Genetic inducible fate mapping in mouse: Establishing genetic lineages and defining genetic neuroanatomy in the nervous system

Developmental Dynamics

Volumn 235, Issue 9, 2006, Pages 2376-2385

  Joyner, Alexandra L ^a   Zervas, Mark ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Cellular phenotyping alleles; Cerebellum; CreER; Genetic inducible fate mapping; Hindbrain

Indexed keywords

RECOMBINASE; TRACER;

ALLELE; CELL FATE; CELL FUNCTION; CELL LINEAGE; CELL STRUCTURE; EMBRYO DEVELOPMENT; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE INDUCTION; GENE MAPPING; GENE TARGETING; GENETIC INDUCIBLE FATE MAPPING; GENETIC LINE; GENETIC RECOMBINATION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROANATOMY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RHOMBENCEPHALON; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BODY PATTERNING; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC TECHNIQUES; MICE; NERVOUS SYSTEM; NEURONS; PREGNANCY; RHOMBENCEPHALON;

EID: 33748328362     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.20884     Document Type: Review

References (64)

1. Ahn S, Joyner AT, 2004. Dynamic changes in the response of cells to positive Hedgehog-signaling during mouse limb patterning. Cell 118:505-516.
2. Ahn S, Joyner AL. 2005. Quiescent adult neural stem cells are targets of Sonic hedgehog signaling. Nature 437:894-897.
3. Alvarez Otero R, Sotelo C, Alvarado-Mallart RM. 1993. Chick/quail chimeras with partial cerebellar grafts: an analysis of the origin and migration of cerebellar cells. J Comp Neurol 333:597-615.
4. Ambrosiani J, Armengol JA, Martinez S, Puelles L. 1996. The avian inferior olive derives from the alar neuroepithelium of the rhombomeres 7 and 8: an analysis by using chick-quail chimeric embryos. Neuroreport 7:1285-1288.
5. Awatramani R, Soriano P, Mai JJ, Dymecki SM. 2001. A FLP indicator strain, R26::FRAP, driving alkaline phosphatase expression from the ROSA26 locus. Nat Genet 29:257-259.
6. Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM. 2003. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet 35:70-75.
7. Belteki G, Haigh J, Kabacs N, Haigh K, Sison K, Costantini F, Whitsett J, Quaggin SE, Nagy A. 2005. Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res 33:51.
8. Branda CS, Dymecki SM. 2004. Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6:7-28.
9. Braz JM, Rico B, Basbaum AI. 2002. Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci U S A 99:15148-15153.
10. Brocard J, Warot X, Wendung O, Messaddeq N, Vonesch JL, Chambon P, Metzger D. 1997. Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc Natl Acad Sci U S A 94:14559-14563.
11. Buch T, Heppner FL, Tertilt C, Keinen TJ, Kremer M, Wunderlich FT, Jung S, Waisman A. 2005. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2:419-426.
12. Cohen B, Dafni H, Meir G, Harmelin A, Neeman M. 2005. Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors. Neoplasia 7:109-117.
13. Currle DS, Cheng X, Hsu CM, Monuki ES. 2005. Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. Development 132:3549-3559.
14. Deans AE, Wadghiri YZ, Bernas L, Yu X, Rutt BK, Turnbull DH. 2006. Cellular MRI contrast via co-expression of transferrin receptor and ferritin. Magn Reson Med 56:51-59.
15. Dymecki SM. 2000. Site-specific recombination in cells and mice. In: Joyner AL, editor. A practical approach. Oxford: Oxford University Press, p 37-99.
16. Dymecki SM, Tomasiewicz H. 1998. Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse. Dev Biol 201:57-65.
17. Farago AF, Awatramani RB, Dymecki SM. 2006. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50:205-218.
18. Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P. 1996. Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A 93:10887-10890.
19. Feil R, Wagner J, Metzger D, Chambon P. 1997. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 237:752-757.
20. Funfschilling U, Reichardt LF. 2002. Cre-mediated recombination in rhombic lip derivatives. Genesis 33:160-169.
21. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET. 2005. A new transgene reporter for in vivo magnetic resonance imaging. Nat Med 11:450-454.
22. Gothert JR, Gustin SE, Hall MA, Green AR, Gottgens B, Izon DJ, Begley CG. 2005. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood 105:2724-2732.
23. Guo Q, Loomis C, Joyner AL. 2003. Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge. Dev Biol 264:166-178.
24. Hadjantonakis AK, Dickinson ME, Fraser SE, Papaioannou VE. 2003. Technicolor transgenics: imaging tools for functional genomics in the mouse. Nat Rev Genet 4:613-625.
25. Hallonet ME, Le Douarin NM. 1993. Tracing neuroepithelial mesencephalic and metencephalic alar plates during ontogeny in quail-chick chimaeras. Eur J Neurosci 5:1145-1155.
26. Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. 2004. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118:517-528.
27. Hayashi S, McMahon AP. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244:305-318.
28. Hunter NL, Awatramani RB, Parley FW, Dymecki SM. 2005. Ligand-activated Flpe for temporally regulated gene modifications. Genesis 41:99-109.
29. Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, Metzger D. 1999. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase ac-tivity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res 27:4324-4327.
30. Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP. 2005. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis 43:129-135.
31. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. 2002. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32:128-134.
32. Kimmel R, Turnbull DH, Blanquet V, Wolfgang W, Loomis CA, Joyner AL. 2000. Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev 14:1377-1389.
33. Kuhbandner S, Brummer S, Metzger D, Chambon P, Hofmann F, Feil R. 2000. Temporally controlled somatic mutagenesis in smooth muscle. Genesis 28:15-22.
34. Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki SM. 2005. Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron 22:933-947.
35. Legue E, Nicolas JF. 2005. Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors. Development 132:4143-4154.
36. Levy V, Lindon C, Harfe BD, Morgan BA. 2005. Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell 9:855-861.
37. Li JYH, Lao Z, Joyner AL. 2002. Changing requirement for Gbx2 in the cerebellum and mid/hindbrain organizer. Neuron 36:31-43.
38. Lin JC, Cai L, Cepko CL. 2001. The external granule layer of the developing chick cerebellum generates granule cells and cells of the isthmus and rostral hindbrain. J Neurosci 21:159-168.
39. Lobe CG, Koop KE, Kreppner W, Lomeli H, Gertsenstein M, Nagy A. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208:281-292.
40. Machold R, Fishell G. 2005. Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron 48:17-24.
41. Marin F, Puelles L. 1995. Morphological fate of rhombomeres in quail/chick chimeras: a segmental analysis of hindbrain nuclei. Eur J Neurosci 7:1714-1738.
42. Maskos U, Kissa K, St Cloment C, Brulet P. 2002. Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice. proc Natl Acad Sci U S A 99:10120-10125.
43. Mathis L, Bonnerot C, Puelles L, Nicolas JF. 1997. Retrospective clonal analysis of the cerebellum using genetic laacZ/lacZ mouse mosaics. Development 124:4089-4104.
44. Michael SK, Brennan J, Robertson EJ. 1999. Efficient gene-specific expression of ere recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci. Mech Dev 85:35-47.
45. Morris RJ, Liu Y, Maries L, Yang Z, Trempus C, Li S, Lin JS, Sawicki JA, Cotsarelis G. 2004. Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 22:411-417.
46. Novak A, Guo C, Yang W, Nagy A, Lobe CG. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28:147-155.
47. Park JY, Luo Q, Jiang W, Rang Q, Peng Y, Strom C, Luu HH, Haydon RC, He TC. 2004. Dual regulation of gene expression mediated by tetracycline and Cre recombinase. Biotechniques 36:390-392; 394; 396.
48. Pearse RV Jr, Tabin CJ. 2006. Development: twists of fate in the brain. Nature 439:404-405.
49. Robinson SP, Langan-Fahey SM, Johnson DA, Jordan VC. 1991. Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab Dispos 19:36-43.
50. Rodriguez CI, Dymecki SM. 2000. Origin of the precerebellar system. Neuron 27:475-486.
51. Rodriguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM. 2000. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25:139-140.
52. Sgaier S, Millet S, Villanueva M, Berenshteyn F, Song C, Joyner A. 2005. Morphogenetic and cellular movements that shape the mouse cerebellum: insights from genetic fate mapping. Neuron 45:27-40.
53. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
54. Wang VY, Rose MF, Zoghbi HY. 2005. Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron 48:31-43.
55. Wingate R. 2005. Math-Map(ic)s. Neuron 48:1-4.
56. Wingate RJ, Hatten ME. 1999. The role of the rhombic lip in avian cerebellum development. Development 126:4395-4404.
57. Yu CR, Power J, Barnea G, O'Donnell S, Brown HE, Osborne J, Axel R, Gogos JA. 2004. Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron 42:553-566.
58. Yu HM, Liu B, Chiu SY, Costantini F, Hsu W. 2005. Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A 102:8615-8620.
59. Zeller R. 2004. It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digits. Sei STKE p53.
60. Zervas M, Millet S, Ahn S, Joyner AL. 2004. Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron 43:345-357.
61. Zervas M, Blaess S, Joyner AJ. 2005. Classical embryological studies and modern genetic analysis of midbrain and cerebellum development. Curr Top Dev Biol 69:103-138.
62. Zinyk DL, Mercer EH, Harris E, Anderson DJ, Joyner AL. 1998. Fate map of the mouse midbrain-hindbrain constriction using a site-specific recombination system. Curr Biol 8:665-668.
63. Zirlinger M, Lo L, McMahon J, McMahon AP, Anderson DJ. 2002. Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci USA 99:8084-8089.
64. Zong H, Espinosa JS, Su HH, Muzumdar MD, Luo L. 2005. Mosaic analysis with double markers in mice. Cell 6:479-492.