Disinhibition of the cardiac limb of the arterial baroreflex in rat: A role for metabotropic glutamate receptors in the nucleus tractus solitarii

Journal of Physiology

Volumn 575, Issue 3, 2006, Pages 727-738

  Simms, Annabel E ^a   Paton, Julian F R ^a   Pickering, Anthony E ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ALPHA ETHYLGLUTAMIC ACID; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ATENOLOL; BICUCULLINE; GLUTAMATE RECEPTOR ANTAGONIST; KYNURENIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; UNCLASSIFIED DRUG; 4 METHYLGLUTAMIC ACID;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMORECEPTOR REFLEX; CONCENTRATION RESPONSE; CONTROLLED STUDY; GABAERGIC TRANSMISSION; HEART RATE; MICROINJECTION; NEUROMODULATION; NONHUMAN; PARASYMPATHETIC INNERVATION; POSITIVE FEEDBACK; PRESSORECEPTOR REFLEX; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; RAT STRAIN; SOLITARY TRACT NUCLEUS; CARDIAC LIMB OF THE BAROREFLEX; CHEMORECEPTOR; PARASYMPATHETIC TONE; SYMPATHETIC TONE; VAGUS TONE;

ANIMALS; ATROPINE DERIVATIVES; BAROREFLEX; BICUCULLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMATES; GLYCINE; HEART; HEART RATE; MUSCARINIC ANTAGONISTS; NEURAL INHIBITION; PERFUSION; PRESSURE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SOLITARY NUCLEUS; VAGUS NERVE;

EID: 33748335571     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.112672     Document Type: Article

References (56)

1. Antunes VR & Machado BH (2003). Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex. Auton Neurosci 103, 65-71.
2. Blessing W (1997). The Lower Brainstem and Bodily Homeostasis. Oxford University Press, New York.
3. Boscan P, Kasparov S & Paton JF (2002). Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex. Eur J Neurosci 16, 907-920.
4. Boscan P & Paton JF (2001). Role of the solitary tract nucleus in mediating nociceptive evoked cardiorespiratory responses. Auton Neurosci 86, 170-182.
5. Chan R, Peto C & Sawchenko P (2000). Fine structure and plasticity of barosensitive neurons in the nucleus of solitary tract. J Comp Neurol 422, 338-351.
6. Chen C-Y & Bonham AC (2005). Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats. J Physiol 562, 535-551.
7. Chen C-Y, Ling E-H, Horowitz JM & Bonham AC (2002). Synaptic transmission in nucleus tractus solitarius is depressed by Group II and III but not Group I presynaptic metabotropic glutamate receptors in rats. J Physiol 538, 773-786.
8. Conn PJ & Pin JP (1997). Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37, 205-237.
9. Deuchars J, Li YW, Kasparov S & Paton JFR (2000). Morphological and electrophysiological properties of neurones in the dorsal vagal complex of the rat activated by arterial baroreceptors. J Comparative Neurol 417, 233-249.
10. Foley CM, Moffitt JA, Hay M & Hasser EM (1998). Glutamate in the nucleus of the solitary tract activates both ionotropic and metabotropic glutamate receptors. Am J Physiol Regul Integr Comp Physiol 275, R1858-R1866.
11. Foley CM, Vogl HW, Mueller PJ, Hay M & Hasser EM (1999). Cardiovascular response to group I metabotropic glutamate receptor activation in NTS. Am J Physiol Regul Integr Comp Physiol 276, R1469-R1478.
12. Frigero M, Bonagamba LG & Machado BH (2000). The gain of the baroreflex bradycardia is reduced by microinjection of NMDA receptor antagonists into the nucleus tractus solitarii of awake rats. J Auton Nerv Syst 79, 28-33.
13. Glaum SR & Miller RJ (1993). Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat. J Neurosci 13, 1636-1641.
14. Glaum SR, Sunter DC, Udvarhelyi PM, Watkins JC & Miller RJ (1993). The actions of phenylglycine derived metabotropic glutamate receptor antagonists on multiple (1S,3R)-ACPD responses in the rat nucleus of the tractus solitarius. Neuropharmacology 32, 1419-1425.
15. Guyenet PG, Filtz TM & Donaldson SR (1987). Role of excitatory amino acids in rat vagal and sympathetic baroreflexes. Brain Res 407, 272-284.
16. Hay M & Hasser EM (1998). Measurement of synaptic vesicle exocytosis in aortic baroreceptor neurons. Am J Physiol 275, H710-H716.
17. Hay M, McKenzie H, Lindsley K, Dietz N, Bradley SR, Conn PJ & Hasser EM (1999). Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat. J Comp Neurol 403, 486-501.
18. Hoang CJ & Hay M (2001). Expression of metabotropic glutamate receptors in nodose ganglia and the nucleus of the solitary tract. Am J Physiol Heart Circ Physiol 281, H457-H462.
19. Jin YH, Bailey TW & Andresen MC (2004). Cranial afferent glutamate heterosynaptically modulates GABA release onto second-order neurons via distinctly segregated metabotropic glutamate receptors. J Neurosci 24, 9332-9340.
20. Jones NM, Beart PM, Monn JA & Widdop RE (1999). Type I and II metabotropic glutamate receptors mediate depressor and bradycardic actions in the nucleus of the solitary tract of anaesthetized rats. Eur J Pharmacol 380, 129-135.
21. Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S & Schoepp DD (1998). LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 37, 1-12.
22. Leone C & Gordon F (1989). Is L -glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius? J Pharmacol Exp Ther 250, 953-962.
23. Liu Z, Chen CY & Bonham AC (1998). Metabotropic glutamate receptors depress vagal and aortic baroreceptor signal transmission in the NTS. Am J Physiol Heart Circ Physiol 275, H1682-H1694.
24. Loewy AD (1990). Central Autonomic Pathways. In Central Regulation of Autonomic Functions, ed. Loewy AD & Spyer KM, pp. 88-103. Oxford University Press, New York.
25. Machado BH (2001). Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats. Ann N Y Acad Sci 940, 179-196.
26. Machado BH & Bonagamba LG (1998). Cardiovascular responses to microinjection of trans-(±)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats. Braz J Med Biol Res 31, 573-579.
27. Maqbool A, Batten TF & McWilliam PN (1991). Ultrastructural relationships between GABAergic terminals and cardiac vagal preganglionic motoneurons and vagal afferents in the cat: A combined HRP tracing and immunogold labelling study. Eur J Neurosci 3, 501-513.
28. Matsumura K, Tsuchihashi T, Kagiyama S, Abe I & Fujishima M (1999). Subtypes of metabotropic glutamate receptors in the nucleus of the solitary tract of rats. Brain Res 842, 461-468.
29. Mifflin SW (2001). What does the brain know about blood pressure? News Physiol Sci 16, 266-271.
30. Mifflin SW & Felder RB (1988). An intracellular study of time-dependent cardiovascular afferent interactions in nucleus tractus solitarius. J Neurophysiol 59, 1798-1813.
31. Mitchell SJ & Silver RA (2000). Glutamate spillover suppresses inhibition by activating presynaptic mGluRs. Nature 404, 498-502.
32. Ozawa S, Kamiya H & Tsuzuki K (1998). Glutamate receptors in the mammalian central nervous system. Prog Neurobiol 54, 581-618.
33. Palkovits M & Zaborszky L (1977). Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: Afferent and efferent neuronal connections in relation to the baroreceptor reflex arc. Prog Brain Res 47, 9-34.
34. Pamidimukkala J & Hay M (2001). Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs. Am J Physiol Heart Circ Physiol 281, H387-H395.
35. Paton JF (1996). A working heart-brainstem preparation of the mouse. J Neurosci Meth 65, 63-68.
36. Paton JF, Boscan P, Murphy D & Kasparov S (2001). Unravelling mechanisms of action of angiotensin II on cardiorespiratory function using in vivo gene transfer. Acta Physiol Scand 173, 127-137.
37. Paton JF & Kasparov S (1999). Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat. J Physiol 521, 213-225.
38. Pawloski-Dahm C & Gordon FJ (1992). Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii. Am J Physiol 262, H1611-H1615.
39. Paxinos G & Watson C (1986). The Rat Brain in Stereotaxic Coordinates. Academic, New York.
40. Perrone MH (1981). Biochemical evidence that L-glutamate is a neurotransmitter of primary vagal afferent nerve fibers. Brain Res 230, 283-293.
41. Pickering AE, Boscan P & Paton JFR (2003). Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii. J Physiol 551, 589-599.
42. Pickering AE & Paton JFR (2006). A decerebrate, artificially-perfused in situ preparation of rat: Utility for the study of autonomic and nociceptive processing. J Neurosci Methods (in press).
43. Schoepp DD, Jane DE & Monn JA (1999). Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38, 1431-1476.
44. Seagard JL, Dean C & Hopp FA (2000). Neurochemical transmission of baroreceptor input in the nucleus tractus solitarius. Brain Res Bull 51, 111-118.
45. 2+ exchange current. J Neurophysiol 95, 882-892.
46. Semyanov A & Kullmann DM (2000). Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors. Neuron 25, 663-672.
47. Simms AE, Paton JFR & Pickering AE (2005). Characterization of the role of metabotropic glutamate receptors in the baroreceptor reflex arc at the level of the nucleus tractus solitarii in the rat. J Physiol 567.P, PC40 (abstract)
48. Stornetta RL, Guyenet PG & McCarty RC (1987). Autonomic nervous system control of heart rate during baroreceptor activation in conscious and anesthetized rats. J Auton Nerv Syst 20, 121-127.
49. Sved A (1994). GABA-mediated neural transmission in mechanisms of cardiovascular control by the NTS. In Nucleus of the Solitary Tract, ed. Barraco I, pp. 245-253. CRC Press, Boca Raton.
50. Talman WT (1989). Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate. Neurosci Lett 102, 247-252.
51. Talman WT, Perrone MH & Reis DJ (1980). Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science 209, 813-815.
52. Thoren P & Jones JV (1977). Characteristics of aortic baroreceptor C-fibres in the rabbit. Acta Physiol Scand 99, 448-456.
53. Thoren P, Munch PA & Brown AM (1999). Mechanisms for activation of aortic baroreceptor C-fibres in rabbits and rats. Acta Physiol Scand 166, 167-174.
54. Viard E & Sapru HN (2002). Cardiovascular responses to activation of metabotropic glutamate receptors in the nTS of the rat. Brain Res 952, 308-321.
55. Viard E & Sapru HN (2004). Carotid baroreflex in the rat: Role of glutamate receptors in the medial subnucleus of the solitary tract. Neuroscience 126, 785-794.
56. Zhang W & Mifflin SW (1995). Excitatory amino-acid receptors contribute to carotid sinus and vagus nerve evoked excitation of neurons in the nucleus of the tractus solitarius. J Auton Nerv Syst 55, 50-56.