High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation

RNA

Volumn 11, Issue 1, 2005, Pages 77-89

  Mochizuki, Kiyotaka ^a   Oguro, Akihiro ^a   Ohtsu, Takashi ^a   Sonenberg, Nahum ^b   Nakamura, Yoshikazu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Cap binding; eIF4E; RNA aptamer; SELEX; Translation initiation

Indexed keywords

APTAMER; APTAMER 1; APTAMER 2; INITIATION FACTOR 4A; INITIATION FACTOR 4E; INITIATION FACTOR 4G; MESSENGER RNA; NUCLEOTIDE; POLYPEPTIDE; RIBONUCLEASE; RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL GROWTH; EUKARYOTE; GENE MUTATION; MALIGNANT TRANSFORMATION; MAMMAL; PRIORITY JOURNAL; PROTEIN BINDING; RNA TRANSLATION; TRANSLATION INITIATION; TRANSLATION REGULATION;

AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; ELECTROSTATICS; EUKARYOTIC INITIATION FACTOR-4E; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; PHOSPHOPROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RNA CAP ANALOGS; RNA CAPS; VARIATION (GENETICS);

EUKARYOTA; HEPATITIS C VIRUS; MAMMALIA;

EID: 11144319427     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.7108205     Document Type: Article

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