The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs

Journal of Nutrition

Volumn 136, Issue 9, 2006, Pages 2338-2344

  Hall, Jean A ^a   Picton, Rebecca A ^a   Skinner, Monica M ^a   Jewell, Dennis E ^b   Wander, Rosemary C ^c  

^a OREGON STATE UNIVERSITY   (United States)

^b Science and Technology Center   (United States)

^c UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CORN OIL; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LINOLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DOG; FATTY ACID BLOOD LEVEL; FEMALE; FOOD INTAKE; LIPID COMPOSITION; NONHUMAN;

CANIS FAMILIARIS; ZEA MAYS;

EID: 33748305813     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.9.2338     Document Type: Article

References (33)

1. Wander R, Hall JA, Gradin JL, Du SH, Jewell DE. The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation, and vitamin E status in aged dogs. J Nutr. 1997;127:1198-205.
2. Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002;61:345-58.
3. Hall JA, Van Saun RJ, Wander RC. Dietary (n-3) fatty acids from Menhaden fish oil alter plasma fatty acids and leukotriene B synthesis in healthy horses. J Vet Intern Med. 2004;18:871-9.
4. Whelan J, Surette ME, Hardardottir I, Lu G, Golemboski KA, Larsen E, Kinsella JE. Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters. J Nutr. 1993;123:2174-85.
5. Cleland LG, James MJ, Gibson RA, Hawkes JS, Betts WH. Effect of dietary oils on the production of n-3 and n-6 metabolites of leukocyte 5-lipoxygenase in five rat strains. Biochim Biophys Acta. 1990;1043:253-8.
6. Hall JA, Wander RC, Gradin JL, Du SH, Jewell DE. Effect of dietary n-6-to-n-3 fatty acid ratio on complete blood and total white blood cell counts, and T-cell subpopulations in aged dogs. Am J Vet Res. 1999;60:319-27.
7. Hall JA, Tooley KA, Gradin JL, Jewell DE, Wander RC. Effects of dietary n-6 and n-3 fatty acids and vitamin E on the immune response of healthy geriatric dogs. Am J Vet Res. 2003;64:762-72.
8. Filburn CR, Griffin D. Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. Vet Ther. 2005;6:29-42.
9. Hall JA, Henry LR, Jha S, Skinner MM, Jewell DE, Wander RC. Dietary (n-3) fatty acids alter plasma fatty acids and leukotriene B synthesis by stimulated neutrophils from healthy geriatric Beagles. Prostaglandins Leukot Essent Fatty Acids. 2005;73:335-41.
10. Calder PC. Polyunsaturated fatty acids and inflammation. Biochem Soc Trans. 2005;33:423-7.
11. Lands WE, Morris A, Libelt B. Quantitative effects of dietary polyunsaturated fats on the composition of fatty acids in rat tissues. Lipids. 1990;25:505-16.
12. Lands WE, Libelt B, Morris A, Kramer NC, Prewitt TE, Bowen P, Schmeisser D, Davidson MH, Burns JH. Maintenance of lower proportions of (n-6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n-3) fatty acids. Biochim Biophys Acta. 1992;1180:147-62.
13. Bauer JE, Waldron MK, Spencer AL, Hannah SS. Predictive equations for the quantitation of polyunsaturated fats in dog plasma and neutrophils from dietary fatty acid profiles. J Nutr. 2002;132:1642S-45S.
14. National Research Council (1996) Guide for the Care and Use of Laboratory Animals. National Academy Press. Washington, D.C.
15. Song J, Wander RC. Effects of dietary selenium and fish oil (MaxEPA) on arachidonic acid metabolism and hemostatic function in rats. J Nutr. 1991;121:284-92.
16. Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002;61:345-58.
17. Calder PC. N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids. 2003;38:343-52.
18. Calder PC. n-3 fatty acids, inflammation, and immunity - relevance to postsurgical and critically ill patients. Lipids. 2004;39:1147-61.
19. Biagi G, Mordentia A, Cocchi M. The role of dietary omega-3 and omega-6 essential fatty acids in the nutrition of dogs and cats: a review. Progress in Nutrition. 2004;6:97-107.
20. Billman GE, Kang JX, Leaf A. Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs. Lipids. 1997;32:1161-8.
21. Billman GE, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation. 1999;99:2452-7.
22. Ogilvie GK, Fettman MJ, Mallinckrodt CH, Walton JA, Hansen RA, Davenport DJ, Gross KL, Richardson KL, Rogers Q, Hand MS. Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study. Cancer. 2000;88:1916-28.
23. th Annual Meeting of the American Academy of Veterinary Dermatology. 1997;10-1, Nashville, TN.
24. th Annual Meeting of the American Academy of Veterinary Dermatology. 2001;53-4, Norfolk, VA.
25. Vaughn DM, Reinhardt GA, Swaim SF, Lauten SD, Garner CA, Boudreaux MK, Spano JS, Hoffman CE, Conner B. Evaluation of effects of dietary n-6 to n-3 fatty acid ratios on leukotriene B synthesis in dog skin and neutrophils. Vet Dermatol. 1994;5:163-73.
26. Watson TD. Diet and skin disease in dogs and cats. J Nutr. 1998;128:2783S-9S.
27. Nesbitt GH, Freeman LM, Hannah SS. Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. Vet Dermatol. 2003;14:67-74.
28. Jeffery NM, Newsholme EA, Calder PC. Level of polyunsaturated fatty acids and the n-6 to n-3 polyunsaturated fatty acid ratio in the rat diet alter serum lipid levels and lymphocyte functions. Prostaglandins Leukot Essent Fatty Acids. 1997;57:149-60.
29. Boudreau MD, Chanmugam PS, Hart SB, Lee SH, Hwang D. Lack of dose response by dietary n-3 fatty acids at a constant ratio of n-3 to n-6 fatty acids in suppressing eicosanoid biosynthesis from arachidonic acid. Am J Clin Nutr. 1991;54:111-17.
30. Hwang DH, Chanmugam PS, Ryan DH, Boudreau MD, Windhauser MM, Tulley RT, Brooks ER, Bray GA. Does vegetable oil attenuate the beneficial effects of fish oil in reducing risk factors for cardiovascular disease? Am J Clin Nutr. 1997;66:89-96.
31. Chan JK, McDonald BE, Gerrard JM, Bruce VM, Weaver BJ, Holub BJ. Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis. Lipids. 1993;28:811-7.
32. Emken EA, Adlof RO, Rakoff H, Rohwedder WK, Gulley RM. Human metabolic studies with deuterated alpha-linolenic acid. Nutrition. 1992;8:213-4.
33. Lands WE. Long-term fat intake and biomarkers. Am J Clin Nutr. 1995;61:721S-5S.