Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets

Journal of Biological Chemistry

Volumn 280, Issue 37, 2005, Pages 32531-32538

  Niu, Zhiyv ^a   Yu, Wei ^a   Zhang, Shu Xing ^a   Barron, Matthew ^a   Belaguli, Narasimhaswamy S ^a   Schneider, Michael D ^a   Parmacek, Michael ^b   Nordheim, Alfred ^c   Schwartz, Robert J ^a,d  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CARDIOLOGY; CELLS; MUSCLE; MUTAGENESIS;

EMBRYONIC STEM CELLS; GENE ACTIVITIES; NATURETIC FACTORS; SERUM RESPONSE FACTORS (SRF);

GENES;

ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; BETA GALACTOSIDASE; CRE RECOMBINASE; MYOSIN HEAVY CHAIN ALPHA; PROTEIN SM22ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOREGULATION; CELL COUNT; CELL LINEAGE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; GASTRULA; GENE; GENE ACTIVITY; GENE FUNCTION; GENE TARGETING; HEART DEVELOPMENT; HEART FAILURE; HEART MUSCLE CELL; HOMOZYGOTE; KNOCKOUT GENE; LOXP SITE; MESODERM; MOUSE; MUTAGENESIS; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SERUM RESPONSE FACTOR GENE; SKELETAL MUSCLE; SMOOTH MUSCLE; STEM CELL; TRANSGENIC MOUSE;

ACTINS; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; CELL LINEAGE; DNA-BINDING PROTEINS; DOWN-REGULATION; EMBRYO; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENES, REPORTER; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; LAC OPERON; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MUSCLE, SKELETAL; MUTAGENESIS, SITE-DIRECTED; MYOCARDIUM; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERUM RESPONSE FACTOR; STEM CELLS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSGENES;

MURINAE;

EID: 25444458851     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501372200     Document Type: Article

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