Methylation profiling identifies epigenetic markers for high-grade gliomas

Cancer Genomics and Proteomics

Volumn 1, Issue 3, 2004, Pages 209-214

  Waha, Andreas ^a   Rodrigues, Fausto J ^b   Waha, Anke ^a   Meyer Puttlitz, Birgit ^a   Cavenee, Webster K ^c   Huang, Tim Hui Ming ^b   Wiestler, Otmar D ^a   Yan, Pearlly S ^b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

CpG island microarray; Differential methylation hybridization; DNA methylation; Gliomas; SMARCA5

Indexed keywords

EID: 33748743742     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Esteller M, Corn PG, Baylin SB and Herman JG: A gene hypermethylation profile of human cancer. Cancer Res 61: 3225-3229, 2001.
2. Bird A: DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21, 2002.
3. Dong S, Pang JC, Hu J, Zhou LF and Ng HK: Transcriptional inactivation of TP73 expression in oligodendroglial tumors. Int J Cancer 98: 370-375, 2002.
4. Costello JF, Futscher BW, Tano K, Graunke DM and Pieper RO: Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J Biol Chem 269: 17228-17237, 1994.
5. Costello JF, Berger MS, Huang HS and Cavenee WK: Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 56: 2405-2410, 1996.
6. Herman JG, Jen J, Merlo A and Baylin SB: Hypermethylationassociated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 56: 722-727, 1996.
7. Wolter M, Reifenberger J, Blaschke B, Ichimura K, Schmidt EE, Collins VP and Reifenberger G: Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. J Neuropathol Exp Neurol 60: 1170-1180, 2001.
8. Maegawa S, Yoshioka H, Itaba N, Kubota N, Nishihara S, Shirayoshi Y, Nanba E and Oshimura M: Epigenetic silencing of PEG3 gene expression in human glioma cell lines. Mol Carcinog 31: 1-9, 2001.
9. Nakamura M, Yonekawa Y, Kleihues P and Ohgaki H: Promoter hypermethylation of the RB1 gene in glioblastomas. Lab Invest 81: 77-82, 2001.
10. Kanamori M, Kon H, Nobukuni T, Nomura S, Sugano K, Mashiyama S, Kumabe T, Yoshimoto T, Meuth M, Sekiya T and Murakami Y: Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene. Oncogene 19: 1564-1571, 2000.
11. Li Q, Ahuja N, Burger PC and Issa JP: Methylation and silencing of the Thrombospondin-1 promoter in human cancer. Oncogene 18: 3284-3289, 1999.
12. Li Q, Jedlicka A, Ahuja N, Gibbons MC, Baylin SB, Burger PC and Issa JP: Concordant methylation of the ER and N33 genes in glioblastoma multiforme. Oncogene 16: 3197-3202, 1998.
13. Wales MM, Biel MA, el Deiry W, Nelkin BD, Issa JP, Cavenee WK, Kuerbitz SJ and Baylin SB: p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med 1: 570-577, 1995.
14. Uyeno S, Komura J, Tawa R, Aoki Y, Nata M, Sasano H, Nakura H, Sagisaka K, Sakurai H, Kayama T, Yoshimoto T and Ono T: Alteration of c-fos gene methylation in human gliomas. Mol Carcinog 16: 91-100, 1996.
15. Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomaki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK and Plass C: Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 24: 132-138, 2000.
16. Zardo G, Tiirikaninen MI, Hong C, Misra A, Feuerstein BG, Volik S, Collins CC, Lamborn KR, Bollen A, Pinkel D, Albertson DG and Costello JF: Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nat Genet 32: 453-458, 2002.
17. Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB and Herman JG: Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343: 1350-4, 2000.
18. Huang TH, Perry MR and Laux DE: Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet 8: 459-470, 1999.
19. Yan PS, Chen C-M, Shi H, Rahmatpanah F, Wei SH, Caldwell CW and Huang, TH-M: Dissecting complex epigenetic alterations in breast cancer using CpG island microarrays. Cancer Res 61: 8375-8380, 2001.
20. Clark SJ, Harrison J, Paul CL and Frommer M: High sensitivity mapping of methylated cytosines. Nucleic Acids Res 22: 2990-2997, 1994.
21. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996.
22. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC and Cavenee WK: The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215-225, 2002.
23. Santoro R, Li J and Grummt I: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet 32: 393-396, 2002.
24. von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Muller DJ, Przkora R, Waha A, Blumcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz D and von Ammon K: Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors. J Neuropathol Exp Neurol 59: 544-558, 2000.