Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K/Akt-NF-κB signaling pathway

American Journal of Respiratory Cell and Molecular Biology

Volumn 35, Issue 4, 2006, Pages 444-456

  Tong, Qiangsong ^b   Zheng, Liduan ^b   Lin, Li ^b   Li, Bo ^b   Wang, Danming ^b   Li, Dechun ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Gene expression; Hypoxia induced mitogenic factor; Signal transduction; Vascular adhesion molecule 1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; HYPOXIA INDUCED MITOGENIC FACTOR; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; LUNG ALVEOLUS CELL TYPE 2; MONONUCLEAR CELL; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL ADHESION; CELL LINE; ENDOTHELIAL CELLS; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTOR; NF-KAPPA B; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY MUCOSA; RNA INTERFERENCE; RNA STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33749183547     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2005-0424OC     Document Type: Article

References (35)

1. Lukacs NW, Ward PA. Inflammatory mediators, cytokines, and adhesion molecules in pulmonary inflammation and injury. Adv Immunol 1996;62:257-304.
2. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-314.
3. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994;84:2068-2101.
4. Elices MJ, Osborn L, Takada YL, Grouse C, Luhoowskyi S, Helmer ME, Lobb RR. VCAM-1 on activated endothelium interacts with the specific leukocyte integrin VLA-4 at a site distinct from VLA-4/fibronectin binding site. Cell 1990;60:577-584.
5. Henseleit U, Steinbrink K, Sunderkotter C, Goebeler M, Roth J, Sorg C. Expression of murine VCAM-1 in vitro and in different models of inflammation in vivo: correlation with immigration of monocytes. Exp Dermatol 1994;3:249-256.
6. Haraldsen G, Kvale D, Lien B, Farstad IN, Brandtzaeg P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol 1996;156:2558-2565.
7. Van Kampen C, Mallard BA. Regulation of bovine intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) on cultured aortic endothelial cells. Vet Immunol Immunopathol 2001;79:129-138.
8. van Oosten M, van de Bilt E, de Vries HE, van Berkel TJ, Kuiper J. Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo. Hepatology 1995;22:1538-1546.
9. Woo CH, Lim JH, Kim JH. VCAM-1 upregulation via PKC8-p38 kinase-linked cascade mediates the TNF-α-induced leukocyte adhesion and emigration in the lung airway epithelium. Am J Physiol Lung Cell Mol Physiol 2005;288:L307-L316.
10. Teng X, Li D, Champion HC, Johns RA. FIZZ1/RELMα, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties. Circ Res 2003;92:1065-1067.
11. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ, et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000;19:4046-4055.
12. Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, Enders GH, Silberg DG, Wen X, Wu GD, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 2001;98:502-506.
13. Liu T, Jin H, Ullenbruch M, Hu B, Hashimoto N, Moore B, McKenzie A, Lukacs NW, Phan SH. Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6. J Immunol 2004;173:3425-3431.
14. Li D, Fernandez LG, Dodd-o J, Langer J, Wang D, Laubach VE. Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy. Am J Respir Cell Mol Biol 2005;32:185-191.
15. Wagner KF, Hellberg AK, Balenger S, Depping R, Dodd O, Johns RA, Li D. Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2α. Am J Respir Cell Mol Biol 2004;31:276-282.
16. Tong Q, Zheng L, Dodd-o J, Langer J, Wang D, Li D. Hypoxia-induced mitogenic factor modulates surfactant protein b and c expression in mouse lung. Am J Respir Cell Mol Biol 2006;34:28-38.
17. Fu D, Kobayashi M, Lin L. A p105-based inhibitor broadly represses NF-κB activities. J Biol Chem 2004;279:12819-12826.
18. + cells. Mol Cell Biol 1996;16:6427-6435.
19. Korenaga R, Ando J, Kosaki K, Isshiki M, Takada Y, Kamiya A. Negative transcriptional regulation of the VCAM-1 gene by fluid shear stress in murine endothelial cells. Am J Physiol Cell Physiol 1997;273:C1506-C1515.
20. Croft D, McIntyre P, Wibulswas A, Kramer IJ. Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-α in combination with either IL-4 or IL-13 through increased mRNA stability. Am J Pathol 1999;154:1149-1158.
21. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-κ B and cytokine-inducible enhancers. FASEB J 1995;9:899-909.
22. Nidai Ozes O, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999;401:82-85.
23. Romashkova JA, Makarov SS. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999;401:86-90.
24. Chin JE, Hatfield CA, Winterrowd GE, Brashler JR, Vonderfecht SL, Fidler SF, Griffin RL, Kolbasa KP, Krzesicki RF, Sly LM, et al. Airway recruitment of leukocytes in mice is dependent on α4-integrins and vascular cell adhesion molecule-1. Am J Physiol Lung Cell Mol Physiol 1997;272:L219-L229.
25. Cunningham AC, Milne DS, Wilkes J, Dark JH, Tetley TD, Kirby JA. Constitutive expression of MHC and adhesion molecules by alveolar epithelial cells (type II pneumocytes) isolated from human lung and comparison with immunocytochemical findings. J Cell Sci 1994;107: 443-449.
26. Papi A, Johnston SL. Respiratory epithelial cell expression of vascular cell adhesion molecule-1 and its up-regulation by rhinovirus infection via NF-κ B and GATA transcription factors. J Biol Chem 1999;274:30041-30051.
27. Rosseau S, Selhorst J, Wiechmann K, Leissner K, Maus U, Mayer K, Grimminger F, Seeger W, Lohmeyer J. Monocyte migration through the alveolar epithelial barrier: adhesion molecule mechanisms and impact of chemokines. J Immunol 2000;164:427-435.
28. Neish AS, Williams AJ, Palmer HJ, Whitley MZ, Collins T. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J Exp Med 1992;176:1583-1593.
29. Cybulsky MI, Allan-Motamed M, Collins T. Structure of the murine VCAM1 gene. Genomics 1993;18:387-391.
30. Shu HB, Agranoff AB, Nabel EG, Leung K, Duckett CS, Neish AS, Collins T, Nabel GJ. Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-κB subunits in endothelial and epithelial cells. Mol Cell Biol 1993;13:6283-6289.
31. Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Saito T, Manabe I, Imai Y, Nagai R. C-reactive protein induces VCAM-1 gene expression through NF-κB activation in vascular endothelial cells. Atherosclerosis 2006;185:39-46.
32. Baldwin AS. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-681.
33. Karin M. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 1999;18:6867-6874.
34. Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 1999;284:316-320.
35. Fry MJ. Structure, regulation and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1994;1226:237-268.