Lack of involvement of extracellular signal-regulated kinase (ERK) in the agonist-induced endothelial nitric oxide synthesis

Biochemical Pharmacology

Volumn 63, Issue 6, 2002, Pages 1137-1142

  Schmidt, Kurt ^a   Gibraeil, Hanan D ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Endothelial cells; Endothelial nitric oxide synthase; Extracellular signal regulated kinase; Nitric oxide; Phosphorylation; Smooth muscle relaxation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE TRIPHOSPHATE; BRADYKININ; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SWINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRADYKININ; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; ENZYME INHIBITORS; FLAVONOIDS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; SWINE;

EID: 0037087733     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00936-4     Document Type: Article

References (35)

1. Nitric oxide as a signaling molecule in the vascular system: An overview
2. Nitric oxide signaling in the central nervous system
3. Nitric oxide: A physiologic messenger molecule
4. Molecular control of nitric oxide synthases in the cardiovascular system
5. Biosynthesis and action of nitric oxide in mammalian cells
6. Mammalian nitric oxide synthases
7. Dynamic activation of endothelial nitric oxide synthase by Hsp90
8. 2+-calmodulin and caveolin
9. Direct interaction of endothelial nitric oxide synthase and caveolin-1 inhibits synthase activity
10. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin - Functional significance of the NOS caveolin binding domain in vivo
11. Interaction between caveolin-1 and the reductase domain of endothelial nitric oxide synthase - Consequences for catalysis
12. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric oxide synthase
13. Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
14. Identification of flow-dependent endothelial nitric oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
15. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
16. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
17. The Akt kinase signals directly to endothelial nitric oxide synthase
18. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells
19. Estrogen induces the Akt-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells
20. Reciprocal phosphorylation and regulation of endothelial nitric oxide synthase in response to bradykinin stimulation
21. Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation
22. Coordinated control of endothelial nitric oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
23. AMP activated protein kinase phosphorylation of endothelial NO synthase
24. 2+/calmodulin-dependent endothelial nitric oxide synthase activity
25. Bradykinin-regulated interactions of the MAP kinase pathway with the endothelial nitric oxide synthase
26. Purification of radioiodinated succinyl cyclic nucleotide tyrosine methyl esters by anion-exchange thin-layer chromatography
27. Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells
28. Assay of tissue activity of nitric oxide synthase
29. Comparison of neuronal and endothelial isoforms of nitric oxide synthase in stably transfected HEK 293 cells
30. Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin
31. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
32. Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer
33. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases
34. Tyrosine phosphorylation and bradykinin-induced signaling in endothelial cells
35. Phosphorylation and subcellular translocation of endothelial nitric oxide synthase