Alternative cell death pathways: Lessons learned from a viral protein;Voies de signalisation alternatives de la mort cellulaire programmée: Une perspective virale

Bulletin du Cancer

Volumn 93, Issue 9, 2006, Pages 921-930

  Landry, Marie Claude ^a   Robert, Amélie ^a   Lavoie, Josée N ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Actin; Adenovirus; Apoptosis; Cancer; E4orf4; Src

Indexed keywords

ADENOVIRUS PROTEIN E4ORF; CASPASE; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; ACTIN; E4ORF4 PROTEIN, ADENOVIRUS; PROTEIN BAX; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; STAT3 PROTEIN;

ADENOVIRUS; APOPTOSIS; ENDOSOME; MUTATION; NONHUMAN; REVIEW; TUMOR CELL; CELL DEATH; CELL DIVISION; DISEASE COURSE; ENZYME ACTIVATION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VIRUS CELL TRANSFORMATION; VIRUS REPLICATION;

ACTINS; ADENOVIRIDAE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL DEATH; CELL DIVISION; CELL TRANSFORMATION, VIRAL; DISEASE PROGRESSION; ENZYME ACTIVATION; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 33749050199     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: None     Document Type: Review

References (65)

1. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004; 43: 307-15.
2. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
3. Jaattela M, Tschopp J. Caspase-independent cell death in T lymphocytes. Nat Immunol 2003; 4: 416-23.
4. Dilworth SM. Polyoma virus middle T antigen and its role in identifying cancer-related molecules. Nat Rev Cancer 2002; 2: 951-6.
5. Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001; 2: 589-98.
6. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-57.
7. Denial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116: 205-19.
8. Raff M. Cell suicide for beginners. Nature 1998; 396: 119-22.
9. Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci USA 1996; 93: 14559-63.
10. Lavoie JN, Nguyen M, Marcellus RC, Branton PE, Shore GC. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk. J Cell Biol 1998; 140: 637-45.
11. Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 1998; 273: 32608-13.
12. Foghsgaard L, Wissing D, Mauch D, Lademann U, Bastholm L, Boes M, et al. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 2001; 153: 999-1010.
13. Schotte P, Declercq W, Van Huffel S, Vandenabeele P, Beyaert R. Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Lett 1999; 442: 117-21.
14. Abraham MC, Shaham S. Death without caspases, caspases without death. Trends Cell Biol 2004; 14: 184-93.
15. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, et al. BCL-2, BCL-X (L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 2001; 8: 705-11.
16. Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G, Vandenabeele P. Toxic proteins released from mitochondria in cell death. Oncogens 2004; 23: 2861-74.
17. Mathiasen IS, Jaattela M. Triggering caspase-independent cell death to combat cancer. Trends Mol Med 2002; 8: 212-20.
18. Maag RS, Hicks SW, Machamer CE. Death from within: apoptosis and the secretory pathway. Curr Opin Cell Biol 2003; 15: 456-61.
19. Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5: 886-97.
20. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res 2005; 11: 3155-62.
21. Robert A, Miron MJ, Champagne C, Gingras MC, Branton PE, Lavoie JN. Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein. J Cell Biol 2002; 158: 519-28.
22. Kleinberger T. Induction of transformed cell-specific apoptosis by the adenovirus E4orf4 protein. Prog Mol Subcell Biol 2004; 36: 245-67.
23. Teodoro JG, Shore GC, Branton PE. Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms. Oncogene 1995; 11: 467-74.
24. Marcellus RC, Teodoro JG, Wu T, Brough DE, Ketner G, Shore GC, et al. Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis. J Virol 1996; 70: 6207-15.
25. Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA 1992; 89: 7742-6.
26. Moran E. DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev 1993; 3: 63-70.
27. Akusjarvi G. Proteins with transcription regulatory properties encoded by human adenoviruses. Trends Microbiol 1993; 1: 163-70.
28. Tollefson AE, Scaria A, Hermiston TW, Ryerse JS, Wold LJ, Wold WS. The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells. J Virol 1996; 70: 2296-306.
29. Marcellus RC, Lavoie JN, Boivin D, Shore GC, Ketner G, Branton PE. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis. J Virol 1998; 72: 7144-53.
30. Shtrichman R, Kleinberger T. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J Virol 1998; 72: 2975-82.
31. Shtrichman R, Sharf R, Barr H, Dobner T, Kieinberger T. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A. Proc Natl Acad Sci USA 1999; 96: 10080-5.
32. Branton PE, Roopchand DE. The role of adenovirus E4orf4 protein in viral replication and cell killing. Oncogene 2001; 20: 7855-65.
33. Ben-Israel H, Kleinberger T. Adenovirus and cell cycle control. Front Biosci 2002; 7: d1369-d1395.
34. O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, et al. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J 2005; 24: 1211-21.
35. Livne A, Shtrichman R, Kleinberger T. Caspase activation by adenovirus e4orf4 protein is cell line specific and Is mediated by the death receptor pathway. J Virol 2001; 75: 789-98.
36. Robert A, Smadja-Lamère N, Landry MC, Champagne C, Petrie R, Lamarche-Vane N, et al. Adenovirus E4orf4 hijacks Rho GTPases-dependent actin-myosin dynamics to kill cells: a role for endosomes-associated actin assembly. Mol Biol Cell 2006; 17: 3329-44.
37. Kleinberger T, Shenk T. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription. J Virol 1993; 67: 7556-60.
38. Marcellus RC, Chan H, Paquette D, Thirlwell S, Boivin D, Branton PE. Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A. J Virol 2000; 74: 7869-77.
39. Lavoie JN, Champagne C, Gingras MC, Robert A. Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases. J Cell Biol 2000; 150: 1037-56.
40. Champagne C, Landry MC, Gingras MC, Lavoie JN. Activation of adenovirus type 2 early region 4 ORF4 cytoplasmic death function by direct binding to Src kinase domain. J Biol Chem 2004; 279: 25905-15.
41. Miron MJ, Gallouzi IE, Lavoie JN, Branton PE. Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death. Oncogene 2004; 23: 7458-68.
42. Kornitzer D, Sharf R, Kleinberger T. Adenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome. J Cell Biol 2001; 154: 331-44.
43. Roopchand DE, Lee JM, Shahinian S, Paquette D, Bussey H, Branton PE. Toxicity of human adenovirus E4orf4 protein in Saccharomyces cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A. Oncogene 2001; 20: 5279-90.
44. Gingras MC, Champagne C, Roy M, Lavoie JN. Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein. Mol Cell Biol 2002; 22: 41-56.
45. Glover HR, Brewster CE, Dilworth SM. Association between src-kinases and the polyoma virus oncogene middle T-antigen requires PP2A and a specific sequence motif. Oncogene 1999; 18: 4364-70.
46. Ichaso N, Dilworth SM. Cell transformation by the middle T-antigen of polyoma virus. Oncogene 2001; 20: 7908-16.
47. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21: 247-69.
48. Fritz G, Kaina B. Rho GTPases: promising cellular targets for novel anticancer drugs. Curr Cancer Drug Targets 2006; 6: 1-14.
49. Mills JC, Stone NL, Pittman RN. Extranuclear apoptosis. The role of the cytoplasm in the execution phase. J Cell Biol 1999; 146: 703-8.
50. Mills JC, Stone NL, Erhardt J, Pittman RN. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J Cell Biol 1998; 140: 627-36.
51. Sebbagh M, Renvoize C, Hamelin J, Riche N, Bertoglio J, Breard J. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol 2001; 3: 346-52.
52. Coleman ML, Olson MF. Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ 2002; 9: 493-504.
53. Pienta KJ, Coffey DS. Cell motility as a chemotherapeutic target. Cancer Surv 1991; 11: 255-63.
54. Wang LG, Liu XM, Kreis W, Budman DR. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol 1999; 44: 355-61.
55. Rodriguez-Menocal L, D'Urso G. Programmed cell death in fission yeast. FEMS Yeast Res 2004; 5: 111-7.
56. Gourlay CW, Carpp LN, Timpson P, Winder SJ, Ayscough KR. A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 2004; 164: 803-9.
57. Rao J, Li N. Microfilament actin remodeling as a potential target for cancer drug development. Curr Cancer Drug Targets 2004; 4: 345-54.
58. Sebbagh M, Hamelin J, Bertoglio J, Solary E, Breard J. Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med 2005; 201: 465-71.
59. Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, et al. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci USA 1997; 94: 13642-7.
60. Vilas GL, Corvi MM, Plummer GJ, Seime AM, Lambkin GR, Berthiaume LG. Posttransiational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events. Proc Natl Acad Sci USA 2006; 103: 6542-7.
61. Stradal TE, Scita G. Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol 2006; 18: 4-10.
62. Gouin E, Welch MD, Cossart P. Actin-based motility of intracellular pathogens. Curr Opin Microbiol 2005; 8: 35-45.
63. Baum B, Kunda P. Actin nucleation: spire-actin nucleator in a class of its own. Curr Biol 2005; 15: R305-R308.
64. Schafer DA. Regulating actin dynamics at membranes: a focus on dynamin. Traffic 2004; 5: 463-9.
65. Hicks SW, Machamer CE. Golgi structure in stress sensing and apoptosis. Biochim Biophys Acta 2005; 174: 406-14.