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Volumn 11, Issue 3, 2006, Pages 403-417

Emerging drugs for Parkinson's disease

Author keywords

ACP 103; Coenzyme Q10; Creatine; Dementia; Depression; Donepezil; Dopamine agonist; Dyskinesias; Galantamine; GDNF; Glutamic acid decarboxylase; GPI 1485; MAO B inhibitor; Memantine; Minocycline; Modafinil; Nefazodone; Neuroprotection; Neurturin; Paroxetine

Indexed keywords

AMANTADINE; APOMORPHINE; BENZATROPINE; BROMOCRIPTINE; CARBIDOPA PLUS LEVODOPA; CEP 1347; DOPAMINE; ENTACAPONE; ETIRACETAM; FIPAMEZOLE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMATE DECARBOXYLASE; GPI 1485; ISTRADEFYLLINE; LEVODOPA; LISURIDE; MINOCYCLINE; MONOAMINE OXIDASE INHIBITOR; NEUROPROTECTIVE AGENT; NEURTURIN; PERGOLIDE; PRAMIPEXOLE; PROCYCLIDINE; ROPINIROLE; ROTIGOTINE; SAFINAMIDE; SARIZOTAN; TALAMPANEL; UBIDECARENONE; UNINDEXED DRUG;

EID: 33748665990     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.11.3.403     Document Type: Review
Times cited : (17)

References (107)
  • 2
    • 0023257041 scopus 로고
    • History of parkinsonism
    • DUVOISIN RC: History of parkinsonism. Pharmacol. Ther. (1987) 32:1-17.
    • (1987) Pharmacol. Ther. , vol.32 , pp. 1-17
    • Duvoisin, R.C.1
  • 4
    • 0014673226 scopus 로고
    • Modification of Parkinsonism - Chronic treatment with L-dopa
    • COTZIAS GC, PAPAVASILIOU PS, GELLENE R: Modification of Parkinsonism - chronic treatment with L-dopa. N. Engl. J. Med. (1969) 280:337-345.
    • (1969) N. Engl. J. Med. , vol.280 , pp. 337-345
    • Cotzias, G.C.1    Papavasiliou, P.S.2    Gellene, R.3
  • 5
    • 20444489689 scopus 로고    scopus 로고
    • Motor fluctuations and dyskinesias in Parkinsons disease: Clinical manifestations
    • JANKOVIC J: Motor fluctuations and dyskinesias in Parkinsons disease: clinical manifestations. Mov. Disord. (2005) 20(Suppl. 11):S11-S16.
    • (2005) Mov. Disord. , vol.20 , Issue.SUPPL. 11
    • Jankovic, J.1
  • 6
    • 7944228085 scopus 로고    scopus 로고
    • Dopamine receptor agonists in the therapy of Parkinsons disease
    • FOLEY P, GERLACH M, DOUBLE KL, RIEDERER P: Dopamine receptor agonists in the therapy of Parkinsons disease. J. Neural. Transm. (2004) 111:1375-1446.
    • (2004) J. Neural. Transm. , vol.111 , pp. 1375-1446
    • Foley, P.1    Gerlach, M.2    Double, K.L.3    Riederer, P.4
  • 7
    • 14944354884 scopus 로고    scopus 로고
    • Sydney Multicenter Study of Parkinson's disease: Non-L-dopa-responsive problems dominate at 15 years
    • HELY MA, MORRIS JG, REID WG, TRAFFICANTE R: Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years. Mov. Disord. (2005) 20:190-199.
    • (2005) Mov. Disord. , vol.20 , pp. 190-199
    • Hely, M.A.1    Morris, J.G.2    Reid, W.G.3    Trafficante, R.4
  • 8
    • 23144455501 scopus 로고    scopus 로고
    • Neurodegenerative disorders: Parkinsons disease and Huntington's disease
    • HAGUE SM, KLAFFKE S, BANDMANN O: Neurodegenerative disorders: Parkinsons disease and Huntington's disease. J. Neurol. Neurosurg. Psychiatry (2005) 76:1058-1063.
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 1058-1063
    • Hague, S.M.1    Klaffke, S.2    Bandmann, O.3
  • 10
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • KITADA I, ASAKAWA S, HATTORI N et al.: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature (1998) 392:605-608.
    • (1998) Nature , vol.392 , pp. 605-608
    • Kitada, I.1    Asakawa, S.2    Hattori, N.3
  • 12
    • 2342619394 scopus 로고    scopus 로고
    • Effect of psychiatric and other nonmotor symptoms on disability in Parkinson's disease
    • WEINTRAUB D, MOBERG PJ, DUDA JE et al.: Effect of psychiatric and other nonmotor symptoms on disability in Parkinson's disease. J. Am. Geriatr. Soc. (2004) 52:784-788.
    • (2004) J. Am. Geriatr. Soc. , vol.52 , pp. 784-788
    • Weintraub, D.1    Moberg, P.J.2    Duda, J.E.3
  • 13
    • 0024457355 scopus 로고
    • DATATOP: A multicenter controlled clinical trial in early Parkinson's disease
    • PARKINSON STUDY GROUP: DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Arch. Neurol. (1989) 46:1052-1060.
    • (1989) Arch. Neurol. , vol.46 , pp. 1052-1060
  • 14
    • 0037378740 scopus 로고    scopus 로고
    • Neuroprotection in Parkinson's disease: Clinical trials
    • STOCCHI F, OLANOW CW. Neuroprotection in Parkinson's disease: clinical trials. Ann. Neurol. (2003) 53(Suppl. 3):S87-S99.
    • (2003) Ann. Neurol. , vol.53 , Issue.SUPPL. 3
    • Stocchi, F.1    Olanow, C.W.2
  • 15
    • 0025232430 scopus 로고
    • Parkinsons disease
    • MARSDEN CD: Parkinsons disease. Lancet (1990) 335(8695):948-952.
    • (1990) Lancet , vol.335 , Issue.8695 , pp. 948-952
    • Marsden, C.D.1
  • 16
    • 0025954066 scopus 로고
    • Aging and Parkinsons disease: Substantia nigra regional selectivity
    • FEARNLEY JM, LEES AJ: Aging and Parkinsons disease: substantia nigra regional selectivity. Brain (1991) 114:2283-2301.
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 18
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • DAWSON TM, DAWSON VL: Molecular pathways of neurodegeneration in Parkinson's disease. Science (2003) 302:819-822.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 19
    • 5644228612 scopus 로고    scopus 로고
    • PINK, PANK or PARK? a clinicians' guide to familial parkinsonism
    • HEALY DG, ABOU-SLEIMAN PM, WOOD NW: PINK, PANK or PARK? A clinicians' guide to familial parkinsonism. Lancet Neurol. (2004) 3:652-672.
    • (2004) Lancet Neurol. , vol.3 , pp. 652-672
    • Healy, D.G.1    Abou-Sleiman, P.M.2    Wood, N.W.3
  • 20
    • 0042521076 scopus 로고    scopus 로고
    • The environment and Parkinson's disease: Is the nigrostriatal system preferentially targeted by neurotoxins?
    • DI MONTE DA: The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol. (2003) 2:531-538.
    • (2003) Lancet Neurol. , vol.2 , pp. 531-538
    • Di Monte, D.A.1
  • 21
    • 18844394828 scopus 로고    scopus 로고
    • Pathogenesis of nigral cell death in Parkinson's disease
    • PRZEDBORSKI S: Pathogenesis of nigral cell death in Parkinson's disease. Parkinsonism Relat. Disord. (2005) 11(Suppl. 1):S3-S7.
    • (2005) Parkinsonism Relat. Disord. , vol.11 , Issue.SUPPL. 1
    • Przedborski, S.1
  • 22
    • 2442570592 scopus 로고    scopus 로고
    • Disease modification in Parkinson's disease
    • SCHAPIRA AH: Disease modification in Parkinson's disease. Lancet Neurol. (2004) 3:362-368.
    • (2004) Lancet Neurol. , vol.3 , pp. 362-368
    • Schapira, A.H.1
  • 23
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinsons disease
    • PARKER WD Jr, BOYSON SJ, PARKS JK: Abnormalities of the electron transport chain in idiopathic Parkinsons disease. Ann. Neurol. (1989) 26:719-723.
    • (1989) Ann. Neurol. , vol.26 , pp. 719-723
    • Parker Jr., W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 24
    • 0024390719 scopus 로고
    • Mitochondrial complex I deficiency in Parkinson's disease
    • SCHAPIRA AH, COOPER JM, DEXTER D et al.: Mitochondrial complex I deficiency in Parkinson's disease. Lancet (1989) 1(8649):1269.
    • (1989) Lancet , vol.1 , Issue.8649 , pp. 1269
    • Schapira, A.H.1    Cooper, J.M.2    Dexter, D.3
  • 25
    • 29644434199 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant α-synuclein-induced toxicity
    • SMITH WW, JIANG H, PEI Z et al.: Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant α-synuclein-induced toxicity. Hum. Mol. Genet. (2005) 14:3801-3811.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3801-3811
    • Smith, W.W.1    Jiang, H.2    Pei, Z.3
  • 26
    • 0034090891 scopus 로고    scopus 로고
    • AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys
    • KONITSIOTIS S, BLANCHET PJ, VERHAGEN L et al.: AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys. Neurology (2000) 54:1589-1595.
    • (2000) Neurology , vol.54 , pp. 1589-1595
    • Konitsiotis, S.1    Blanchet, P.J.2    Verhagen, L.3
  • 27
    • 27644531857 scopus 로고    scopus 로고
    • A possible role for humoral immunity in the pathogenesis of Parkinson's disease
    • ORR CF, ROWE DB, MIZUNO Y et al.: A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain (2005) 128:2665-2674.
    • (2005) Brain , vol.128 , pp. 2665-2674
    • Orr, C.F.1    Rowe, D.B.2    Mizuno, Y.3
  • 28
    • 13144258735 scopus 로고    scopus 로고
    • Microglial activation and dopamine terminal loss in early Parkinson's disease
    • OUCHI Y, OSHIKAWA E, SEKINE Y et al.: Microglial activation and dopamine terminal loss in early Parkinson's disease. Ann. Neurol. (2005) 57:168-175.
    • (2005) Ann. Neurol. , vol.57 , pp. 168-175
    • Ouchi, Y.1    Oshikawa, E.2    Sekine, Y.3
  • 29
    • 0041653249 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of Parkinson's disease
    • CHEN H, ZHANG SM, HERNAN MA et al.: Nonsteroidal anti-inflammatory drugs and the risk of Parkinson's disease. Arch. Neurol. (2003) 60:1059-1064.
    • (2003) Arch. Neurol. , vol.60 , pp. 1059-1064
    • Chen, H.1    Zhang, S.M.2    Hernan, M.A.3
  • 30
    • 28544451467 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease
    • CHEN H, JACOBS E, SCHWARZSCHILD MA et al.: Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann. Neurol. (2005) 58:963-967.
    • (2005) Ann. Neurol. , vol.58 , pp. 963-967
    • Chen, H.1    Jacobs, E.2    Schwarzschild, M.A.3
  • 31
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • BECK KD, VALVERDE J, ALEXI T et al.: Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature (1995) 373:339-341.
    • (1995) Nature , vol.373 , pp. 339-341
    • Beck, K.D.1    Valverde, J.2    Alexi, T.3
  • 32
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • TOMAC A, LINDQVIST E, LIN LF et al.: Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature (1995) 373(6512):335-339.
    • (1995) Nature , vol.373 , Issue.6512 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.3
  • 33
    • 0030725572 scopus 로고    scopus 로고
    • Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • BJÖRKLUND A, ROSENBLAD C, WINKLER C, KIRIK D: Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol. Dis. (1997) 4:186-200.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 186-200
    • Björklund, A.1    Rosenblad, C.2    Winkler, C.3    Kirik, D.4
  • 34
    • 0032125462 scopus 로고    scopus 로고
    • Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons
    • HORGER BA, NISHIMURA MC, ARMANINI MP et al.: Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci. (1998) 18:4929-4937.
    • (1998) J. Neurosci. , vol.18 , pp. 4929-4937
    • Horger, B.A.1    Nishimura, M.C.2    Armanini, M.P.3
  • 35
    • 0036462452 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands in the treatment of Parkinson's disease
    • GOLD BG, NUTT JG: Neuroimmunophilin ligands in the treatment of Parkinson's disease. Curr. Opin. Pharmacol. (2002) 2:82-86.
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 82-86
    • Gold, B.G.1    Nutt, J.G.2
  • 36
    • 0037461309 scopus 로고    scopus 로고
    • Neuroprotective agents for clinical trials in Parkinsons disease: A systematic assessment
    • RAVINA BM, FAGAN SC, HART RG et al.: Neuroprotective agents for clinical trials in Parkinsons disease: a systematic assessment. Neurology (2003) 60:1234-1240.
    • (2003) Neurology , vol.60 , pp. 1234-1240
    • Ravina, B.M.1    Fagan, S.C.2    Hart, R.G.3
  • 37
    • 4544326052 scopus 로고    scopus 로고
    • Transdermal lisuride delivery in the treatment of Parkinson's disease
    • WOITALLA D, MULLER T, BENZ S et al.: Transdermal lisuride delivery in the treatment of Parkinson's disease. J. Neural Transm. Suppl. (2004) 68:89-95.
    • (2004) J. Neural Transm. Suppl. , vol.68 , pp. 89-95
    • Woitalla, D.1    Muller, T.2    Benz, S.3
  • 38
  • 39
    • 3242763710 scopus 로고    scopus 로고
    • Pergolide use in Parkinson's disease is associated with cardiac valve regurgitation
    • BASEMAN DG, O'SUILLEABHAIN PE, REIMOLD SC et al.: Pergolide use in Parkinson's disease is associated with cardiac valve regurgitation. Neurology (2004) 63:301-304.
    • (2004) Neurology , vol.63 , pp. 301-304
    • Baseman, D.G.1    O'Suilleabhain, P.E.2    Reimold, S.C.3
  • 40
    • 34249945382 scopus 로고    scopus 로고
    • Investigational pharmacological treatments for Parkinson's disease
    • Pahwa R, Lyons KE, Koller WC (Eds.), Marcel Dekker, New York
    • ONDO W: Investigational pharmacological treatments for Parkinson's disease. In: Handbook of Parkinson's disease. Pahwa R, Lyons KE, Koller WC (Eds.), Marcel Dekker, New York (2003):453-461.
    • (2003) Handbook of Parkinson's Disease , pp. 453-461
    • Ondo, W.1
  • 41
    • 0035353743 scopus 로고    scopus 로고
    • Transdermal dopaminergic D(2) receptor agonist therapy in Parkinson's disease with N-0923 TDS: A double-blind, placebo-controlled study
    • HUTTON JT, METMAN LV, CHASE TN et al.: Transdermal dopaminergic D(2) receptor agonist therapy in Parkinson's disease with N-0923 TDS: a double-blind, placebo-controlled study. Mov. Disord. (2001) 16:459-463.
    • (2001) Mov. Disord. , vol.16 , pp. 459-463
    • Hutton, J.T.1    Metman, L.V.2    Chase, T.N.3
  • 42
    • 0034971541 scopus 로고    scopus 로고
    • Continuous transdermal dopaminergic stimulation in advanced Parkinson's disease
    • METMAN LV, GILLESPIE M, FARMER C et al.: Continuous transdermal dopaminergic stimulation in advanced Parkinson's disease. Clin. Neuropharmacol. (2001) 24:163-169.
    • (2001) Clin. Neuropharmacol. , vol.24 , pp. 163-169
    • Metman, L.V.1    Gillespie, M.2    Farmer, C.3
  • 43
    • 21544434051 scopus 로고    scopus 로고
    • Safety, tolerability, and efficacy of continuous transdermal dopaminergic stimulation with rotigotine patch in early-stage idiopathic Parkinson's disease
    • GÜLDENPFENNIG WM, POOLE KH, SOMMERVILLE KW, BOROOJERDI B: Safety, tolerability, and efficacy of continuous transdermal dopaminergic stimulation with rotigotine patch in early-stage idiopathic Parkinson's disease. Clin. Neuropharmacol. (2005) 28:106-110.
    • (2005) Clin. Neuropharmacol. , vol.28 , pp. 106-110
    • Güldenpfennig, W.M.1    Poole, K.H.2    Sommerville, K.W.3    Boroojerdi, B.4
  • 44
    • 4243721247 scopus 로고    scopus 로고
    • Efficacy and dose response of the novel transdermally applied dopamine agonist rotigotine CDS in early Parkinson's disease
    • BIANCHINE J, POOLE K, WOLTERING F: Efficacy and dose response of the novel transdermally applied dopamine agonist rotigotine CDS in early Parkinson's disease. Neurology (2002) 58(Suppl. 3):A162-A163.
    • (2002) Neurology , vol.58 , Issue.SUPPL. 3
    • Bianchine, J.1    Poole, K.2    Woltering, F.3
  • 45
    • 0346754905 scopus 로고    scopus 로고
    • A controlled trial of rotigotine monotherapy in early Parkinson's disease
    • PARKINSON STUDY GROUP: A controlled trial of rotigotine monotherapy in early Parkinson's disease. Arch. Neurol. (2003) 60:1721-1728.
    • (2003) Arch. Neurol. , vol.60 , pp. 1721-1728
  • 46
    • 7944234344 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of the rotigotine transdermal patch in patients with early-stage, idiopathic Parkinson's disease: A multicenter, multinational, randomized, double-blind, placebo-controlled trial
    • WATTS RL, WENDT RL, NAUSIED B et al.: Efficacy, safety, and tolerability of the rotigotine transdermal patch in patients with early-stage, idiopathic Parkinson's disease: a multicenter, multinational, randomized, double-blind, placebo-controlled trial. Mov. Disord. (2004) 19(Suppl. 9):S258.
    • (2004) Mov. Disord. , vol.19 , Issue.SUPPL. 9
    • Watts, R.L.1    Wendt, R.L.2    Nausied, B.3
  • 47
    • 0029774181 scopus 로고    scopus 로고
    • Pharmacology of selegiline
    • GERLACH M, YOUDIM MB, RIEDERER P: Pharmacology of selegiline. Neurology (1996) 47(6 Suppl. 3):S137-S145.
    • (1996) Neurology , vol.476 , Issue.SUPPL. 3
    • Gerlach, M.1    Youdim, M.B.2    Riederer, P.3
  • 48
    • 0036894795 scopus 로고    scopus 로고
    • A controlled trial of rasagiline in early Parkinsons disease: The TEMPO Study
    • PARKINSON STUDY GROUP: A controlled trial of rasagiline in early Parkinsons disease: the TEMPO Study. Arch. Neurol. (2002) 59:1937-1943.
    • (2002) Arch. Neurol. , vol.59 , pp. 1937-1943
  • 49
    • 13444302612 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson's disease and motor fluctuations: The PRESTO study
    • PARKINSON STUDY GROUP: A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson's disease and motor fluctuations: the PRESTO study. Arch. Neurol. (2005) 62:241-248.
    • (2005) Arch. Neurol. , vol.62 , pp. 241-248
  • 50
    • 15844386001 scopus 로고    scopus 로고
    • Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): A randomised, double-blind, parallel-group trial
    • RASCOL O, BROOKS DJ, MELAMED E et al.: Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial. Lancet (2005) 365(9463):947-954.
    • (2005) Lancet , vol.365 , Issue.9463 , pp. 947-954
    • Rascol, O.1    Brooks, D.J.2    Melamed, E.3
  • 51
    • 4043114410 scopus 로고    scopus 로고
    • Rasagiline treatment can improve freezing of gait in advanced Parkinson's disease; a prospective randomized, double blind, placebo and entacapone controlled study
    • GILADI N, RASCOL O, BROOKS DJ et al.: Rasagiline treatment can improve freezing of gait in advanced Parkinson's disease; a prospective randomized, double blind, placebo and entacapone controlled study. Neurology (2004) 62(Suppl. 5):A329-A330.
    • (2004) Neurology , vol.62 , Issue.SUPPL. 5
    • Giladi, N.1    Rascol, O.2    Brooks, D.J.3
  • 52
    • 0034799446 scopus 로고    scopus 로고
    • Safinamide (Newron Pharmaceuticals)
    • CHAZO PL: Safinamide (Newron Pharmaceuticals). Curr. Opin. Investig. Drugs (2001) 2:809-813.
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , pp. 809-813
    • Chazo, P.L.1
  • 53
    • 4143093673 scopus 로고    scopus 로고
    • Improvement of motor function in early Parkinson's disease by safinamide
    • STOCCHI F, ARNOLD G, ONOFRJ M et al.: Improvement of motor function in early Parkinson's disease by safinamide. Neurology (2004) 63:746-748.
    • (2004) Neurology , vol.63 , pp. 746-748
    • Stocchi, F.1    Arnold, G.2    Onofrj, M.3
  • 54
    • 3142554932 scopus 로고    scopus 로고
    • Zydis selegiline reduces 'off' time and improves symptoms in patients with Parkinson's disease
    • SHELLENBERGER MK, CLARKE A, DONOGHUE S: Zydis selegiline reduces 'off' time and improves symptoms in patients with Parkinson's disease. Mov. Disord. (2000) 15(Suppl. 3):116.
    • (2000) Mov. Disord. , vol.15 , Issue.SUPPL. 3 , pp. 116
    • Shellenberger, M.K.1    Clarke, A.2    Donoghue, S.3
  • 55
    • 2342426425 scopus 로고    scopus 로고
    • Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: A 3-month, randomized, placebo-controlled study
    • WATERS CH, SETHI KD, HAUSER RA et al.: Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: a 3-month, randomized, placebo-controlled study. Mov. Disord. (2004) 19:426-432.
    • (2004) Mov. Disord. , vol.19 , pp. 426-432
    • Waters, C.H.1    Sethi, K.D.2    Hauser, R.A.3
  • 56
    • 0032706790 scopus 로고    scopus 로고
    • The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat
    • HILL MP, BROTCHIE JM: The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat. Br. J. Pharmacol. (1999) 128:1577-1585.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 1577-1585
    • Hill, M.P.1    Brotchie, J.M.2
  • 57
    • 0042474326 scopus 로고    scopus 로고
    • 2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinsons disease
    • 2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinsons disease. Mov. Disord. (2003) 18:872-883.
    • (2003) Mov. Disord. , vol.18 , pp. 872-883
    • Savola, J.M.1    Hill, M.2    Engstrom, M.3
  • 58
    • 0035404473 scopus 로고    scopus 로고
    • New aspects of physiological and pathophysiological functions of adenosine A2A receptor in basal ganglia
    • KASE H: New aspects of physiological and pathophysiological functions of adenosine A2A receptor in basal ganglia. Biosci. Biotechnol. Biochem. (2001) 65:1447-1457.
    • (2001) Biosci. Biotechnol. Biochem. , vol.65 , pp. 1447-1457
    • Kase, H.1
  • 59
    • 0031594271 scopus 로고    scopus 로고
    • Adenosine A2A antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys
    • KANDA T, JACKSON MJ, SMITH LA et al.: Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. Ann. Neurol. (1998) 43:507-513.
    • (1998) Ann. Neurol. , vol.43 , pp. 507-513
    • Kanda, T.1    Jackson, M.J.2    Smith, L.A.3
  • 60
    • 0043126954 scopus 로고    scopus 로고
    • Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD
    • HAUSER RA, HUBBLE JP, TRUONG DD et al.: Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD. Neurology (2003) 61:297-303.
    • (2003) Neurology , vol.61 , pp. 297-303
    • Hauser, R.A.1    Hubble, J.P.2    Truong, D.D.3
  • 61
    • 0035874345 scopus 로고    scopus 로고
    • Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinsons disease
    • CHEN JF, XU K, PETZER JP et al.: Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinsons disease. J. Neurosci. (2001) 21:RC143.
    • (2001) J. Neurosci. , vol.21
    • Chen, J.F.1    Xu, K.2    Petzer, J.P.3
  • 62
    • 23644462322 scopus 로고    scopus 로고
    • Open-label pilot study of levetiracetam (Keppra) for the treatment of levodopa-induced dyskinesias in Parkinson's disease
    • ZESIEWICZ TA, SULLIVAN KL, MALDONADO JL et al.: Open-label pilot study of levetiracetam (Keppra) for the treatment of levodopa-induced dyskinesias in Parkinson's disease. Mov. Disord. (2005) 20:1205-1209.
    • (2005) Mov. Disord. , vol.20 , pp. 1205-1209
    • Zesiewicz, T.A.1    Sullivan, K.L.2    Maldonado, J.L.3
  • 63
    • 2342450729 scopus 로고    scopus 로고
    • Multicenter, open-label, trial of sarizotan in Parkinson's disease patients with levodopa-induced dyskinesias (the SPLENDID Study)
    • OLANOW CW, DAMIER P, GOETZ CG et al. Multicenter, open-label, trial of sarizotan in Parkinson's disease patients with levodopa-induced dyskinesias (the SPLENDID Study). Clin. Neuropharmacol. (2004) 27:58-62.
    • (2004) Clin. Neuropharmacol. , vol.27 , pp. 58-62
    • Olanow, C.W.1    Damier, P.2    Goetz, C.G.3
  • 64
    • 0035960558 scopus 로고    scopus 로고
    • Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models
    • BIBBIANI F, OH JD, CHASE TN: Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology (2001) 57:1829-1834.
    • (2001) Neurology , vol.57 , pp. 1829-1834
    • Bibbiani, F.1    Oh, J.D.2    Chase, T.N.3
  • 66
    • 0037147130 scopus 로고    scopus 로고
    • K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK
    • ROUX PP, DORVAL G, BOUDREAU M et al.: K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J. Biol. Chem. (2002) 277:49473-49480.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49473-49480
    • Roux, P.P.1    Dorval, G.2    Boudreau, M.3
  • 67
    • 0030612117 scopus 로고    scopus 로고
    • 10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
    • 10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann. Neurol. (1997) 42:261-264.
    • (1997) Ann. Neurol. , vol.42 , pp. 261-264
    • Shults, C.W.1    Haas, R.H.2    Passov, D.3    Beal, M.F.4
  • 68
    • 0036771852 scopus 로고    scopus 로고
    • 10 in early Parkinsons disease: Evidence of slowing of the functional decline
    • 10 in early Parkinsons disease: evidence of slowing of the functional decline. Arch. Neurol. (2002) 59:1541-1550.
    • (2002) Arch. Neurol. , vol.59 , pp. 1541-1550
    • Shults, C.W.1    Oakes, D.2    Kieburtz, K.3
  • 70
    • 0037426566 scopus 로고    scopus 로고
    • 10 supplementation provides mild symptomatic benefit in patients with Parkinsons disease
    • 10 supplementation provides mild symptomatic benefit in patients with Parkinsons disease. Neurosci. Lett. (2003) 341:201-204.
    • (2003) Neurosci. Lett. , vol.341 , pp. 201-204
    • Müller, T.1    Buttner Gholipour, A.F.2    Kuhn, W.3
  • 71
    • 0032914740 scopus 로고    scopus 로고
    • Creatine and cyclocreatine attenuate MPTP neurotoxicity
    • MATTHEWS RT, FERRANTE RJ, KILVENYI P et al.: Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp. Neurol. (1999) 157:142-149.
    • (1999) Exp. Neurol. , vol.157 , pp. 142-149
    • Matthews, R.T.1    Ferrante, R.J.2    Kilvenyi, P.3
  • 72
    • 0141959170 scopus 로고    scopus 로고
    • Creatine supplementation in Huntington's disease: A placebo-controlled pilot trial
    • VERBESSEM P, LEMIERE J, EIJNDE BO et al.: Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial. Neurology (2003) 61:925-930.
    • (2003) Neurology , vol.61 , pp. 925-930
    • Verbessem, P.1    Lemiere, J.2    Eijnde, B.O.3
  • 73
    • 18144370445 scopus 로고    scopus 로고
    • High-dose creatine therapy for Huntington's disease: A 2-year clinical and MRS study
    • TABRIZI SJ, BLAMIRE AM, MANNERS DN et al.: High-dose creatine therapy for Huntington's disease: a 2-year clinical and MRS study. Neurology (2005) 64:1655-1666.
    • (2005) Neurology , vol.64 , pp. 1655-1666
    • Tabrizi, S.J.1    Blamire, A.M.2    Manners, D.N.3
  • 74
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • FRIEDLANDER RM: Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. (2003) 348:1365-1375.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1365-1375
    • Friedlander, R.M.1
  • 75
    • 11244317215 scopus 로고    scopus 로고
    • The potential of minocycline for neuroprotection in human neurologic disease
    • ZEMKE D, MAJID A: The potential of minocycline for neuroprotection in human neurologic disease. Clin. Neuropharmacol. (2004) 27:293-298.
    • (2004) Clin. Neuropharmacol. , vol.27 , pp. 293-298
    • Zemke, D.1    Majid, A.2
  • 76
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson's disease
    • GILL SS, PATEL NK, HOTTON GR et al.: Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson's disease. Nat. Med. (2003) 9:589-595.
    • (2003) Nat. Med. , vol.9 , pp. 589-595
    • Gill, S.S.1    Patel, N.K.2    Hotton, G.R.3
  • 77
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson's disease
    • LANG AE, GILL S, PATEL NK et al.: Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson's disease. Ann. Neurol. (2006) 59:459-466.
    • (2006) Ann. Neurol. , vol.59 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3
  • 78
    • 22544461907 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
    • LOVE S, PLAHA P, PATEL NK et al.: Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nat. Med. (2005) 11:703-704.
    • (2005) Nat. Med. , vol.11 , pp. 703-704
    • Love, S.1    Plaha, P.2    Patel, N.K.3
  • 79
    • 20744436538 scopus 로고    scopus 로고
    • Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor
    • AHN Y-H, BENSADOUN J-C, AEBISCHER P et al.: Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor. Brain Res. Bull. (2005) 66:135-142.
    • (2005) Brain Res. Bull. , vol.66 , pp. 135-142
    • Ahn, Y.-H.1    Bensadoun, J.-C.2    Aebischer, P.3
  • 80
    • 23644452944 scopus 로고    scopus 로고
    • Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified neurturin construct
    • FJORD-LARSEN, JOHANSEN JL, KUSK P et al.: Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified neurturin construct. Exp. Neurol. (2005) 195:49-60.
    • (2005) Exp. Neurol. , vol.195 , pp. 49-60
    • Fjord-Larsen1    Johansen, J.L.2    Kusk, P.3
  • 81
    • 0037064165 scopus 로고    scopus 로고
    • Subthalamic GAD gene therapy in a Parkinsons disease rat model
    • LUO J, KAPLITT MG, FITZSIMONS HL et al.: Subthalamic GAD gene therapy in a Parkinsons disease rat model. Science (2002) 298:425-429.
    • (2002) Science , vol.298 , pp. 425-429
    • Luo, J.1    Kaplitt, M.G.2    Fitzsimons, H.L.3
  • 82
    • 14244253740 scopus 로고    scopus 로고
    • Gene therapy for Parkinsons disease set to enter Phase I trials
    • BUTCHER J: Gene therapy for Parkinsons disease set to enter Phase I trials. Lancet Neurol. (2002) 1:462.
    • (2002) Lancet Neurol. , vol.1 , pp. 462
    • Butcher, J.1
  • 83
    • 0141940594 scopus 로고    scopus 로고
    • Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: A potential new cell therapy for Parkinsons disease
    • WATTS RL, RAISER CD, STOVER NP et al.: Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinsons disease. J. Neural Transm. Suppl. (2003) 65:215-227.
    • (2003) J. Neural Transm. Suppl. , vol.65 , pp. 215-227
    • Watts, R.L.1    Raiser, C.D.2    Stover, N.P.3
  • 84
    • 28944447738 scopus 로고    scopus 로고
    • Intrastriatal implantation of human retinal pigment epithelial cells attached to microcarriers in advanced Parkinsons disease
    • STOVER NP, BAKAY RAE, SUBRAMANIAN T et al.: Intrastriatal implantation of human retinal pigment epithelial cells attached to microcarriers in advanced Parkinsons disease. Arch. Neurol. (2005) 62:1833-1837.
    • (2005) Arch. Neurol. , vol.62 , pp. 1833-1837
    • Stover, N.P.1    Bakay, R.A.E.2    Subramanian, T.3
  • 85
    • 0031681206 scopus 로고    scopus 로고
    • Donepezil for treatment of dementia with Lewy bodies: A case series of nine patients
    • SHEA C, MACKNIGHT C, ROCKWOOD K: Donepezil for treatment of dementia with Lewy bodies: a case series of nine patients. Int. Pychogeriatr. (1998) 10:229-238.
    • (1998) Int. Pychogeriatr. , vol.10 , pp. 229-238
    • Shea, C.1    Macknight, C.2    Rockwood, K.3
  • 86
    • 0036868921 scopus 로고    scopus 로고
    • Worsening of motor function and mood in a patient with Parkinsons disease after pharmacologic challenge with oral rivastigmine
    • RICHARD IH, JUSTUS AW, GREIG NH et al.: Worsening of motor function and mood in a patient with Parkinsons disease after pharmacologic challenge with oral rivastigmine. Clin. Neuropharmacol. (2002) 25:296-299.
    • (2002) Clin. Neuropharmacol. , vol.25 , pp. 296-299
    • Richard, I.H.1    Justus, A.W.2    Greig, N.H.3
  • 87
    • 0142091310 scopus 로고    scopus 로고
    • Cognitive, psychiatric and motor response to galantamine in Parkinsons disease with dementia
    • AARSLAND D, HUTCHINSON M, LARSEN JP: Cognitive, psychiatric and motor response to galantamine in Parkinsons disease with dementia. Int. J. Geriatr. Psychiatry (2003) 18:937-941.
    • (2003) Int. J. Geriatr. Psychiatry , vol.18 , pp. 937-941
    • Aarsland, D.1    Hutchinson, M.2    Larsen, J.P.3
  • 88
    • 23644461632 scopus 로고    scopus 로고
    • Efficacy and safety of donepezil in the treatment of executive dysfunction in Parkinsons disease: A pilot study
    • LINAZASORO G, LASA A, VAN BLERCOM N: Efficacy and safety of donepezil in the treatment of executive dysfunction in Parkinsons disease: a pilot study. Clin. Neuropharmacol. (2005) 28:176-178.
    • (2005) Clin. Neuropharmacol. , vol.28 , pp. 176-178
    • Linazasoro, G.1    Lasa, A.2    Van Blercom, N.3
  • 89
    • 28044457416 scopus 로고    scopus 로고
    • Benefits of rivastigmine on attention in dementia associated with Parkinsons disease
    • WESNES KA, McKEITH I, EDGAR C et al.: Benefits of rivastigmine on attention in dementia associated with Parkinsons disease. Neurology (2005) 65:1654-1656.
    • (2005) Neurology , vol.65 , pp. 1654-1656
    • Wesnes, K.A.1    McKeith, I.2    Edgar, C.3
  • 90
    • 0036265213 scopus 로고    scopus 로고
    • Donepezil for cognitive impairment in Parkinsons disease: A randomised controlled study
    • AARSLAND D, LAAKE K, LARSEN JP, JANVIN C: Donepezil for cognitive impairment in Parkinsons disease: a randomised controlled study. J. Neurol. Neurosurg. Psychiatry (2002) 72:708-712.
    • (2002) J. Neurol. Neurosurg. Psychiatry , vol.72 , pp. 708-712
    • Aarsland, D.1    Laake, K.2    Larsen, J.P.3    Janvin, C.4
  • 91
    • 21344444811 scopus 로고    scopus 로고
    • Donepezil for dementia in Parkinsons disease: A randomised, double blind, placebo controlled, crossover study
    • RAVINA B, PUTT M, SIDEROWF A et al.: Donepezil for dementia in Parkinsons disease: a randomised, double blind, placebo controlled, crossover study. J. Neurol. Neurosurg. Psychiatry (2005) 76:934-939.
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 934-939
    • Ravina, B.1    Putt, M.2    Siderowf, A.3
  • 92
    • 10044283107 scopus 로고    scopus 로고
    • Rivastigmine for dementia associated with Parkinson s disease
    • EMRE M, AARSLAND D, ALBANESE A et al.: Rivastigmine for dementia associated with Parkinson s disease. N. Engl. J. Med. (2004) 351:2509-2518.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2509-2518
    • Emre, M.1    Aarsland, D.2    Albanese, A.3
  • 93
    • 0026701318 scopus 로고
    • Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinsons disease
    • RABEY JM, NISSIPEANU P, KORCZYN A: Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinsons disease. J. Neural Transm. Park. Dis. Dement. Sect. (1992) 4:277-282.
    • (1992) J. Neural Transm. Park. Dis. Dement. Sect. , vol.4 , pp. 277-282
    • Rabey, J.M.1    Nissipeanu, P.2    Korczyn, A.3
  • 94
    • 0032730121 scopus 로고    scopus 로고
    • Effect of memantine (NMDA antagonist) on Parkinson's disease: A double-blind crossover randomized study
    • MERRELLO M, NOUZEILLES MI, CAMMAROTA A, LEIGUARDA R: Effect of memantine (NMDA antagonist) on Parkinson's disease: a double-blind crossover randomized study. Clin. Neuropharmacol. (1999) 22:273-276.
    • (1999) Clin. Neuropharmacol. , vol.22 , pp. 273-276
    • Merrello, M.1    Nouzeilles, M.I.2    Cammarota, A.3    Leiguarda, R.4
  • 95
    • 3042567248 scopus 로고    scopus 로고
    • Memantine can relieve certain symptoms in Parkinson's disease. Improvement achieved in two out of three described cases with dyskinesia and cognitive failure
    • LOKK J: [Memantine can relieve certain symptoms in Parkinson's disease. Improvement achieved in two out of three described cases with dyskinesia and cognitive failure]. Lakartidningen (2004) 101:2003-2006.
    • (2004) Lakartidningen , vol.101 , pp. 2003-2006
    • Lokk, J.1
  • 96
    • 3442894212 scopus 로고    scopus 로고
    • Repetitive transcranial magnetic stimulation is as effective as fluoxetine in the treatment of depression in patients with Parkinson's disease
    • FREGNI F, SANTOS CM, MYCZKOWSKI ML et al.: Repetitive transcranial magnetic stimulation is as effective as fluoxetine in the treatment of depression in patients with Parkinson's disease. J. Neurol. Neurosurg. Psychiatry (2004) 75:1171-1174.
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 1171-1174
    • Fregni, F.1    Santos, C.M.2    Myczkowski, M.L.3
  • 97
    • 4544229556 scopus 로고    scopus 로고
    • Citalopram treatment of depression in Parkinson's disease: The impact on anxiety, disability, and cognition
    • MENZA M, MARIN H, KAUFMAN K et al.: Citalopram treatment of depression in Parkinson's disease: the impact on anxiety, disability, and cognition. J. Neuropsychiatry Clin. Neurosci. (2004) 16:315-319.
    • (2004) J. Neuropsychiatry Clin. Neurosci. , vol.16 , pp. 315-319
    • Menza, M.1    Marin, H.2    Kaufman, K.3
  • 98
    • 0141705744 scopus 로고    scopus 로고
    • Does nefazodone improve both depression and Parkinsons disease? A pilot randomized trial
    • AVILA A, CARDONA X, MARTIN-BARANERA M et al.: Does nefazodone improve both depression and Parkinsons disease? A pilot randomized trial. J. Clin. Psychopharmacol. (2003) 23:509-513.
    • (2003) J. Clin. Psychopharmacol. , vol.23 , pp. 509-513
    • Avila, A.1    Cardona, X.2    Martin-Baranera, M.3
  • 99
    • 3042647039 scopus 로고    scopus 로고
    • Continuous apomorphine infusion (CAI) and neuropsychiatric disorders in patients with advanced Parkinsons disease: A follow-up of two years
    • MORGANTE L, BASILE G, EPIFANIO A et al.: Continuous apomorphine infusion (CAI) and neuropsychiatric disorders in patients with advanced Parkinsons disease: a follow-up of two years. Arch. Gerontol. Geriatr. Suppl. (2004) 9:291-296.
    • (2004) Arch. Gerontol. Geriatr. Suppl. , vol.9 , pp. 291-296
    • Morgante, L.1    Basile, G.2    Epifanio, A.3
  • 100
    • 20844449074 scopus 로고    scopus 로고
    • Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: Results from a European multicenter trial
    • MOLLER JC, OERTEL WH, KOSTER J et al.: Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: results from a European multicenter trial. Mov. Disord. (2005) 20:602-610.
    • (2005) Mov. Disord. , vol.20 , pp. 602-610
    • Moller, J.C.1    Oertel, W.H.2    Koster, J.3
  • 101
    • 85047693394 scopus 로고    scopus 로고
    • Anhedonia, depression, and motor functioning in Parkinson's disease during treatment with pramipexole
    • LEMKE MR, BRECHT HM, KOESTER J et al.: Anhedonia, depression, and motor functioning in Parkinson's disease during treatment with pramipexole. J. Neuropsychiatry Clin. Neurosci. (2005) 17:214-220.
    • (2005) J. Neuropsychiatry Clin. Neurosci. , vol.17 , pp. 214-220
    • Lemke, M.R.1    Brecht, H.M.2    Koester, J.3
  • 102
    • 1942454228 scopus 로고    scopus 로고
    • Sleep and fatigue in Parkinsons disease
    • FRIEDMAN JH, CHOU KL: Sleep and fatigue in Parkinsons disease. Parkinsonism Mat. Disord. (2004) 10(Suppl. 1):S27-S35.
    • (2004) Parkinsonism Mat. Disord. , vol.10 , Issue.SUPPL. 1
    • Friedman, J.H.1    Chou, K.L.2
  • 103
    • 23844533619 scopus 로고    scopus 로고
    • Sudden uncontrollable somnolence and medication use in Parkinson's disease
    • AVORN J, SCHNEEWEISS S, SUDARSKY LR et al.: Sudden uncontrollable somnolence and medication use in Parkinson's disease. Arch. Neurol. (2005) 62:1242-1248.
    • (2005) Arch. Neurol. , vol.62 , pp. 1242-1248
    • Avorn, J.1    Schneeweiss, S.2    Sudarsky, L.R.3
  • 104
    • 0036112840 scopus 로고    scopus 로고
    • Treatment of excessive daytime sleepiness in patients with Parkinsons disease with modafinil
    • NIEVES AV, LANG AE: Treatment of excessive daytime sleepiness in patients with Parkinsons disease with modafinil. Clin. Neuropharmacol. (2002) 25:111-114.
    • (2002) Clin. Neuropharmacol. , vol.25 , pp. 111-114
    • Nieves, A.V.1    Lang, A.E.2
  • 105
    • 0037114678 scopus 로고    scopus 로고
    • Modafinil for the treatment of daytime sleepiness in Parkinsons disease: A double-blind, randomized, crossover, placebo-controlled polygraphic trial
    • HOGL B, SALETU M, BRANDAUER E et al.: Modafinil for the treatment of daytime sleepiness in Parkinsons disease: a double-blind, randomized, crossover, placebo-controlled polygraphic trial. Sleep (2002) 25:905-909.
    • (2002) Sleep , vol.25 , pp. 905-909
    • Hogl, B.1    Saletu, M.2    Brandauer, E.3
  • 106
    • 0037355884 scopus 로고    scopus 로고
    • Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease
    • ADLER CH, CAVINESS JN, HENTZ JG et al.: Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease. Mov. Disord. (2003) 18:287-293.
    • (2003) Mov. Disord. , vol.18 , pp. 287-293
    • Adler, C.H.1    Caviness, J.N.2    Hentz, J.G.3
  • 107
    • 28144435110 scopus 로고    scopus 로고
    • Modafinil for daytime somnolence in Parkinson's disease: Double blind, placebo controlled parallel trial
    • ONDO W, FAYLE R, ATASSI F, JANKOVIC J: Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial. J. Neurol. Neurosurg. Psychiatry (2005) 76:1636-1639.
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 1636-1639
    • Ondo, W.1    Fayle, R.2    Atassi, F.3    Jankovic, J.4


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