Incidence of p53 and Ha-ras gene mutations in chemically induced rat mammary carcinomas

Molecular Carcinogenesis

Volumn 17, Issue 2, 1996, Pages 78-83

  Kito, Katsumi ^a   Kihana, Toshimasa ^a   Sugita, Atsuro ^a   Murao, Shinichi ^a   Akehi, Shun ^a   Sato, Motomichi ^a   Tachibana, Mari ^a   Kimura, Shigeru ^a   Ueda, Norifumi ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

7,12 dimethylbenz a anthracene; Ha ras; Mammary cancer; N nitroso N methylurea; p53

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; METHYLNITROSOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; DNA, NEOPLASM; FEMALE; GENES, P53; GENES, RAS; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

ANIMALIA;

EID: 0029842410     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199610)17:2<78::AID-MC4>3.0.CO;2-P     Document Type: Article

References (45)

1. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 253:49-53,1991.
2. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in thep53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878,1994.
3. Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350:429-431,1991.
4. Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ, Harris CC. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350: 427-428,1991.
5. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal tumor development. N Engl J Med 319:525- 532,1988.
6. Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 70:523-526,1992.
7. Parada LF, Land H, Weinberg RA, Wolf D, Rotter V. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature 312:649-651,1984.
8. Hinds P, Finlay C, Levine AJ. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol 63:739-746,1989.
9. Eliyahu D, Michalovitz D, Eliyahu S, Pinhasi-Kimhi O, Oren N. Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci USA 86:8763-3767,1989.
10. Finlay CA, Hinds PW, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083-1093,1989.
11. Coles C, Condie A, Chetty U, Steel CM, Evans HJ, Presser J. p53 mutations in breast cancer. Cancer Res 52:5291-5298,1992.
12. Sasa M, Kondo K, Komaki K, Uyama T, Morimoto T, Monden Y. Frequency of spontaneous p53 mutations (CpG site) in breast cancer in Japan. Breast Cancer Res Treat 27:247- 252,1993.
13. Huggins CB, Ueda N, Weissler M. N-nitroso-W-methylurea elicits mammary cancer in resistant and sensitive rat strains. Proc Natl Acad Sci USA 78:1185-1188,1981.
14. Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N- methylurea during initiation of mammary carcinogenesis in rats. Nature 315:382-386,1985.
15. Sukumar S, Notario V, Martin-Zanca D, Sarbacid M. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature 306:658-661,1983.
16. Soussi T, Caron de Fromentel C, Breugnot C, May E. Nudeotide sequence of a cDNA encoding the ratp53 nuclear oncoprotein. Nucleic Acids Res 16:11384,1988.
17. Ruta M, Wolford R, Dhar R, Defeo-Jones D, Ellis RW, Scolnick EM. Nudeotide sequence of the two rat cellular ras genes. Mol Cell Biol 6:1706-1710,1986.
18. Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformational polymorphisms. Proc Natl Acad Sci USA 86:2766-2770,1989.
19. Higuchi RG, Ochman H. Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction. Nucleic Acids Res 17:58-65,1989.
20. Sharma DS, Rajalarsmi S, Farber E. Chemical carcinogenesis: Interaction of carcinogens with nucleic acid. In: Becker FF (ed), Cancer, A Comprehensive Treatise, Vol. 1. Plenum Press, New York, London,1975, pp. 235-287.
21. Miller JA, Miller EC. the metabolic activation of chemical carcinogens to reactive eledrophiles. In: Yuhas JM, Tennant RW, Regan JD (eds), Biology of Radiation Carcinogenesis. Raven Press, New York,1976, pp. 147-164.
22. Vuorio T, Warri A, Sandberg M, Alitalo K, Vuorio E. Expression of the c-Ha-ras and neu oncogenes in DMBA-induced, anti- estrogen-treated rat mammary tumors. Int J Cancer 42:774- 779,1988.
23. Sakai H, Ogawa K. Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary gland. Int J Cancer 49:140-144,1991.
24. Osaka M, Matsuo S, Koh T, et al. N-ras mutation in 7,12- dimethylbenz(a)anthracene(DMBA)-induced erylhroleukemia in Long-Evans rats. Cancer Lett 91:25-31,1995.
25. Cardiff RD, Gumerlock PH, Soong MM, et al. c-Ha-ras expression in 7,12-dimethyl benzanthracene-induced Balb/c mouse mammary hyperplasias and their tumors. Oncogene 3:205-213,1988.
26. Kumar R, Medina D, Sukumar S. Activation of Ha-ras oncogenes in preneoplastic mouse mammary tissues. Oncogene 5:1271- 1277,1990.
27. Dandekar S, Sukumar S, Zarbl H, Young LJ, Cardiff RD. Specific activation of the cellular Harvey-ras oncogene in dimethyl- benzanthracene-induced mouse mammary tumors Mol Cell Biol 6:4104-4108,1986.
28. Manam S, Storer RD, Prahalada S, et al. Activation of the Ha-, Ki-, and N-ras genes in chemically induced liver tumors from CD-1 mice. Cancer Res 52:3347-3352,1992.
29. Baker JS, Preisinger AC, Jessup M, et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorgenesis. Cancer Res 50:7717-7722,1990.
30. Murakami Y, Hayashi K, Hirohashi S, Sekiya T. Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas. Cancer Res 51:5520- 5525,1991.
31. Mazars R, Pujol P, Maudelonde T, Jeanteur P, Theillet C. p53 mutations in ovarian cancer: A late event? Oncogene 6:1685- 1690,1991.
32. Faille A, De Cremoux P, Extra JM, et al. p53 mutations and overexpression in locally advanced breast cancers. Br J Cancer 69:1145-1150,1994.
33. Tsuda H, Hirohashi S. Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive pheno- type in breast cancer. Int J Cancer 57:498-503,1994.
34. Caleffi M, league MW, Jensen RA, Vnencak-Jones CL, Dupont WD, Pari FF. p53 gene mutations and steroid receptor status in breast cancer. Clinicopathologic correlations and prognostic assessment. Cancer 73:2147-2156,1994.
35. Tsuda H, Iwaya K, Fukutomi T, et al. p53 mutations and c- erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade. Jpn J Cancer Res 84:394-401,1993.
36. Makino H, Ushijima T, Kakiuchi H, et al. Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2- a:3′,2′-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridme. Jpn J Cancer Res 85:510-514,1994.
37. Tokusashi Y, Fukuda I, Ogawa K. Absence of p53 mutations and various frequencies of Ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens. Mol Carcinog 10:45- 51,1994.
38. Ushijima T, Kakiuchi H, Makino H, et al. Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine Mol Caronog 10:38- 44,1994.
39. Jerry DJ, Butel JS, Donehower LA, et al. Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice. Mol Carcinog 9:175-183,1994.
40. Goodrow TL, Storer RD, Leander KR, Prahalda SR, van Zwieten MJ, Bradley MO. Murine p53 intron sequences 5-8 and their use in polymerase chain reaction-direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors. Mol Carcinog 5:9-15, 1992
41. Ruggeri B, DiRado M, Zhang SY, Bauer B, Goodrow T, Klein SA. Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci USA 90:1013-1017,1993.
42. Makino H, Ishizaka Y, Tsujimoto A, et al. Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3- methylimidazo[4,5-f]quinoline, a food mutagen. Proc Natl Acad Sci USA 89:4850-4854,1992.
43. Ethier SP, Ullrich RL. Induction of mammary tumors in virgin female BALB/c mice by single low doses of 7,12- dimethylbenz[a]anthracene. J Natl Cancer Inst 69:1199- 1203,1982.
44. Bos JL. The ras gene family and human carcinogenesis. Mutat Res 195:255-271,1988.
45. Roschlitz CF, Scott GK, Dodson JM, et al. Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer. Cancer Res 49:357-360,1989.