IA-2 antibodies - A sensitive marker of IDDM with clinical onset in childhood and adolescence

Diabetologia

Volumn 41, Issue 4, 1998, Pages 424-429

  Savola, K ^a   Bonifacio, E ^b   Sabbah, E ^a   Kulmala, P ^a   Vahasalo P ^a   Karjalainen, J ^a   Tuomilehto Wolf, E ^c   Merilainen J ^a   Akerblom H K ^d   Knip, M ^a,e,f  

^a UNIVERSITY OF OULU   (Finland)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^f TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

GAD antibodies; HLA risk markers; IA 2 antibodies; Insulin autoantibodies; Islet cell antibodies

Indexed keywords

ADOLESCENT; ALLELE; ARTICLE; AUTOIMMUNITY; CHILD; DISEASE MARKER; DISEASE PREDISPOSITION; HLA SYSTEM; HUMAN; IMMUNOASSAY; IMMUNOFLUORESCENCE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; ONSET AGE; PANCREAS ISLET CELL; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SCREENING TEST;

ADOLESCENT; AGE FACTORS; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HLA-DR ANTIGENS; HUMANS; INFANT; INSULIN ANTIBODIES; MALE; MEMBRANE PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; SCINTILLATION COUNTING; SENSITIVITY AND SPECIFICITY; SEX FACTORS; SULFUR RADIOISOTOPES;

EID: 6844252890     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050925     Document Type: Article

References (34)

1. Christie MR (1996) Islet cell autoantigens in type 1 diabetes. Eur J Clin Invest 26: 827-838
2. Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet II: 1279-1282
3. Palmer J, Asplin C, Clemons P et al. (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337-1339
4. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark Å (1982) Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167-169
5. Baekkeskov S, Aanstoot H-J, Christgau S et al. (1990) Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156
6. r autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. J Clin Invest 92: 240-248
7. Rabin DU, Pleasic SM, Shapiro JA et al. (1994) Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152: 3183-3188
8. Lan MS, Lu J, Goto Y, Notkins AL (1994) Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13: 505-514
9. Pietropaolo M, Hutton JC, Eisenbarth GS (1997) Protein tyrosine phosphatase-like proteins: link with IDDM. Diabetes Care 20: 208-214
10. Passini N, Larigan JD, Genovese S, Appella E, Sinigaglia F, Rogge L (1995) The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc Natl Acad Sci USA 92: 9412-9416
11. Solimena M, Dirkx Jr RD, Hermel J-M et al. (1996) ICA512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J 15: 2102-2114
12. 65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia 40: 95-99
13. Tuomilehto J, Lounamaa R, Tuomilehto-Wolf E et al. (1992) Epidemiology of childhood diabetes mellitus in Finland - background of a nationwide study of type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35: 70-76
14. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E (1995) Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J Immunol 155: 5419-5426
15. Sambrook J. Fritsch EF, Maniatis T (1989) Plasmid vectors. In: Ford N, Nolan C, Ferguson M (eds) Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY, pp 1.3-1.110
16. 65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43: 459-467
17. Sabbah E, Kulmala P, Veijola R et al. (1996) Glutamic acid decarboxylase antibodies in relation to other autoantibodies and genetic risk markers in children with newly diagnosed insulin-dependent diabetes. J Clin Endocrinol Metab 81: 2455-2459
18. Bonifacio E, Lernmark Å, Dawkins RL (1988) Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies. J Immunol Methods 106: 83-88
19. Lernmark Å, Molenaar JL, van Beers VA (1991) The fourth international serum exchange workshop to standardize cytoplasmic islet cell antibodies. Diabetologia 34: 534-535
20. Tuomilehto Wolf E, Tuomilehto J, Cepaitis Z, Lounamaa R, the Childhood Diabetes in Finland Study Group (1989) New susceptibility haplotype for type 1 diabetes. Lancet 2: 299-302
21. Nomenclature for factors of the HLA system (1984) In: Albert ED, Mayr WR (eds) Histocomatibility testing. Berlin Springer Verlag, 1984, pp. 4-8
22. Genovese S, Bonfanti R, Bazzigaluppi E et al. (1996) Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM. Diabetologia 39: 1223-1226
23. Ilonen J, Reijonen H (1993) Special genetic features of the population in Nordic countries as related to risk of IDDM. Diabetes in the Young 29: 10-16
24. Bingley PJ, Christie MR, Bonifacio E et al. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43: 1304-1310
25. Bonifacio E, Genovese S, Braghi S et al. (1995) Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 38: 816-822
26. Arslanian SA, Becker D, Rabin B et al. (1985) Correlates of insulin antibodies in newly diagnosed children with insulin-dependent diabetes before insulin therapy. Diabetes 34: 926-930
27. Karjalainen J, Knip M, Mustonen A, Ilonen J, Åkerblom HK (1986) Relation between insulin antibody and complement-fixing islet cell antibody at clinical diagnosis of IDDM. Diabetes 35: 620-622
28. Hagopian WA, Sanjeevi CB, Kockum I et al. (1995) Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95: 1505-1511
29. Vähäsalo P, Miettinen A, Kulmala P et al. (1997) GAD antibodies are associated with thyroid antibodies in children with IDDM and in their siblings. Diabetologia 40 [Suppl 1]: A77 (Abstract)
30. Pagano G, Cavallo-Perin P, Cavalot F et al. (1987) Genetic, immunologic, and environmental heterogeneity of IDDM. Incidence and 12-mo follow-up of an Italian population. Diabetes 36: 859-863
31. Serjeantson S, Court J, Mackay I et al. (1993) HLA-DQ genotypes are associated with autoimmunity to GAD in IDDM patients. Hum Immunol 38: 97-104
32. Verge CF, Gianini R, Kawasaki E et al. (1996) Prediction of type 1 diabetes in first-degree relatives using a combination of insulin. GAD and ICA512bcd/IA-2 autoantibodies. Diabetes 45: 926-933
33. Roll U, Ziegler AG (1997) Combined antibody screening for improved prediction of IDDM. Modern strategies. Exp Clin Endocrinol Diabetes 105: 1-14
34. Kulmala P, Savola K, Petersen JS et al. (1998) Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes - a population-based study. J Clin Invest 101: 327-336