.R.5    Dingman, C.W.6
  • 59
    • 0023949255 scopus 로고
    • Schizophrenic births and viral diseases in two states
    • Torrey E.F., Rawlings R., and Waldman I.N. Schizophrenic births and viral diseases in two states. Schizophr Res 1 (1988) 73-77
    • (1988) Schizophr Res , vol.1 , pp. 73-77
    • Torrey, E.F.1    Rawlings, R.2    Waldman, I.N.3
  • 60
    • 0033559082 scopus 로고    scopus 로고
    • Antiretroviral antibodies: implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder
    • Hart D.J., Heath R.G., Sautter Jr. F.J., Schwartz B.D., Garry R.F., Choi B., et al. Antiretroviral antibodies: implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder. Biol Psychiatry 45 (1999) 704-714
    • (1999) Biol Psychiatry , vol.45 , pp. 704-714
    • Hart, D.J.1    Heath, R.G.2    Sautter Jr., F.J.3    Schwartz, B.D.4    Garry, R.F.5    Choi, B.6
  • 62
    • 0033006691 scopus 로고    scopus 로고
    • High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan
    • Chen C.H., Chiu Y.L., Wei F.C., Koong F.J., Liu H.C., Shaw C.K., et al. High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan. Mol Psychiatry 4 (1999) 33-38
    • (1999) Mol Psychiatry , vol.4 , pp. 33-38
    • Chen, C.H.1    Chiu, Y.L.2    Wei, F.C.3    Koong, F.J.4    Liu, H.C.5    Shaw, C.K.6
  • 64
    • 0025996766 scopus 로고
    • Elevated IGG and IGM anticardiolipin antibodies in a subgroup of medicated and unmedicated schizophrenic patients
    • Chengappa K.N., Carpenter A.B., Keshavan M.S., Yang Z.W., Kelly R.H., Rabin B.S., et al. Elevated IGG and IGM anticardiolipin antibodies in a subgroup of medicated and unmedicated schizophrenic patients. Biol Psychiatry 30 (1991) 731-735
    • (1991) Biol Psychiatry , vol.30 , pp. 731-735
    • Chengappa, K.N.1    Carpenter, A.B.2    Keshavan, M.S.3    Yang, Z.W.4    Kelly, R.H.5    Rabin, B.S.6
  • 65
    • 0028324385 scopus 로고
    • Anticardiolipin antibodies are elevated in drug-free, multiply affected families with schizophrenia
    • Firer M., Sirota P., Schild K., Elizur A., and Slor H. Anticardiolipin antibodies are elevated in drug-free, multiply affected families with schizophrenia. J Clin Immunol 14 (1994) 73-78
    • (1994) J Clin Immunol , vol.14 , pp. 73-78
    • Firer, M.1    Sirota, P.2    Schild, K.3    Elizur, A.4    Slor, H.5
  • 66
    • 0026526315 scopus 로고
    • Antinuclear and gastric parietal cell autoantibodies in schizophrenic patients
    • Ganguli R., Rabin B.S., and Brar J.S. Antinuclear and gastric parietal cell autoantibodies in schizophrenic patients. Biol Psychiatry 32 (1992) 735-738
    • (1992) Biol Psychiatry , vol.32 , pp. 735-738
    • Ganguli, R.1    Rabin, B.S.2    Brar, J.S.3
  • 69
    • 0026528349 scopus 로고
    • Autoantibodies to brain and polynucleotides in patients with schizophrenia: a puzzle
    • Teplizki H.A., Sela B., and Shoenfeld Y. Autoantibodies to brain and polynucleotides in patients with schizophrenia: a puzzle. Immunol Res 11 (1992) 66-73
    • (1992) Immunol Res , vol.11 , pp. 66-73
    • Teplizki, H.A.1    Sela, B.2    Shoenfeld, Y.3
  • 70
    • 33644990839 scopus 로고    scopus 로고
    • Loss of autoimmune T cells correlates with brain diseases: possible implications for schizophrenia?
    • Kipnis J., Cardon M., Strous R.D., and Schwartz M. Loss of autoimmune T cells correlates with brain diseases: possible implications for schizophrenia?. Trends Mol Med 12 (2006) 107-112
    • (2006) Trends Mol Med , vol.12 , pp. 107-112
    • Kipnis, J.1    Cardon, M.2    Strous, R.D.3    Schwartz, M.4
  • 71
    • 2542596271 scopus 로고    scopus 로고
    • T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    • Kipnis J., Cohen H., Cardon M., Ziv Y., and Schwartz M. T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc Natl Acad Sci U S A 101 (2004) 8180-8185
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8180-8185
    • Kipnis, J.1    Cohen, H.2    Cardon, M.3    Ziv, Y.4    Schwartz, M.5
  • 72
    • 33645901208 scopus 로고    scopus 로고
    • Association between the CCR5 32-bp deletion allele and late onset of schizophrenia
    • Rasmussen H.B., Timm S., Wang A.G., Soeby K., Lublin H., Fenger M., et al. Association between the CCR5 32-bp deletion allele and late onset of schizophrenia. Am J Psychiatry 163 (2006) 507-511
    • (2006) Am J Psychiatry , vol.163 , pp. 507-511
    • Rasmussen, H.B.1    Timm, S.2    Wang, A.G.3    Soeby, K.4    Lublin, H.5    Fenger, M.6
  • 74
    • 17244369095 scopus 로고    scopus 로고
    • ICAM G241A polymorphism and soluble ICAM-1 serum levels: evidence for an active immune process in schizophrenia
    • Kronig H., Riedel M., Schwarz M.J., Strassnig M., Moller H.J., Ackenheil M., et al. ICAM G241A polymorphism and soluble ICAM-1 serum levels: evidence for an active immune process in schizophrenia. Neuroimmunomodulation 12 (2005) 54-59
    • (2005) Neuroimmunomodulation , vol.12 , pp. 54-59
    • Kronig, H.1    Riedel, M.2    Schwarz, M.J.3    Strassnig, M.4    Moller, H.J.5    Ackenheil, M.6
  • 75
    • 4444308550 scopus 로고    scopus 로고
    • An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population
    • Yu L., Yang M.S., Zhao J., Shi Y.Y., Zhao X.Z., Yang J.D., et al. An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population. Schizophr Res 71 (2004) 179-183
    • (2004) Schizophr Res , vol.71 , pp. 179-183
    • Yu, L.1    Yang, M.S.2    Zhao, J.3    Shi, Y.Y.4    Zhao, X.Z.5    Yang, J.D.6
  • 76
    • 9444234453 scopus 로고    scopus 로고
    • Dopaminergic regulation of immune cells via D3 dopamine receptor: a pathway mediated by activated T cells
    • Ilani T., Strous R.D., and Fuchs S. Dopaminergic regulation of immune cells via D3 dopamine receptor: a pathway mediated by activated T cells. FASEB J 18 (2004) 1600-1602
    • (2004) FASEB J , vol.18 , pp. 1600-1602
    • Ilani, T.1    Strous, R.D.2    Fuchs, S.3
  • 77
    • 33744735362 scopus 로고    scopus 로고
    • Dopamine D3 receptor and schizophrenia: A widened scope for the immune hypothesis
    • Vogel M., Busse S., Freyberger H.J., and Grabe H.J. Dopamine D3 receptor and schizophrenia: A widened scope for the immune hypothesis. Med Hypotheses 67 (2006) 354-358
    • (2006) Med Hypotheses , vol.67 , pp. 354-358
    • Vogel, M.1    Busse, S.2    Freyberger, H.J.3    Grabe, H.J.4
  • 78
    • 13144279297 scopus 로고    scopus 로고
    • Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?
    • Jones A.L., Mowry B.J., Pender M.P., and Greer J.M. Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?. Immunol Cell Biol 83 (2005) 9-17
    • (2005) Immunol Cell Biol , vol.83 , pp. 9-17
    • Jones, A.L.1    Mowry, B.J.2    Pender, M.P.3    Greer, J.M.4
  • 79
    • 13844276635 scopus 로고    scopus 로고
    • Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring
    • Zuckerman L., and Weiner I. Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J Psychiatr Res 39 (2005) 311-323
    • (2005) J Psychiatr Res , vol.39 , pp. 311-323
    • Zuckerman, L.1    Weiner, I.2
  • 81
    • 0002119171 scopus 로고
    • Phenothiazine effect on human antibody synthesis
    • Saunders J.C., and Muchmore E. Phenothiazine effect on human antibody synthesis. Br J Psychiatry 110 (1964) 84-89
    • (1964) Br J Psychiatry , vol.110 , pp. 84-89
    • Saunders, J.C.1    Muchmore, E.2
  • 82
    • 0030872320 scopus 로고    scopus 로고
    • Short and long-term immunosuppressive effects of clozapine and haloperidol
    • Leykin I., Mayer R., and Shinitzky M. Short and long-term immunosuppressive effects of clozapine and haloperidol. Immunopharmacology 37 (1997) 75-86
    • (1997) Immunopharmacology , vol.37 , pp. 75-86
    • Leykin, I.1    Mayer, R.2    Shinitzky, M.3
  • 83
    • 0028820554 scopus 로고
    • Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors
    • Pollmacher T., Hinze-Selch D., Mullington J., and Holsboer F. Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors. Arch Gen Psychiatry 52 (1995) 877-878
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 877-878
    • Pollmacher, T.1    Hinze-Selch, D.2    Mullington, J.3    Holsboer, F.4
  • 84
    • 0027523694 scopus 로고
    • T-cells and psychopathology in schizophrenia: relationship to the outcome of neuroleptic therapy
    • Muller N., Hofschuster E., Ackenheil M., and Eckstein R. T-cells and psychopathology in schizophrenia: relationship to the outcome of neuroleptic therapy. Acta Psychiatr Scand 87 (1993) 66-71
    • (1993) Acta Psychiatr Scand , vol.87 , pp. 66-71
    • Muller, N.1    Hofschuster, E.2    Ackenheil, M.3    Eckstein, R.4
  • 85
    • 0031434889 scopus 로고    scopus 로고
    • Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia
    • Muller N., Empl M., Riedel M., Schwarz M., and Ackenheil M. Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia. Eur Arch Psychiatry Clin Neurosci 247 (1997) 308-313
    • (1997) Eur Arch Psychiatry Clin Neurosci , vol.247 , pp. 308-313
    • Muller, N.1    Empl, M.2    Riedel, M.3    Schwarz, M.4    Ackenheil, M.5
  • 86
    • 0025351623 scopus 로고
    • Lymphocyte subsets in schizophrenic disorders. Relationship with clinical, neuromorphological and treatment variables
    • Masserini C., Vita A., Basile R., Morselli R., Boato P., Peruzzi C., et al. Lymphocyte subsets in schizophrenic disorders. Relationship with clinical, neuromorphological and treatment variables. Schizophr Res 3 (1990) 269-275
    • (1990) Schizophr Res , vol.3 , pp. 269-275
    • Masserini, C.1    Vita, A.2    Basile, R.3    Morselli, R.4    Boato, P.5    Peruzzi, C.6
  • 87
    • 17444417493 scopus 로고    scopus 로고
    • Effect of neuroleptic administration on serum levels of soluble IL-2 receptor-alpha and IL-1 receptor antagonist in schizophrenic patients
    • Sirota P., Meiman M., Herschko R., and Bessler H. Effect of neuroleptic administration on serum levels of soluble IL-2 receptor-alpha and IL-1 receptor antagonist in schizophrenic patients. Psychiatry Res 134 (2005) 151-159
    • (2005) Psychiatry Res , vol.134 , pp. 151-159
    • Sirota, P.1    Meiman, M.2    Herschko, R.3    Bessler, H.4
  • 88
    • 25444433811 scopus 로고    scopus 로고
    • Anticytokine therapy, especially anti-interferon-{gamma}, as a pathogenetic treatment in TH-1 autoimmune diseases
    • Skurkovich S., and Skurkovich B. Anticytokine therapy, especially anti-interferon-{gamma}, as a pathogenetic treatment in TH-1 autoimmune diseases. Ann NY Acad Sci 1051 (2005) 684-700
    • (2005) Ann NY Acad Sci , vol.1051 , pp. 684-700
    • Skurkovich, S.1    Skurkovich, B.2
  • 89
    • 23744461373 scopus 로고    scopus 로고
    • Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications
    • Sperner-Unterweger B. Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications. Drugs 65 (2005) 1493-1520
    • (2005) Drugs , vol.65 , pp. 1493-1520
    • Sperner-Unterweger, B.1
  • 90
    • 0037300753 scopus 로고    scopus 로고
    • Anti-interferon-gamma antibodies in the treatment of autoimmune diseases
    • Skurkovich B., and Skurkovich S. Anti-interferon-gamma antibodies in the treatment of autoimmune diseases. Curr Opin Mol Ther 5 (2003) 52-57
    • (2003) Curr Opin Mol Ther , vol.5 , pp. 52-57
    • Skurkovich, B.1    Skurkovich, S.2
  • 91
    • 0030764538 scopus 로고    scopus 로고
    • Natural antibodies to interferon-gamma
    • Caruso A., and Turano A. Natural antibodies to interferon-gamma. Biotherapy 10 (1997) 29-37
    • (1997) Biotherapy , vol.10 , pp. 29-37
    • Caruso, A.1    Turano, A.2
  • 92
    • 0030093270 scopus 로고    scopus 로고
    • Differences in the natural autoantibody patterns of patients with schizophrenia and normal individuals
    • Levy-Soussan P., Berneman A., Poirier M.F., Galinowski A., Loo H., Olie J.P., et al. Differences in the natural autoantibody patterns of patients with schizophrenia and normal individuals. J Psychiatry Neurosci 21 (1996) 89-95
    • (1996) J Psychiatry Neurosci , vol.21 , pp. 89-95
    • Levy-Soussan, P.1    Berneman, A.2    Poirier, M.F.3    Galinowski, A.4    Loo, H.5    Olie, J.P.6
  • 94
    • 8844287740 scopus 로고    scopus 로고
    • Psychotropic effects of COX-2 inhibitors-a possible new approach for the treatment of psychiatric disorders
    • Muller N., Riedel M., and Schwarz M.J. Psychotropic effects of COX-2 inhibitors-a possible new approach for the treatment of psychiatric disorders. Pharmacopsychiatry 37 (2004) 266-269
    • (2004) Pharmacopsychiatry , vol.37 , pp. 266-269
    • Muller, N.1    Riedel, M.2    Schwarz, M.J.3
  • 95
    • 31344446924 scopus 로고    scopus 로고
    • COX-2 inhibitors as adjunctive therapy in schizophrenia: rationale for use and evidence to date
    • Riedel M., Strassnig M., Schwarz M.J., and Muller N. COX-2 inhibitors as adjunctive therapy in schizophrenia: rationale for use and evidence to date. CNS Drugs 19 (2005) 805-819
    • (2005) CNS Drugs , vol.19 , pp. 805-819
    • Riedel, M.1    Strassnig, M.2    Schwarz, M.J.3    Muller, N.4
  • 96
    • 0037264969 scopus 로고    scopus 로고
    • Therapeutic antibodies for human diseases at the dawn of the twenty-first century
    • Brekke O.H., and Sandlie I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat Rev Drug Discov 2 (2003) 52-62
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 52-62
    • Brekke, O.H.1    Sandlie, I.2
  • 97
    • 24744468469 scopus 로고    scopus 로고
    • Anti-ribosomal P-protein and its role in psychiatric manifestations of systemic lupus erythematosus: myth or reality?
    • Ebert T., Chapman J., and Shoenfeld Y. Anti-ribosomal P-protein and its role in psychiatric manifestations of systemic lupus erythematosus: myth or reality?. Lupus 14 (2005) 571-575
    • (2005) Lupus , vol.14 , pp. 571-575
    • Ebert, T.1    Chapman, J.2    Shoenfeld, Y.3
  • 98
    • 0035863268 scopus 로고    scopus 로고
    • Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients
    • Theodoropoulou S., Spanakos G., Baxevanis C.N., Economou M., Gritzapis A.D., Papamichail M.P., et al. Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients. Schizophr Res 47 (2001) 13-25
    • (2001) Schizophr Res , vol.47 , pp. 13-25
    • Theodoropoulou, S.1    Spanakos, G.2    Baxevanis, C.N.3    Economou, M.4    Gritzapis, A.D.5    Papamichail, M.P.6
  • 99
    • 0030596090 scopus 로고    scopus 로고
    • Increased production of interleukin-2 (IL-2) but not soluble interleukin-2 receptors (sIL-2R) in unmedicated patients with schizophrenia and schizophreniform disorder
    • O'Donnell M.C., Catts S.V., Ward P.B., Liebert B., Lloyd A., Wakefield D., et al. Increased production of interleukin-2 (IL-2) but not soluble interleukin-2 receptors (sIL-2R) in unmedicated patients with schizophrenia and schizophreniform disorder. Psychiatry Res 65 (1996) 171-178
    • (1996) Psychiatry Res , vol.65 , pp. 171-178
    • O'Donnell, M.C.1    Catts, S.V.2    Ward, P.B.3    Liebert, B.4    Lloyd, A.5    Wakefield, D.6
  • 100
    • 0029113540 scopus 로고
    • Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status
    • McAllister C.G., van Kammen D.P., Rehn T.J., Miller A.L., Gurklis J., Kelley M.E., et al. Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status. Am J Psychiatry 152 (1995) 1291-1297
    • (1995) Am J Psychiatry , vol.152 , pp. 1291-1297
    • McAllister, C.G.1    van Kammen, D.P.2    Rehn, T.J.3    Miller, A.L.4    Gurklis, J.5    Kelley, M.E.6
  • 101
    • 0029157792 scopus 로고
    • Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. The influence of age at onset and negative symptoms
    • Ganguli R., Brar J.S., Chengappa K.R., DeLeo M., Yang Z.W., Shurin G., et al. Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. The influence of age at onset and negative symptoms. Arch Gen Psychiatry 52 (1995) 668-672
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 668-672
    • Ganguli, R.1    Brar, J.S.2    Chengappa, K.R.3    DeLeo, M.4    Yang, Z.W.5    Shurin, G.6
  • 103
    • 0030570544 scopus 로고    scopus 로고
    • Elevated circulating levels of IL-6 in schizophrenia
    • Naudin J., Mege J.L., Azorin J.M., and Dassa D. Elevated circulating levels of IL-6 in schizophrenia. Schizophr Res 20 (1996) 269-273
    • (1996) Schizophr Res , vol.20 , pp. 269-273
    • Naudin, J.1    Mege, J.L.2    Azorin, J.M.3    Dassa, D.4
  • 104
    • 0034283785 scopus 로고    scopus 로고
    • Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics
    • Kim Y.K., Kim L., and Lee M.S. Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics. Schizophr Res 44 (2000) 165-175
    • (2000) Schizophr Res , vol.44 , pp. 165-175
    • Kim, Y.K.1    Kim, L.2    Lee, M.S.3
  • 105
    • 0042470703 scopus 로고    scopus 로고
    • Serum cytokine level and production of reactive oxygen species (ROS) by blood neutrophils from a schizophrenic patient with hypersensitivity to neuroleptics
    • Kaminska T., Szuster-Ciesielska A., Wysocka A., Marmurowska-Michalowska H., Dubas-Slemp H., and Kandefer-Szerszen M. Serum cytokine level and production of reactive oxygen species (ROS) by blood neutrophils from a schizophrenic patient with hypersensitivity to neuroleptics. Med Sci Monit 9 (2003) CS71-CS75
    • (2003) Med Sci Monit , vol.9
    • Kaminska, T.1    Szuster-Ciesielska, A.2    Wysocka, A.3    Marmurowska-Michalowska, H.4    Dubas-Slemp, H.5    Kandefer-Szerszen, M.6
  • 106
    • 0034742546 scopus 로고    scopus 로고
    • Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment
    • Erbagci A.B., Herken H., Koyluoglu O., Yilmaz N., and Tarakcioglu M. Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment. Mediators Inflamm 10 (2001) 109-115
    • (2001) Mediators Inflamm , vol.10 , pp. 109-115
    • Erbagci, A.B.1    Herken, H.2    Koyluoglu, O.3    Yilmaz, N.4    Tarakcioglu, M.5


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