17β-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFκB cascade

Aging Cell

Volumn 4, Issue 3, 2005, Pages 113-118

  Borrás, Consuelo ^a   Gambini, Juan ^a   Gómez Cabrera, Ma Carmen ^a   Sastre, Juan ^a   Pallardó, Federico V ^a   Mann, Giovanni E ^b   Viña, José ^a,c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Antioxidants; Females; Longevity; Mitogen activated protein kinases; Nuclear factor kappa b; Oestrogens; Peroxides

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXIDE; PROTEIN P50; PROTEIN SUBUNIT; TAMOXIFEN; ANTIOXIDANT; HYDROGEN PEROXIDE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LONGEVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANALYSIS OF VARIANCE; BIOSYNTHESIS; CELL NUCLEUS; DRUG ANTAGONISM; FEMALE; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

MINK CELL FOCUS-FORMING VIRUS;

ANALYSIS OF VARIANCE; ANTIOXIDANTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL NUCLEUS; ENZYME ACTIVATION; ESTRADIOL; FEMALE; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; LONGEVITY; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SEX FACTORS; SUPEROXIDE DISMUTASE; TAMOXIFEN; UP-REGULATION;

EID: 23844445847     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2005.00151.x     Document Type: Article

References (26)

1. Abid MR, Schools IG, Spokes KC, Wu SQ, Mawhinney C, Aird WC (2004) Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J. Biol. Chem. 279, 44030-44038.
2. Arnal JF, Clamens S, Pechet C, Negre-Salvayre A, Allera C, Girolami J-P, Salvayre R, Bayard F (1996) Ethinyloestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc. Natl Acad. Sci. USA 93, 4108-4113.
3. Barja G (1999) Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity and relation to aging and longevity. J. Bioenerg. Biomembr. 31, 347-366.
4. Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
5. Bi R, Broutman G, Foy MR, Thompson RF, Baudry M (2000) The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of oestrogen in hippocampus. Proc. Natl Acad. Sci. USA 97, 3602-3607.
6. Borrás C, Sastre J, Garcia-Sala D, Lloret A, Pallardo FV, Vina J (2003) Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic. Biol. Med. 34, 546-552.
7. Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A, Auricchio F (1999) Non-transcriptional action of ooestradiol and progestin triggers DNA synthesis. EMBO J. 18, 2500-2510.
8. Das KC, Lewis-Molock Y, White CW (1995) Activation of NF-κB and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells. Am. J. Physiol. 5, L588-L602.
9. Fernández-Ballesteros R, Diez-Nicolas J, Ruiz-Torres A. (1999) Spain. In Aging in Europe (Schroots J, Fernandez Ballesteros R, Rudinger G, eds). Washington, DC: IOS Press, 107-121.
10. Green S, Chambon P (1988) Nuclear receptors enhance our understanding of transcription regulation. Trends Genet. 4, 309-314.
11. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300.
12. Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, McCleary CA, Klein RA, Hake AM, Farlow MR (2000) Oestrogen for Alzheimer's disease in women. Randomized, doulbe-blind, placebo-controlled trial. Neurology 54, 295-301.
13. Jordan VC (1998) Designer estrogens. Sci. Am. 279, 60-67.
14. Kawagoe J, Ohmichi M, Takahashi T, Ohshima C, Mabuchi S, Takahashi K, Igarashi H, Mori-Abe A, Du Saitoh MB, Ohta T, Kimura A, Kyo S, Inoue M, Kurachi H (2003) Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line. J. Biol. Chem. 278, 43363-43372.
15. Medvedev Z (1990) An attempt at a rational classification of theories of aging. Biol. Rev. Camb. Philos. Soc. 65, 375-398.
16. Migliaccio A, Di Domenico M, Castoria G, de Falco A, Bontempo P, Nola E, Auricchio F (1996) Tyrosine kinase/p21ras/MAP-kinase pathway activation by oestradiol receptor complex in MCF-7 cells. EMBO J. 15, 1292-1300.
17. Orr WC, Sohal R (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-1130.
18. Romashkova JA, Makarov SS (1999) NF-κB is a target of AKT in anti-apoptotic PDGF signaling. Nature 401, 86-90.
19. Ruiz-Larrea MB, Leal AM, Martín C, Martinez R, Lacort M (1997) Antioxidant action of oestrogens in rat hepatocytes. J. Physiol. Biochem. 53, 225-230.
20. Song RX, McPherson RA, Adam L, Bao Y, Shupnik M, Kumar R, Santen RJ (2002) Linkage of rapid oestrogen action to MAPK activation by ERalpha-Shc association and She pathway activation. Mol. Endocrinol. 16, 116-127.
21. Strehlow K, Rotter S, Wassmann S, Adam O, Grohe C, Laufs K, Bohm M, Nickenig G (2003) Modulation of antioxidant enzyme expression and function by oestrogen. Circ. Res. 93, 170-177.
22. Tamasi V, Jeffries JM, Arteel GE, Falkner KC (2004) Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription. Arch. Biochem. Biophys. 431, 161-168.
23. Viña J, Sastre J, Pallardó FV, Borrás C (2003) Mitochondrial theory of aging: importance to explain why females live longer than males. Antioxid. Redox Signal 5, 549-556.
24. Watson CS, Norfleet AM, Pappas TC, Gametchu B (1999) Rapid actions of oestrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of oestrogen receptor-alpha. Steroids 64, 5-13.
25. Wilmoth JR, Deegan LJ, Lundstrom H, Horiuchi S (2000) Increase of maximum life span in Sweden, 1861-1999. Science 289, 2366-2368.
26. Zhou LZ, Johnson AP, Rando TA (2001) NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic. Biol. Med. 31, 1405-1416.