Structural refinement of inhibitors of urea-based soluble epoxide hydrolases

Biochemical Pharmacology

Volumn 63, Issue 9, 2002, Pages 1599-1608

  Morisseau, Christophe ^a,b   Goodrow, Marvin H ^a   Newman, John W ^a,b   Wheelock, Craig E ^a,b   Dowdy, Deanna L ^a   Hammock, Bruce D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood pressure; Epoxide hydrolase; Immune response; Solubility; Structure activity relationships; Urea inhibitors

Indexed keywords

AMIDE; CARBAMIC ACID DERIVATIVE; ENZYME INHIBITOR; EPOXIDE HYDROLASE; UREA DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TOPOGRAPHY;

ANIMALS; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; MICE; MODELS, CHEMICAL; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 0036570198     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00952-8     Document Type: Article

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