Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons

Molecular and Cellular Biology

Volumn 22, Issue 13, 2002, Pages 4499-4511

  Byrd, Marshall P ^a   Zamora, Miguel ^a   Lloyd, Richard E ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DODECYL SULFATE SODIUM; INITIATION FACTOR 4G;

ARTICLE; CATALYSIS; CELL MIGRATION; CHROMOSOME 3; DNA SEQUENCE; EXON; HELA CELL; HUMAN; HUMAN CELL; INTERNAL RIBOSOME ENTRY SITE; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; TRANSLATION INITIATION; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, WESTERN; CODON, INITIATOR; DNA, COMPLEMENTARY; EUKARYOTIC INITIATION FACTOR-4G; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PEPTIDE FRAGMENTS; PEPTIDE INITIATION FACTORS; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; RIBOSOMES; RNA CAPS; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

EUKARYOTA;

EID: 0036272304     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.13.4499-4511.2002     Document Type: Article

References (55)

1. Efficient cleavage of p220 by poliovirus 2A(pro) expression in mammalian cells: Effects on vaccinia virus
2. Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus
3. eIF4G and its proteolytic cleavage products: Effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs
4. Biochemical characterisation of cap-poly (A) synergy in rabbit reticulocyte lysates: The eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5′ end
5. Direct cleavage of eIF4G by poliovirus 2A protease is inefficient in vitro
6. Mass spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms
7. The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site
8. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: Different deadenylation kinetics and uncoupling from translation
9. A four-nucleotide translation enhancer in the 3′-terminal consensus sequence of the nonpolyadenylated mRNAs of rotavirus
10. SV40 DNA transfection of cells in suspension: Analysis of efficiency of transcription and translation of T-antigen
11. Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines
12. Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes
13. Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F
14. Translation driven by an eIF4G core domain in vivo
15. Efficient translation of distal cistrons of a polycistronic mRNA of a plant pararetrovirus requires a compatible interaction between the mRNA 3′ end and the proteinaceous trans-activator
16. Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro
17. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eukaryotic initiation factor 3 and a cap binding protein complex
18. Internal initiation of translation directed by the 5′-untranslated region of the mRNA for eIF4G, a factor involved in the picornavirus-induced switch from cap-dependent to internal initiation
19. Functional characterization of the internal ribosome entry site of eIF4G mRNA
20. eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
21. A novel functional human eukaryotic translation initiation factor 4G
22. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
23. New initiation factor activity required for globin mRNA translation
24. Cell cycle regulation of hepatitis C virus internal ribosomal entry site-directed translation
25. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
26. Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro
27. Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP and eIF4G conferred by internal ribosome entry sites
28. In vitro synthesis of human protein synthesis initiation factor-4 gamma and its localization on 43-S and 48-S initiation complexes
29. Translation eukaryotic initiation factor 4G recognizes a specific structural element within the internal ribosome entry site of encephalomyocarditis virus RNA
30. Characterization of the two eIF4A-binding sites on human eIF4G-1
31. Regulation of translation in eukaryotic systems
32. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases: Implications for cap-dependent and cap-independent translational initiation
33. Heat shock impairs the interaction of cap-binding protein complex with 5′ messenger RNA cap
34. Mapping the cleavage site in protein synthesis initiation factor-eIF-4γ of the 2A proteases from human coxsackievirus and rhinovirus
35. Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity
36. Restriction of translation of capped mRNA in vitro as a model for poliovirus-induced inhibition of host cell protein synthesis: Relationship to p220 cleavage
37. Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation
38. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins
39. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery
40. Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis
41. Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells
42. Cap-poly(A) synergy in mammalian cell-free extracts
43. Eukaryotic translation initiation factor 4E (eIF4E) site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as modulatory region
44. eIF4G: Translation's mystery factor begins to yield its secrets
45. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
46. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
47. Inhibition of translation by poliovirus: Inactivation of a specific initiation factor
48. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells
49. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia
50. Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G
51. A common function for mRNA 5′ and 3′ ends in translation initiation in yeast
52. Wheat germ poly(a) binding protein enhances the binding affinity of eukaryotic initiation factor 4f and (iso)4f for cap analogues
53. Circularization of mRNA by eukaryotic translation initiation factors
54. Amino acid sequence of the human protein synthesis initiation factor eIF-4γ
55. Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells