Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5265-5269

  Choi, Won Jun ^a   Shi, Zhen Dan ^a   Worthy, Karen M ^b   Bindu, Lakshman ^b   Karki, Rajeshri G ^a   Nicklaus, Marc C ^a   Fisher, Robert J ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Click chemistry; Cycloaddition; Grb2 SH2 domain; Macrocycle; Peptide mimetic

Indexed keywords

1 AMINOCYCLOHEXANECARBOXYLIC ACID; 4 PHOSPHONOMETHYLPHENYLALANINE; ALKYNE; AZIDE; CARBOXYLIC ACID DERIVATIVE; COPPER; DIMER; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MACROCYCLIC COMPOUND; PHENYLALANINE DERIVATIVE; PROTEIN SH2; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CYCLIZATION; CYCLOADDITION; DRUG SYNTHESIS;

ALKYNES; AZIDES; BINDING SITES; COPPER; CYCLIZATION; GRB2 ADAPTOR PROTEIN; LIGANDS; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SRC HOMOLOGY DOMAINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TIME FACTORS; TRIAZOLES;

EID: 33748300613     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.004     Document Type: Article

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