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Volumn 11, Issue 3, 2006, Pages 489-501

Emerging drugs to replace current leaders in first-line therapy for breast cancer

Author keywords

Adjuvant therapy; Bevacizumab; Ixabepilone; Lapatinib; Pertuzumab

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CIMETIDINE; CLARITHROMYCIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPOTHILONE DERIVATIVE; EVEROLIMUS; IXABEPILONE; LAPATINIB; LETROZOLE; LONAFARNIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PACLITAXEL; PERTUZUMAB; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RANITIDINE; SUNITINIB; TAXANE DERIVATIVE; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; WARFARIN;

EID: 33748643613     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.11.3.489     Document Type: Review
Times cited : (15)

References (103)
  • 3
    • 85007758538 scopus 로고    scopus 로고
    • ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics
    • MCPHERSON K, STEEL CM, DIXON JM: ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ (2000) 321(7261):624-628.
    • (2000) BMJ , vol.321 , Issue.7261 , pp. 624-628
    • Mcpherson, K.1    Steel, C.M.2    Dixon, J.M.3
  • 5
    • 0037102997 scopus 로고    scopus 로고
    • Predicting the survival of patients with breast carcinoma using tumor size
    • MICHAELSON JS, SILVERSTEIN M, WYATT J et al.: Predicting the survival of patients with breast carcinoma using tumor size. Cancer (2002) 95(4):713-723.
    • (2002) Cancer , vol.95 , Issue.4 , pp. 713-723
    • Michaelson, J.S.1    Silverstein, M.2    Wyatt, J.3
  • 6
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • EARLY BREAST CANCER TRIALISTS' COLLABORATIVE GROUP: Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 365(9472):1687-1717.
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 7
    • 13244268450 scopus 로고    scopus 로고
    • 30 Years' follow up of randomised studies of adjuvant CMF in operable breast cancer: Cohort study
    • BONADONNA G, MOLITERNI A, ZAMBETTI M et al.: 30 years' follow up of randomised studies of adjuvant CMF in operable breast cancer: cohort study. BMJ (2005) 330(7485):217.
    • (2005) BMJ , vol.330 , Issue.7485 , pp. 217
    • Bonadonna, G.1    Moliterni, A.2    Zambetti, M.3
  • 8
    • 0028909867 scopus 로고
    • Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node-positive breast cancer - The results of 20 years of follow-up
    • BONADONNA G, VALAGUSSA P, MOLITERNI A, ZAMBETTI M, BRAMBILLA C: Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node-positive breast cancer - the results of 20 years of follow-up. N. Engl. J. Med. (1995) 332(14):901-906.
    • (1995) N. Engl. J. Med. , vol.332 , Issue.14 , pp. 901-906
    • Bonadonna, G.1    Valagussa, P.2    Moliterni, A.3    Zambetti, M.4    Brambilla, C.5
  • 9
    • 0026354712 scopus 로고
    • Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer
    • HOLMES FA, WALTERS RS, THERIAULT RL et al.: Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst. (1991) 83(24):1797-1805.
    • (1991) J. Natl. Cancer Inst. , vol.83 , Issue.24 , pp. 1797-1805
    • Holmes, F.A.1    Walters, R.S.2    Theriault, R.L.3
  • 10
    • 21844458437 scopus 로고    scopus 로고
    • The role of taxanes in the treatment of breast cancer
    • NABHOLTZ JM, GLIGOROV J: The role of taxanes in the treatment of breast cancer. Expert Opin. Pharmacother. (2005) 6(7):1073-1094.
    • (2005) Expert Opin. Pharmacother. , vol.6 , Issue.7 , pp. 1073-1094
    • Nabholtz, J.M.1    Gligorov, J.2
  • 11
    • 0037445132 scopus 로고    scopus 로고
    • Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer
    • HENDERSON IC, BERRY DA, DEMETRI GD et al.: Improved outcomes from adding sequential paclitaxel but not from escalating doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer. J. Clin. Oncol. (2003) 21(6):976-983.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.6 , pp. 976-983
    • Henderson, I.C.1    Berry, D.A.2    Demetri, G.D.3
  • 12
    • 20544434991 scopus 로고    scopus 로고
    • Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: Results from NSABP B-28
    • MAMOUNAS EP, BRYANT J, LEMBERSKY BC et al.: Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28. J. Clin. Oncol. (2005) 23(16):3686-3696.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 , pp. 3686-3696
    • Mamounas, E.P.1    Bryant, J.2    Lembersky, B.C.3
  • 13
    • 0037687355 scopus 로고    scopus 로고
    • Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: First report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741
    • CITRON M, BERRY DA, CIRRINCIONE C et al.: Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer And Leukemia Group B Trial 9741. J. Clin. Oncol. (2003) 21(8):1431-1439.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.8 , pp. 1431-1439
    • Citron, M.1    Berry, D.A.2    Cirrincione, C.3
  • 14
    • 33645648902 scopus 로고    scopus 로고
    • Five year follow-up of INT C9741: Dose-dense (DD) chemotherapy (CRx) is safe and effective
    • San Antonio, TX, USA abstract 41
    • HUDIS C, CITRON M, BERRY D et al.: Five year follow-up of INT C9741: dose-dense (DD) chemotherapy (CRx) is safe and effective. San Antonio Breast Cancer Symposium 2005. San Antonio, TX, USA (2005):abstract 41.
    • (2005) San Antonio Breast Cancer Symposium 2005
    • Hudis, C.1    Citron, M.2    Berry, D.3
  • 15
    • 21144435932 scopus 로고    scopus 로고
    • Adjuvant docetaxel for node-positive breast cancer
    • MARTIN M, PIENKOWSKI T, MACKEY J et al.: Adjuvant docetaxel for node-positive breast cancer. N. Engl. J. Med. (2005) 352(22):2302-2313.
    • (2005) N. Engl. J. Med. , vol.352 , Issue.22 , pp. 2302-2313
    • Martin, M.1    Pienkowski, T.2    Mackey, J.3
  • 16
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • SLAMON DJ, CLARK GM, WONG SG et al.: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (1987) 235(4785):177-182.
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 17
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • SLAMON DJ, GODOLPHIN W, JONES LA et al.: Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science (1989) 244:707-712.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 18
    • 2942659576 scopus 로고    scopus 로고
    • Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
    • PEGRAM MD, KONECNY GE, O'CALLAGHAN C et al.: Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J. Natl. Cancer Inst. (2004) 96(10):739-749.
    • (2004) J. Natl. Cancer Inst. , vol.96 , Issue.10 , pp. 739-749
    • Pegram, M.D.1    Konecny, G.E.2    O'Callaghan, C.3
  • 19
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • NAGATA Y, LAN KH, ZHOU X et al.: PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell (2004) 6(2):117-127.
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 20
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • COBLEIGH MA, VOGEL CL, TRIPATHY D et al.: Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. (1999) 17(9):2639-2648.
    • (1999) J. Clin. Oncol. , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 21
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • SLAMON DJ, LEYLAND-JONES B, SHAK S et al.: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. (2001) 344(11):783-792.
    • (2001) N. Engl. J. Med. , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 22
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • ROMOND EH, PEREZ EA, BRYANT J et al.: Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. (2005) 353(16):1673-1684.
    • (2005) N. Engl. J. Med. , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 23
    • 0036814469 scopus 로고    scopus 로고
    • HER2-positive breast cancer: Update on Breast Cancer International Research Group trials
    • NABHOLTZ JM, REESE DM, LINDSAY MA, RIVA A: HER2-positive breast cancer: update on Breast Cancer International Research Group trials. Clin. Breast Cancer (2002) 3(Suppl. 2):S75-S79.
    • (2002) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 2
    • Nabholtz, J.M.1    Reese, D.M.2    Lindsay, M.A.3    Riva, A.4
  • 24
    • 33645720799 scopus 로고    scopus 로고
    • Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin, and trastuzumab (TCH) in HER2 positive early breast cancer patients; BCIRG 006 study
    • San Antonio, TX, USA abstract 1
    • SLAMON DJ, EIERMANN W, ROBERT NJ et al.: Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin, and trastuzumab (TCH) in HER2 positive early breast cancer patients; BCIRG 006 study. San Antonio Breast Cancer Symposium 2005. San Antonio, TX, USA (2005):abstract 1.
    • (2005) San Antonio Breast Cancer Symposium 2005
    • Slamon, D.J.1    Eiermann, W.2    Robert, N.J.3
  • 25
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • PICCART-GEBHART MJ, PROCTER M, LEYLAND-JONES B et al.: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. (2005) 353(16):1659-1672.
    • (2005) N. Engl. J. Med. , vol.353 , Issue.16 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 26
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles: Implications for cancer chemotherapy
    • TEN TIJE AJ, VERWEIJ J, LOOS WJ, SPARREBOOM A: Pharmacological effects of formulation vehicles: implications for cancer chemotherapy. Clin. Pharmacokinet. (2003) 42(7):665-685.
    • (2003) Clin. Pharmacokinet. , vol.42 , Issue.7 , pp. 665-685
    • Ten Tije, A.J.1    Verweij, J.2    Loos, W.J.3    Sparreboom, A.4
  • 27
    • 27644562207 scopus 로고    scopus 로고
    • Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer
    • MIELKE S, SPARREBOOM A, STEINBERG SM et al.: Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer. Clin. Cancer Res. (2005) 11(13):4843-4850.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.13 , pp. 4843-4850
    • Mielke, S.1    Sparreboom, A.2    Steinberg, S.M.3
  • 28
    • 25144494618 scopus 로고    scopus 로고
    • Comparative in vitro properties and clinical pharmacokinetics of paclitaxel following the administration of taxol(R) and paxene(R)
    • SCRIPTURE CD, SZEBENI J, LOOS WJ, FIGG WD, SPARREBOOM A: Comparative in vitro properties and clinical pharmacokinetics of paclitaxel following the administration of taxol(R) and paxene(R). Cancer Biol. Ther. (2005) 4(5):555-560.
    • (2005) Cancer Biol. Ther. , vol.4 , Issue.5 , pp. 555-560
    • Scripture, C.D.1    Szebeni, J.2    Loos, W.J.3    Figg, W.D.4    Sparreboom, A.5
  • 29
    • 0036096946 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ABI-007, a cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel
    • IBRAHIM NK, DESAI N, LEGHA S et al.: Phase I and pharmacokinetic study of ABI-007, a cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. Clin. Cancer Res. (2002) 8(5):1038-1044.
    • (2002) Clin. Cancer Res. , vol.8 , Issue.5 , pp. 1038-1044
    • Ibrahim, N.K.1    Desai, N.2    Legha, S.3
  • 30
    • 20344370984 scopus 로고    scopus 로고
    • Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in cremophor (taxol)
    • SPARREBOOM A, SCRIPTURE CD, TRIEU V et al.: Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in cremophor (taxol). Clin. Cancer Res. (2005) 11(11):4136-4143.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.11 , pp. 4136-4143
    • Sparreboom, A.1    Scripture, C.D.2    Trieu, V.3
  • 31
    • 16844376697 scopus 로고    scopus 로고
    • ABI-007 (abraxane), a nanoparticle albumin-bound (nab) paclitaxel demonstrates superior efficacy versus taxol in MBC; a Phase III trial
    • San Antonio, TX, USA abstract 44
    • O'SHAUGHNESSY JA, TJULANDIN SA, DAVIDSON N et al.: ABI-007 (abraxane), a nanoparticle albumin-bound (nab) paclitaxel demonstrates superior efficacy versus taxol in MBC; a Phase III trial. 26th Annual San Antonio Breast Cancer Symposium 2003. San Antonio, TX, USA (2003):abstract 44.
    • (2003) 26th Annual San Antonio Breast Cancer Symposium 2003
    • O'Shaughnessy, J.A.1    Tjulandin, S.A.2    Davidson, N.3
  • 32
    • 21844447521 scopus 로고    scopus 로고
    • Long term disease control in taxane-refractory metastatic breast cancer treated with nab paclitaxel
    • abstract 543
    • BLUM J, SAVIN M, EDELMAN G et al.: Long term disease control in taxane-refractory metastatic breast cancer treated with nab paclitaxel. Proc. Am. Soc. Clin. Oncol. (2004):abstract 543.
    • (2004) Proc. Am. Soc. Clin. Oncol.
    • Blum, J.1    Savin, M.2    Edelman, G.3
  • 33
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • LEE FY, BORZILLERI R, FAIRCHILD CR et al.: BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res. (2001) 7(5):1429-1437.
    • (2001) Clin. Cancer Res. , vol.7 , Issue.5 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 34
    • 0037081329 scopus 로고    scopus 로고
    • Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells
    • YAMAGUCHI H, PARANAWITHANA SR, LEE MW et al.: Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells. Cancer Res. (2002) 62(2):466-471.
    • (2002) Cancer Res. , vol.62 , Issue.2 , pp. 466-471
    • Yamaguchi, H.1    Paranawithana, S.R.2    Lee, M.W.3
  • 35
    • 0038811741 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of BMS-247550, an epothilone analog, administered intravenously on a daily schedule for five days
    • ABRAHAM J, AGRAWAL M, BAKKE S et al.: Phase I trial and pharmacokinetic study of BMS-247550, an epothilone analog, administered intravenously on a daily schedule for five days. J. Clin. Oncol. (2003) 21(9):1866-1873.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.9 , pp. 1866-1873
    • Abraham, J.1    Agrawal, M.2    Bakke, S.3
  • 36
    • 12144285977 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
    • MANI S, MCDAID H, HAMILTON A et al.: Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin. Cancer Res. (2004) 10(4):1289-1298.
    • (2004) Clin. Cancer Res. , vol.10 , Issue.4 , pp. 1289-1298
    • Mani, S.1    Mcdaid, H.2    Hamilton, A.3
  • 37
    • 20244376916 scopus 로고    scopus 로고
    • A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days
    • ZHUANG SH, AGRAWAL M, EDGERLY M et al.: A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days. Cancer (2005) 103(9):1932-1938.
    • (2005) Cancer , vol.103 , Issue.9 , pp. 1932-1938
    • Zhuang, S.H.1    Agrawal, M.2    Edgerly, M.3
  • 38
    • 21044441003 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
    • LOW JA, WEDAM SB, LEE JJ et al.: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J. Clin. Oncol. (2005) 23(12):2726-2734.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.12 , pp. 2726-2734
    • Low, J.A.1    Wedam, S.B.2    Lee, J.J.3
  • 39
    • 0034062934 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers
    • BROPHY DF, ISRAEL DS, PASTOR A et al.: Pharmacokinetic interaction between amprenavir and clarithromycin in healthy male volunteers. Antimicrob. Agents Chemother. (2000) 44(4):978-984.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , Issue.4 , pp. 978-984
    • Brophy, D.F.1    Israel, D.S.2    Pastor, A.3
  • 40
    • 13944250702 scopus 로고    scopus 로고
    • Inhibition of human intestinal wall metabolism by macrolide antibiotics: Effect of clarithromycin on cytochrome P450 3A4/5 activity and expression
    • PINTO AG, WANG YH, CHALASANI N et al.: Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression. Clin. Pharmacol. Ther. (2005) 77(3):178-188.
    • (2005) Clin. Pharmacol. Ther. , vol.77 , Issue.3 , pp. 178-188
    • Pinto, A.G.1    Wang, Y.H.2    Chalasani, N.3
  • 41
    • 0042504783 scopus 로고    scopus 로고
    • A Phase II study of the epothilone B analog BMS-247550 in patients (pts) with taxane-resistant metastatic breast cancer
    • abstract 30
    • THOMAS E, TABERNERO J, FORNIER M et al.: A Phase II study of the epothilone B analog BMS-247550 in patients (pts) with taxane-resistant metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. (2003):abstract 30.
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Thomas, E.1    Tabernero, J.2    Fornier, M.3
  • 42
    • 0041503044 scopus 로고    scopus 로고
    • A Phase II study of epothilone analog BMS-247550 in patients (pts) with metastatic breast cacner (MBC) previously treated with an anthracycline
    • abstract 69
    • ROCHE HH, CURE H, BUNNELL C et al.: A Phase II study of epothilone analog BMS-247550 in patients (pts) with metastatic breast cacner (MBC) previously treated with an anthracycline. Proc. Am. Soc. Clin. Oncol. (2003):abstract 69.
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Roche, H.H.1    Cure, H.2    Bunnell, C.3
  • 43
    • 34548167969 scopus 로고    scopus 로고
    • Ixabepilone (BMS-247550) plus trastuzumab combination chemotherapy induces synergistic antitumor efficacy in HER2 dependent breast cancer and is accompanied by modulation of molecular reponse markers
    • abstract 561
    • LEE F, CASTANEDA S, INIGO I et al.: Ixabepilone (BMS-247550) plus trastuzumab combination chemotherapy induces synergistic antitumor efficacy in HER2 dependent breast cancer and is accompanied by modulation of molecular reponse markers. Proc. Am. Soc. Clin. Oncol. (2005):abstract 561.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Lee, F.1    Castaneda, S.2    Inigo, I.3
  • 44
    • 33644831567 scopus 로고    scopus 로고
    • Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors
    • RUBIN EH, ROTHERMEL J, TESFAYE F et al.: Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors. J. Clin. Oncol. (2005) 23(36):9120-9129.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.36 , pp. 9120-9129
    • Rubin, E.H.1    Rothermel, J.2    Tesfaye, F.3
  • 45
    • 85013312416 scopus 로고
    • Tumour angiogenesis: Therapeutic implications
    • FOLKMAN J: Tumour angiogenesis: therapeutic implications. N. Engl. J. Med. (1971) 285:1182-1186.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 46
    • 84975525035 scopus 로고
    • Clinical applications of research on angiogenesis
    • FOLKMAN J: Clinical applications of research on angiogenesis. N. Engl. J. Med. (1995) 333(26):1757-1763.
    • (1995) N. Engl. J. Med. , vol.333 , Issue.26 , pp. 1757-1763
    • Folkman, J.1
  • 47
    • 3242806189 scopus 로고    scopus 로고
    • Angiogenesis and prostate cancer tumor growth
    • NICHOLSON B, THEODORESCU D: Angiogenesis and prostate cancer tumor growth. J. Cell Biochem. (2004) 91(1):125-150.
    • (2004) J. Cell Biochem. , vol.91 , Issue.1 , pp. 125-150
    • Nicholson, B.1    Theodorescu, D.2
  • 48
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • HOUCK KA, LEUNG DW, ROWLAND AM, WINER J, FERRARA N: Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. (1992) 267(36):26031-26037.
    • (1992) J. Biol. Chem. , vol.267 , Issue.36 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 49
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • PARK JE, KELLER GA, FERRARA N: The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell (1993) 4(12):1317-1326.
    • (1993) Mol. Biol. Cell , vol.4 , Issue.12 , pp. 1317-1326
    • Park, J.E.1    Keller, G.A.2    Ferrara, N.3
  • 50
    • 0017842951 scopus 로고
    • Angiogenesis as a marker of preneoplastic lesions of the human breast
    • BREM SS, JENSEN HM, GULLINO PM: Angiogenesis as a marker of preneoplastic lesions of the human breast. Cancer (1978) 41(1):239-244.
    • (1978) Cancer , vol.41 , Issue.1 , pp. 239-244
    • Brem, S.S.1    Jensen, H.M.2    Gullino, P.M.3
  • 51
    • 0029935566 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer
    • YOSHIJI H, GOMEZ DE, SHIBUYA M, THORGEIRSSON UP: Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res. (1996) 56(9):2013-2016.
    • (1996) Cancer Res. , vol.56 , Issue.9 , pp. 2013-2016
    • Yoshiji, H.1    Gomez, D.E.2    Shibuya, M.3    Thorgeirsson, U.P.4
  • 52
    • 0028861231 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
    • BROWN LF, BERSE B, JACKMAN RW et al.: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol. (1995) 26(1):86-91.
    • (1995) Hum. Pathol. , vol.26 , Issue.1 , pp. 86-91
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3
  • 53
    • 0032897455 scopus 로고    scopus 로고
    • Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours
    • SPEIRS V, ATKIN SL: Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours. Br. J. Cancer (1999) 80(5-6):898-903.
    • (1999) Br. J. Cancer , vol.80 , Issue.5-6 , pp. 898-903
    • Speirs, V.1    Atkin, S.L.2
  • 54
    • 0032758072 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) family members in breast cancer
    • KUREBAYASHI J, OTSUKI T, KUNISUE H et al.: Expression of vascular endothelial growth factor (VEGF) family members in breast cancer. Jpn. J. Cancer Res. (1999) 90(9):977-981.
    • (1999) Jpn. J. Cancer Res. , vol.90 , Issue.9 , pp. 977-981
    • Kurebayashi, J.1    Otsuki, T.2    Kunisue, H.3
  • 55
    • 6444221837 scopus 로고    scopus 로고
    • Circulating levels of VEGF-A, VEGF-D and soluble VEGF-A receptor (sFIt-1) in human breast cancer
    • HOAR FJ, LIP GY, BELGORE F, STONELAKE PS: Circulating levels of VEGF-A, VEGF-D and soluble VEGF-A receptor (sFIt-1) in human breast cancer. Int. J. Biol. Markers (2004) 19(3):229-235.
    • (2004) Int. J. Biol. Markers , vol.19 , Issue.3 , pp. 229-235
    • Hoar, F.J.1    Lip, G.Y.2    Belgore, F.3    Stonelake, P.S.4
  • 56
    • 0034000338 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor in breast cancer
    • GASPARINI G: Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist (2000) 5(Suppl. 1):37-44.
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 37-44
    • Gasparini, G.1
  • 57
    • 0035170092 scopus 로고    scopus 로고
    • Thrombospondin-1 and -2 in node-negative breast cancer: Correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis
    • GASPARINI G, TOI M, BIGANZOLI E et al.: Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis. Oncology (2001) 60(1):72-80.
    • (2001) Oncology , vol.60 , Issue.1 , pp. 72-80
    • Gasparini, G.1    Toi, M.2    Biganzoli, E.3
  • 58
    • 0346244031 scopus 로고    scopus 로고
    • Tumor specific VEGF-A and VEGFR2/KDR protein are co-expressed in breast cancer
    • RYDEN L, LINDERHOLM B, NIELSEN NH et al.: Tumor specific VEGF-A and VEGFR2/KDR protein are co-expressed in breast cancer. Breast Cancer Res. Treat. (2003) 82(3):147-154.
    • (2003) Breast Cancer Res. Treat. , vol.82 , Issue.3 , pp. 147-154
    • Ryden, L.1    Linderholm, B.2    Nielsen, N.H.3
  • 59
    • 3042643346 scopus 로고    scopus 로고
    • Bevacizumab: An angiogenesis inhibitor with efficacy in colorectal and other malignancies
    • ZONDOR SD, MEDINA PJ: Bevacizumab: an angiogenesis inhibitor with efficacy in colorectal and other malignancies. Ann. Pharmacother. (2004) 38(7-8):1258-1264.
    • (2004) Ann. Pharmacother. , vol.38 , Issue.7-8 , pp. 1258-1264
    • Zondor, S.D.1    Medina, P.J.2
  • 60
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • GORDON MS, MARGOLIN K, TALPAZ M et al.: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J. Clin. Oncol. (2001) 19(3):843-850.
    • (2001) J. Clin. Oncol. , vol.19 , Issue.3 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 61
    • 0242468884 scopus 로고    scopus 로고
    • A Phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
    • COBLEIGH MA, LANGMUIR VK, SLEDGE GW et al.: A Phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol (2003) 30(5 Suppl. 16):117-124.
    • (2003) Semin Oncol , vol.30 , Issue.5 SUPPL. 16 , pp. 117-124
    • Cobleigh, M.A.1    Langmuir, V.K.2    Sledge, G.W.3
  • 62
    • 20044364346 scopus 로고    scopus 로고
    • Randomized Phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • MILLER KD, CHAP LI, HOLMES FA et al.: Randomized Phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J. Clin. Oncol. (2005) 23(4):792-799.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.4 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 63
    • 33746622572 scopus 로고    scopus 로고
    • A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer: A trial coordinated by the Eastern Cooperative Oncology Group (E2100)
    • abstract 3
    • MILLER KD, WANG M, GRALOW J et al.: A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer: a trial coordinated by the Eastern Cooperative Oncology Group (E2100). SABCS (2005):abstract 3.
    • (2005) SABCS
    • Miller, K.D.1    Wang, M.2    Gralow, J.3
  • 65
    • 33645364706 scopus 로고    scopus 로고
    • Phase II study of SU-11248, a multitargeted receptor tyrosine kinase inhibitor (TKI), in patients (pts) with previously treated metastatic breast cancer (MBC)
    • abstract 563
    • MILLER K, BURNSTEIN H, ELIAS A et al.: Phase II study of SU-11248, a multitargeted receptor tyrosine kinase inhibitor (TKI), in patients (pts) with previously treated metastatic breast cancer (MBC). Proc. Am. Soc. Clin. Oncol. (2005):abstract 563.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Miller, K.1    Burnstein, H.2    Elias, A.3
  • 66
    • 78650874372 scopus 로고    scopus 로고
    • SU-11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • ABRAMS TJ, LEE LB, MURRAY LJ, PRYER NK, CHERRINGTON JM: SU-11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol. Cancer Ther. (2003) 2(5):471-478.
    • (2003) Mol. Cancer Ther. , vol.2 , Issue.5 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 67
    • 0038204144 scopus 로고    scopus 로고
    • SU-11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'FARRELL AM, ABRAMS TJ, YUEN HA et al.: SU-11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood (2003) 101(9):3597-3605.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 68
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU-11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • FAIVRE S, DELBALDO C, VERA K et al.: Safety, pharmacokinetic, and antitumor activity of SU-11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. (2006) 24(1):25-35.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.1 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3
  • 69
    • 3242880503 scopus 로고    scopus 로고
    • Technology evaluation: Pertuzumab, Roche/Genentech/Chugai
    • SPICER J: Technology evaluation: pertuzumab, Roche/Genentech/Chugai. Curr. Opin. Mol. Ther. (2004) 6(3):337-343.
    • (2004) Curr. Opin. Mol. Ther. , vol.6 , Issue.3 , pp. 337-343
    • Spicer, J.1
  • 70
    • 1942474587 scopus 로고    scopus 로고
    • The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
    • NAHTA R, HUNG MC, ESTEVA FJ: The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. (2004) 64(7):2343-2346.
    • (2004) Cancer Res. , vol.64 , Issue.7 , pp. 2343-2346
    • Nahta, R.1    Hung, M.C.2    Esteva, F.J.3
  • 71
    • 20244378677 scopus 로고    scopus 로고
    • Phase I clinical study of pertuzumab, a novel her dimerization inhibitor, in patients with advanced cancer
    • AGUS DB, GORDON MS, TAYLOR C et al.: Phase I clinical study of pertuzumab, a novel her dimerization inhibitor, in patients with advanced cancer. J. Clin. Oncol. (2005) 23(11):2534-2543.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.11 , pp. 2534-2543
    • Agus, D.B.1    Gordon, M.S.2    Taylor, C.3
  • 72
    • 33745206649 scopus 로고    scopus 로고
    • Open label, randomized, Phase II study of pertuzumab (P) in patients (pts) with metastatic breast cancer (MBC) with low expression of HER2
    • abstract 3068
    • CORTES J, BASELGA J, KELLOKUMPU-LEHTINEN P et al.: Open label, randomized, Phase II study of pertuzumab (P) in patients (pts) with metastatic breast cancer (MBC) with low expression of HER2. Proc. Am. Soc. Clin. Oncol. (2005):abstract 3068.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Cortes, J.1    Baselga, J.2    Kellokumpu-Lehtinen, P.3
  • 73
    • 0037068741 scopus 로고    scopus 로고
    • Anti-tumor activity of GW-572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
    • XIA W, MULLIN RJ, KEITH BR et al.: Anti-tumor activity of GW-572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene (2002) 21(41):6255-6263.
    • (2002) Oncogene , vol.21 , Issue.41 , pp. 6255-6263
    • Xia, W.1    Mullin, R.J.2    Keith, B.R.3
  • 74
    • 11244257032 scopus 로고    scopus 로고
    • The dual ErbB1/ErbB2 inhibitor, lapatinib (GW-572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer
    • CHU I, BLACKWELL K, CHEN S, SLINGERLAND J: The dual ErbB1/ErbB2 inhibitor, lapatinib (GW-572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. (2005) 65(1):18-25.
    • (2005) Cancer Res. , vol.65 , Issue.1 , pp. 18-25
    • Chu, I.1    Blackwell, K.2    Chen, S.3    Slingerland, J.4
  • 75
    • 34248580084 scopus 로고    scopus 로고
    • Combining lapatinib (GW-572016) with anti-erbB2 antibodies elicits synergistic apoptotic effects in erbB2 overexpressing breast cancer cells
    • abstract 557
    • SPECTOR NL, LIU L, GERARD C et al.: Combining lapatinib (GW-572016) with anti-erbB2 antibodies elicits synergistic apoptotic effects in erbB2 overexpressing breast cancer cells. Proc. Am. Soc. Clin. Oncol. (2005):abstract 557.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Spector, N.L.1    Liu, L.2    Gerard, C.3
  • 76
    • 33748645174 scopus 로고    scopus 로고
    • Biomarker results from a Phase II randomized study of lapatinib (GW-572016) as first-line treatment for paitnes with ErbB2-amplified advanced or metastatic breast cancer
    • San Antonio, TX, USA abstract 1071
    • GOMEZ H, CHAVEZ MA, DOVAL DC et al.: Biomarker results from a Phase II randomized study of lapatinib (GW-572016) as first-line treatment for paitnes with ErbB2-amplified advanced or metastatic breast cancer. San Antonio Breast Cancer Symposium 2005. San Antonio, TX, USA (2005) abstract 1071.
    • (2005) San Antonio Breast Cancer Symposium 2005
    • Gomez, H.1    Chavez, M.A.2    Doval, D.C.3
  • 77
    • 14844339449 scopus 로고    scopus 로고
    • Clinical activity of GW-572016 in EGF-1003 in patients with solid tumors
    • abstract 3047
    • VERSOLA M, BURRIS HA 3rd, JONES S et al.: Clinical activity of GW-572016 in EGF-1003 in patients with solid tumors. Proc. Am. Soc. Clin. Oncol. (2004): abstract 3047.
    • (2004) Proc. Am. Soc. Clin. Oncol.
    • Versola, M.1    Burris III, H.A.2    Jones, S.3
  • 78
    • 23944476155 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (gw572016), a reversible, dual inhibitor of epidermal growth factor receptor tyrosine kinases in heavily pretreated patients with metastatic carcinomas
    • BURRIS HA 3rd, HURWITZ HI, DEES EC et al.: Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (gw572016), a reversible, dual inhibitor of epidermal growth factor receptor tyrosine kinases in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. (2005) 23(23):5305-5313.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.23 , pp. 5305-5313
    • Burris III, H.A.1    Hurwitz, H.I.2    Dees, E.C.3
  • 79
    • 20244388653 scopus 로고    scopus 로고
    • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
    • SPECTOR NL, XIA W, BURRIS HA 3rd et al.: Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J. Clin. Oncol. 2300:2502-2512.
    • J. Clin. Oncol. , vol.2300 , pp. 2502-2512
    • Spector, N.L.1    Xia, W.2    Burris III, H.A.3
  • 80
    • 21244449472 scopus 로고    scopus 로고
    • A Phase I study of the dual kinase inhibitor GW-572016 in combination with paclitaxel (EGF-10009)
    • abstract 2083
    • JONES SF, HAINSWORTH JD, SPIGEL DR et al.: A Phase I study of the dual kinase inhibitor GW-572016 in combination with paclitaxel (EGF-10009). Proc. Am. Soc. Clin. Oncol. (2004): abstract 2083.
    • (2004) Proc. Am. Soc. Clin. Oncol.
    • Jones, S.F.1    Hainsworth, J.D.2    Spigel, D.R.3
  • 81
    • 23844544970 scopus 로고    scopus 로고
    • A Phase I, open-label study of lapatinib (GW-572016) plus trastuzumab; a clinically active regimen
    • abstract 559
    • STORNIOLO A, BURRIS HA 3rd, PEGRAM MD et al.: A Phase I, open-label study of lapatinib (GW-572016) plus trastuzumab; a clinically active regimen. Proc. Am. Soc. Clin. Oncol. (2005): abstract 559.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Storniolo, A.1    Burris III, H.A.2    Pegram, M.D.3
  • 82
    • 33144471773 scopus 로고    scopus 로고
    • A Phase I, open-label study of the safety, tolerability and pharmacokinetics of lapatinib (GW-572016) in combination with letrozole in cancer patients
    • abstract 3001
    • CHU Q, GOLDSTEIN LJ, MURRAY N et al.: A Phase I, open-label study of the safety, tolerability and pharmacokinetics of lapatinib (GW-572016) in combination with letrozole in cancer patients. Proc. Am. Soc. Clin. Oncol. (2005):abstract 3001.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Chu, Q.1    Goldstein, L.J.2    Murray, N.3
  • 83
    • 4544284509 scopus 로고    scopus 로고
    • A Phase II, open-label, multi-center study of GW-572016 in patients with trastuzumab-refractory metastatic breast cancer
    • abstract 3006
    • BLACKWELL KL, KAPLAN EH, FRANCO SX et al.: A Phase II, open-label, multi-center study of GW-572016 in patients with trastuzumab-refractory metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. (2005):abstract 3006.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Blackwell, K.L.1    Kaplan, E.H.2    Franco, S.X.3
  • 84
    • 32944461676 scopus 로고    scopus 로고
    • A Phase II, randomized trial using the small molecule tyrosine kinase inhibitor lapatinib as a first-line treatment in patients with FISH-positive advanced or metastatic breast cancer
    • abstract 3046
    • GOMEZ HL, CHAVEZ MA, DOVAL DC et al.: A Phase II, randomized trial using the small molecule tyrosine kinase inhibitor lapatinib as a first-line treatment in patients with FISH-positive advanced or metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. (2005):abstract 3046.
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Gomez, H.L.1    Chavez, M.A.2    Doval, D.C.3
  • 85
    • 33748653842 scopus 로고    scopus 로고
    • An open-label, randomized, two-way crossover study to evaluate the potential inhibition of GW-572016 metabolism by ketoconazole
    • abstract 3071
    • SMITH DA, BOWEN C, HERENDEEN JM et al.: An open-label, randomized, two-way crossover study to evaluate the potential inhibition of GW-572016 metabolism by ketoconazole. Proc. Am. Soc. Clin. Oncol. (2004): abstract 3071.
    • (2004) Proc. Am. Soc. Clin. Oncol.
    • Smith, D.A.1    Bowen, C.2    Herendeen, J.M.3
  • 86
    • 34848924172 scopus 로고    scopus 로고
    • An open-label, fixed sequence, two period study to evaluate the potential induction of GW-572016 metabolism by carbamazepine
    • abstract 3081
    • HERENDEEN JM, SMITH DA, STEAD A et al.: An open-label, fixed sequence, two period study to evaluate the potential induction of GW-572016 metabolism by carbamazepine. Proc. Am. Soc. Clin. Oncol. (2004):abstract 3081.
    • (2004) Proc. Am. Soc. Clin. Oncol.
    • Herendeen, J.M.1    Smith, D.A.2    Stead, A.3
  • 87
    • 0023279839 scopus 로고
    • Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer
    • SAINSBURY JR, FARNDON JR, NEEDHAM GK, MALCOLM AJ, HARRIS AL: Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet (1987) 1(8547):1398-1402.
    • (1987) Lancet , vol.1 , Issue.8547 , pp. 1398-1402
    • Sainsbury, J.R.1    Farndon, J.R.2    Needham, G.K.3    Malcolm, A.J.4    Harris, A.L.5
  • 88
    • 2442701289 scopus 로고    scopus 로고
    • The ErbB/HER receptor protein-tyrosine kinases and cancer
    • ROSKOSKI R Jr: The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem. Biophys. Res. Commun. (2004) 319(1):1-11.
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , Issue.1 , pp. 1-11
    • Roskoski Jr., R.1
  • 89
    • 23944464495 scopus 로고    scopus 로고
    • Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
    • BASELGA J, ALBANELL J, RUIZ A et al.: Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J. Clin. Oncol. (2005) 23(23):5323-5333.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.23 , pp. 5323-5333
    • Baselga, J.1    Albanell, J.2    Ruiz, A.3
  • 90
    • 20844456577 scopus 로고    scopus 로고
    • A multicentre Phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer
    • VON MINCKWITZ G, JONAT W, FASCHING P et al.: A multicentre Phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer Res. Treat. (2005) 89(2):165-172.
    • (2005) Breast Cancer Res. Treat. , vol.89 , Issue.2 , pp. 165-172
    • Von Minckwitz, G.1    Jonat, W.2    Fasching, P.3
  • 91
    • 0842304369 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition as therapy for hematologic malignancies
    • PANWALKAR A, VERSTOVSEK S, GILES FJ: Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer (2004) 100(4):657-666.
    • (2004) Cancer , vol.100 , Issue.4 , pp. 657-666
    • Panwalkar, A.1    Verstovsek, S.2    Giles, F.J.3
  • 92
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • BOULAY A, RUDLOFF J, YE J et al.: Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin. Cancer Res. (2005) 11(14):5319-5328.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.14 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3
  • 93
    • 0034746371 scopus 로고    scopus 로고
    • Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: Pharmacokinetics, exposure-response relationships, and influence on cyclosporine
    • KOVARIK JM, KAHAN BD, KAPLAN B et al.: Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: pharmacokinetics, exposure-response relationships, and influence on cyclosporine. Clin. Pharmacol. Ther. (2001) 69(1):48-56.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , Issue.1 , pp. 48-56
    • Kovarik, J.M.1    Kahan, B.D.2    Kaplan, B.3
  • 94
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • RAYMOND E, ALEXANDRE J, FAIVRE S et al.: Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J. Clin. Oncol. (2004) 22(12):2336-2347.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.12 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3
  • 95
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR in heavily pretreated patients with locally advanced or metastatic breast cancer
    • CHAN S, SCHEULEN ME, JOHNSTON S et al.: Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR in heavily pretreated patients with locally advanced or metastatic breast cancer. J. Clin. Oncol. (2005) 23(23):5314-5322.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3
  • 96
    • 24744465206 scopus 로고    scopus 로고
    • The farnesyl transferee inhibitor (FTI) SCH-6336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity
    • BASSO AD, MIRZA A, LIU G et al.: The farnesyl transferee inhibitor (FTI) SCH-6336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity. J. Biol. Chem. (2005) 280(35):31101-31108.
    • (2005) J. Biol. Chem. , vol.280 , Issue.35 , pp. 31101-31108
    • Basso, A.D.1    Mirza, A.2    Liu, G.3
  • 97
    • 20944437248 scopus 로고    scopus 로고
    • The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase
    • MARCUS AI, ZHOU J, O'BRATE A et al.: The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res. (2005) 65(9):3883-3893.
    • (2005) Cancer Res. , vol.65 , Issue.9 , pp. 3883-3893
    • Marcus, A.I.1    Zhou, J.2    O'Brate, A.3
  • 98
    • 0037367224 scopus 로고    scopus 로고
    • Tamoxifen and the farnesyl transferase inhibitor FTI-277 synergize to inhibit growth in estrogen receptor-positive breast tumor cell lines
    • ELLIS CA, VOS MD, WICKLINE M et al.: Tamoxifen and the farnesyl transferase inhibitor FTI-277 synergize to inhibit growth in estrogen receptor-positive breast tumor cell lines. Breast Cancer Res. Treat. (2003) 78(1):59-67.
    • (2003) Breast Cancer Res. Treat. , vol.78 , Issue.1 , pp. 59-67
    • Ellis, C.A.1    Vos, M.D.2    Wickline, M.3
  • 99
    • 0036605562 scopus 로고    scopus 로고
    • Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R-115777 in advanced cancer
    • CRUL M, DE KLERK GJ, SWART M et al.: Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R-115777 in advanced cancer. J. Clin. Oncol. (2002) 20(11):2726-2735.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.11 , pp. 2726-2735
    • Crul, M.1    De Klerk, G.J.2    Swart, M.3
  • 100
    • 19944434195 scopus 로고    scopus 로고
    • A Phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer
    • LEBOWITZ PF, ENG-WONG J, WIDEMANN BC et al.: A Phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer. Clin. Cancer Res. (2005) 11(3):1247-1252.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.3 , pp. 1247-1252
    • Lebowitz, P.F.1    Eng-Wong, J.2    Widemann, B.C.3
  • 101
    • 0038352147 scopus 로고    scopus 로고
    • Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R-115777, in advanced breast cancer
    • JOHNSTON SR, HICKISH T, ELLIS P et al.: Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R-115777, in advanced breast cancer. J. Clin. Oncol. (2003) 21(13):2492-2499.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.13 , pp. 2492-2499
    • Johnston, S.R.1    Hickish, T.2    Ellis, P.3
  • 103
    • 21344453004 scopus 로고    scopus 로고
    • Pharmacogenetics for individualized cancer chemotherapy
    • EFFERTH T, VOLM M: Pharmacogenetics for individualized cancer chemotherapy. Pharmacol. Ther. (2005) 107(2):155-176.
    • (2005) Pharmacol. Ther. , vol.107 , Issue.2 , pp. 155-176
    • Efferth, T.1    Volm, M.2


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