The gain of the baroreflex bradycardia is reduced by microinjection of NMDA receptor antagonists into the nucleus tractus solitarii of awake rats

Journal of the Autonomic Nervous System

Volumn 79, Issue 1, 2000, Pages 28-33

  Frigero, Mateus ^a   Bonagamba, Leni G H ^a   MacHado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

AP 5; Baroreflex gain; Baroreflex sensitivity; Bradycardia; Cardiovascular regulation; Excitatory amino acid receptors; Ionotropic receptors; Neurotransmission; Phenylephrine infusion

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DRUG EFFECT; MICROINJECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC INHIBITION; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SOLITARY TRACT NUCLEUS; STIMULUS RESPONSE; WAKEFULNESS;

2-AMINO-5-PHOSPHONOVALERATE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BAROREFLEX; BRADYCARDIA; CARDIOVASCULAR SYSTEM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MICROINJECTIONS; N-METHYLASPARTATE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SOLITARY NUCLEUS;

EID: 0033976169     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(99)00089-2     Document Type: Article

References (18)

1. Chianca D.A. Jr., Machado B.H. Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex. Brain Res. 718:1996;185-188.
2. Colombari E., Bonagamba L.G.H., Machado B.H. Mechanisms of pressor and bradycardic responses to L-glutamate microinjected into the nucleus tractus solitarii of conscious rats. Am. J. Physiol. 266:(Regulatory Integrative Comp. Physiol. 35):1994;R730-R738.
3. Colombari E., Bonagamba L.G.H., Machado B.H. NMDA receptor antagonist blocks the bradycardic but not the pressor response to L-glutamate into the nucleus tractus solitarius (NTS) of unanesthetized rats. Brain Res. 749:1997;209-213.
4. Gordon F.J., Talman W.T. Role of excitatory amino acids and their receptors in bulbospinal control of cardiovascular function. Kunos G., Ciriello J. Central Neural Mechanisms in Cardiovascular Regulation. Vol. 2:1992;209-225 Birkauser, Boston, MA.
5. Haibara A.S., Colombari E., Chianca D.A. Jr., Bonagamba L.G.H., Machado B.H. NMDA receptors in the NTS are involved in bradycardic but not in pressor response of the chemoreflex. Am. J. Physiol. 269:(Heart Circ. Physiol. 38):1995;H1421-H1427.
6. Haibara A.S., Bonagamba L.G.H., Machado B.H. Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats. Am. J. Physiol. 276:(Regulatory Integrative Comp. Physiol. 45):1999;R69-R80.
7. Izzo P.N., Deuchars J., Spyer K.M. Localization of cardiac vagal preganglionic motorneurons in the rat: Immunocytochemical evidence of synaptic inputs containing 5-hydroxytryptamine. J. Comp. Neurol. 327:1993;572-583.
8. Machado B.H., Bonagamba L.G.H. Microinjection of L-glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats. Brain Res. 576:1992;131-138.
9. Machado B.H., Mauad H., Chianca D.A. Jr., Haibara A.S., Colombari E. Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii. Braz. J. Med. Biol. Res. 30:1997;533-543.
10. Machado B.H., Frigero M., Bonagamba L.G.H., Okamoto R. NMDA receptors in the NTS mediates bradycardic responses to L-glutamate microinjection or to baroreflex activation. Soc. Neurosci. Abstr. 23:(Part 1):1997;65.6.
11. Michelini L.C., Bonagamba L.G.H. Baroreceptor reflex modulation by vasopressin microinjected into the nucleus tractus solitarii of conscious rats. Hypertension. 11:(Suppl. 1):1988;75I-79I.
12. Nosaka S., Yamamoto T., Yasunaga K. Localization of vagal cardioinhibitory preganglionic neurons within rat brain stem. J. Comp. Neurol. 186:1979;79-92.
13. Ohta H., Talman W.T. Both NMDA and non-NMDA receptor in the NTS participate in the baroreceptor reflex in rats. Am. J. Physiol. 267:1994;R1065-R1070.
14. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, New York.
15. Spyer K.M. The central nervous organization of reflex circulatory control. Loewy A.D., Spyer K.M. Central Regulation of Autonomic Functions. 1990;Oxford University Press, New York.
16. Stuesse S.L., Fish S.E. Projections to the cardioinhibitory region of the nucleus ambiguus of rat. J. Comp. Neurol. 229:1984;271-278.
17. Talman W.T., Perrone M.H., Reis D.J. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science. 209:1980;813-815.
18. Tian B., Hartle D.K. Cardiovascular effects of NMDA and MK-801 infusion at area postrema and mNTS in rat. Pharmacol. Biochem. Behav. 49:(3):1994;489-495.