High levels of fat and (n-6) fatty acids in cancellous bone in osteoarthritis

Lipids in Health and Disease

Volumn 3, Issue , 2004, Pages

  Plumb, Mandy S ^a   Aspden, Richard M ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Bone; Fatty acids; Lipid; Osteoarthritis; Osteoporosis

Indexed keywords

ARACHIDONIC ACID; CHLOROFORM; FAT; LIPID; METHANOL; OMEGA 6 FATTY ACID;

ARTICLE; BONE MASS; CANCELLOUS BONE; CONTROLLED STUDY; FATTY ACID ANALYSIS; FEMUR HEAD; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYPOTHESIS; OSTEOARTHRITIS; OSTEOPOROSIS; PATHOGENESIS;

EID: 13444278842     PISSN: 1476511X     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-3-12     Document Type: Article

References (10)

1. Li B, Aspden RM: Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Miner Res 1997, 12:641-651.
2. Hart DJ, Doyle DV, Spector TD: Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J Rheumatol 1995, 22:1118-1123.
3. Aspden RM, Scheven BAA, Hutchison JD: Osteoarthritis is a systemic disorder involving stromal cell differentiation and lipid metabolism. Lancet 2001, 357:1118-1120.
4. Kruger MC, Horrobin DF: Calcium metabolism, osteoporosis and essential fatty acids: a review. Prog Lipid Res 1997, 36:131-151.
5. Diascro D.D., Jr., Vogel RL, Johnson TE, Witherup KM, Pitzenberger SM, Rutledge SJ, Prescott DJ, Rodan GA, Schmidt A: High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells. J Bone Miner Res 1998, 13:96-106.
6. Meunier P, Aaron J, Edouard C, Vignon G: Osteoporosis and the replacement of cell populations of the marrow by adipose tissue: A quantitative study of 84 iliac bone biopsies. Clin Orthop 1971, 80:147-154.
7. Aspden RM: Mechanical testing of bone ex vivo. Bone Research Protocols (Edited by: Helfrich MH and Ralston SH). Totowa, New Jersey, Human Press Inc 2003, 369-379.
8. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Med Sci 1959, 37:911-917.
9. Christie WW: Lipid Analysis 2 Edition Oxford, Pergamon Press 1982.
10. Lippiello L, Walsh T, Fienhold M: The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage. Metabolism 1991, 40:571-576.