Exploring the role of the active site cysteine in human muscle creatine kinase

Biochemistry

Volumn 45, Issue 38, 2006, Pages 11464-11472

  Wang, Pan Fen ^a   Flynn, Allen J ^a   Naor, Mor M ^b,d   Jensen, Jan H ^b   Cui, Guanglei ^c   Merz Jr , Kenneth M ^c   Kenyon, George L ^a   McLeish, Michael J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b E11 SSH   (United States)

^c University of Florida ^*  (United States)

^d University of Memphis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; ENZYME KINETICS; HYDROGEN BONDS; MUSCLE; MUTAGENESIS; PH EFFECTS;

CYSTEINE; HUMAN MUSCLE CREATINE KINASE (HMCK); KINASE; MUTATIONS;

ENZYMES;

CREATINE KINASE; CYSTEINE; MUSCLE ENZYME; PROLINE; SERINE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HYDROGEN BOND; IONIZATION; MOLECULAR DYNAMICS; PH; PKA; PREDICTION; PRIORITY JOURNAL; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; ULTRAVIOLET SPECTROSCOPY;

ADENOSINE DIPHOSPHATE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CREATINE; CREATINE KINASE, MM FORM; CYSTEINE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTANT PROTEINS; PHOSPHORYLATION; PROLINE; SERINE; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

EID: 33749011194     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0607002     Document Type: Article

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