-
2
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix- loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix- loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92 (1995) 5510-5514
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
3
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
Holash J., Maisonpierre P.C., Compton D., Boland P., Alexander C.R., Zagzag D., et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284 (1999) 1994-1998
-
(1999)
Science
, vol.284
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
Boland, P.4
Alexander, C.R.5
Zagzag, D.6
-
4
-
-
0029117223
-
Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cell
-
Ikeda E., Achen M.G., Breier G., and Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cell. J. Biol. Chem. 270 (1995) 19761-19766
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19761-19766
-
-
Ikeda, E.1
Achen, M.G.2
Breier, G.3
Risau, W.4
-
5
-
-
14644399862
-
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 {gamma} 2 correlates with the invasiveness of human glioma
-
Guo P., Imanishi Y., Cackowski F.C., Jarzynka M.J., Tao H.Q., Nishikawa R., et al. Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 {gamma} 2 correlates with the invasiveness of human glioma. Am. J. Pathol. 166 (2005) 877-890
-
(2005)
Am. J. Pathol.
, vol.166
, pp. 877-890
-
-
Guo, P.1
Imanishi, Y.2
Cackowski, F.C.3
Jarzynka, M.J.4
Tao, H.Q.5
Nishikawa, R.6
-
6
-
-
0035266253
-
Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases
-
Etoh T., Inoue H., Tanaka S., Barnard G.F., Kitano S., and Mori M. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res. 61 (2001) 2145-2153
-
(2001)
Cancer Res.
, vol.61
, pp. 2145-2153
-
-
Etoh, T.1
Inoue, H.2
Tanaka, S.3
Barnard, G.F.4
Kitano, S.5
Mori, M.6
-
7
-
-
0032985888
-
Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells
-
Oh H., Takagi H., Suzuma K., Otani A., Matsumura M., and Honda Y. Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells. J. Biol. Chem. 274 (1999) 15732-15739
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15732-15739
-
-
Oh, H.1
Takagi, H.2
Suzuma, K.3
Otani, A.4
Matsumura, M.5
Honda, Y.6
-
8
-
-
0032547764
-
Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
-
Mandriota S.J., and Pepper M.S. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ. Res. 83 (1998) 852-859
-
(1998)
Circ. Res.
, vol.83
, pp. 852-859
-
-
Mandriota, S.J.1
Pepper, M.S.2
-
9
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly B.D., Hackett S.F., Hirota K., Oshima Y., Cai Z., Berg-Dixon S., et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 93 (2003) 1074-1081
-
(2003)
Circ. Res.
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, S.F.2
Hirota, K.3
Oshima, Y.4
Cai, Z.5
Berg-Dixon, S.6
-
10
-
-
4444319403
-
Differential activation of vascular genes by hypoxia in primary endothelial cells
-
Nilsson I., Shibuya M., and Wennstrom S. Differential activation of vascular genes by hypoxia in primary endothelial cells. Exp. Cell Res. 299 (2004) 476-485
-
(2004)
Exp. Cell Res.
, vol.299
, pp. 476-485
-
-
Nilsson, I.1
Shibuya, M.2
Wennstrom, S.3
-
11
-
-
0033753391
-
Hypoxia upregulates angiopoietin-2, a tie-2 ligand in mouse mesangial cells
-
Yuan H.T., Yang S.P., and Woolf A.S. Hypoxia upregulates angiopoietin-2, a tie-2 ligand in mouse mesangial cells. Kidney Int. 58 (2000) 1912-1919
-
(2000)
Kidney Int.
, vol.58
, pp. 1912-1919
-
-
Yuan, H.T.1
Yang, S.P.2
Woolf, A.S.3
-
12
-
-
1842478183
-
Hypoxic regulation of angiopoietin-2 expression in endothelial cells.
-
Pichiule P., Chavez J.C., and LaManna J.C. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J. Biol. Chem. 279 (2004) 12171-12180
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12171-12180
-
-
Pichiule, P.1
Chavez, J.C.2
LaManna, J.C.3
-
13
-
-
10744219591
-
Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO
-
Liu C., Shi Y., Han Z., Pan Y., Liu N., Han S., et al. Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO. Biochem. Biophys. Res. Commun. 312 (2003) 780-786
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.312
, pp. 780-786
-
-
Liu, C.1
Shi, Y.2
Han, Z.3
Pan, Y.4
Liu, N.5
Han, S.6
-
14
-
-
0034045741
-
The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas
-
Wong M.P., Chan S.Y., Fu K.H., Leung S.Y., Cheung N., Yuen S.T., and Chung L.P. The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. Lung Cancer 29 (2000) 11-22
-
(2000)
Lung Cancer
, vol.29
, pp. 11-22
-
-
Wong, M.P.1
Chan, S.Y.2
Fu, K.H.3
Leung, S.Y.4
Cheung, N.5
Yuen, S.T.6
Chung, L.P.7
-
15
-
-
12244267687
-
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells
-
Park J.H., Kim T.Y., Jong H.S., Kim T.Y., Chun Y.S., Park J.W., et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Clin. Cancer Res. 9 (2003) 433-440
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 433-440
-
-
Park, J.H.1
Kim, T.Y.2
Jong, H.S.3
Kim, T.Y.4
Chun, Y.S.5
Park, J.W.6
-
16
-
-
24944488029
-
Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK
-
(Epub ahead of print)
-
Liu C., Shi Y., Du Y., Ning X., Liu N., Huang D., et al. Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK. Exp. Cell Res. (2005) (Epub ahead of print)
-
(2005)
Exp. Cell Res.
-
-
Liu, C.1
Shi, Y.2
Du, Y.3
Ning, X.4
Liu, N.5
Huang, D.6
-
17
-
-
0037757694
-
PGE2 is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells
-
Eibl G., Bruemmer D., Okada Y., Duffy J.P., Law R.E., Reber H.A., and Hines O.J. PGE2 is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. Biochem. Biophys. Res. Commun. 306 (2003) 887-897
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 887-897
-
-
Eibl, G.1
Bruemmer, D.2
Okada, Y.3
Duffy, J.P.4
Law, R.E.5
Reber, H.A.6
Hines, O.J.7
-
18
-
-
0028785860
-
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
-
Wang G.L., Jiang B.H., and Semenza G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 216 (1995) 669-675
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.216
, pp. 669-675
-
-
Wang, G.L.1
Jiang, B.H.2
Semenza, G.L.3
-
19
-
-
0346217046
-
Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression
-
Buchler P., Reber H.A., Buchler M.W., Friess H., Lavey R.S., and Hines O.J. Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression. Cancer 100 (2004) 201-210
-
(2004)
Cancer
, vol.100
, pp. 201-210
-
-
Buchler, P.1
Reber, H.A.2
Buchler, M.W.3
Friess, H.4
Lavey, R.S.5
Hines, O.J.6
-
20
-
-
0033366794
-
Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line
-
Liu X.H., Kirschenbaum A., Yao S., Stearns M.E., Holland J.F., Claffey K., and Levine A.C. Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. Clin. Exp. Metastas. 17 (1999) 687-694
-
(1999)
Clin. Exp. Metastas.
, vol.17
, pp. 687-694
-
-
Liu, X.H.1
Kirschenbaum, A.2
Yao, S.3
Stearns, M.E.4
Holland, J.F.5
Claffey, K.6
Levine, A.C.7
-
21
-
-
11144354466
-
Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma.
-
Torimura T., Ueno T., Kin M., Harada R., Taniguchi E., Nakamura T., et al. Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. J. Hepatol. 40 (2004) 799-807
-
(2004)
J. Hepatol.
, vol.40
, pp. 799-807
-
-
Torimura, T.1
Ueno, T.2
Kin, M.3
Harada, R.4
Taniguchi, E.5
Nakamura, T.6
-
22
-
-
0242408184
-
Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma
-
Sugimachi K., Tanaka S., Taguchi K., Aishima S., Shimada M., and Tsuneyoshi M. Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma. J. Clin. Pathol. 56 (2003) 854-860
-
(2003)
J. Clin. Pathol.
, vol.56
, pp. 854-860
-
-
Sugimachi, K.1
Tanaka, S.2
Taguchi, K.3
Aishima, S.4
Shimada, M.5
Tsuneyoshi, M.6
-
24
-
-
0037414180
-
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo E.J., Chun Y.S., Cho Y.S., Kim J., Lee J.C., Kim M.S., and Park J.W. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J. Natl Cancer Inst. 95 (2003) 516-525
-
(2003)
J. Natl Cancer Inst.
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
Kim, J.4
Lee, J.C.5
Kim, M.S.6
Park, J.W.7
-
25
-
-
0031034814
-
Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells
-
Schmedtje Jr. J.F., Ji Y.S., Liu W.L., DuBois R.N., and Runge M.S. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 272 (1997) 601-608
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 601-608
-
-
Schmedtje Jr., J.F.1
Ji, Y.S.2
Liu, W.L.3
DuBois, R.N.4
Runge, M.S.5
-
26
-
-
0034637541
-
Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure
-
Xu Q., Ji Y.S., and Schmedtje Jr. J.F. Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. J. Biol. Chem. 275 (2000) 24583-24839
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24583-24839
-
-
Xu, Q.1
Ji, Y.S.2
Schmedtje Jr., J.F.3
-
27
-
-
0033591346
-
Hypoxia-associated induction of early growth response-1 gene expression
-
Yan S.F., Lu J., Zou Y.S., Soh-Won J., Cohen D.M., Buttrick P.M., et al. Hypoxia-associated induction of early growth response-1 gene expression. J. Biol. Chem. 274 (1999) 15030-15040
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15030-15040
-
-
Yan, S.F.1
Lu, J.2
Zou, Y.S.3
Soh-Won, J.4
Cohen, D.M.5
Buttrick, P.M.6
-
28
-
-
0034723274
-
Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium
-
Bonazzi A., Mastyugin V., Mieyal P.A., Dunn M.W., and Laniado-Schwartzman M. Regulation of cyclooxygenase-2 by hypoxia and peroxisome proliferators in the corneal epithelium. J. Biol. Chem. 275 (2000) 2837-2844
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2837-2844
-
-
Bonazzi, A.1
Mastyugin, V.2
Mieyal, P.A.3
Dunn, M.W.4
Laniado-Schwartzman, M.5
-
29
-
-
0037081197
-
Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin E receptors, and angiogenic factors by cyclooxygenase-1
-
Sales K.J., Katz A.A., Howard B., Soeters R.P., Millar R.P., and Jabbour H.N. Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin E receptors, and angiogenic factors by cyclooxygenase-1. Cancer Res. 62 (2002) 424-432
-
(2002)
Cancer Res.
, vol.62
, pp. 424-432
-
-
Sales, K.J.1
Katz, A.A.2
Howard, B.3
Soeters, R.P.4
Millar, R.P.5
Jabbour, H.N.6
-
30
-
-
0141765733
-
Coordinate activation of HIF-1 and NF-kB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia
-
Lukiw W.J., Ottlecz A., Lambrou G., Grueninger M., Finley J., Thompson H.W., and Bazan N.G. Coordinate activation of HIF-1 and NF-kB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4163-4170
-
(2003)
Invest. Ophthalmol. Vis. Sci.
, vol.44
, pp. 4163-4170
-
-
Lukiw, W.J.1
Ottlecz, A.2
Lambrou, G.3
Grueninger, M.4
Finley, J.5
Thompson, H.W.6
Bazan, N.G.7
-
31
-
-
0033888525
-
Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia
-
Mandriota S.J., Pyke C., Di S.C., Quinodoz P., Pittet B., and Pepper M.S. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am. J. Pathol. 156 (2000) 2077-2089
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 2077-2089
-
-
Mandriota, S.J.1
Pyke, C.2
Di, S.C.3
Quinodoz, P.4
Pittet, B.5
Pepper, M.S.6
-
32
-
-
0037146555
-
Prostaglandin E2 induces hypoxia-inducible factor-1a stabilization and nuclear localization in a human prostate cancer cell line
-
Liu X.H., Kirschenbaum A., Lu M., Yao S., Dosoretz A., Holland J.F., and Levine A.C. Prostaglandin E2 induces hypoxia-inducible factor-1a stabilization and nuclear localization in a human prostate cancer cell line. J. Biol. Chem. 277 (2002) 50081-50086
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50081-50086
-
-
Liu, X.H.1
Kirschenbaum, A.2
Lu, M.3
Yao, S.4
Dosoretz, A.5
Holland, J.F.6
Levine, A.C.7
-
33
-
-
0038375038
-
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
-
Fukuda R., Kelly B., and Semenza G.L. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res. 63 (2003) 2330-2334
-
(2003)
Cancer Res.
, vol.63
, pp. 2330-2334
-
-
Fukuda, R.1
Kelly, B.2
Semenza, G.L.3
-
34
-
-
1842426689
-
Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells
-
Wang Y.Q., Luk J.M., Ikeda K., Man K., Chu A.C., Kaneda K., and Fan S.T. Regulatory role of vHL/HIF-1a in hypoxia-induced VEGF production in hepatic stellate cells. Biochem. Biophys. Res. Commun. 317 (2004) 358-362
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.317
, pp. 358-362
-
-
Wang, Y.Q.1
Luk, J.M.2
Ikeda, K.3
Man, K.4
Chu, A.C.5
Kaneda, K.6
Fan, S.T.7
-
35
-
-
7044227910
-
NS398 reduces hypoxia-inducible factor (Hif)-1a and Hif-1a activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms
-
Zhong H., Willard M., and Simons J. NS398 reduces hypoxia-inducible factor (Hif)-1a and Hif-1a activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int. J. Cancer 112 (2004) 585-595
-
(2004)
Int. J. Cancer
, vol.112
, pp. 585-595
-
-
Zhong, H.1
Willard, M.2
Simons, J.3
-
36
-
-
0041464531
-
Ibuprofen-mediated reduction of hypoxia- inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells
-
Palayoor S.T., Tofilon P.J., and Coleman C.N. Ibuprofen-mediated reduction of hypoxia- inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin. Cancer Res. 9 (2003) 3150-3157
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3150-3157
-
-
Palayoor, S.T.1
Tofilon, P.J.2
Coleman, C.N.3
-
37
-
-
16344389993
-
Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism
-
Patel M.I., Subbaramaiah K., Du B., Chang M., Yang P., Newman R.A., et al. Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism. Clin. Cancer Res. 11 (2005) 1999-2007
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1999-2007
-
-
Patel, M.I.1
Subbaramaiah, K.2
Du, B.3
Chang, M.4
Yang, P.5
Newman, R.A.6
-
38
-
-
3343013829
-
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor flt-1
-
Takeda N., Maemura K., Imai Y., Harada T., Kawanami D., Nojiri T., et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor flt-1. Circ. Res. 95 (2004) 146-153
-
(2004)
Circ. Res.
, vol.95
, pp. 146-153
-
-
Takeda, N.1
Maemura, K.2
Imai, Y.3
Harada, T.4
Kawanami, D.5
Nojiri, T.6
|