Vinpocetine blockade of sodium channels inhibits the rise in sodium and calcium induced by 4-aminopyridine in synaptosomes

Neurochemistry International

Volumn 46, Issue 7, 2005, Pages 533-540

  Sitges, María ^a   Galván, Emilio ^a   Nekrassov, Vladimir ^b  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^b HOSPITAL GENERAL DE MÉXICO   (Mexico)

Author keywords

Anticonvulsant; Calcium channels; Sodium channels; Synaptosomes; Tetrodotoxin

Indexed keywords

4 AMINOPYRIDINE; BENZOFURAN DERIVATIVE; BENZOFURAN ISOPHTHALATE; CALCIUM CHANNEL; CALCIUM ION; CONVULSANT AGENT; FURA 2; POTASSIUM ION; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION; TETRODOTOXIN; UNCLASSIFIED DRUG; VINPOCETINE; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; CYTOSOL; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG SENSITIVITY; FLUOROMETRY; INHIBITION KINETICS; MALE; NERVE ENDING; NERVE EXCITABILITY; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

EID: 17444415714     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.02.001     Document Type: Article

References (29)

1. A.F. Ambrosio, A.P. Silva, J.O. Malva, P. Soares-da-Silva, A.P. Carvalho, and C.M. Carvalho Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels Biochem. Pharmacol. 61 2001 1271 1275
2. V. Armand, P. Hoffmann, M. Vergnes, and U. Heinemann Epileptiform activity induced by 4-aminopyridine in entorhinal cortex hippocampal slices of rats with a genetically determined absence epilepsy (GAERS) Brain Res. 841 1999 62 69
3. R. Dohovics, R. Janáky, V. Varga, P. Saransaari, and S.S. Oja Cyclic AMP-mediated regulation of striatal glutamate release: interactions of presynaptic ligand- and voltage-gated ion channels and G-protein-coupled receptors Neurochem. Int. 43 2003 425 430
4. + channels Eur. J. Pharmacol. 314 1996 69 73
5. C.A. Galindo, and M. Sitges Dihydropiridines mechanism of action in striatal isolated nerve endings: comparison with omega-agatoxin IVA Neurochem. Res. 29 2004 659 669
6. E. Galván, and M. Sitges Characterization of the participation of sodium channels on the rise in Na+ induced by 4-aminopyridine (4-AP) in synaptosomes Neurochem. Res. 29 2004 347 355
7. 2+ indicators with greatly improved fluorescence properties J. Biol. Chem. 260 1985 3440 3450
8. 2+ concentration and its relationship to B-50 (GAP-43) phosphorylation J. Neurochem. 56 1991 1827 1835
9. A.E. Ives, and J.G. Jefferys Synchronization of epileptiform bursts induced by 4-aminopyridine in the in vitro hippocampal slice preparation Neurosci. Lett. 112 1990 239 245
10. V. Lakics, P. Molnár, and S.L. Erdö Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade Neuroreport 7 1995 89 92
11. V. Lakics, M.G. Sebestyén, and S.L. Erdö Vinpocetine is a highly potent neuroprotectant against veratridine-induced cell death in primary cultures of rat cerebral cortex Neurosci. Lett. 185 1995 127 130
12. 2+ channels, and GABA(A) receptors Br. J. Anaesth. 90 2003 199 211
13. + channels in rat cortical neurons Eur. J. Pharmacol. 273 1995 303 306
14. A. Morales-Villagrán, S. López-Pérez, L. Medina-Ceja, and R. Tapia Cortical catecholamine changes and seizures induced by 4-aminopyridine in awake rats, studied with a dual microdialysis-electrical recording technique Neurosci. Lett. 275 1999 133 136
15. V. Nekrassov, and M. Sitges Effects of pentylenetetrazole and 4-aminopyridine on the auditory brainstem response (ABR) and on the hearing sensitivity in the guinea pig in vivo Epilepsy Res. 53 2003 245 254
16. C. Psarropoulou, and M. Avoli Developmental features of 4-aminopyridine induced epileptogenesis Brain Res. Dev. 94 1996 52 59
17. D.S. Ragsdale, and M. Avoli Sodium channels as molecular targets for antiepileptic drugs Brain Res. Rev. 26 1998 16 28
18. 3H]GABA release Neurochem. Res. 21 1996 889 895
19. M. Sitges, and V. Nekrassov Characterization of vinpocetine mechanism of action in rat striatum synaptosomes J. Neurochem. 71 Suppl. 1998 S19A
20. M. Sitges, F. Peña, L.M. Chiu, and A. Guarneros Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels Neurochem. Int. 32 1998 177 190
21. M. Sitges, and V. Nekrassov Vinpocetine selectively inhibits neurotransmitter release triggered by sodium channel activation Neurochem. Res. 24 1999 1585 1591
22. M. Sitges, V. Nekrassov, and A. Guarneros Simultaneous action of MK-801 (dizclopine) on dopamine, glutamate, aspartate and GABA release from striatum isolated nerve endings Brain Res. 854 2000 48 56
23. 2+ and glutamate release in depolarised brain nerve terminals Neurochem. Int. 46 2005 53 60
24. M. Sitges, and V. Nekrassov Vinpocetine prevents 4-aminopyridine-induced changes in the EEG, the auditory brainstem responses and hearing Clin. Neurophysiol. 115 2004 2711 2717
25. 2+ and glutamate release J. Neurochem. 53 1989 1693 1699
26. F. Trejo, V. Nekrassov, and M. Sitges Characterization of vinpocetine effects on DA and DOPAC release in striatal isolated nerve endings Brain Res. 909 2001 59 67
27. i rise in synaptosomes Neuroreport 9 1998 1849 1853
28. + channels: a rational and effective strategy against ischemic brain damage Pharmacol. Rev. 48 1996 21 67
29. i increase in rat hippocampal CA1 pyramidal cells Neurochem. Res. 26 2001 1095 1100