Functional characterization of sodium channel blockers by membrane potential measurements in cerebellar neurons: Prediction of compound preference for the open/inactivated state

Neurochemistry International

Volumn 49, Issue 6, 2006, Pages 593-604

  Kolok, Sándor ^a   Nagy, József ^a   Szombathelyi, Zsolt ^a   Tarnawa, István ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

Cerebellar neurons; GBR 12909; Membrane potential fluorometry; Sodium channel blockers; Veratridine

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; CARBAMAZEPINE; DIZOCILPINE; LAMOTRIGINE; LIDOCAINE; OMEGA CONOTOXIN; PHENYTOIN; SNX 482; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VANOXERINE; VERATRIDINE; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOASSAY; BRAIN NERVE CELL; CELL MEMBRANE DEPOLARIZATION; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; FETUS; INCUBATION TIME; INHIBITION KINETICS; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NEUROPHARMACOLOGY; NONHUMAN; PHARMACODYNAMICS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; CEREBELLUM; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGY; EVOKED POTENTIALS; FLUOROMETRY; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; NEURONS; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; VERATRIDINE;

EID: 33749510649     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2006.04.014     Document Type: Article

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