Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2

Biological and Pharmaceutical Bulletin

Volumn 29, Issue 10, 2006, Pages 2140-2142

  Kim, Young Ho ^a,b,c   Park, Eun Jung ^c   Park, Mi Hyun ^a   Badarch, Uranchimeg ^c   Woldemichael, Girma Moges ^b   Beutler, John Albert ^b  

^a Chungnam National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

Crinamine; Crinum asiaticum var. Japonicum; HIF1 ; HRE assay

Indexed keywords

ALKALOID DERIVATIVE; CRINAMINE; CRINUM ASIATICUM EXTRACT; EPINORGALANTHAMINE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2; LYCORINE; NORGALANTAMINE; PLANT EXTRACT; TOPOTECAN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRINUM; DRUG ISOLATION; DRUG STRUCTURE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IC 50; REPORTER GENE; TRANSCRIPTION INITIATION;

AMARYLLIDACEAE ALKALOIDS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CRINUM; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INDOLIZINES; NITRIC OXIDE SYNTHASE TYPE II; TRANSCRIPTION FACTORS;

EID: 33749440184     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.29.2140     Document Type: Article

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