Identification of novel RUNXI (AMLI) translocation partner genes SH3D19, YTHDF2, and ZNF687 in acute myeloid leukemia

Genes Chromosomes and Cancer

Volumn 45, Issue 10, 2006, Pages 918-932

  Nguyen, TuDung T ^a   Ma, Lisa N ^a   Slovak, Marilyn L ^b   Bangs, Charles D ^a   Cherry, Athena M ^a   Arber, Daniel A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOPLASM PROTEIN; HYBRID PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR RUNX1; ONCOPROTEIN; RUNX1 PROTEIN, HUMAN; ZINC FINGER PROTEIN;

3' UNTRANSLATED REGION; ACUTE GRANULOCYTIC LEUKEMIA; AGED; ALU SEQUENCE; AML1 GENE; ARTICLE; CANCER PATIENT; CASE REPORT; CELL TRANSFORMATION; CHROMOSOME 1; CHROMOSOME 1P; CHROMOSOME 1Q; CHROMOSOME 21Q; CHROMOSOME 4; CHROMOSOME 4Q; CHROMOSOME TRANSLOCATION; DNA STRAND BREAKAGE; FEMALE; GENE; GENE FUSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC RECOMBINATION; HUMAN; HUMAN TISSUE; MALE; NUCLEAR LOCALIZATION SIGNAL; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RUNX1 GENE; SEQUENCE ANALYSIS; SH3D19 GENE; YTHDF2 GENE; ZNF687 GENE; ACUTE DISEASE; CHROMOSOME 21; FLUORESCENCE IN SITU HYBRIDIZATION; GENE TRANSLOCATION; GENETICS; INFANT; METABOLISM; MOLECULAR CLONING; MYELOID LEUKEMIA; SRC HOMOLOGY DOMAIN;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 4; CLONING, MOLECULAR; CORE BINDING FACTOR ALPHA 2 SUBUNIT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; LEUKEMIA, MYELOID; MALE; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SRC HOMOLOGY DOMAINS; TRANSLOCATION, GENETIC; ZINC FINGERS;

EID: 33748508842     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20355     Document Type: Article

References (77)

1. Andersen MK, Christiansen DH, Pedersen-Bjergaard J. 2005. Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutation of the TP53 gene in therapy-related MDS and AML. Leukemia 19:197-200.
2. Chan EM, Comer EM, Brown FC, Richkind KE, Holmes ML, Chong BH, Shiffman R, Zhang DE, Slovak ML, Willman CL, Noguchi CT, Li Y, Heiber DJ, Kwan L, Chan RJ, Vance GH, Ramsey HC, Hromas RA. 2005. AML1-FOG2 fusion protein in myelodysplasia. Blood 105:4523-4526.
3. Chen SJ, Chen Z, d'Auriol L, Le Coniat M, Grausz D, Berger R. 1989. Ph1+bcr- acute leukemias: Implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene. Oncogene 4:195-202.
4. Elliott B, Richardson C, Jasin M. 2005. Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Mol Cell 17:885-894.
5. Ferro MT, Hernaez R, Sordo MT, Garcia-Sagredo JM, Garcia-Miguel P, Fernandez Guijarro M, Lopez J, Villalon C, Vallcorba I, Cabello P, San Roman C. 2004. Chromosome 21 tandem repetition and AML1 (RUNX1) gene amplification. Cancer Genet Cytogenet 149:11-16.
6. Gamou T, Kicamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M. 1998. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. Blood 91:4028-4037.
7. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG. 1995. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917-4921.
8. Grover D, Mukerji M, Bhatnagar P, Kannan K, Brahmachari SK. 2004. Alu repeat analysis in the complete human genome: Trends and variations with respect to genomic composition. Bioinformatics 20:813-817.
9. Hall TM. 2005. Multiple modes of RNA recognition by zinc finger proteins. Curr Opin Struct Biol 15:367-373.
10. Hirai H, Ogawa S, Kurokawa M, Yazaki Y, Mitani K. 1999. Molecular characterization of the genomic breakpoints in a case of t(3;21)(q26;q22). Genes Chromosomes Cancer 26:92-96.
11. Hromas R, Busse T, Carroll A, Mack D, Shopnick R, Zhang DE. Nakshatri H, Richkind K. 2001. Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein. Blood 97:2168-2170.
12. Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K. 2000. A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. Blood 95:4011-4013.
13. ISCN 2005. International System for Human Cytogenetic Nomenclature. Basel, Switzerland: S. Karger, 130 p.
14. Ito Y. 1999. Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF. Genes Cells 4:685-696.
15. Ito Y. 2004. Oncogenic potential of the RUNX gene family: 'Overview'. Oncogene 23:4198-4208.
16. Jaffe ES, Harris NL, Stein H, Vardiman JW. 2001. World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon. France: IARC Press, 351 p.
17. Jeffs AR, Wells E, Morris CM. 2001. Nonrandom distribution of interspersed repeat elements in the BCR and ABL1 genes and its relation to breakpoint cluster regions. Genes Chromosomes Cancer 32:144-154.
18. Jurka J, Kapitonov W, Pavlicek A, Klonowski P, Kohany O, Walichiewicz J. 2005. Repbase Update, a database of eukaryotic repetitive elements. Cytogenet Genome Res 110:462-467.
19. Kempski H, Chalker J, Chessells J, Sturt N, Brickell P, Webb J, Clink JM, Reeves B. 1999. An investigation of the t(12;21) rearrangement in children with B-precursor acute lymphoblastic leukaemia using cytogenetic and molecular methods. Br J Haematol 105:684-689.
20. Kitabayashi I, Yokoyama A, Shimizu K, Ohki M. 1998. Inreraction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J 17:2994-3004.
21. Kolomietz E, Al-Maghrabi J, Brennan S, Karaskova J, Minkin S, Lipton J, Squire JA. 2001. Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. Blood 97:3581-3588.
22. Kolomietz E, Meyn MS, Pandita A, Squire JA. 2002. The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors. Genes Chromosomes Cancer 35:97-112.
23. Kurokawa M, Hirai H. 2003. Role of AML1/Runx1 in the pathogenesis of hematological malignancies. Cancer Sci 94:841-846.
24. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Marthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent VVJ1 Kitts P, Koonin EV, Korf I, Kulp D, Lancet D. Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowski J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ. 2001. Initial sequencing and analysis of the human genome. Nature 409:860-921.
25. Levanon D, Glusman G, Bangsow T, Ben-Asher E, Male DA, Avidan N, Bangsow C, Hattori M, Taylor TD, Taudien S, Blechschmidt K, Shimizu N, Rosenthal A, Sakaki Y, Lancet D, Groner Y. 2001. Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1. Gene 262:23-33.
26. Licht JD. 2001. AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:5660-5679.
27. Look AT. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278:1059-1064.
28. Manoharan H, Babcock K, Pilot HC. 2004. Changes in the DNA methylation profile of the rat H19 gene upstream region during development and transgenic hepatocarcinogenesis and its role in the imprinted transcriptional regulation of the H19 gene. Mol Carcinog 41:1-16.
29. Megonigal MD, Rappaport EF, Wilson RB, Jones DH, Whitlock JA, Ortega JA, Slater DJ, Nowell PC, Felix CA. 2000. Panhandle PCR for cDNA: A rapid method for isolation of MLL fusion transcripts involving unknown partner genes. Proc Natl Acad Sci USA 97:9597-9602.
30. Michaud J, Scott HS, Escher R. 2003. AML1 interconnected pathways of leukemogenesis. Cancer Invest 21:105-136.
31. Mikhail FM, Coignet L, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Farahat N, Nucifora G. 2004. A novel gene, FGA7, is fused to RUNX1/AML1 in a t(4;21)(q28;q22) in a patient with T-cell acuce lymphoblastic leukemia. Genes Chromosomes Cancer 39:110-118.
32. Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G. 2002. AML1 gene overexpression in childhood acute lymphoblastic leukemia. Leukemia 16:658-668.
33. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M. 1993. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12:2715-2721.
34. Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E, Ohki M. 1995. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Res 23:2762-2769.
35. Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. 1991. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA 88:10431-10434.
36. Nguyen TT, Mohrbacher AF, Tsai YC, Groffen J, Heisterkamp N, Nichols PW, Yu MC, Lubbert M, Jones PA. 2000. Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: Biological implications. Blood 95:2990-2992.
37. North T, Gu TL, Stacy T, Wang Q, Howard L, Binder M, Marin-Padilla M, Speck NA. 1999. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development 126:2563-2575.
38. North TE, Stacy T, Matheny CJ, Speck NA, de Bruijn MF. 2004. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells 22:158-168.
39. Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton D, Pedersen-Bjergaard J, Parganas E, Ihle JN, Rowley JD. 1994. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc Natl Acad Sci USA 91:4004-4008.
40. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. 1996. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-330.
41. Onno M, Nakamura T, Hillova J, Hill M. 1992. Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes. Oncogene 7:2519-2523.
42. Osato M. 2004. Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia. Oncogene 23:4284-4296.
43. Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T, Suzushima H, Takatsuki K, Kanno T, Shigesada K, Ito Y. 1999. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2aB gene associated with myeloblastic leukemias. Blood 93:1817-1824.
44. Papworth M, Kolasinska R Minczuk M. 2006. Designer zinc-finger proteins and their applications. Gene 366:27-38.
45. Paulsson K, Bekassy AN, Olofsson T, Mitelman F, Johansson B, Panagopoulos I. 2006. A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42. Leukemia 20:224-229.
46. Preudhomme C, Warot-Loze D, Roumier C, Grardel-Duflos N, Garand R, Lai JL, Dastugue N, Macintyre E, Denis C, Bauters F, Kerckaert JP, Cosson A, Fenaux P. 2000. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 96:2862-2869.
47. Putz G, Rosner A, Nuesslein I, Schmitz N, Buchholz F. 2006. AML1 deletion in adult mice causes splenomegaly and lymphomas. Oncogene 25:929-939.
48. Ramsey H, Christopherson K, Hromas R. 2004. Forced expression of AML1-AMP19, a fusion transcript generated from a radiation-associated t(19;21) leukemia, blocks myeloid differentiation. Leuk Res 28:863-868.
49. Ramsey H, Zhang DE, Richkind K, Burcoglu-O'Ral A, Hromas R. 2003. Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation. Leukemia 17:1665-1666.
50. Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S, Srinivasiah J, Varella-Garcia M. 2000. Identification of two new translocations that disrupt the AML1 gene. Cancer Genet Cytogenet 122:141-143.
51. Robinson HM, Broadfield ZJ, Cheung KL, Harewood L, Harris RL, Jalali GR, Martineau M, Moorman AV, Taylor KE, Richards S, Mitchell C, Harrison CJ. 2003. Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome. Leukemia 17:2249-2250.
52. Romana SP, Poirel H, Leconiat M, Flexor MA, Mauchauffe M, Jonveaux P, Macintyre EA, Berger R, Bernard OA. 1995. High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia. Blood 86:4263-4269.
53. Rothman R, Trakhtenbrot L, Bielorai B, Izraeli S, Ishoev G, Amariglio N, Rechavi G, Toren A. 2005. Co-existence of multiple subclones in TEL-AML1 at diagnosis of acute lymphoblastic leukaemia in association with submicroscopic deletion of AML1. Br J Haematol 129:491-498.
54. Roulston D, Espinosa R, III, Nucifora G, Larson RA, Le Beau MM, Rowley JD. 1998. CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: Association with prior therapy. Blood 92:2879-2885.
55. Rouyer F, Simmler MC, Page DC, Weissenbach J. 1987. A sex chromosome rearrangement in a human XX male caused by Alu-Alu recombination. Cell 51:417-425.
56. Sakai I, Tamura T, Narumi H, Uchida N, Yakushijin Y, Hato T, Fujita S, Yasukawa M. 2005. Novel RUNX1-PRDM16 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22). Genes Chromosomes Cancer 44:265-270.
57. Schichman SA, Caligiuri MA, Strout MP, Carter SL, Gu Y, Canaani E, Bloomfield CD, Croce CM. 1994. ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between AIu elements. Cancer Res 54:4277-4280.
58. Shimizu K, Miyoshi H, Kozu T, Nagata J, Enomoto K, Maseki N, Kaneko Y, Ohki M. 1992. Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation. Cancer Res 52:6945-6948.
59. Sinclair PB, Nacheva EP, Leversha M, Telford N, Chang J, Reid A, Bench A, Champion K, Huntly B, Green AR. 2000. Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia. Blood 95:738-743.
60. Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R. 2002. 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: Report from an international workshop. Genes Chromosomes Cancer 33:379-394.
61. So CW, Ma ZG, Price CM, Dong S, Chen SJ, Gu LJ, So CK, Wiedemann LM, Chan LC. 1997. MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes. Cancer Res 57:117-122.
62. Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG. 1999. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 23:166-175.
63. Soulier J, Trakhtenbrot L, Najfeld V, Lipton JM, Mathew S, Avet-Loiseau H, De Braekeleer M, Salem S, Baruchel A, Raimondi SC, Raynaud SD. 2003. Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: An emerging molecular cytogenetic subgroup. Leukemia 17:1679-1682.
64. Speck NA, Gilliland DG. 2002. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2:502-513.
65. Steensma DP, Gibbons RJ, Mesa RA, Tefferi A, Higgs DR. 2005. Somatic point mutations in RUNX1/CBFA2/AML1 are common in high-risk myelodysplastic syndrome, but not in myelofibrosis with myeloid metaplasia. Eur J Haematol 74:47-53.
66. Strout MP, Marcucci G, Bloomfield CD, Caligiuri MA. 1998. The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia. Proc Natl Acad Sci USA 95:2390-2395.
67. Tanaka M, Nanba D, Mori S, Shiba F, Ishiguro H, Yoshino K, Matsuura N, Higashiyama S. 2004. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. J Biol Chem 279:41950-41959.
68. Tanaka T, Tanaka K, Ogawa S, Kurokawa M, Mitani K, Nishida J, Shibata Y, Yazaki Y, Hirai H. 1995. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J 14:341-350.
69. Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS. 2000. The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. EMBO J 19:1263-1271.
70. Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. 1996. The CBFβ subunit is essential for CBFa2 (AML1) function in vivo. Cell 87:697-708.
71. Willis TG, Jadayel DM, Coignet LJ, Abdul-Rauf M, Treleaven JG, Catovsky D, Dyer MJ. 1997. Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction. Blood 90:2456-2464.
72. Yam JW, Jin DY, So CW, Chan LC. 2004. Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Blood 103:1445-1453.
73. Zelent A, Greaves M, Enver T, 2004. Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene 23:4275-4283.
74. Zent CS, Mathieu C, Claxton DF, Zhang DE, Tenen DG, Rowley JD, Nucifora G. 1996. The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties. Proc Natl Acad Sci USA 93:1044-1048.
75. Zhang Y, Emmanuel N, Kamboj G, Chen J, Shurafa M, Van Dyke DL, Wiktor A, Rowley JD. 2004. PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22). Genes Chromosomes Cancer 40:365-370.
76. Zhang Y, Strissel P, Strick R, Chen J, Nucifora G, Le Beau MM, Larson RA, Rowley JD. 2002. Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia. Proc Natl Acad Sci USA 99:3070-3075.
77. Zion M, Ben-Yehuda D, Avraham A, Cohen O, Wetzler M, Melloul D, Ben-Neriah Y. 1994. Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. Proc Natl Acad Sci USA 91:10722-10726.