IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus

International Immunology

Volumn 18, Issue 8, 2006, Pages 1253-1263

  Ito, Hiroaki ^a,b   Esashi, Eiji ^a,b   Akiyama, Taishin ^a   Inoue, Jun Ichiro ^a   Miyajima, Atsushi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

CD11b; Dendritic cells; Fetal thymus; IL 18; Thymic epithelial cells

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 18; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL SELECTION; CELL STIMULATION; CONJUGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EPITHELIUM CELL; FEMALE; FETUS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, CD80; ANTIGENS, CD86; DENDRITIC CELLS; EMBRYO; EPITHELIAL CELLS; FEMALE; INTERLEUKIN-18; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PREGNANCY; THYMUS GLAND; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 33748501704     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl058     Document Type: Article

References (51)

1. Banchereau, J. and Steinman, R. M. 1998. Dendritic cells and the control of immunity. Nature 392:245.
2. Hart, D. N. 1997. Dendritic cells: Unique leukocyte populations which control the primary immune response. Blood 90:3245.
3. Banchereau, J., Briere, F., Caux, C. et al. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767.
4. Brocker, T., Riedinger, M. and Karjalainen, K. 1997. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185:541.
5. Shortman, K. and Liu, Y. J. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:151.
6. Ardavin, C. 2003. Origin, precursors and differentiation of mouse dendritic cells. Nat. Rev. Immunol. 3:582.
7. Aliberti, J., Schulz, O., Pennington, D. J. et al. 2003. Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood 101:305.
8. Guerriero, A., Langmuir, P. B., Spain, L. M. and Scott, E. W. 2000. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 95:879.
9. O'Keeffe, M., Hochrein, H., Vremec, D. et al. 2002. Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice. Blood 99:2122.
10. Wu, L., D'Amico, A., Winkel, K. D., Suter, M., Lo, D. and Shortman, K. 1998. RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity 9:839.
11. Wu, L., Nichogiannopoulou, A., Shortman, K. and Georgopoulos, K. 1997. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 7:483.
12. Suzuki, S., Honma, K., Matsuyama, T. et al. 2004. Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc. Natl Acad. Sci. USA 101:8981.
13. Vremec, D., Zorbas, M., Scollay, R. et al. 1992. The surface phenotype of dendritic cells purified from mouse thymus and spleen: Investigation of the CD8 expression by a subpopulation of dendritic cells. J. Exp. Med. 176:47.
14. Vremec, D. and Shortman, K. 1997. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159:565.
15. Vremec, D., Pooley, J., Hochrein, H., Wu, L. and Shortman, K. 2000. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164:2978.
16. Dakic, A., Shao, Q. X., D'Amico, A. et al. 2004. Development of the dendritic cell system during mouse ontogeny. J. Immunol. 172:1018.
17. Moore, T. A. and Zlotnik, A. 1995. T-cell lineage commitment and cytokine responses of thymic progenitors. Blood 86:1850.
18. Wu, L., Li, C. L. and Shortman, K. 1996. Thymic dendritic cell precursors: Relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184:903.
19. Saunders, D., Lucas, K., Ismaili, J. et al. 1996. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 184:2185.
20. Shen, H. Q., Lu, M., Ikawa, T. et al. 2003. T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells. J. Immunol. 171:3401.
21. Radtke, F., Ferrero, I., Wilson, A., Lees, R., Aguet, M. and MacDonald, H. R. 2000. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J. Exp. Med. 191:1085.
22. Rodewald, H. R., Brocker, T. and Haller, C. 1999. Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice. Proc. Natl Acad. Sci. USA 96:15068.
23. Donskoy, E. and Goldschneider, I. 2003. Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions. J. Immunol. 170:3514.
24. Suss, G. and Shortman, K. 1996. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. 183:1789.
25. Reis e Sousa, C. 2001. Dendritic cells as sensors of infection. Immunity 14:495.
26. Naito, A., Azuma, S., Tanaka, S. et al. 1999. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4:353.
27. Klein, L., Klugmann, M., Nave, K. A., Tuohy, V. K. and Kyewski, B. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6:56.
28. Esashi, E., Ito, H., Ishihara, K., Hirano, T., Koyasu, S. and Miyajima, A. 2004. Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells. J. Immunol. 173:4360.
29. Esashi, E., Sekiguchi, T., Ito, H., Koyasu, S. and Miyajima, A. 2003. Cutting edge: A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytes. J. Immunol. 171:2773.
30. Szilvassy, S. J., Weller, K. P., Lin,W. et al. 1996. Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Blood 87:4618.
31. Wu, H. and Arron, J. R. 2003. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays 25:1096.
32. Kobayashi, T., Walsh, P. T., Walsh, M. C. et al. 2003. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19:353.
33. Inaba, K., Inaba, M., Romani, N. et al. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693.
34. Inaba, K., Inaba, M., Deguchi, M. et al. 1993. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc. Natl Acad. Sci. USA 90:3038.
35. Maraskovsky, E., Brasel, K., Teepe, M. et al. 1996. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified. J. Exp. Med. 184:1953.
36. Fukao, T., Matsuda, S. and Koyasu, S. 2000. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J. Immunol. 164:64.
37. Dinarello, C. A. 1998. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev. Immunol. 16:457.
38. Dayer, J. M. 2002. Evidence for the biological modulation of IL-1 activity: The role of IL-1Ra. Clin. Exp. Rheumatol. 20:S14.
39. Watanabe, N., Hanabuchi, S., Soumelis, V. et al. 2004. Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion. Nat. Immunol. 5:426.
40. Wu, L., D'Amico, A., Hochrein, H., O'Keeffe, M., Shortman, K. and Lucas, K. 2001. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 98:3376.
41. Akiyama, T., Maeda, S., Yamane, S. et al. 2005. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308:248.
42. Gutierrez, J. C. and Palacios, R. 1991. Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo. Proc. Natl Acad. Sci. USA 88:642.
43. Saunders, D. J., Georgiou, H. M., Wu, L. and Shortman, K. 1995. Induction of limited growth and differentiation of early thymic precursor cells by thymic epithelial cell lines. Immunol. Lett. 47:45.
44. Nehls, M., Kyewski, B., Messerle, M. et al. 1996. Two genetically separable steps in the differentiation of thymic epithelium. Science 272:886.
45. Zhang, M., Tang, H., Guo, Z. et al. 2004. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5:1124.
46. Nakanishi, K., Yoshimoto, T., Tsutsui, H. and Okamura, H. 2001. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19:423.
47. Okazawa, A., Kanai, T., Nakamaru, K. et al. 2004. Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes. Clin. Exp. Immunol. 136:269.
48. Hoshino, K., Tsutsui, H., Kawai, T. et al. 1999. Cutting edge: generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol. 162:5041.
49. Grant, E. P., Coyle, A. J. and Gutierrez-Ramos, J. C. 2003. Informatics and the immune system: The expanding IL-1 and B7 protein families. Semin. Immunol. 15:225.
50. Dunn, E., Sims, J. E., Nicklin, M. J. and O'Neill, L. A. 2001. Annotating genes with potential roles in the immune system: Six new members of the IL-1 family. Trends Immunol. 22:533.
51. Buhlmann, J. E., Elkin, S. K. and Sharpe, A. H. 2003. A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection. J. Immunol. 170:5421