Determination of the bound conformation of a competitive nanomolar inhibitor of Mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy

ChemMedChem

Volumn 1, Issue 9, 2006, Pages 990-996

  Prazeres, Verónica F V ^a   Sänchez Sixto, Cristina ^a   Castedo, Luis ^a   Canales, Ángeles ^b   Cañada, Francisco Javier ^b   Jiménez Barbero, Jesús ^b   Lamb, Heather ^c   Hawkins, Alastair R ^c   González Bello, Concepción ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Bound conformation; NMR spectroscopy; STD; TR NOESY; Tuberculosis

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; 3-DEHYDROQUINATE DEHYDRATASE; ENZYME INHIBITOR; HYDROLYASE; TUBERCULOSTATIC AGENT;

ARTICLE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING;

ANTITUBERCULAR AGENTS; COMPUTATIONAL BIOLOGY; ENZYME INHIBITORS; HYDRO-LYASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING;

EID: 33749005103     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200600100     Document Type: Article

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