Protein phosphatase 1 regulates the stability of the circadian protein PER2

Biochemical Journal

Volumn 399, Issue 1, 2006, Pages 169-175

  Gallego, Monica ^a   Kang, Heeseog ^a,c   Virshup, David M ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Casein kinase I ; Circadian rhythms; Mammalian clock; PER2; Phosphorylation; Protein phosphatase 1

Indexed keywords

BRAIN; DEGRADATION; ENZYME INHIBITION; FEEDBACK; IMMUNOLOGY; PRECIPITATION (CHEMICAL);

CIRCADIAN RHYTHMS; MAMMALIAN CLOCK; PER2; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1;

ENZYMES;

CASEIN KINASE IEPSILON; HOLOENZYME; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEASOME; PROTEIN; PROTEIN INHIBITOR 1; PROTEIN INHIBITOR 2; PROTEIN PERIOD 2; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA TRANSLATION; TRANSCRIPTION TERMINATION;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CIRCADIAN RHYTHM; HUMANS; MALE; MICE; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; TRANSCRIPTION FACTORS; XENOPUS;

MAMMALIA;

EID: 33749360459     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060678     Document Type: Article

References (44)

1. Reppert, S. M. and Weaver, D. R. (2002) Co-ordination of circadian timing in mammals. Nature (London) 418, 935-941
2. Gachon, F., Nagoshi, E., Brown, S. A., Ripperger, J. and Schibler, U. (2004) The mammalian circadian timing system: from gene expression to physiology. Chromosoma 113, 103-112
3. Emery, P. and Reppert, S. M. (2004) A rhythmic Ror. Neuron 43, 443-446
4. Frisch, B., Hardin, P. E., Hamblen-Coyle, M. J., Rosbash, M. and Hall, J. C. (1994) A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron 12, 555-570
5. Vosshall, L. B. and Young, M. W. (1995) Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. Neuron 15, 345-360
6. Yang, Z. and Sehgal, A. (2001) Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron 29, 453-467
7. Cheng, Y. and Hardin, P. E. (1998) Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling. J. Neurosci. 18, 741-750
8. Lee, C., Etchegaray, J. P., Cagampang, F. R., Loudon, A. S. and Reppert, S. M. (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107, 855-867
9. Harms, E., Kivimae, S., Young, M. W. and Saez, L. (2004) Posttranscriptional and posttranslational regulation of clock genes. J. Biol. Rhythms 19, 361-373
10. Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B. and Young, M. W. (1998) Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 94, 83-95
11. Kloss, B., Rothenfluh, A., Young, M. W. and Saez, L. (2001) Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron 30, 699-706
12. Ko, H. W., Jiang, J. and Edery, I. (2002) Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature (London) 420, 673-678
13. Grima, B., Lamouroux, A., Chelot, E., Papin, C., Limbourg-Bouchon, B. and Rouyer, F. (2002) The F-box protein slimb controls the levels of clock proteins period and timeless. Nature (London) 420, 178-182
14. Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptacek, L. J. and Fu, Y. H. (2005) Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome. Nature (London) 434, 640-644
15. Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M. and Takahashi, J. S. (2000) Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 288, 483-492
16. Ralph, M. R. and Menaker, M. (1988) A mutation of the circadian system in golden hamsters. Science 241, 1225-1227
17. Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A. and Virshup, D. M. (2005) Control of mammalian circadian rhythm by CKIε-regulated proteasome-mediated PER2 degradation. Mol. Cell. Biol. 25, 2795-2807
18. Shirogane, T., Jin, J., Ang, X. L. and Harper, J. W. (2005) SCFβ-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280, 26863-26872
19. Gallego, M. and Virshup, D. M. (2005) Protein serine/threonine phosphatases: life, death, and sleeping. Curr. Opin. Cell Biol. 17, 197-202
20. Honkanen, R. E. and Golden, T. (2002) Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr. Med. Chem. 9, 2055-2075
21. Cegielska, A., Moarefi, I., Fanning, E. and Virshup, D. M. (1994) T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. J. Virol. 68, 269-275
22. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol. Rev. 84, 1-39
23. Janssens, V. and Goris, J. (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417-439
24. Comolli, J., Taylor, W., Rehman, J. and Hastings, J. W. (1996) Inhibitors of serine/threonine phosphoprotein phosphatases alter circadian properties in Gonyaulax polyedra. Plant Physiol. 111, 285-291
25. Schafmeier, T., Haase, A., Kaldi, K., Scholz, J., Fuchs, M. and Brunner, M. (2005) Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. Cell 122, 235-246
26. Yang, Y., He, Q., Cheng, P., Wrage, P., Yarden, O. and Liu, Y (2004) Distinct roles for PP1 and PP2A in the Neurospora circadian clock. Genes Dev. 18, 255-260
27. Sathyanarayanan, S., Zheng, X., Xiao, R. and Sehgal, A. (2004) Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 116, 603-615
28. Kim, E. Y. and Edery, I. (2006) Balance between DBT/CKIε kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc. Natl. Acad. Sci. U.S.A. 103, 6178-6183
29. Li, X., Yost, H. J., Virshup, D. M. and Seeling, J. M. (2001) Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J. 20, 4122-4131
30. McCright, B. and Virshup, D. M. (1995) Identification of a new family of protein phosphatase 2A regulatory subunits. J. Biol. Chem. 270, 26123-26128
31. Salic, A., Lee, E., Mayer, L. and Kirschner, M. W. (2000) Control of β-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol. Cell 5, 523-532
32. Myles, T., Schmidt, K., Evans, D. R., Cron, P. and Hemmings, B. A. (2001) Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells. Biochem. J. 357, 225-232
33. Zhang, J., Zhang, Z., Brew, K. and Lee, E. Y. (1996) Mutational analysis of the catalytic subunit of muscle protein phosphatase-1. Biochemistry 35, 6276-6282
34. Eto, M., Karginov, A. and Brautigan, D. L. (1999) A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. Biochemistry 38, 16952-16957
35. Huang, F. L. and Glinsmann, W. H. (1976) Separation and characterization of two phosphorylase phosphatase inhibitors from rabbit skeletal muscle. Eur. J. Biochem. 70, 419-426
36. Terry-Lorenzo, R. T., Elliot, E., Weiser, D. C., Prickett, T. D., Brautigan, D. L. and Shenolikar, S. (2002) Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. J. Biol. Chem. 277, 46535-46543
37. Eto, M., Elliott, E., Prickett, T. D. and Brautigan, D. L. (2002) Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J. Biol. Chem. 277, 44013-44020
38. Pallas, D. C., Shahrik, L. K., Martin, B. L., Jaspers, S., Miller, T. B., Brautigan, D. L. and Roberts, T. M. (1990) Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60, 167-176
39. Sontag, E., Fedorov, S., Kamibayashi, C., Robbins, D., Cobb, M. and Mumby, M. (1993) The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell 75, 887-897
40. Chen, W., Possemato, R., Campbell, K. T., Plattner, C. A., Pallas, D. C. and Hahn, W. C. (2004) Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell 5, 127-136
41. He, Q., Cheng, P., Yang, Y., He, Q., Yu, H. and Liu, Y. (2003) FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J. 22, 4421-4430
42. Egloff, M. P., Johnson, D. F., Moorhead, G., Cohen, P. T., Cohen, P. and Barford, D. (1997) Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J. 16, 1876-1887
43. Wakula, P., Beullens, M., Ceulemans, H., Stalmans, W. and Bollen, M. (2003) Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1. J. Biol. Chem. 278, 18817-18823
44. Ueda, H. R., Chen, W., Adachi, A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S. et al. (2002) A transcription factor response element for gene expression during circadian night. Nature (London) 418, 534-539