From cardiac repair to cardiac regeneration - Ready to translate?

Expert Opinion on Biological Therapy

Volumn 6, Issue 9, 2006, Pages 867-878

  Ott, Harald C ^b   Taylor, Doris A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cardiac regeneration; Cardiac repair; Cardiac stem cells; Cell therapy; Cellular cardiomyoplasty; Heart failure

Indexed keywords

ANIMAL; BONE MARROW CELL; CARDIOLOGY; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; HEART MUSCLE CELL; HEART PAPILLARY MUSCLE; HUMAN; MUSCLE CELL; PHYSIOLOGY; REGENERATION; REGENERATIVE MEDICINE; REVIEW; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TRANSPLANTATION;

ANIMALS; BONE MARROW CELLS; CARDIOLOGY; CARDIOVASCULAR DISEASES; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; MUSCLE FIBERS; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; REGENERATION; REGENERATIVE MEDICINE; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING;

EID: 33749041984     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.9.867     Document Type: Review

References (150)

1. NO AUTHORS LISTED: Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group. Lancet (1994) 343:311-322. (Pubitemid 124000789)
2. YUSUF S, WITTES J, FRIEDMAN L: Overview of results of randomized clinical trials in heart disease. I. Treatments following myocardial infarction. JAMA (1988) 260:2088-2093. (Pubitemid 18230571)
3. MCGOVERN PG, PANKOW JS, SHAHAR E et al.: Recent trends in acute coronary heart disease-mortality, morbidity, medical care, and risk factors. The Minnesota Heart Survey Investigators. N. Engl. J. Med. (1996) 334:884-890.
4. NAYLOR CD, CHEN E: Population-wide mortality trends among patients hospitalized for acute myocardial infarction: the Ontario experience, 1981 to 1991. J. Am. Coll. Cardiol. (1994) 24:1431-1438.
5. GOLDBERG RJ, GORAK EJ, YARZEBSKI J et al.: A communitywide perspective of sex differences and temporal trends in the incidence and survival rates after acute myocardial infarction and out-of-hospital deaths caused by coronary heart disease. Circulation (1993) 87:1947-1953. (Pubitemid 23165638)
6. HELLERMANN JP, GORAYA TY, JACOBSEN SJ et al.: Incidence of heart failure after myocardial infarction: is it changing over time? Am. J. Epidemiol. (2003) 157:1101-1107. (Pubitemid 36686701)
7. AHNVE S, GILPIN E, HENNING H, CURTIS G, COLLINS D, ROSS J JR: Limitations and advantages of the ejection fraction for defining high risk after acute myocardial infarction. Am. J. Cardiol. (1986) 58:872-878. (Pubitemid 17175818)
8. LAMAS GA, MITCHELL GF, FLAKER GC et al.: Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators. Circulation (1997) 96:827-833.
9. OBEIDAT O, ALAM M, DIVINE GW, KHAJA F, GOLDSTEIN S, SABBAH H: Echocardiographic predictors of prognosis after first acute myocardial infarction. Am. J. Cardiol. (2004) 94:1278-1280. (Pubitemid 39469948)
10. PARODI G, CARRABBA N, SANTORO GM et al.: Heart failure and left ventricular remodeling after reperfused acute myocardial infarction in patients with Hypertension. Hypertension. (2006) 47:706-710. (Pubitemid 43740242)
11. ROHDE LE, AIKAWA M, CHENG GC et al.: Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction. J. Am. Coll. Cardiol. (1999) 33:835-842.
12. KOSTUK WJ, KAZAMIAS TM, GANDER MP, SIMON AL, ROSS J JR: Left ventricular size after acute myocardial infarction. Serial changes and their prognostic significance. Circulation (1973) 47:1174-1179.
13. PFEFFER MA, BRAUNWALD E: Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation (1990) 81:1161-1172. (Pubitemid 20119612)
14. MOSS AJ, ZAREBA W, HALL WJ et al.: Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N. Engl. J. Med. (2002) 346:877-883. (Pubitemid 34984635)
15. COHN JN, FRANCIS GS: Cardiac failure: a revised paradigm. J. Card. Fail. (1995) 1:261-266.
16. COHN JN: Structural basis for heart failure. Ventricular remodeling and its pharmacological inhibition. Circulation (1995) 91:2504-2507.
17. COHN JN, FERRARI R, SHARPE N: Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J. Am. Coll. Cardiol. (2000) 35:569-582.
18. HERTZ MI, TAYLOR DO, TRULOCK EP et al.: The registry of the international society for heart and lung transplantation: nineteenth official report-2002. J. Heart Lung Transplant. (2002) 21:950-970. (Pubitemid 35286679)
19. ROSE EA, GELIJNS AC, MOSKOWITZ AJ et al.: Long-term mechanical left ventricular assistance for end-stage heart failure. N. Engl. J. Med. (2001) 345:1435-1443. (Pubitemid 34936630)
20. BANK AJ, MIR SH, NGUYEN DQ et al.: Effects of left ventricular assist devices on outcomes in patients undergoing heart transplantation. Ann. Thorac. Surg. (2000) 69:1369-1374; discussion 1375. (Pubitemid 30434860)
21. LIETZ K, MILLER LW: Will left-ventricular assist device therapy replace heart transplantation in the foreseeable future? Curr. Opin. Cardiol. (2005) 20:132-137. (Pubitemid 40392866)
22. MILLER LW: Patient selection for the use of ventricular assist devices as a bridge to transplantation. Ann. Thorac. Surg. (2003) 75:S66-971.
23. STEVENSON LW, MILLER LW, DESVIGNE-NICKENS P et al.: Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure). Circulation (2004) 110:975-981. (Pubitemid 39128623)
24. MANCINI DM, BENIAMINOVITZ A, LEVIN H et al.: Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation (1998) 98:2383-2389. (Pubitemid 28549781)
25. TAYLOR DA, ATKINS BZ, HUNGSPREUGS P et al.: Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. (1998) 4:929-933. (Pubitemid 28364032)
26. OTT HC, MCCUE J, TAYLOR DA: Cell-based cardiovascular repair-the hurdles and the opportunities. Basic Res. Cardiol. (2005) 100:504-517. (Pubitemid 41662430)
27. MAURO A: Satellite cell of skeletal muscle fibers. J. Biophys. Biochem. Cytol. (1961) 9:493-495.
28. CHACHQUES JC, GRANDJEAN PA, TOMMASI JJ et al.: Dynamic cardiomyoplasty: a new approach to assist chronic myocardial failure. Life Support Syst. (1987) 5:323-327. (Pubitemid 18019277)
29. KOH GY, KLUG MG, SOONPAA MH, FIELD LJ: Differentiation and long-term survival of C2C12 myoblast grafts in heart. J. Clin. Invest. (1993) 92:1548-1554. (Pubitemid 23273936)
30. ZIBAITIS A, GREENTREE D, MA F, MARELLI D, DUONG M, CHIU RC: Myocardial regeneration with satellite cell implantation. Transplant. Proc. (1994) 26:3294.
31. MENASCHE P, HAGEGE A, SCORSIN M et al.: Myoblast transplantation for heart failure. Lancet (2001) 357:279-280. (Pubitemid 32120862)
32. MENASCHE P, HAGEGE AA, VILQUIN JT et al.: Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J. Am. Coll. Cardiol. (2003) 41:1078-1083. (Pubitemid 36384891)
33. HERREROS J, PROSPER F, PEREZ A et al.: Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur. Heart J. (2003) 24:2012-2020. (Pubitemid 37420448)
34. SIMINIAK T, KALAWSKI R, FISZER D et al.: Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: Phase I clinical study with 12 months of follow-up. Am. Heart J. (2004) 148:531-537. (Pubitemid 39265130)
35. SMITS PC, VAN GEUNS RJ, POLDERMANS D et al.: Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J. Am. Coll. Cardiol. (2003) 42:2063-2069. (Pubitemid 37549885)
36. SIMINIAK T, FISZER D, JERZYKOWSKA O et al.: Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment: the POZNAN trial. Eur. Heart J. (2005) 26:1188-1195. (Pubitemid 40863125)
37. DIB N, MICHLER RE, PAGANI FD et al.: Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation (2005) 112:1748-1755. (Pubitemid 41368151)
38. GAVIRA JJ, HERREROS J, PEREZ A et al.: Autologous skeletal myoblast transplantation in patients with nonacute myocardial infarction: 1-year follow-up. J. Thorac. Cardiovasc. Surg. (2006) 131:799-804.
39. STEENDIJK P, SMITS PC, VALGIMIGLI M et al.: Intramyocardial injection of skeletal myoblasts: long-term follow-up with pressure-volume loops. Nat. Clin. Pract. Cardiovasc. Med. (2006) 3(Suppl. 1):S94-S100. (Pubitemid 43315484)
40. ATKINS BZ, LEWIS CW, KRAUS WE, HUTCHESON KA, GLOWER DD, TAYLOR DA: Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ. Ann. Thorac. Surg. (1999) 67:124-129. (Pubitemid 29138740)
41. OTT HC, BERJUKOW S, MARKSTEINER R et al.: On the fate of skeletal myoblasts in a cardiac environment: down-regulation of voltage-gated ion channels. J. Physiol. (2004) 558:793-805. (Pubitemid 39199105)
42. MURRY CE, WISEMAN RW, SCHWARTZ SM, HAUSCHKA SD: Skeletal myoblast transplantation for repair of myocardial necrosis. J. Clin. Invest. (1996) 98:2512-2523. (Pubitemid 26415072)
43. YEH ET, ZHANG S, WU HD, KORBLING M, WILLERSON JT, ESTROV Z: Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation (2003) 108:2070-2073. (Pubitemid 37337581)
44. MURRY CE, SOONPAA MH, REINECKE H et al.: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature (2004) 428:664-668. (Pubitemid 38524810)
45. DETEN A, VOLZ HC, CLAMORS S et al.: Hematopoietic stem cells do not repair the infarcted mouse heart. Cardiovasc. Res. (2005) 65:52-63. (Pubitemid 40038478)
46. JIANG Y, JAHAGIRDAR BN, REINHARDT RL et al.: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 418:41-49. (Pubitemid 34742565)
47. VERFAILLIE CM, PERA MF, LANSDORP PM: Stem cells: hype and reality. Hematology (Am. Soc. Hematol. Educ. Program). (2002):369-391.
48. HU Y, WANG QY, MA L, MA GJ, JIANG XY, ZHAO CH: [Identification and isolation of mesenchymal stem cells from human fetal pancreas]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2002) 24:45-49.
49. KAWADA H, FUJITA J, KINJO K et al.: Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood (2004) 104:3581-3587. (Pubitemid 39564430)
50. STRAUER BE, BREHM M, ZEUS T et al.: Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation (2002) 106:1913-1918. (Pubitemid 35176294)
51. SCHUSTER MD, KOCHER AA, SEKI T et al.: Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration. Am. J. Physiol. Heart Circ. Physiol. (2004) 287:H525-H532. (Pubitemid 38955280)
52. KOCHER AA, SCHUSTER MD, SZABOLCS MJ et al.: Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. (2001) 7:430-436. (Pubitemid 32298545)
53. THOMPSON RB, VAN DEN BOS EJ, DAVIS BH et al.: Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation. J. Heart Lung Transplant. (2005) 24:205-214. (Pubitemid 40215599)
54. THOMPSON RB, EMANI SM, DAVIS BH et al.: Comparison of intracardiac cell transplantation: autologous skeletal myoblasts versus bone marrow cells. Circulation (2003) 108(Suppl. 1):II264-II271. (Pubitemid 37099966)
55. BITTIRA B, SHUM-TIM D, AL-KHALDI A, CHIU RC: Mobilization and homing of bone marrow stromal cells in myocardial infarction. Eur. J. Cardiothorac. Surg. (2003) 24:393-398. (Pubitemid 37083532)
56. VULLIET PR, GREELEY M, HALLORAN SM, MACDONALD KA, KITTLESON MD: Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet (2004) 363:783-784. (Pubitemid 38315169)
57. JIANG XX, ZHANG Y, LIU B et al.: Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood (2005) 105:4120-4126. (Pubitemid 40656164)
58. KALKA C, MASUDA H, TAKAHASHI T et al.: Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc. Natl. Acad. Sci. USA (2000) 97:3422-3427. (Pubitemid 30183318)
59. KHAKOO AY, FINKEL T: Endothelial progenitor cells. Annu. Rev. Med. (2005) 56:79-101. (Pubitemid 40299775)
60. SHINTANI S, MUROHARA T, IKEDA H et al.: Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation (2001) 103:2776-2779. (Pubitemid 32550062)
61. WERNER N, KOSIOL S, SCHIEGL T et al.: Circulating endothelial progenitor cells and cardiovascular outcomes. N. Engl. J. Med. (2005) 353:999-1007. (Pubitemid 41262334)
62. SCHMIDT-LUCKE C, ROSSIG L, FICHTLSCHERER S et al.: Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation (2005) 111:2981-2987. (Pubitemid 40814192)
63. AICHER A, BRENNER W, ZUHAYRA M et al.: Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation (2003) 107:2134-2139. (Pubitemid 36532196)
64. KAWAMOTO A, GWON HC, IWAGURO H et al.: Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation (2001) 103:634-637. (Pubitemid 32144189)
65. MASUDA H, KALKA C, ASAHARA T: Endothelial progenitor cells for regeneration. Hum. Cell (2000) 13:153-160.
66. URBICH C, KNAU A, FICHTLSCHERER S et al.: FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells. FASEB J. (2005) 19:974-976. (Pubitemid 40827722)
67. HENNING RJ, ABU-ALI H, BALIS JU, MORGAN MB, WILLING AE, SANBERG PR: Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infarction. Cell Transplant. (2004) 13:729-739. (Pubitemid 40280210)
68. MA N, STAMM C, KAMINSKI A et al.: Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc. Res. (2005) 66:45-54. (Pubitemid 40357867)
69. ANVERSA P, KAJSTURA J, LERI A, BOLLI R: Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation (2006) 113:1451-1463. (Pubitemid 43739442)
70. BELTRAMI A, URBANEK K, KAJSTURA J et al.: Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. (2001) 344:1750-1757. (Pubitemid 32497029)
71. QUAINI F, URBANEK K, BELTRAMI AP et al.: Chimerism of the transplanted heart. N. Engl. J. Med. (2002) 346:5-15. (Pubitemid 34438914)
72. URBANEK K, TORELLA D, SHEIKH F et al.: Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc. Natl. Acad. Sci. USA (2005) 102:8692-8697. (Pubitemid 40862797)
73. BELTRAMI AP, BARLUCCHI L, TORELLA D et al.: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 114:763-776. (Pubitemid 37186770)
74. MATSUURA K, NAGAI T, NISHIGAKI N et al.: Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J. Biol. Chem. (2004) 279:11384-11391. (Pubitemid 38401637)
75. LINKE A, MULLER P, NURZYNSKA D et al.: Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc. Natl. Acad. Sci. USA (2005) 102:8966-8971. (Pubitemid 40881062)
76. URBANEK K, QUAINI F, TASCA G et al.: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc. Natl. Acad. Sci. USA (2003) 100:10440-10445. (Pubitemid 37071897)
77. URBANEK K, ROTA M, CASCAPERA S et al.: Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ. Res. (2005) 97:663-673. (Pubitemid 41416335)
78. ROSENBLATT-VELIN N, LEPORE MG, CARTONI C, BEERMANN F, PEDRAZZINI T: FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J. Clin. Invest. (2005) 115:1724-1733. (Pubitemid 40979711)
79. OH H, BRADFUTE SB, GALLARDO TD et al.: Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl. Acad. Sci. USA (2003) 100:12313-12318. (Pubitemid 37271557)
80. MARTIN CM, MEESON AP, ROBERTSON SM et al.: Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev. Biol. (2004) 265:262-275. (Pubitemid 38018836)
81. PFISTER O, MOUQUET F, JAIN M et al.: CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ. Res. (2005) 97:52-61. (Pubitemid 40982322)
82. MOUQUET F, PFISTER O, JAIN M et al.: Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ. Res. (2005) 97:1090-1092. (Pubitemid 43755201)
83. HIERLIHY AM, SEALE P, LOBE CG, RUDNICKI MA, MEGENEY LA: The post-natal heart contains a myocardial stem cell population. FEBS Lett. (2002) 530:239-243. (Pubitemid 35248218)
84. ZHOU S, SCHUETZ JD, BUNTING KD et al.: The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat. Med. (2001) 7:1028-1034. (Pubitemid 32937383)
85. LAUGWITZ KL, MORETTI A, LAM J et al.: Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 433:647-653. (Pubitemid 40282999)
86. MESSINA E, DE ANGELIS L, FRATI G et al.: Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ. Res. (2004) 95:911-921. (Pubitemid 39435006)
87. VASSILIEVA S, GUAN K, PICH U, WOBUS AM: Establishment of SSEA-1- and Oct-4-expressing rat embryonic stem-like cell lines and effects of cytokines of the IL-6 family on clonal growth. Exp. Cell Res. (2000) 258:361-373. (Pubitemid 30483514)
88. IIDA M, HEIKE T, YOSHIMOTO M, BABA S, DOI H, NAKAHATA T: Identification of cardiac stem cells with FLK1, CD31, and VE-cadherin expression during embryonic stem cell differentiation. FASEB J. (2005) 19:371-378. (Pubitemid 40316525)
89. KATAOKA H, TAKAKURA N, NISHIKAWA S et al.: Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells. Dev. Growth Differ. (1997) 39:729-740. (Pubitemid 27525337)
90. MINASI MG, RIMINUCCI M, DE ANGELIS L et al.: The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues. Development (2002) 129:2773-2783. (Pubitemid 34874259)
91. CAI CL, LIANG X, SHI Y et al.: Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell (2003) 5:877-889. (Pubitemid 37527688)
92. DUROCHER D, CHARRON F, WARREN R, SCHWARTZ RJ, NEMER M: The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. (1997) 16:5687-5696. (Pubitemid 27399860)
93. TANAKA M, CHEN Z, BARTUNKOVA S, YAMASAKI N, IZUMO S: The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development (1999) 126:1269-1280. (Pubitemid 29182122)
94. ERDO F, BUHRLE C, BLUNK J et al.: Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J. Cereb. Blood Flow Metab. (2003) 23:780-785. (Pubitemid 36818686)
95. KOFIDIS T, DE BRUIN JL, YAMANE T et al.: Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury. Circulation (2005) 111:2486-2493. (Pubitemid 40696137)
96. LAFLAMME MA, MURRY CE: Regenerating the heart. Nat. Biotechnol. (2005) 23:845-856. (Pubitemid 43093128)
97. BIAGINI E, VALGIMIGLI M, SMITS PC et al.: Stress and tissue Doppler echocardiographic evidence of effectiveness of myoblast transplantation in patients with ischaemic heart failure. Eur. J. Heart Fail. (2006) (In Press). (Pubitemid 44604354)
98. FERNANDEZ-AVILES F, SAN ROMAN JA, GARCIA-FRADE J et al.: Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ. Res. (2004) 95:742-748. (Pubitemid 39331935)
99. KUETHE F, RICHARTZ BM, SAYER HG et al.: Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions. Int. J. Cardiol. (2004) 97:123-127. (Pubitemid 39178533)
100. WOLLERT KC, MEYER GP, LOTZ J et al.: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet (2004) 364:141-148. (Pubitemid 38891685)
101. CHEN SL, FANG WW, YE F et al.: Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol. (2004) 94:92-95. (Pubitemid 38813459)
102. VANDERHEYDEN MS, VANDEKERCKHOVE B, DE BONDT P et al.: Selected intracoronary CD133+ bone marrow cells promote cardiac regeneration after acute myocardial infarction. Circ. Res. (2004) 110:324-325.
103. STAMM C, WESTPHAL B, KLEINE HD et al.: Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet (2003) 361:45-46. (Pubitemid 36050962)
104. STAMM C, KLEINE HD, WESTPHAL B et al.: CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac. Cardiovasc. Surg. (2004) 52:152-158. (Pubitemid 38832922)
105. HAMANO K, NISHIDA M, HIRATA K et al.: Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results. Jpn. Circ. J. (2001) 65:845-847. (Pubitemid 32845720)
106. TSE HF, KWONG YL, CHAN JK, LO G, HO CL, LAU CP: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet (2003) 361:47-49. (Pubitemid 36050963)
107. FUCHS S, SATLER LF, KORNOWSKI R et al.: Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study. J. Am. Coll. Cardiol. (2003) 41:1721-1724. (Pubitemid 36584242)
108. PERIN EC, DOHMANN HF, BOROJEVIC R et al.: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation (2003) 107:2294-2302. (Pubitemid 36578498)
109. PERIN EC, DOHMANN HF, BOROJEVIC R et al.: Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation (2004) 110:II213-II218. (Pubitemid 39263725)
110. FUCHS S, KORNOWSKI R, WEISZ G et al.: Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease. Am. J. Cardiol. (2006) 97:823-829. (Pubitemid 43313253)
111. JANSSENS S, DUBOIS C, BOGAERT J et al.: Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet (2006) 367:113-121. (Pubitemid 43077127)
112. ASSMUS B, SCHACHINGER V, TEUPE C et al.: Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation (2002) 106:3009-3017. (Pubitemid 35440281)
113. BRITTEN MB, ABOLMAALI ND, ASSMUS B et al.: Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation (2003) 108:2212-2218. (Pubitemid 37368893)
114. SCHACHINGER V, ASSMUS B, BRITTEN MB et al.: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial. J. Am. Coll. Cardiol. (2004) 44:1690-1699. (Pubitemid 39369805)
115. LI ZQ, ZHANG M, JIN YZ et al.: [Safety and efficacy of intracoronary transplantation of G-CSF mobilized autologous peripheral blood stem cells in patients with acute myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi (2006) 34:99-102.
116. BARTUNEK J, DIMMELER S, DREXLER H et al.: The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur. Heart J. (2006) 27:1338-1340. (Pubitemid 43998109)
117. CONBOY IM, CONBOY MJ, WAGERS AJ, GIRMA ER, WEISSMAN IL, RANDO TA: Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 433:760-764. (Pubitemid 40292986)
118. BAJ A, BETTACCINI AA, CASALONE R, SALA A, CHERUBINO P, TONIOLO AQ: Culture of skeletal myoblasts from human donors aged over 40 years: dynamics of cell growth and expression of differentiation markers. J. Transl. Med. (2005) 3:21. (Pubitemid 41522086)
119. BRACK AS, BILDSOE H, HUGHES SM: Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy. J. Cell Sci. (2005) 118:4813-4821. (Pubitemid 41646389)
120. ROURA S, FARRE J, SOLER-BOTIJA C et al.: Effect of aging on the pluripotential capacity of human CD105(+) mesenchymal stem cells. Eur. J. Heart Fail. (2006) (In Press). (Pubitemid 44604351)
121. KERN S, EICHLER H, STOEVE J, KLUTER H, BIEBACK K: Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood or adipose tissue. Stem Cells (2006) 24(5):1294-1301. (Pubitemid 44464698)
122. VALGIMIGLI M, RIGOLIN GM, FUCILI A et al.: CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation (2004) 110:1209-1212. (Pubitemid 39202334)
123. CHIN BB, NAKAMOTO Y, BULTE JW, PITTENGER MF, WAHL R, KRAITCHMAN DL: 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl. Med. Commun. (2003) 24:1149-1154. (Pubitemid 39625401)
124. CHIMENTI C, KAJSTURA J, TORELLA D et al.: Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ. Res. (2003) 93:604-613. (Pubitemid 37222156)
125. RANDO TA: The adult muscle stem cell comes of age. Nat. Med. (2005) 11:829-831. (Pubitemid 41161111)
126. MINAMI E, LAFLAMME MA, SAFFITZ JE, MURRY CE: Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart. Circulation (2005) 112:2951-2958. (Pubitemid 41612297)
127. STUCK WG, O'DONOGHUE DH et al: Fractures. Arch. Surg. (1949) 59:1139-1190.
128. KLONER RA, GANOTE CE, JENNINGS RB: The 'no-reflow' phenomenon after temporary coronary occlusion in the dog. J. Clin. Invest. (1974) 54:1496-1508.
129. XYDAS S, ROSEN RS, NG C et al.: Mechanical unloading leads to echocardiographic, electrocardiographic, neurohormonal, and histologic recovery. J. Heart Lung Transplant. (2006) 25:7-15. (Pubitemid 43049658)
130. BIRKS EJ, HALL JL, BARTON PJ et al.: Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support. Circulation (2005) 112:I57-I64. (Pubitemid 41266654)
131. WOHLSCHLAEGER J, SCHMITZ KJ, SCHMID C et al.: Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes. Cardiovasc. Res. (2005) 68:376-386. (Pubitemid 41566557)
132. LIETZ K, MILLER LW: Left ventricular assist devices: evolving devices and indications for use in ischemic heart disease. Curr. Opin. Cardiol. (2004) 19:613-618. (Pubitemid 39482288)
133. SUZUKI K, MURTUZA B, BEAUCHAMP JR et al.: Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart. FASEB J. (2004) 18:1153-1155. (Pubitemid 39561554)
134. TAMBARA K, SAKAKIBARA Y, SAKAGUCHI G et al.: Transplanted skeletal myoblasts can fully replace the infarcted myocardium when they survive in the host in large numbers. Circulation (2003) 108(Suppl. 1):II259-II263. (Pubitemid 37099965)
135. WEBER KT: Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation. Circulation (1997) 96:4065-4082. (Pubitemid 27506067)
136. SPINALE FG, COKER ML, HEUNG LJ et al.: A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure. Circulation (2000) 102:1944-1949. (Pubitemid 30776007)
137. DESCHAMPS AM, SPINALE FG: Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation. Cardiovasc. Res. (2006) 69:666-676. (Pubitemid 43139729)
138. WEBER KT, SUN Y, TYAGI SC, CLEUTJENS JP: Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms. J. Mol. Cell. Cardiol. (1994) 26:279-292. (Pubitemid 24199288)
139. BADYLAK SF: The extracellular matrix as a scaffold for tissue reconstruction. Semin. Cell Dev. Biol. (2002) 13:377-383. (Pubitemid 35300815)
140. HAUSCHKA SD, KONIGSBERG IR: The influence of collagen on the development of muscle clones. Proc. Natl. Acad. Sci. USA (1966) 55:119-126.
141. BISSELL MJ, AGGELER J: Dynamic reciprocity: how do extracellular matrix and hormones direct gene expression? Prog. Clin. Biol. Res. (1987) 249:251-262.
142. SUN Y, RATAJSKA A, WEBER KT: Inhibition of angiotensin-converting enzyme and attenuation of myocardial fibrosis by lisinopril in rats receiving angiotensin II. J. Lab. Clin. Med. (1995) 126:95-101.
143. HUMPHRIES MJ, TRAVIS MA, CLARK K, MOULD AP: Mechanisms of integration of cells and extracellular matrices by integrins. Biochem. Soc. Trans. (2004) 32:822-825. (Pubitemid 39524388)
144. EISENBERG LM, MARKWALD RR: Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. (1995) 77:1-6.
145. TAMBARA K, PREMARATNE GU, SAKAGUCHI G et al.: Administration of control-released hepatocyte growth factor enhances the efficacy of skeletal myoblast transplantation in rat infarcted hearts by greatly increasing both quantity and quality of the graft. Circulation (2005) 112:I129-I134. (Pubitemid 41266664)
146. KOFIDIS T, DE BRUIN JL, HOYT G et al.: Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscle. J. Thorac. Cardiovasc. Surg. (2004) 128:571-578. (Pubitemid 39278391)
147. ZIMMERMANN WH, MELNYCHENKO I, WASMEIER G et al.: Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat. Med. (2006) 12:452-458.
148. SEKINE H, SHIMIZU T, KOSAKA S, KOBAYASHI E, OKANO T: Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells. J. Heart Lung Transplant. (2006) 25:324-332. (Pubitemid 43290664)
149. ROBINSON KA, LI J, MATHISON M et al.: Extracellular matrix scaffold for cardiac repair. Circulation (2005) 112:I135-I143. (Pubitemid 41266665)
150. FEDAK PW, SZMITKO PE, WEISEL RD et al.: Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism. J. Thorac. Cardiovasc. Surg. (2005) 130:1430-1439. (Pubitemid 41543215)