Antiproliferative and apoptotic effects of zinc-citrate compound (CIZAR®) on human epithelial ovarian cancer cell line, OVCAR-3

Gynecologic Oncology

Volumn 103, Issue 1, 2006, Pages 127-136

  Bae, Seog Nyeon ^a   Lee, Yong Seok ^a   Kim, Mi Yun ^a   Kim, Jae Dong ^a   Park, Lae Ok ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; Ovarian cancer cells; Zinc citrate

Indexed keywords

ACONITATE HYDRATASE; CASPASE 12; CASPASE 3; CIZAR; DNA FRAGMENT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; TELOMERASE; ZINC CITRATE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CELL CYCLE ARREST; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACONITATE HYDRATASE; ADENOCARCINOMA; APOPTOSIS; BLOTTING, WESTERN; CASPASE 12; CASPASE 3; CASPASES; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CHLORIDES; CITRIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; MITOCHONDRIA; OVARIAN NEOPLASMS; TELOMERASE; ZINC; ZINC COMPOUNDS;

EID: 33748701919     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2006.02.009     Document Type: Article

References (38)

1. Fathalla M.F. Incessant ovulation-A factor in ovarian neoplasia?. Lancet 2 (1971) 163
2. La Vecchia C., Franceschi S., and Decarli A. Oral contraceptive use and the risk of epithelial ovarian cancer. Br. J. Cancer 50 (1984) 31-34
3. Vallee B.L., and Galdes A. The metallobiochemistry of zinc enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. 56 (1984) 283-430
4. Epner D.E., and Herschman H.R. Heavy metals induce expression of the TPA-inducible sequence (TIS) genes. J. Cell. Physiol. 148 (1991) 68-74
5. Richards R.I., Heguy A., and Karin M. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Cell 37 (1984) 263-272
6. Untergasser G., Rumpold H., Plas E., Witkwski G., and Berger P. High levels of zinc ions induce loss of mitochondrial potential and degradation of antiapoptotic Bcl-2 protein in in vitro cultivated human prostate epithelial cell. Biochem. Biophys. Res. Commun. 279 (2000) 607-614
7. el-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E., Jackman J., et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54 (1994) 1169-1174
8. Iitaka M., Kakinuma S., Fujimaki S., Oosuga I., Fujita T., Yamanaka K., et al. Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines. J. Endocrinol. 169 (2001) 417-424
9. Park K.S., Ahn Y., Kim J.A., Yun M.S., Seong B.L., and Choi K.Y. Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibit proliferation of colorectal cancer cells. Br. J. Pharmacol. 137 (2002) 597-607
10. Park L.O., Yoon J.H., Kim J.D., Seo J.T., and Bae S.N. Necrotic cell death of ovarian adenocarcinoma caused by seminal plasma. Gynecol. Oncol. 93 (2004) 671-679
11. Auersperg N., Siemens C.H., and Myrdal S.E. Human ovarian surface epithelium in primary cultures. In Vitro 20 (1984) 743-755
12. Auersperg N., Naubes-Bandiera S.L., and Kruk P.A. Human ovarian surface epithelium: growth patterns and differentiation. In: Sharp F., Mason P., Blackett T., and Berek J. (Eds). Ovarian cancer 3 (1995), Chapman and Hall Medical, U.K. London 157-170
13. Bradford M. A Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
14. Cario E., Jung S., Harder D'Heureuse J., Schulte C., Sturm A., Wiedenmann B., et al. Effects of exogenous zinc supplementation on intestinal epithelial repair in vitro. Eur. J. Clin. Invest. 5 (2000) 419-428
15. Liang J.Y., Liu Y.Y., Zou J., Franklin R.B., Costello L.C., and Feng P. Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate 40 (1999) 200-207
16. Fong L.Y., Lau K.M., Huebner K., and Magee P.N. Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes. Carcinogenesis 18 (1997) 1477-1484
17. Fong L.Y., Nguyen V.T., and Farber J.L. Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. J. Natl. Cancer Inst. 93 (2001) 1525-1533
18. Rudolf E., Rudolf K., Radocha J., Peychl J., and Èervinka M. The role of intracellular zinc in modulation of life and death of Hep-2 cells. Biometals 16 (2003) 295-309
19. Wood J.P., and Osborne N.N. The influence of zinc on caspase-3 and DNA breakdown in cultured human retinal pigment epithelial cells. Arch. Ophthalmol. 119 (2001) 81-88
20. Costello L.C., and Franklin R.B. Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer. Prostate 35 (1998) 285-296
21. Fraker P.J., and Telford W.G. A reappraisal of the role of zinc in life and death decisions of cells. Proc. Soc. Exp. Biol. Med. 215 (1997) 229-236
22. Provinciali M., Di Stefano G., and Fabris N. Dose-dependent opposite effect of zinc on apoptosis in mouse thymocytes. Int. J. Immunopharmacol. 17 (1995) 735-744
23. Sheikh M.S., Rochefort H., and Garcia M. Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 11 (1995) 1899-1905
24. Cheung A.N., Shen D.H., Khoo U.S., Wong L.C., and Ngan H.Y. p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and Ki67 and p53 gene expression. J. Clin. Pathol. 51 (1998) 159-162
25. Shao Z.M., Dawson M.I., Li X.S., Rishi A.K., Sheikh M.S., Han Q.X., et al. p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene 11 (1995) 493-504
26. Korsmeyer S.J. Bcl-2 gene family and the regulation of programmed cell death. Cancer Res. 59 (1999) 1693s-1700s
27. Reed J.C. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr. Opin. Oncol. 7 (1995) 541-546
28. Vander Heiden M.G., and Thompson C.B. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?. Nat. Cell Biol. 1 (1999) E209-E216
29. Fan T.J., Xia L., and Han Y.R. Mitochondrion and apoptosis. Shengwu Huaxue Yu shengwu Wuli Xuebao (Shanghai) 33 (2001) 7-12
30. Launay S., Hermine O., Fontenay M., Kroemer G., Solary E., and Garrido C. Vital functions for lethal caspases. Oncogene 24 (2005) 5137-5148
31. Daniel P.T. Dissecting the pathways to death. Leukemia 14 (2000) 2035-2044
32. Hyun H.J., Sohn J., Ahn Y.H., Shin H.C., Koh J.Y., and Yoon Y.H. Depletion of intracellular zinc induces macromolecule synthesis- and caspase-dependent apoptosis of cultured retinal cells. Brain Res. 869 (2000) 39-48
33. Perry D.K., Smyth M.J., Stennicke H.R., Salvesen G.S., Duriez P., Porier G.G., et al. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J. Biol. Chem. 272 (1997) 18530-18533
34. Truong-Tran A.Q., Ho L.H., and Zalewski P.D. Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death. J. Nutr. 130 (2000) 1459S-1466S
35. Nodera M., Yanagisawa H., and Wada O. Increased apoptosis in a variety of tissues of zinc-deficient rats. Life Sci. 69 (2001) 1639-1649
36. Schrantz N., Auffredou M.T., Bourgeade M.F., Besnault L., Leca G., and Vazquez A. Zinc-mediated regulation of caspase activity: dose-dependent inhibition or activation of caspase-3 in the human Burkitt lymphoma B cells (Ramos). Cell Death Differ. 8 (2001) 152-161
37. Ellis C.D., Wang F., MacDiarmid C.W., Clark S., Lyons T., and Eide D.J. Zinc and the MSC 2 zinc transporter protein are required for endoplasmic reticulum function. J. Cell Biol. 166 (2004) 325-335
38. Nemoto K., Kondo Y., Himeno S., Suzuki Y., Hara S., Akimoto M., et al. Modulation of telomerase activity by zinc in human prostatic and renal cancer cells. Biochem. Pharmacol. 59 (2000) 401-405