Abnormal properties of creatine kinase in Alzheimer's disease brain: Correlation of reduced enzyme activity and active site photolabeling with aberrant cytosol-membrane partitioning

Molecular Brain Research

Volumn 54, Issue 2, 1998, Pages 276-287

  David, Satyajit ^a   Shoemaker, Michael ^a   Haley, Boyd E ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Activity; Alzheimer's; Creatine kinase; Microtubule; Nucleotidylation; Partitioning; Photoaffinity

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BRAIN ENZYME; CREATINE KINASE; GUANOSINE TRIPHOSPHATE; NUCLEOTIDE; PHOSPHORUS 32; TUBULIN;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; BRAIN; BRAIN HOMOGENATE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME MODIFICATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; ISOTOPE LABELING; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

ALZHEIMER DISEASE; BINDING SITES; BRAIN; CASE-CONTROL STUDIES; CELL COMPARTMENTATION; CREATINE KINASE; CYTOSOL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INTRACELLULAR MEMBRANES; ISOENZYMES; PHOSPHORYLATION; PHOTOAFFINITY LABELS; SOLUBILITY; TUBULIN;

EID: 0032030854     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00343-4     Document Type: Article

References (53)

1. Bessman S.P., Carpenter C.L. The creatine-creatine phosphate energy shuttle. Ann. Rev. Biochem. 54:1985;831-863.
2. Blum H., Balschi J.A., Johnson R.G. Coupled in vivo activity of creatine phosphokinase and the membrane bound (Na, K)-ATPase in the resting and stimulated electric organ of the electric fish Narcine brasiliensis. J. Biol. Chem. 266:1991;10254-10259.
3. Borthwick N.M., Yates C.M., Gordon A. Reduced proteins in the temporal cortex in Alzheimer's disease: An electrophoretic study. J. Neurochem. 44(5):1985;1436-1441.
4. Bowen D. Br. J. Psych. 157:1990;327-330.
5. Burbaeva G.S., Aksenova M.V., Makarenko I.G. Decreased level of creatine kinase BB in the frontal cortex of Alzheimer patients. Dementia. 3:1992;91-94.
6. Czarneki J., Geahlen R.T., Haley B.E. Synthesis and use of azido photoaffinity analogs of adenine and guanine nucleotides. Methods Enzymol. 60:1979;642-653.
7. Dunant Y., Loctin F., Marsal J., Muller D., Parducz A., Rabasseda X. Energy metabolism and quantal acetylcholine release: Effects of botulinium toxin, 1-fluoro 2,4-dinitrobenzene and diamide in the torpedo electric organ. J. Neurochem. 50:1998;431-439.
8. Friedhoff A.J., Lerner M.H. Creatine kinase isoenzyme associated with synaptosomal membrane and synaptic vesicles. Life Sci. 20:1977;867-873.
9. Fritz-Wolf K., Schnyder T., Walliman T., Kabsch W. Structure of mitochondrial creatine kinase. Nature. 381:1996;341-345.
10. Geahlen R.L., Haley B.E. Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization. J. Biol. Chem. 254:1979;11982-11987.
11. Gross M., Wallimann T. Kinetics of assembly and dissociation of the mitochondrial creatine kinase octamer, a fluorescence study. Biochemistry. 32:1993;13933-13940.
12. Gunnersen D., Haley B.E. Detection of glutamine synthetase in cerebrospinal fluid of Alzheimer's diseased patients: A potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA. 89:1992;11949-11953.
13. Hemmer W., Furter-Graves E.M., Frank G., Walliman T., Furter R. Autophosphorylation of creatine kinase: Characterization and identification of a specifically phosphorylated peptide. Biochim. Biophys. Acta. 1251:1995;81-90.
14. W. Hemmer, S.J. Glaser, G.R. Hartmann, H.M. Eppengerger, T. Walliman, Covalent modification of creatine kinase by ATP: Evidence for autophosphorylation, in: L.M.G. Heilmeyer (Ed.), Cellular Regulation by Protein Phosphorylation, NATO ASI series, Vol. H56, 1991, 143-147.
15. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Akesenova M., Gabbita S.P., Wu J.F., Carney J.M., Lovell M., Markesbery W.R., Butterfield D.A. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J. Neurochem. 65:1995;2146-2156.
16. K. Iqbal, I. Grundke-Iqbal, H.M. Wisniewski, Defective brain microtubule assembly in Alzheimer's disease, The Lancet, August 1986, 421-426.
17. Iyengar M.R. Creatine kinase as an intracellular regulator. J. Muscle Res. Cell Motil. 5:1984;527-534.
18. J.F. Kachmar, D.W. Moss, in: N.W. Tietz (Ed.), Enzymes in Fundamentals of Clinical Chemistry, Chap. 12, W.B. Saunders, Philadelphia, PA, 1976, 682-683.
19. Khatoon S., Campbell S.R., Haley B.E., Slevin J.T. Aberrant guanine triphosphate β-tubulin interaction in Alzheimer's disease. Ann. Neurol. 19:1990;371-376.
20. Korge P., Campbell K.B. The effect of changes in iron redox state on the activity of enzymes sensitive to modification of SH groups. Arch. Biochem. Biophys. 304:1993;420-428.
21. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
22. Levin R.M., Longhurst P.A., Levin S.S., Hangaard N., Wein A.J. Creatine kinase activity of urinary bladder and skeletal muscle from control and streptozotocin-diabetic rats. Mol. Cell. Biochem. 97:1990;153-159.
23. Lim L., Hall C., Leung T., Mahadevan L., Whatley S. Neurone-specific enolase and creatine phosphokinase are protein components of rat brain synaptic plasma membranes. J. Neurochem. 41:1983;1177-1181.
24. Manos P., Bryan G.K., Edmund J. Creatine kinase activity in postnatal rat brain development and in cultured neurons, astrocytes, and oligodendrocytes. J. Neurochem. 56:1991;2101-2107.
25. Mantyh P.W., Ghilardi J.R., Rogers S., DeMaster E., Allen C.J., Stimson E.R., Maggio J.E. Aluminum, iron and zinc promote aggregation of physiological concentrations of β-amyloid peptide. J. Neurochem. 61:1993;1171-1174.
26. W.R. Markesbery, W.D. Ehman, Trace elements in dementing disorders, In Nutritional modulation of neuronal function, Academic Press, New York, 1988, 179-190.
27. 31P NMR saturation transfer study of the regulation of creatine kinase in the rat heart. Biochem. Biophys. Acta. 721:1982;312-330.
28. Mattson M.P. Calcium as sculptor and destroyer of neural circuitry. Exp. Gerontol. 27:1992;29-49.
29. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. Clinical diagnosis of Alzheimer's disease. Neurology. 34:1984;939-944.
30. Olcott M.C., Bradley M.L., Haley B.E. Photoaffinity labeling of creatine kinase with 2-azido- and 8-azidoadenosine triphosphate: Identification of two peptides from the ATP-binding domain. Biochemistry. 33:1994;11935-11941.
31. Osuna E., Perez-Carceles M.D., Luna A., Pounder D.J. Efficacy of cerebrospinal fluid in the diagnosis of brian insult. Forensic Sci. Int. 52:1992;193-198.
32. Pearson R.C., Esiri M.M., Hiorns R.W., Wilcock G.K., Powell T.P.S. Anatomial correlations of the distribution of the pathological changes in the neocortex in Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 82:1985;4531-4534.
33. J.C. Pendergrass, B.E. Haley, Mercury-EDTA complex specifically blocks brain β-tubulin-GTP interactions: Similarity to observations in Alzheimer's disease, in: L.T. Fribergs, G.N. Schrauzer (Eds.), Status Quo and Perspective of Amalgam and Other Dental Materials, Int. Symposium Proc., Georg Thieme Verlag, Stuttgart, 1995, pp. 98-105.
34. Pendergrass J.C., Haley B., Vimy M., Winfield S., Lorscheider F. Mercury vapor inhalation inhibits binding of GTP to tubulin in rat brain: Similarity to a molecular lesion in Alzheimer's diseased brain. Neurotoxicology. 18(2):1997;1-10.
35. Pettegrew J.W., Panchalingam K., Klunk W.E., McLure R.J., Muenz L.R. Alterations of cerebral metabolism in probable Alzheimer's disease: A preliminary study. Neurobiol. Aging. 15:1994;117-132.
36. Potter R., Haley B.E. Nucleotide binding sites with 8-azido purine analogs: Techniques and applications. Methods Enzymol. 91:1983;613-633.
37. Quest A.F.G., Soldati T., Hemmer W., Perriard J.C., Eppenberger H.M., Walliman T. Phosphorylation of chicken brain-type creatine kinase affects a physiologically important kinetic parameter and gives rise to protein microheterogeneity in vivo. FEBS Lett. 269(2):1990;457-464.
38. Salvucci M., Chavan A., Haley B.E. Identification of peptides from the adenine binding domain of ATP and AMP in adenylate kinase: Isolation of photoaffinity labeled peptides by metal chelate chromatography. Biochemistry. 31:1992;884-891.
39. B. Sankaran, J. Clemens, B. Haley, A comparison of changes in nucleotide-protein interactions in the striatal, hippocampus and paramedian cortex after cerebral ischemia and reperfusion: Correlations to regional vulnerability, Mol. Brain Res., 1997, in press.
40. C.D. Smith, J.M. Carney, P.E. Stark-Reed, C.N. Oliver, E.R. Stadtman, R.A. Floyd, W.R. Markesbery, Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer's disease, Proc. Natl. Acad. Sci. USA, (1991) 10540-10543.
41. Smith C.D., Carney J.M., Tatsumo T., Stadtman E.R., Floyd R.A., Markesbery W.R. Protein oxidation in aging brain. Ann. NY Acad. Sci. 663:1992;110-119.
42. 2+-pump functionally coupled with a membrane associated creatine phosphokinase. Acta Biol. Med. Germany. 40:1981;1111-1122.
43. Szaz G., Gruber W., Bernt E. Creatine kinase in serum: Determination of optimum reaction conditions. Clin. Chem. 22:1979;650.
44. Vazquez M.D., Sanchez-Rodriguez E., Osuna J., Diaz D.E., Cox M.D., Perez-Carceles P., Martinez A., Luna A., Pounder D.J. Creatine kinase BB and neuron-specific enolase in cerebrospinal fluid in the diagnosis of brain insult. Am. J. Forensic Med. Pathol. 16(3):1995;210-214.
45. Villarreal-Levy G., Ma T.S., Kerner S.A., Roberts R., Perryman M.B. Human creatine kinase: Isolation and sequence analysis of cDNA clones for the β-subunit, development of subunit specific probes and determination of gene copy number. Biochem. Biophys. Res. Commun. 108:1987;1116-1127.
46. Walliman T., Wyss M., Brdiczka D., Nicolay K., Eppenberger H.M. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasis. Biochem. J. 281:1992;21-40.
47. Yamashita K., Yoshioka T. Profiles of creatine kinase isoenzyme compositions in single muscle fibres of different types. J. Muscle Res. Cell Motil. 12:1991;37-44.
48. Yoshimine T., Morimoto K., Homberger H.A., Yanagihara T. Immunohistochemical localization of creatine kinase BB-isoenzyme in human brain: Comparison with tubulin and astroprotein. Brain Res. 265:1983;101-108.
49. Alonso A., Grundke-Iqbal I., Iqbal K. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nature Med. 2:1996;783-787.
50. Grundke-Iqbal I., Iqbal K., Yunn-Chyn T., Quinlan M., Wisniewski H., Binder L. Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA. 83:1986;4914-4917.
51. Khatoon S., Grundke-Iqbal I., Iqbal K. Guanosine triphosphate binding to β-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein τ J. Neurochem. 64:1995;777-787.
52. S. David, C. Pendergrass, M. Shoemaker, B. Haley, Abstr. # 641.16, 27th Annual Meeting, Society of Neuroscience, New Orleans, Oct. 25-30, 1997, p. 1653.
53. J.C. Pendergrass, B.E. Haley, Inhibition of brain tubulin-guanosine 5′-triphosphate interactions by mercury: Similarity to observations in Alzheimer's disease brain, in: H. Sigel, A. Sigel (Eds.), Metal Ions in Biological Systems V34, Mercury and its Effects on Environment and Biology, Chap. 16, Marcel Dekker, New York, 1996, 461-478.