Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus

Veterinary Dermatology

Volumn 14, Issue 2, 2003, Pages 67-74

  Nesbitt, Gene H ^a,c   Freeman, Lisa M ^a   Hannah, Steven S ^b  

^a TUFTS UNIVERSITY   (United States)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c NONE   (United States)

Author keywords

C reactive protein; Docosahexaenoic acid; Dogs; Eicosapentaenoic acid; Fatty acids; Prostaglandin E2; Pruritus

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; FATTY ACID;

ARTICLE; CONTROLLED STUDY; DIET; DOG; DOSE RESPONSE; DRUG EFFECT; FATTY ACID BLOOD LEVEL; NONHUMAN; PRURITUS; RANDOMIZATION; TREATMENT OUTCOME; ANIMAL; ANIMAL DISEASE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIET SUPPLEMENTATION; DIET THERAPY; DOG DISEASE; FEMALE; HOSPITALIZATION; MALE; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL;

CANIS FAMILIARIS;

ANIMALS; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOG DISEASES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; FATTY ACIDS; FEMALE; MALE; PRURITUS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0038050769     PISSN: 09594493     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3164.2003.00328.x     Document Type: Article

References (32)

1. Ackerman, L. Canine allergic disorders. In: Nesbitt, G.H., Ackerman, L.J. eds. Canine and Feline Dermatology. Trenton, NJ: Veterinary Learning Systems, 1998: 109-39.
2. Marsella, R. Managing dogs with chronic atopic dermatitis. Compendium of Continuing Education for the Practicing Veterinarian 2001; 23: 454-63.
3. Scott, D.W., Miller, W.H., Griffin, C.E. Small Animal Dermatology, 6th edn. Philadelphia: W.B. Saunders, 2001: 239.
4. Freeman, L.M., Rush, J.E., Kehayias, J.J. et al. Nutritional alterations and the effect of fish oil supplementation in dogs with heart failure. Journal of Veterinary Internal Medicine 1998; 12: 440-8.
5. Wander, R.C., Hall, J.A., Gradin, J.L. et al. The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. Journal of Nutrition 1997; 127: 1198-205.
6. Sardino, M.S., Swaim, S.F., Sartin, E.A. et al. The effects of omega-3 fatty acid diet enrichment on wound healing. Veterinary Dermatology 1999; 10: 283-90.
7. Kietzmann, M. Eicosanoid levels in canine inflammatory skin diseases. Advances in Veterinary Dermatology 1990; 1: 211-20.
8. Endres, S., Ghorbani, R., Kelley, V.E. et al. Effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 1989; 320: 265-71.
9. Meydani, S.N., Endres, S., Woods, M.M. et al. Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation. Journal of Nutrition 1991; 121: 547-55.
10. Scarff, D.H., Lloyd, D.H. Double blind, placebo-controlled, crossover study of evening primrose oil in the treatment of canine atopy. Veterinary Record 1992; 13: 97-9.
11. Bond, R., Lloyd, D.H. A double-blind comparison of olive oil and a combination of evening primrose oil and fish oil in the management of canine atopy. Veterinary Record 1992; 131: 558-60.
12. Bond, R., Lloyd, D.H. Randomized single-blind parallel comparison of an evening primrose oil and fish oil combination and concentrates of these oils in the management of canine atopy. Veterinary Dermatology 1992; 3: 215-19.
13. Scott, D.W., Miller, W.H., Decker, G.A. et al. Comparison of the clinical efficacy of two commercial fatty acid supplements (Efavet and DVM DermCaps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. Cornell Veterinarian 1992; 82: 319-29.
14. Bond, R., Lloyd, D.H. Double blind comparison of three concentrated essential fatty acid supplements in the management of canine atopy. Veterinary Dermatology 1993; 4: 185-9.
15. Logas, D., Kunkle, G.A. Double-blinded crossover study with marine fish oil supplementation containing high-dose eicosapentaenoic acid for the treatment of canine pruritic skin disease. Veterinary Dermatology 1994; 5: 99-104.
16. Sture, G.H., Lloyd, D.H. Canine atopic skin disease therapeutic use of an evening primrose oil and fish-oil combination. Veterinary Record 1995; 137: 169-70.
17. Harvey, R.G. A blinded, placebo-controlled study of the efficacy of borage seed oil and fish oil in the management of canine atopy. Veterinary Record 1999; 144: 405-7.
18. Campbell, K.L., Dorn, G.P. Effects of oral sunflower oil and olive oil on serum and cutaneous fatty acid concentrations in dogs. Research in Veterinary Science 1992; 53: 72-178.
19. Hanson, R.A., Oglivie, G.K., Davenport, D.J. et al. Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. American Journal of Veterinary Research 1998; 59: 864-8.
20. Campbell, K.L., Czarnecki-Maulden, G.L., Schaeffer, D.J. Effects of animal and soy fats and proteins in the diet on fatty-acid concentrations in the serum and skin of dogs. American Journal of Veterinary Research 1995; 56: 1465-9.
21. Olivry, T., Marsella, R., Hillier, A. The ACVD task force on canine atopic dermatitis (XXIII): are essential fatty acids effective? Veterinary Immunology and Immunopathology 2001; 81: 347-62.
22. Roudebush, P., Bloom, P.B., Jewell, D.J. Consumption of essential fatty acids in selected commercial dog foods compared to dietary supplements. Proceedings of the 13th Annual Meeting of the American Academy of Veterinary Dermatology 1997: 10-11, Nashville, TN.
23. Roudebush, P. Consumption of essential fatty acids in selected commercial dog foods compared to dietary supplementation: An update. Proceedings of the 16th Annual Meeting of the American Academy of Veterinary Dermatology 2001: 53-4, Norfolk, VA.
24. Case, L.P., Carey, D.P., Hirakawa, D.A. et al. Canine and Feline Nutrition, 2nd edn. St Louis, MO: Mosby, 2000: 443.
25. Vaughn, D.M., Reinhart, G.A., Swaim, S.F. et al. Evaluation of dietary omega-6 and omega-3 fatty acid ratios on leukotriene B synthesis in dog skin and neutrophils. Veterinary Dermatology 1994; 5: 163-73.
26. 4 generation by canine neutrophils. Veterinary Dermatology 2000; 1: 123-31.
27. Folch, K., Lees, M., Sloane-Stanley, G.H. A simple method for the isolation and purification of total lipids from animal tissue. The Journal of Biological Chemistry 1957; 226: 497-509.
28. Conner, J.G., Eckersall, P.D., Ferguson, J. et al. Acute phase response in the dog following surgical trauma. Research in Veterinary Science 1988; 45: 107-10.
29. Otabe, K., Ito, T., Sugimoto, T. et al. C-reactive protein (CRP) measurement in canine serum following experimentally induced acute gastric mucosal injury. Laboratory Animals 2000; 34: 434-8.
30. Taubes, G. Cardiovascular disease: does inflammation cut to the heart of the matter? Science 2002; 296: 242-5.
31. Mantovani, G., Maccio, A., Madeddu, C. et al. Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: correlation with stage and performance status. International Journal of Cancer 2002; 98: 84-91.
32. Willemse, T. Atopic skin disease: a review and reconsideration of diagnostic criteria. Journal of Small Animal Practice 1986; 27: 771-8.