Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin

Journal of Autoimmunity

Volumn 27, Issue 1, 2006, Pages 54-61

  Mäkelä, Miia ^a   Vaarala, Outi ^b,c   Hermann, Robert ^a,d   Salminen, Kimmo ^a   Vahlberg, Tero ^a   Veijola, Riitta ^e   Hyöty, Heikki ^f,g   Knip, Mikael ^g,h   Simell, Olli ^a   Ilonen, Jorma ^a,i  

^a UNIVERSITY OF TURKU   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c LINKÖPING UNIVERSITY   (Sweden)

^d SEMMELWEIS UNIVERSITY   (Hungary)

^e UNIVERSITY OF OULU   (Finland)

^f TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^g TAMPERE UNIVERSITY HOSPITAL   (Finland)

^h UNIVERSITY OF HELSINKI   (Finland)

ⁱ UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Immunization; Insulin; Type 1 diabetes; Virus infection

Indexed keywords

ADENOVIRUS; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE ASSOCIATION; ENTEROVIRUS; FEMALE; FOLLOW UP; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; INFANT; INSULIN BINDING; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; ROTAVIRUS; VIRUS INFECTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; AUTOANTIBODIES; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DISEASE SUSCEPTIBILITY; GASTROINTESTINAL DISEASES; HUMANS; INFANT; INSULIN; MILK; VIRUS DISEASES;

EID: 33748782259     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2006.04.003     Document Type: Article

References (34)

1. Kupila A., Keskinen P., Simell T., Erkkilä S., Arvilommi P., Korhonen S., et al. Genetic risk determines the emergence of diabetes-associated autoantibodies in young children. Diabetes 51 (2002) 646-651
2. Knip M., Veijola R., Virtanen S.M., Hyöty H., Vaarala O., and Åkerblom H.K. Environmental triggers and determinants of type 1 diabetes. Diabetes 54 (2005) S125-S136
3. Vaarala O., Saukkonen T., Savilahti E., Klemola T., and Åkerblom H.K. Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula. J Allergy Clin Immunol 96 (1995) 917-923
4. Vaarala O., Knip M., Paronen J., Hämäläinen A.M., Muona P., Väätäinen M., et al. Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 48 (1999) 1389-1394
5. Palmer J.P., Asplin C.M., Clemons P., Lyen K., Tatpati O., Raghu P.K., et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222 (1983) 1337-1339
6. Atkinson M.A., Maclaren N.K., Riley W.J., Winter W.E., Fisk D.D., and Spillar R.P. Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?. Diabetes 35 (1986) 894-898
7. Karjalainen J., Knip M., Mustonen A., Ilonen J., and Åkerblom H.K. Relation between insulin antibody and complement-fixing islet cell antibody at clinical diagnosis of IDDM. Diabetes 35 (1986) 620-622
8. Srikanta S., Ricker A.T., McCulloch D.K., Soeldner J.S., Eisenbarth G.S., and Palmer J.P. Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus. Diabetes 35 (1986) 139-142
9. Ziegler A.G., Hummel M., Schenker M., and Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB study. Diabetes 48 (1999) 460-468
10. Kimpimäki T., Kupila A., Hämäläinen A.M., Kukko M., Kulmala P., Savola K., et al. The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 86 (2001) 4782-4788
11. Lévy-Marchal C., Bridel M.P., Sodoyez-Goffaux F., Koch M., Tichet J., Czernichow P., et al. Superiority of radiobinding assay over ELISA for detection of IAAs in newly diagnosed type 1 diabetic children. Diabetes Care 14 (1991) 61-63
12. Paronen J., Knip M., Savilahti E., Virtanen S.M., Ilonen J., Åkerblom H.K., et al. Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group. Diabetes 49 (2000) 1657-1665
13. Kupila A., Muona P., Simell T., Arvilommi P., Savolainen H., Hämäläinen A.M., et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 44 (2001) 290-297
14. Kupila A., Sipilä J., Keskinen P., Simell T., Knip M., Pulkki K., et al. Intranasally administered insulin intended for prevention of type 1 diabetes-a safety study in healthy adults. Diabetes Metab Res Rev 19 (2003) 415-420
15. Sarkkinen H.K., Meurman O.H., and Halonen P.E. Solid-phase radioimmunoassay of IgA, IgG, and IgM antibodies to human rotavirus. J Med Virol 3 (1979) 281-289
16. Lönnrot M., Korpela K., Knip M., Ilonen J., Simell O., Korhonen S., et al. Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study. Diabetes 49 (2000) 1314-1318
17. Savola K., Sabbah E., Kulmala P., Vähäsalo P., Ilonen J., and Knip M. Autoantibodies associated with Type I diabetes mellitus persist after diagnosis in children. Diabetologia 41 (1998) 1293-1297
18. Savola K., Bonifacio E., Sabbah E., Kulmala P., Vähäsalo P., Karjalainen J., et al. IA-2 antibodies-a sensitive marker of IDDM with clinical onset in childhood and adolescence. Childhood Diabetes in Finland Study Group. Diabetologia 41 (1998) 424-429
19. Williams A.J., Bingley P.J., Bonifacio E., Palmer J.P., and Gale E.A. A novel micro-assay for insulin autoantibodies. J Autoimmun 10 (1997) 473-478
20. Salminen K., Sadeharju K., Lönnrot M., Vähäsalo P., Kupila A., Korhonen S., et al. Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study. J Med Virol 69 (2003) 91-98
21. Blomqvist M., Juhela S., Erkkilä S., Korhonen S., Simell T., Kupila A., et al. Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life. Clin Exp Immunol 128 (2002) 511-515
22. Jones D.B., and Crosby I. Proliferative lymphocyte responses to virus antigens homologous to GAD65 in IDDM. Diabetologia 39 (1996) 1318-1324
23. Honeyman M.C., Stone N.L., and Harrison L.C. T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for molecular mimicry with rotavirus and other environmental agents. Mol Med 4 (1998) 231-239
24. Honeyman M.C., Coulson B.S., Stone N.L., Gellert S.A., Goldwater P.N., Steele C.E., et al. Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes 49 (2000) 1319-1324
25. Walker W.A. Allergen absorption in the intestine: implication for food allergy in infants. J Allergy Clin Immunol 78 (1986) 1003-1009
26. Keljo D.J., Butler D.G., and Hamilton J.R. Altered jejunal permeability to macromolecules during viral enteritis in the piglet. Gastroenterology 88 (1985) 998-1004
27. Heyman M., Corthier G., Petit A., Meslin J.C., Moreau C., and Desjeux J.F. Intestinal absorption of macromolecules during viral enteritis: an experimental study on rotavirus-infected conventional and germ-free mice. Pediatr Res 22 (1987) 72-78
28. Jalonen T., Isolauri E., Heyman M., Crain-Denoyelle A.M., Sillanaukee P., and Koivula T. Increased beta-lactoglobulin absorption during rotavirus enteritis in infants: relationship to sugar permeability. Pediatr Res 30 (1991) 290-293
29. Ahmed T., Sumazaki R., Shin K., Nagai Y., Shibasaki M., Fuchs G.J., et al. Humoral immune and clinical responses to food antigens following acute diarrhoea in children. J Paediatr Child Health 34 (1998) 229-232
30. Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., and Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416 (2002) 603-607
31. Ruprecht C.R., and Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 36 (2006) 810-816
32. Vaarala O., Klemetti P., Juhela S., Simell O., Hyöty H., and Ilonen J. Effect of coincident enterovirus infection and cows' milk exposure on immunisation to insulin in early infancy. Diabetologia 45 (2002) 531-534
33. Juhela S., Hyöty H., Lönnrot M., Roivainen M., Simell O., and Ilonen J. Enterovirus infections and enterovirus specific T-cell responses in infancy. J Med Virol 54 (1998) 226-232
34. Greenbaum C.J., Palmer J.P., Kuglin B., and Kolb H. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. J Clin Endocrinol Metab 74 (1992) 1040-1044