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Volumn 54, Issue 2, 2006, Pages 263-273

Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine

Author keywords

[No Author keywords available]

Indexed keywords

AES 14; CYCLIN DEPENDENT KINASE INHIBITOR 1; DIMETHYLBENZ[A]ANTHRACENE; DNA; GLUTAMINE; GLUTATHIONE; MESSENGER RNA; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; SOMATOMEDIN C RECEPTOR;

EID: 33748132632     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/s15327914nc5402_13     Document Type: Article
Times cited : (15)

References (65)
  • 3
    • 0036372619 scopus 로고    scopus 로고
    • Redox potential of GSH/GSSG couple: Assay and biological significance
    • Jones DP: Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol 348, 93-112, 2002.
    • (2002) Methods Enzymol , vol.348 , pp. 93-112
    • Jones, D.P.1
  • 4
    • 0033231351 scopus 로고    scopus 로고
    • Gene expression and the thiol redox state
    • Arrigo AP: Gene expression and the thiol redox state. Free Radic Biol Med 27, 936-944, 1999.
    • (1999) Free Radic Biol Med , vol.27 , pp. 936-944
    • Arrigo, A.P.1
  • 6
    • 0025267740 scopus 로고
    • Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblast
    • Atzori L, Dypbukt JM, Sundqvist K, Cotgreave I, Edman CC, et al.: Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblast. J Cell Physiol 143, 165-171, 1989.
    • (1989) J Cell Physiol , vol.143 , pp. 165-171
    • Atzori, L.1    Dypbukt, J.M.2    Sundqvist, K.3    Cotgreave, I.4    Edman, C.C.5
  • 7
    • 0036372619 scopus 로고    scopus 로고
    • Redox potential of GSH/GSSG couple: Assay and biological significance
    • Jones DP: Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol 348, 93-112, 2002.
    • (2002) Methods Enzymol , vol.348 , pp. 93-112
    • Jones, D.P.1
  • 8
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra J, Samali A, and Orrenius S: Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29, 323-333, 2000.
    • (2000) Free Radic Biol Med , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 9
    • 0033230015 scopus 로고    scopus 로고
    • Bcl-2 and glutathione alterations in cellular redox state that regulate apoptotic sensitivity
    • Voehringer DW: Bcl-2 and glutathione alterations in cellular redox state that regulate apoptotic sensitivity. Free Radic Biol Med 27, 945-950, 1999.
    • (1999) Free Radic Biol Med , vol.27 , pp. 945-950
    • Voehringer, D.W.1
  • 10
    • 0033231351 scopus 로고    scopus 로고
    • Gene expression and the thiol redox state
    • Arrigo AP: Gene expression and the thiol redox state. Free Radic Biol Med 27, 936-944, 1999.
    • (1999) Free Radic Biol Med , vol.27 , pp. 936-944
    • Arrigo, A.P.1
  • 11
    • 4344577088 scopus 로고    scopus 로고
    • Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents
    • Achanta G and Huang P: Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents. Cancer Res 64, 6233-6239, 2004.
    • (2004) Cancer Res , vol.64 , pp. 6233-6239
    • Achanta, G.1    Huang, P.2
  • 12
    • 0033088957 scopus 로고    scopus 로고
    • The role of glutathione in the regulation of apoptosis
    • Hall AG: The role of glutathione in the regulation of apoptosis. Eur J of Clin Investig 29, 238-245, 1999.
    • (1999) Eur J of Clin Investig , vol.29 , pp. 238-245
    • Hall, A.G.1
  • 15
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, and Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967, 1993.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 16
    • 0023203801 scopus 로고
    • The rule of glutathione in determining the response of normal and tumor cells to anticancer drugs
    • Wolf CR, Lewis AD, Carmichael J, Adams DJ, Allan SG, et al.: The rule of glutathione in determining the response of normal and tumor cells to anticancer drugs. Biochem Soc Trans 15, 728-730, 1987.
    • (1987) Biochem Soc Trans , vol.15 , pp. 728-730
    • Wolf, C.R.1    Lewis, A.D.2    Carmichael, J.3    Adams, D.J.4    Allan, S.G.5
  • 17
    • 0021127473 scopus 로고
    • SH metabolism as a determinant of therapeutic efficacy: A review
    • Arrick B and Nathan C: SH metabolism as a determinant of therapeutic efficacy: a review. Cancer Res 44, 4224-4232, 1984.
    • (1984) Cancer Res , vol.44 , pp. 4224-4232
    • Arrick, B.1    Nathan, C.2
  • 19
    • 0036195042 scopus 로고    scopus 로고
    • Regulative potential of glutamine-relation to glutathione metabolism
    • Roth E, Oehler R, Manhart N, Exner R, Wessner B, et al.: Regulative potential of glutamine-relation to glutathione metabolism. Nutrition 18, 217-221, 2002.
    • (2002) Nutrition , vol.18 , pp. 217-221
    • Roth, E.1    Oehler, R.2    Manhart, N.3    Exner, R.4    Wessner, B.5
  • 22
    • 12344266778 scopus 로고    scopus 로고
    • Glutamine supplementation reduces glutathione levels and stimulates apoptosis in DMBA-induced mammary tumors
    • Todorova VK, Kaufmann Y, Luo S, Harms SA, Babb KB, et al.: Glutamine supplementation reduces glutathione levels and stimulates apoptosis in DMBA-induced mammary tumors. Breast Cancer Res Treat 88, 247-256, 2004.
    • (2004) Breast Cancer Res Treat , vol.88 , pp. 247-256
    • Todorova, V.K.1    Kaufmann, Y.2    Luo, S.3    Harms, S.A.4    Babb, K.B.5
  • 25
    • 0025314287 scopus 로고
    • Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth
    • Klimberg VS, Souba WW, Salloum RM, Plumley DA, Cohen FS, et al.: Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J Surg Res 48, 319-323, 1990.
    • (1990) J Surg Res , vol.48 , pp. 319-323
    • Klimberg, V.S.1    Souba, W.W.2    Salloum, R.M.3    Plumley, D.A.4    Cohen, F.S.5
  • 26
    • 0029931781 scopus 로고    scopus 로고
    • Experimentally induced mammary tumors in rats
    • Russo J and Russo IH: Experimentally induced mammary tumors in rats. Breast Cancer Res Treat 39, 7-20, 1996
    • (1996) Breast Cancer Res Treat , vol.39 , pp. 7-20
    • Russo, J.1    Russo, I.H.2
  • 27
    • 84984145817 scopus 로고
    • Studies on tumor induction in rats with 7, 12-DMBA with special references to the morphogenesis and fine structural changes in the target organs. Acta
    • Fukunishi R: Studies on tumor induction in rats with 7, 12-DMBA with special references to the morphogenesis and fine structural changes in the target organs. Acta Pathol Jpn 18, 51-72, 1968.
    • (1968) Pathol Jpn , vol.18 , pp. 51-72
    • Fukunishi, R.1
  • 28
    • 0036673935 scopus 로고    scopus 로고
    • Histopathologic characterization of mammary neoplastic lesions induced with 7,12 dimethylbenz(alpha)anthracene in the rat: A comparative analysis with human breast tumors
    • Costa I, Solanas M, and Escrich E: Histopathologic characterization of mammary neoplastic lesions induced with 7,12 dimethylbenz(alpha)anthracene in the rat: a comparative analysis with human breast tumors. Arch Pathol Lab Med 126, 915-927, 2002.
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 915-927
    • Costa, I.1    Solanas, M.2    Escrich, E.3
  • 29
    • 0029842410 scopus 로고    scopus 로고
    • Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas
    • Kito K, Kihana T, Sugita A, Murao S, Akehi S, et al.: Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas. Mol Carcinog 17, 78-83, 1996.
    • (1996) Mol Carcinog , vol.17 , pp. 78-83
    • Kito, K.1    Kihana, T.2    Sugita, A.3    Murao, S.4    Akehi, S.5
  • 30
    • 0028335432 scopus 로고
    • Infrequent p53 mutations in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice
    • Jerry DJ, Butel JS, Donehower LA, Paulson EJ, Cochran C, et al.: Infrequent p53 mutations in 7,12-dimethylbenz(a)anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice. Mol Carcinog 9, 175-183, 1994.
    • (1994) Mol Carcinog , vol.9 , pp. 175-183
    • Jerry, D.J.1    Butel, J.S.2    Donehower, L.A.3    Paulson, E.J.4    Cochran, C.5
  • 31
    • 1642513490 scopus 로고    scopus 로고
    • Oral glutamine supplementation inhibits P13K/Akt signaling pathway in experimental breast cancer
    • Todorova VK, Luo S, Kaufmann Y, Babb K, Harms SA, et al.: Oral glutamine supplementation inhibits P13K/Akt signaling pathway in experimental breast cancer. J Parent Ent Nutr 27, 404-410, 2003.
    • (2003) J Parent Ent Nutr , vol.27 , pp. 404-410
    • Todorova, V.K.1    Luo, S.2    Kaufmann, Y.3    Babb, K.4    Harms, S.A.5
  • 32
    • 0005261199 scopus 로고    scopus 로고
    • Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample
    • Marone M, Mozzetti S, Ritis DD, Pierelli L, and Scambia G: Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample. Biol Proced Online 3, 19-25, 2001.
    • (2001) Biol Proced Online , vol.3 , pp. 19-25
    • Marone, M.1    Mozzetti, S.2    Ritis, D.D.3    Pierelli, L.4    Scambia, G.5
  • 33
    • 0034749340 scopus 로고    scopus 로고
    • Comparison of the quantitative competitive and semiquantitative RT-PCR methods for the determination of interferon-gamma mRNA levels in AIDS-free HIV-infected individuals
    • Barabas E, Nagy K, Varkonyi V, and Horvath A: Comparison of the quantitative competitive and semiquantitative RT-PCR methods for the determination of interferon-gamma mRNA levels in AIDS-free HIV-infected individuals. Braz J Med Biol Res 34, 1271-1275, 2001.
    • (2001) Braz J Med Biol Res , vol.34 , pp. 1271-1275
    • Barabas, E.1    Nagy, K.2    Varkonyi, V.3    Horvath, A.4
  • 36
    • 0033119627 scopus 로고    scopus 로고
    • Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
    • Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, et al.: Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J 18, 1805-1814, 1999.
    • (1999) EMBO J , vol.18 , pp. 1805-1814
    • Unger, T.1    Juven-Gershon, T.2    Moallem, E.3    Berger, M.4    Vogt Sionov, R.5
  • 37
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
    • Chehab NH, Malikzay A, Stavridi ES, and Halazonetis TD: Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96, 13777-13782, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 38
    • 0036829983 scopus 로고    scopus 로고
    • The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras
    • Jimenez C, Hernandez C, Pimentel B, and Carrera AC: The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras. J Biol Chem 277, 41556-41562, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 41556-41562
    • Jimenez, C.1    Hernandez, C.2    Pimentel, B.3    Carrera, A.C.4
  • 39
    • 0242552555 scopus 로고    scopus 로고
    • Influence of induced reactive oxygen species in p53-mediated cell late decisions
    • Maeip S, Igarashi M, Berggren P, Yu J, Lee SW, et al.: Influence of induced reactive oxygen species in p53-mediated cell late decisions. Mol Cell Biol 23, 8576-8585, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 8576-8585
    • Maeip, S.1    Igarashi, M.2    Berggren, P.3    Yu, J.4    Lee, S.W.5
  • 40
    • 0029561319 scopus 로고
    • Glutathionein health and disease: Pharmacotherapeutic issues
    • Lomaestro BM and Malone M: Glutathionein health and disease: pharmacotherapeutic issues. The Ann Pharmacother 29, 1263-1273, 1995.
    • (1995) The Ann Pharmacother , vol.29 , pp. 1263-1273
    • Lomaestro, B.M.1    Malone, M.2
  • 41
    • 0035953394 scopus 로고    scopus 로고
    • DNA microarrays identification of primary and secondary target genes regulated by p53
    • Kannan K, Amariglio N, and Rechavi GSL: DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 20, 2225-2234, 2001.
    • (2001) Oncogene , vol.20 , pp. 2225-2234
    • Kannan, K.1    Amariglio, N.2    Rechavi, G.S.L.3
  • 44
    • 0028963841 scopus 로고
    • p53-dependent and independent expression of p21 during cell growth, differentation, and DNA damage
    • Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, et al.: p53-dependent and independent expression of p21 during cell growth, differentation, and DNA damage. Genes Dev 9, 935-944, 1995.
    • (1995) Genes Dev , vol.9 , pp. 935-944
    • Macleod, K.F.1    Sherry, N.2    Hannon, G.3    Beach, D.4    Tokino, T.5
  • 46
    • 3242781701 scopus 로고    scopus 로고
    • Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer
    • Chung MJ, Jung SH, Lee BJ, Kang MJ, and Lee DG: Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer. Pathol Int 54, 10-15, 2004.
    • (2004) Pathol Int , vol.54 , pp. 10-15
    • Chung, M.J.1    Jung, S.H.2    Lee, B.J.3    Kang, M.J.4    Lee, D.G.5
  • 47
    • 0034044571 scopus 로고    scopus 로고
    • MDM2 oncogene as a novel target for human cancer therapy
    • Zhang R, and Wang H: MDM2 oncogene as a novel target for human cancer therapy. Curr Pharm Des 6, 393-416, 2002.
    • (2002) Curr Pharm des , vol.6 , pp. 393-416
    • Zhang, R.1    Wang, H.2
  • 48
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, and Oren M: Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299, 1997.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 49
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat MH, Jones SN, and Vousden KH: Regulation of p53 stability by Mdm2. Nature 387, 299-303, 1997.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 50
    • 0346455771 scopus 로고    scopus 로고
    • The MDM2-p53 interaction
    • Moll UM and Petrenko O: The MDM2-p53 interaction. Mol Cancer Res 1, 1001-1008, 2003.
    • (2003) Mol Cancer Res , vol.1 , pp. 1001-1008
    • Moll, U.M.1    Petrenko, O.2
  • 51
    • 0031769052 scopus 로고    scopus 로고
    • p53 regulates insulin-like growth factor-1 (IGF-1) receptor expression and IGF-1-induced tyrosine phosphorylation in an osteosarcoma cell line:interaction between p53 and Spl
    • Ohlsson C, Kley N, Werner H, and LeRoith D: p53 regulates insulin-like growth factor-1 (IGF-1) receptor expression and IGF-1-induced tyrosine phosphorylation in an osteosarcoma cell line:interaction between p53 and Spl. Endocrinology 139, 1101-1107, 1998.
    • (1998) Endocrinology , vol.139 , pp. 1101-1107
    • Ohlsson, C.1    Kley, N.2    Werner, H.3    LeRoith, D.4
  • 53
    • 0031743951 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor signal transduction: At the interface between physiology and cell biology
    • Butler AA, Yakar S, Gewolb IH, Karas M, Okuho Y, et al.: Insulin-like growth factor-1 receptor signal transduction: at the interface between physiology and cell biology. Comp Biochem Physiol 121, 19-26, 1998.
    • (1998) Comp Biochem Physiol , vol.121 , pp. 19-26
    • Butler, A.A.1    Yakar, S.2    Gewolb, I.H.3    Karas, M.4    Okuho, Y.5
  • 56
    • 0027207207 scopus 로고
    • Relationship of c-myc amplification to progression of breast cancer from in situ to invasive tumor and lymph node metastasis
    • Watson PH, Safneck JR, Le K, Dubik D, and Shiu RP: Relationship of c-myc amplification to progression of breast cancer from in situ to invasive tumor and lymph node metastasis. J Natl Cancer Inst 85, 902-907, 1993.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 902-907
    • Watson, P.H.1    Safneck, J.R.2    Le, K.3    Dubik, D.4    Shiu, R.P.5
  • 57
    • 0036483866 scopus 로고    scopus 로고
    • Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction
    • Naidu R, Wahab NA, Yadav M, and Kutty MK: Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction. Int J Mol Med 9, 189-196, 2002.
    • (2002) Int J Mol Med , vol.9 , pp. 189-196
    • Naidu, R.1    Wahab, N.A.2    Yadav, M.3    Kutty, M.K.4
  • 58
    • 0034936765 scopus 로고    scopus 로고
    • Inducible transgenics: New lessons on events governing the induction and commitment in mammary tumorigenesis
    • Hulit J, Di Vizio D, and Pestell RG: Inducible transgenics: New lessons on events governing the induction and commitment in mammary tumorigenesis. Breast Cancer Res 3, 209-212, 2001.
    • (2001) Breast Cancer Res , vol.3 , pp. 209-212
    • Hulit, J.1    Di Vizio, D.2    Pestell, R.G.3
  • 59
    • 0030822196 scopus 로고    scopus 로고
    • Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
    • Alevizopoulos K, Vladi J, Hennecke S, and Amali B: Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. EMBO J 16, 5322-5333, 1997.
    • (1997) EMBO J , vol.16 , pp. 5322-5333
    • Alevizopoulos, K.1    Vladi, J.2    Hennecke, S.3    Amali, B.4
  • 60
    • 0037075895 scopus 로고    scopus 로고
    • Contributions of Myc to tumorigenesis
    • Lutz W, Leon J, and Eilers M: Contributions of Myc to tumorigenesis. Biochim Biophys Acta 1602, 61-71, 2002.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 61-71
    • Lutz, W.1    Leon, J.2    Eilers, M.3
  • 61
    • 0037113935 scopus 로고    scopus 로고
    • Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells
    • Biroccio A, Benassi B, Filomeni G, Amodei S, Marchini S, et al.: Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells. J Biol Chem 277, 43763-43770, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 43763-43770
    • Biroccio, A.1    Benassi, B.2    Filomeni, G.3    Amodei, S.4    Marchini, S.5
  • 63
    • 0030294493 scopus 로고    scopus 로고
    • Glutamine, cancer, and its therapy
    • Klimberg VS and McClellan JL: Glutamine, cancer, and its therapy. Am J Surg 172, 418-424, 1996.
    • (1996) Am J Surg , vol.172 , pp. 418-424
    • Klimberg, V.S.1    McClellan, J.L.2
  • 65
    • 0028940320 scopus 로고
    • Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism
    • Rouse K, Nwokedi E, Woodliff J, Epstein J, and Klimberg VS: Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann Surg 221, 420-426, 1995.
    • (1995) Ann Surg , vol.221 , pp. 420-426
    • Rouse, K.1    Nwokedi, E.2    Woodliff, J.3    Epstein, J.4    Klimberg, V.S.5


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