-
1
-
-
0033358671
-
Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum
-
Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, et al. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet 1999; 65: 664-70.
-
(1999)
Am J Hum Genet
, vol.65
, pp. 664-670
-
-
Campion, D.1
Dumanchin, C.2
Hannequin, D.3
Dubois, B.4
Belliard, S.5
Puel, M.6
-
2
-
-
0024581727
-
Molecular genetics of Alzheimer's disease
-
Hardy JA, Owen MJ, Goate AM, James LA, Haynes AR, Rossor MN, et al. Molecular genetics of Alzheimer's disease. Biochem Soc Trans 1989; 17: 75-6.
-
(1989)
Biochem Soc Trans
, vol.17
, pp. 75-76
-
-
Hardy, J.A.1
Owen, M.J.2
Goate, A.M.3
James, L.A.4
Haynes, A.R.5
Rossor, M.N.6
-
3
-
-
0023722957
-
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease
-
Schellenberg GD, Bird TD, Wijsman EM, Moore DK, Boehnke M, Bryant EM, et al. Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science 1988; 241: 1507-10.
-
(1988)
Science
, vol.241
, pp. 1507-1510
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Moore, D.K.4
Boehnke, M.5
Bryant, E.M.6
-
4
-
-
0025179972
-
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. FAD Collaborative Study Group
-
St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. FAD Collaborative Study Group. Nature 1990; 347: 194-7.
-
(1990)
Nature
, vol.347
, pp. 194-197
-
-
St George-Hyslop, P.H.1
Haines, J.L.2
Farrer, L.A.3
Polinsky, R.4
Van Broeckhoven, C.5
Goate, A.6
-
5
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-6.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
-
6
-
-
0032150877
-
Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau
-
Hardy J, Duff K, Hardy KG, Pérez-Tur, J, Hutton M. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat Neurosci 1998; 1: 355-86.
-
(1998)
Nat Neurosci
, vol.1
, pp. 355-386
-
-
Hardy, J.1
Duff, K.2
Hardy, K.G.3
Pérez-Tur, J.4
Hutton, M.5
-
7
-
-
0034966403
-
Closing in on the amyloid cascade: Recent insights into the cell biology of Alzheimer's disease
-
Huse JT, Doms RW. Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease. Mol Neurobiol 2000; 22: 81-98.
-
(2000)
Mol Neurobiol
, vol.22
, pp. 81-98
-
-
Huse, J.T.1
Doms, R.W.2
-
8
-
-
0033600301
-
Molecular basis of the neurodegenerative disorders
-
Martin JB. Molecular basis of the neurodegenerative disorders. N Engl J Med 1999; 340: 1970-80.
-
(1999)
N Engl J Med
, vol.340
, pp. 1970-1980
-
-
Martin, J.B.1
-
9
-
-
0031057837
-
Exploring the etiology of Alzheimer disease using molecular genetics
-
Lendon CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 1997; 277: 825-31.
-
(1997)
JAMA
, vol.277
, pp. 825-831
-
-
Lendon, C.L.1
Ashall, F.2
Goate, A.M.3
-
10
-
-
0026471656
-
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
-
Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258: 668-71.
-
(1992)
Science
, vol.258
, pp. 668-671
-
-
Schellenberg, G.D.1
Bird, T.D.2
Wijsman, E.M.3
Orr, H.T.4
Anderson, L.5
Nemens, E.6
-
11
-
-
0027032695
-
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
-
St George-Hyslop P, Haines J, Rogaev E, Mortilla M, Vaula G, Pericak-Vance M, et al. Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14. Nat Genet 1992; 2: 330-4.
-
(1992)
Nat Genet
, vol.2
, pp. 330-334
-
-
St George-Hyslop, P.1
Haines, J.2
Rogaev, E.3
Mortilla, M.4
Vaula, G.5
Pericak-Vance, M.6
-
12
-
-
0027024651
-
-
Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Díaz P, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nat Genet 1992; 2: 340-2.
-
Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Díaz P, et al. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nat Genet 1992; 2: 340-2.
-
-
-
-
13
-
-
0027031612
-
-
Van Broeckhoven C, Backhovens H, Cruts M, De Winter G, Bruyland M, Cras P, et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nat Genet 1992; 2: 335-9.
-
Van Broeckhoven C, Backhovens H, Cruts M, De Winter G, Bruyland M, Cras P, et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nat Genet 1992; 2: 335-9.
-
-
-
-
14
-
-
0031938304
-
Presenilin mutations in Alzheimer's disease
-
Cruts M, Van Broeckhoven C. Presenilin mutations in Alzheimer's disease. Hum Mutat 1998; 11: 183-90.
-
(1998)
Hum Mutat
, vol.11
, pp. 183-190
-
-
Cruts, M.1
Van Broeckhoven, C.2
-
15
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995; 376: 775-8.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
-
16
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995; 269: 973-7.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
Romano, D.M.4
Oshima, J.5
Pettingell, W.H.6
-
17
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, et al. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 2000; 405: 689-94.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
-
18
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, et al. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci U S A 2000; 97: 6138-43.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
DiMuzio-Mower, J.5
Sardana, M.K.6
-
19
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimer's disease
-
Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999; 399 (Suppl 6738): A23-31.
-
(1999)
Nature
, vol.399
, Issue.SUPPL. 6738
-
-
Selkoe, D.J.1
-
20
-
-
0033966452
-
Notch and presenilins in vertebrates and invertebrates: Implications for neuronal development and degeneration
-
Selkoe DJ. Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration. Curr Opin Neurobiol 2000; 10: 50-7.
-
(2000)
Curr Opin Neurobiol
, vol.10
, pp. 50-57
-
-
Selkoe, D.J.1
-
21
-
-
0033959997
-
Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?
-
Anderton BH, Dayanandan R, Killick R, Lovestone S. Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease? Mol Med Today 2000; 6: 54-9.
-
(2000)
Mol Med Today
, vol.6
, pp. 54-59
-
-
Anderton, B.H.1
Dayanandan, R.2
Killick, R.3
Lovestone, S.4
-
22
-
-
12944305721
-
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically
-
Grilli M, Diodato E, Lozza G, Brusa R, Casarini M, Uberti D, et al. Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically. Proc Natl Acad Sci U S A 2000; 97: 12822-7.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12822-12827
-
-
Grilli, M.1
Diodato, E.2
Lozza, G.3
Brusa, R.4
Casarini, M.5
Uberti, D.6
-
23
-
-
0028172930
-
E in animal models of CNS injury and in Alzheimer's disease
-
Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994; 17: 525-30.
-
(1994)
Trends Neurosci
, vol.17
, pp. 525-530
-
-
Apolipoprotein, P.J.1
-
24
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 1993; 90: 1977-81.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
-
25
-
-
0030823158
-
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
-
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997; 278: 1349-56.
-
(1997)
JAMA
, vol.278
, pp. 1349-1356
-
-
Farrer, L.A.1
Cupples, L.A.2
Haines, J.L.3
Hyman, B.4
Kukull, W.A.5
Mayeux, R.6
-
26
-
-
0029664414
-
Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study
-
Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A, et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: the Framingham study. Neurology 1996; 46: 673-7.
-
(1996)
Neurology
, vol.46
, pp. 673-677
-
-
Myers, R.H.1
Schaefer, E.J.2
Wilson, P.W.3
D'Agostino, R.4
Ordovas, J.M.5
Espino, A.6
-
27
-
-
0028035306
-
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease
-
Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci U S A 1994; 91: 11183-6.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 11183-11186
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Goedert, M.3
Weisgraber, K.H.4
Dong, L.M.5
Jakes, R.6
-
28
-
-
0028303072
-
E: Structure-function relationships
-
Weisgraber KH. Apolipoprotein E: structure-function relationships. Adv Protein Chem 1994; 45: 249-320.
-
(1994)
Adv Protein Chem
, vol.45
, pp. 249-320
-
-
Apolipoprotein, W.K.H.1
-
29
-
-
4143105546
-
-
Crutcher KA. Apolipoprotein E is a prime suspect, not just an accomplice, in Alzheimer's disease. J Mol Neurosci 2004; 23: 181-8.
-
Crutcher KA. Apolipoprotein E is a prime suspect, not just an accomplice, in Alzheimer's disease. J Mol Neurosci 2004; 23: 181-8.
-
-
-
-
30
-
-
9444271770
-
Allelic expression of APOE in human brain: Effects of epsilon status and promoter haplotypes
-
Bray NJ, Jehu L, Moskvina V, Buxbaum JD, Dracheva S, Haroutunian V, et al. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Hum Mol Genet 2004; 13: 2885-92.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2885-2892
-
-
Bray, N.J.1
Jehu, L.2
Moskvina, V.3
Buxbaum, J.D.4
Dracheva, S.5
Haroutunian, V.6
|