Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols

Biochemical Journal

Volumn 398, Issue 2, 2006, Pages 197-206

  Zeng, Jingmin ^a   Dunlop, Rachael A ^a   Rodgers, Kenneth J ^a   Davies, Michael J ^a,b  

^a HEART RESEARCH INSTITUTE   (Australia)

^b University of Sydney   (Australia)

Author keywords

Aldehyde; Cathepsin; Cysteine protease; Hyperglycaemia; Protein glycation; Thiol

Indexed keywords

ALDEHYDES; AMINO ACIDS; CELLS; DECOMPOSITION; SULFUR COMPOUNDS; TISSUE;

CATHEPSIN; CYSTEINE PROTEASE; HYPERGLYCAEMIA; PROTEIN GLYCATION;

ENZYMES;

ALDEHYDE; CARBOCISTEINE; CARBONYL DERIVATIVE; CATHEPSIN B; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; GLUCOSE; GLYOXAL; METHYLGLYOXAL; OVALBUMIN; PAPAIN; PHTHALALDEHYDE; THIOL; CATHEPSIN; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; AUTOLYSIS; CELL LYSATE; CROSS LINKING; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; GLYCATION; MACROPHAGE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; ANIMAL; BINDING SITE; CATTLE; CELL LINE; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; GLYCOSYLATION; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOUSE;

ANIMALS; BINDING SITES; CARBOCYSTEINE; CATHEPSINS; CATTLE; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENZYME ACTIVATION; GLYCOSYLATION; GLYOXAL; HUMANS; MICE; MOLECULAR WEIGHT; O-PHTHALALDEHYDE; PAPAIN; PROTEIN BINDING; SULFHYDRYL COMPOUNDS;

EID: 33748354683     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060019     Document Type: Article

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