Loss of autoimmune T cells correlates with brain diseases: Possible implications for schizophrenia?

Trends in Molecular Medicine

Volumn 12, Issue 3, 2006, Pages 107-112

  Kipnis, Jonathan ^a,b   Cardon, Michal ^a   Strous, Rael D ^c,d   Schwartz, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c BEER YAAKOV MENTAL HEALTH CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; MYELIN BASIC PROTEIN;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; BRAIN DISEASE; CELLULAR IMMUNITY; COGNITION; DEGENERATIVE DISEASE; DISEASE COURSE; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; NERVE CELL DIFFERENTIATION; NEUROPHYSIOLOGY; NONHUMAN; REVIEW; RODENT; SCHIZOPHRENIA; T LYMPHOCYTE;

RODENTIA;

EID: 33644990839     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2006.01.003     Document Type: Article

References (55)

1. G. Moalem Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy Nat. Med. 5 1999 49 55
2. E. Yoles Protective autoimmunity is a physiological response to CNS trauma J. Neurosci. 21 2001 3740 3748
3. + regulatory T cells suppress the ability to withstand injury to the central nervous system Proc. Natl. Acad. Sci. U. S. A. 99 2002 15620 15625
4. M. Schwartz, and J. Kipnis Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries Trends Mol. Med. 7 2001 252 258
5. J. Kipnis T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions Proc. Natl. Acad. Sci. U. S. A. 101 2004 8180 8185
6. I.R. Cohen, and D.B. Young Autoimmunity, microbial immunity and the immunological homunculus Immunol. Today 12 1991 105 110
7. + T cell memory: lifelong persistence of encephalitogenic T cell clones in healthy immune repertoire J. Immunol. 175 2005 69 81
8. Ziv, Y. et al. (2006) Immune Cells Contribute to the Maintenance of Neurogenesis and Spatial learning abilities in Adulthood. Nat. Neurosci. doi:10.1038/nn1629
9. + regulatory T-cell activity: implications for neurodegeneration J. Neurosci. 24 2004 6133 6143
10. L. de Haan, and J.M. Bakker Overview of neuropathological theories of schizophrenia: from degeneration to progressive developmental disorder Psychopathology 37 2004 1 7
11. A.W. Grossman Experience effects on brain development: possible contributions to psychopathology J. Child Psychol. Psychiatry 44 2003 33 63
12. S.E. Arnold Neurodevelopmental abnormalities in schizophrenia: insights from neuropathology Dev. Psychopathol. 11 1999 439 456
13. J.A. Lieberman Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective Biol. Psychiatry 46 1999 729 739
14. S.E. Arnold Cognition and neuropathology in schizophrenia Acta Psychiatr. Scand. Suppl. 395 1999 41 50
15. L. Brent The discovery of immunologic tolerance Hum. Immunol. 52 1997 75 81
16. A.W. Lohse Estimation of the frequency of self-reactive T cells in health and inflammatory diseases by limiting dilution analysis and single cell cloning J. Autoimmun. 9 1996 667 675
17. S. Sakaguchi T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases J. Autoimmun. 9 1996 211 220
18. + T cells: a common basis between tumor immunity and autoimmunity J. Immunol. 163 1999 5211 5218
19. J. Lieberman Longitudinal study of brain morphology in first episode schizophrenia Biol. Psychiatry 49 2001 487 499
20. D. Velakoulis Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study Arch. Gen. Psychiatry 56 1999 133 141
21. R.E. McCullumsmith, and J.H. Meador-Woodruff Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder Neuropsychopharmacology 26 2002 368 375
22. D.A. Lewis Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia Biol. Psychiatry 46 1999 616 626
23. L.M. Brzustowicz Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22 Hum. Hered. 54 2002 199 209
24. P. Falkai Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study Eur. Arch. Psychiatry Clin. Neurosci. 253 2003 92 99
25. D.C. Javitt Treatment of negative and cognitive symptoms Curr. Psychiatry Rep. 1 1999 25 30
26. C. Rummel New generation antipsychotics for first episode schizophrenia Cochrane Database Syst. Rev. 4 2003 CD004410
27. E.R. de Kloet Hormones, brain and stress Endocr. Regul. 37 2003 51 68
28. P.G. Popovich Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system J. Neurosci. Res. 45 1996 349 363
29. P.G. Popovich Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats J. Comp. Neurol. 377 1997 443 464
30. E. Hauben Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease J. Clin. Invest. 108 2001 591 599
31. T. Mizrahi The tissue-specific self-pathogen is the protective self-antigen: the case of uveitis J. Immunol. 169 2002 5971 5977
32. M. Cosentino Assessment of lymphocyte subsets and neutrophil leukocyte function in chronic psychiatric patients on long-term drug therapy Prog. Neuropsychopharmacol. Biol. Psychiatry 20 1996 1117 1129
33. R. Ganguli Clinical and laboratory evidence of autoimmunity in acute schizophrenia Ann. N. Y. Acad. Sci. 496 1987 676 685
34. M.H. Rapaport Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins Eur. Arch. Psychiatry Clin. Neurosci. 243 1993 7 10
35. T. Ilani A peripheral marker for schizophrenia: increased levels of D3 dopamine receptor mRNA in blood lymphocytes Proc. Natl. Acad. Sci. U. S. A. 98 2001 625 628
36. S. Noy Schizophrenia and autoimmunity - a possible etiological mechanism? Neuropsychobiology 30 1994 157 159
37. A. Fontana An immunological basis of schizophrenia and affective disorders? Neuropsychobiology 6 1980 284 289
38. J. Knight Can autoimmune mechanisms account for the genetic predisposition to schizophrenia? Br. J. Psychiatry 160 1992 533 540
39. O. Abramsky, and Y. Litvin Automimmune response to dopamine-receptor as a possible mechanism in the pathogenesis of Parkinson's disease and schizophrenia Perspect. Biol. Med. 22 1978 104 114
40. T. Sato Psychopathology of early-onset versus late-onset schizophrenia revisited: an observation of 473 neuroleptic-naive patients before and after first-admission treatments Schizophr. Res. 67 2004 175 183
41. S. Bellino Relationships of age at onset with clinical features and cognitive functions in a sample of schizophrenia patients J. Clin. Psychiatry 65 2004 908 914
42. D.J. Castle Rates of schizophrenia among males and females Am. J. Psychiatry 150 1993 1431 1432
43. L.E. DeLisi The significance of age of onset for schizophrenia Schizophr. Bull. 18 1992 209 215
44. A.E. Harris Physical disease and schizophrenia Schizophr. Bull. 14 1988 85 96
45. J.M. Goldstein, and B.G. Link Gender and the expression of schizophrenia J. Psychiatr. Res. 22 1988 141 155
46. R.R. Lewine Sex differences in schizophrenia: timing or subtypes? Psychol. Bull. 90 1981 432 434
47. B.D. Jankovic, and D. Djordjijevic Differential appearance of autoantibodies to human brain S100 protein, neuron specific enolase and myelin basic protein in psychiatric patients Int. J. Neurosci. 60 1991 119 127
48. N. Mueller Cellular immunity in schizophrenic patients before and during neuroleptic treatment Psychiatry Res. 37 1991 147 160
49. O. Butovsky Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation FASEB J. 15 2001 1065 1067
50. E. Hauben Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion J. Neurosci. 20 2000 6421 6430
51. R.H. Yolken, and E.F. Torrey Viruses, schizophrenia, and bipolar disorder Clin. Microbiol. Rev. 8 1995 131 145
52. E.F. Torrey, and R.H. Yolken Could schizophrenia be a viral zoonosis transmitted from house cats? Schizophr. Bull. 21 1995 167 171
53. H. Schori Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma Proc. Natl. Acad. Sci. U. S. A. 98 2001 3398 3403
54. P. Seeman Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases Neuropsychopharmacology 1 1987 5 15
55. J.W. Dennert, and N.C. Andreasen CT scanning and schizophrenia: a review Psychiatr. Dev. 1 1983 105 122