Increased production of interleukin-2 (IL-2) but not soluble interleukin-2 receptors (sIL-2R) in unmedicated patients with schizophrenia and schizophreniform disorder

Psychiatry Research

Volumn 65, Issue 3, 1996, Pages 171-178

  O'Donnell, Maryanne C ^a,b   Catts, Stanley V ^a,b   Ward, Philip B ^a,b   Liebert, Barbara ^b   Lloyd, Andrew ^a   Wakefield, Denis ^a   McConaghy, Neil ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

interleukin 2; schizophrenia; soluble interleukin 2 receptors

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ADULT; ARTICLE; BEHAVIOR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNITY; LYMPHOCYTE; MALE; PRIORITY JOURNAL; SCHIZOIDISM; SCHIZOPHRENIA; THOUGHT DISORDER;

ADULT; FEMALE; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; RECEPTORS, INTERLEUKIN-2; REFERENCE VALUES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0030596090     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(96)02824-7     Document Type: Article

References (43)

1. 3H]dopamine in rat cultured mesencephalic cells. J Neurochem 61, 1284-1290.
2. American Psychiatric Association (1987) DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders. 3rd Edn., Revised. American Psychiatric Press, Washington, DC.
3. Andreasen, N.C. (1984a) Scale for the Assessment of Positive Symptoms. University of Iowa, Iowa City, IA.
4. Andreasen, N.C. (1984b) Scale for the Assessment of Negative Symptoms. University of Iowa, Iowa City, IA.
5. Araujo, D.M., Lapchak, P.A., Collier, B. and Quirion, R. (1989) Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system. Brain Res 498, 257-266.
6. Bartfai, T. and Schultzberg, M. (1993) Cytokines in neuronal cell types. (Review). Neurochem Int 22, 435-444.
7. Becker, D., Kritschmann, E., Floru, S., Shlomo-David, Y. and Gotlieb-Stematsky, T. (1990) Serum interferon in first psychotic attack. Br J Psychiatry 157, 136-138.
8. Boukhris, W., Kouassi, E. and Revillard, J.P. (1988) Differential effect of mixed D1/D2 and selective D2 dopaminergic antagonists on mouse T and B lymphocyte proliferation and interleukin production in vitro. Immunopharmacol Immunotoxicol 10, 501-512.
9. Campen, D.H., Horwitz, D.A., Quismorio, F.P. Jr., Ehresmann, G.R. and Martin, W.J. (1988) Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation. Arthritis Rheum 31, 1358-1364.
10. Carlsson, M. and Carlsson, A. (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia: implications for schizophrenia and Parkinson's disease. Trends Neurosci 13, 272-276.
11. Curry, S.H. (1976) Metabolism and kinetics of chlorpromazine in relation to effect. In: Sedvall, G., Uvnas, B. and Zutterman, Y. (Eds.), Antipsychotic Drugs: Pharmacodynamics and Pharmacokinetics. Pergamon, Oxford.
12. Dobbin, J.P., Harth, M., McCain, G.A., Martin, R.A. and Cousin, K. (1991) Cytokine production and lymphocyte transformation during stress. Brain Behav Immun 5, 339-348.
13. Dunbar, P.R., Hill, J., Neale, T.J. and Mellsop, G.W. (1992) Neopterin measurement provides evidence of altered cell-mediated immunity in patients with depression, but not with schizophrenia. Psychol Med 22, 1051-1057.
14. Ganguli, R., Brar, J.S., Chengappa, K.N., Yang, Z.W., Nimgaonkar, V.L. and Rabin, B.S. (1993) Autoimmunity in schizophrenia: a review of recent findings. Ann Med 25, 489-496.
15. Ganguli, R., Brar, J.S., Solomon, W., Chengappa, K.N. and Rabin, B.S. (1992) Altered interleukin-2 production in schizophrenia: association between clinical state and autoantibody production. Psychiatry Res 44, 113-123.
16. Ganguli, R. and Rabin, B.S. (1989) Increased serum interleukin 2 receptor concentration in schizophrenic and brain-damaged subjects (letter). Arch Gen Psychiatry 46, 292.
17. Ganguli, R., Rabin, B.S. and Belle, S.H. (1989) Decreased interleukin-2 production in schizophrenic patients. Biol Psychiatry 26, 427-430.
18. Gattaz, W.F., Dalgalarrondo, P. and Schroder, H.C. (1992) Abnormalities in serum concentrations of interleukin-2, interferon-alpha and interferon-gamma in schizophrenia not detected. Schizophr Res 6, 237-241.
19. Hanisch, U.K., Seto, D. and Quirion, R. (1993) Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2. J Neurosci 13, 3368-3374.
20. Katila, H., Appelberg, B., Hurme, M. and Rimon, R. (1993) Plasma levels of interleukin-6 in schizophrenia, other psychoses, and affective disorders. Schizophr Res 12, 29-34.
21. Kim, J.S., Kornhuber, H.H., Schmid-Burgk, W. and Holzmuller, B. (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20, 379-382.
22. Knight, J.G. (1982) Dopamine-receptor-stimulating autoantibodies: a possible cause of schizophrenia. Lancet 2 (8307), 1073-1076.
23. Knight, J.G. (1984) Is schizophrenia an autoimmune disease? A review. Methods Find Exp Clin Pharmacol 6, 395-403.
24. Kroemer, G. and Wick, G. (1989) The role of interleukin 2 in autoimmunity. Immunol Today 10, 246-251.
25. Lapchak, P.A. (1992) A role for interleukin-2 in the regulation of striatal dopaminergic function. Neuroreport 3, 165-168.
26. Lapchak, P.A., Araujo, D.M., Quirion, R. and Beaudet, A. (1991) Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain. Neuroscience 44, 173-184.
27. Lukoff, D., Liberman, R.P. and Nuechterlein, K.H. (1986) Symptom monitoring in the rehabilitation of schizophrenic patients. Schizophr Bull 12, 578-602.
28. Müller, N., Ackenheil, M., Hofschuster, E., Mempel, W. and Eckstein, R. (1991) Cellular immunity in schizophrenic patients before and during neuroleptic treatment. Psychiatry Res 37, 147-160.
29. Nistico, G. (1993) Communications among central nervous system, neuroendocrine and immune systems: interleukin-2. Prog Neurobiol 40, 463-475.
30. Nistico, G. and De Sarro, G. (1991) Is interleukin 2 a neuromodulator in the brain? Trends Neurosci 14, 146-150.
31. Oppenheim, J.J., Rusceth, F.W. and Faltynek, C. (1991) Cytokines. In: Stites, D.P. and Terr Abba, I. (Eds.), Basic and Clinical Immunology. Prentice-Hall, London, pp. 78-100.
32. Plata-Salaman, C.R. and Ffrench-Mullen, J.M. (1993) Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons. Neuroreport 4, 579-581.
33. Rapaport, M.H., McAllister, C.G., Pickar, D., Nelson, D.L. and Paul, S.M. (1989) Elevated levels of soluble interleukin 2 receptors in schizophrenia (letter). Arch Gen Psychiatry 46, 291-292.
34. Rapaport, M.H., Torrey, E.F., McAllister, C.G., Nelson, D.L., Pickar, D. and Paul, S.M. (1993) Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins. Eur Arch Psychiatry Clin Neurosci 243, 7-10.
35. Rubin, L.A. and Nelson, D.L. (1990) The soluble interleukin-2 receptor: biology, function, and clinical application. Ann Intern Med 113, 619-627.
36. Sirota, P., Fishman, P., Elizur, A. and Djaldetty, M. (1986) Lymphokine production in schizophrenic patients. Biol Psychiatry Suppl 27, 118A.
37. Spitzer, R.L., Williams, J.B.W., Gibbon, M. and First, M.B. (1990) Structured Clinical Interview for DSM-III-R - Non-Patient Edition (SCID-NP, version 1.0). American Psychiatric Press, Washington, DC.
38. Tancredi, V., Zona, C., Velotti, F., Eusebi, F. and Santoni, A. (1990) Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. Brain Res 525, 149-151.
39. Tollerud, D.J., Weiss, S.T. and Leung, D.Y. (1992) Elevated soluble interleukin-2 receptors in young healthy cigarette smokers: lack of association with atopy or airways hyperresponsiveness. Int Arch Allergy Immunol 97, 25-30.
40. Villemain, F., Chatenoud, L., Galinowski, A., Homo-Delarche, F., Ginestet, D., Zarifian, E. and Bach, J.F. (1989) Aberrant T cell-mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production. Am J Psychiatry 146, 609-616.
41. Waldmann, T.A. (1991) The interleukin-2 receptor. J Biol Chem 266, 2681-2684.
42. Warrington, R.J. (1988) Interleukin-2 abnormalities in systemic lupus erythematosus and rheumatoid arthritis. A role for overproduction of interleukin-2 in human autoimmunity? J Rheumatol 15, 616-620.
43. Wolf, R.E. and Brelsford, W.G. (1988) Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum 31, 729-735.