Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region

Molecular and Cellular Biology

Volumn 20, Issue 2, 2000, Pages 468-477

  Morino, Shigenobu ^a   Imataka, Hiroaki ^a   Svitkin, Yuri V ^a   Pestova, Tatyana V ^b   Sonenberg, Nahum ^a  

^a MCGILL UNIVERSITY   (Canada)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR; INITIATION FACTOR 4E;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EUKARYOTE; GENE DELETION; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; RIBOSOME; RNA TRANSLATION;

AMINO ACID SEQUENCE; BINDING SITES; EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4G; GLOBINS; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE INITIATION FACTORS; POINT MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RIBOSOMES; RNA CAPS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE DELETION; TEMPLATES, GENETIC;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0033957406     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.2.468-477.2000     Document Type: Article

References (32)

1. Allen, M., A. M. Metz, R. T. Timmer, R. E. Rhoads, and K. S. Browning. 1992. Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F. J. Biol. Chem. 267:23232-23236.
2. De Gregorio, E., T. Preiss, and M. W. Hentze. 1998. Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependent. RNA 4:828-836.
3. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122-8126.
4. Fukunaga, R., and T. Hunter. 1997. MNK1, a new MAP kinase-activated protein kinase. isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1921-1933.
5. Gingras, A.-C., B. Raught, and N. Sonenberg. 1999. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:913-963.
6. Goyer, C., M. Altmann, H. S. Lee, A. Blanc, M. Deshmukh, J. L. Woolford, Jr., H. Trachsel, and N. Sonenberg. 1993. TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function. Mol. Cell. Biol. 13:4860-4874.
7. Gradi, A., H. Imataka, Y. V. Svitkin, E. Rom, B. Raught, S. Morino, and N. Sonenberg. 1998. A novel functional human eukaryotic translation initiation factor 4G. Mol. Cell. Biol. 18:334-342.
8. Gunnery, S., Ü. Mäivali, and M. B. Mathews. 1997. Translation of an uncapped mRNA involves scanning. J. Biol. Chem. 272:21642-21646.
9. Haghighat, A., Y. V. Svitkin, I. Novoa, E. Kuechler, T. Skern, and N. Sonenberg. 1996. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J. Virol. 70:8445-8450.
10. Hellen, C. U. T., G. W. Witherell, M. Schmid, S. H. Shin, T. V. Pestova, A. Gil, and E. Wimmer. 1993. A cytoplasmic 57kDa protein that is required for translation of picornavirus RNA by internal ribosome entry is identical to the nuclear pyrimidine tract-binding protein. Proc. Natl. Acad. Sci. USA 90: 7642-7646.
11. Imataka, H., H. S. Olsen, and N. Sonenberg. 1997. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 16:817-825.
12. Imataka, H., and N. Sonenberg. 1997. Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol. Cell. Biol. 17:6940-6947.
13. Imataka, H., A. Gradi, and N. Sonenberg. 1998. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J. 17:7480-7489.
14. Lamphear, B. J., R. Kirchweger, T. Skern, and R. E. Rhoads. 1995. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases: implications for cap-dependent and cap-independent translational initiation. J. Biol. Chem. 270:21975-21983.
15. Lamphear, B. J., R. Yan, F. Yang, D. Waters, H. D. Liebig, H. Klump, E. Kuechler, T. Skern, and R. E. Rhoads. 1993. Mapping of the cleavage site in protein synthesis initiation factor eIF-4γ of the 2A proteases from human coxsackievirus and rhinovirus. J. Biol. Chem. 268:19200-19203.
16. Levy-Strumpf, N., L. P. Deiss, H. Berissi, and A. Kimchi. 1997. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol. Cell. Biol. 17:1615-1625.
17. Li, Q., H. Imataka, S. Morino, G. W. Rogers, Jr., N. J. Richter-Cook, W. C. Merrick, and N. Sonenberg. 1999. Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol. Cell. Biol. 19:7336-7346.
18. Mader, S., H. Lee, A. Pause, and N. Sonenberg. 1995. The translation initiation factor eIF4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 15:4990-4997.
19. Merrick, W. C., and J. W. B. Hershey. 1996. The pathway and mechanism of eukaryotic protein synthesis, p. 31-70. In J. Hershey, M. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
20. Morley, S. J., P. S. Curtis, and V. M. Pain. 1997. eIF4G: translation's mystery factor begins to yield its secrets. RNA 3:1085-1104.
21. Neff, C. L., and A. B. Sachs. 1999. Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol. Cell. Biol. 19:5557-5564.
22. Pain, V. M. 1996. Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 236:747-771.
23. Pestova, T. V., C. U. T. Hellen, and I. N. Shatsky. 1996. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol. Cell. Biol. 16:6859-6869.
24. Pestova, T. V., I. N. Shatsky, and C. U. T. Hellen. 1996. Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol. Cell. Biol. 16:6870-6878.
25. Pestova, T. V., S. I. Borukhov, and C. U. T. Hellen. 1998. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature 394:854-859.
26. Pyronnet, S., H. Imataka, A.-C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg. 1999. Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E. EMBO J. 18:270-279.
27. Sachs, A. B., P. Sarnow, and M. W. Hentze. 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89:831-838.
28. Sonenberg, N. 1996. mRNA 5′ cap-binding protein eIF4E and control of cell growth, p. 271-294. In J. Hershey, M. Mathews, and N. Sonenberg (ed.). Translational control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
29. Waskiewicz, A. J., A. Flynn, C. G. Proud, and J. A. Cooper. 1997. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16:1909-1920.
30. Waskiewicz, A. J., J. C. Johnson, B. Penn, M. Mahalingam, S. R. Kimball, and J. A. Cooper. 1999. Phosphorylation of the cap-binding protein eIF4E by the protein kinase Mnk1 in vivo Mol. Cell. Biol. 19:1871-1880.
31. Yamanaka, S., K. S. Poksay, K. S. Arnold, and T. L. Innerarity. 1997. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 11:321-333.
32. Yan, R., W. Rychlik, D. Etchsion, and R. E. Rhoads. 1992. Amino acid sequence of the human protein synthesis initiation factor eIF-4γ. J. Biol. Chem. 267:23226-23231.