Oral Glutamine (AES-14) Supplementation Inhibits PI-3K/Akt Signaling in Experimental Breast Cancer

Journal of Parenteral and Enteral Nutrition

Volumn 27, Issue 6, 2003, Pages 404-410

  Todorova, Valentina K ^a   Harms, Stacy A ^a   Luo, Shaoke ^a   Kaufmann, Yihong ^c   Babb, Kirk B ^a   Klimberg, V Suzanne ^a,b,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AES 14; DIMETHYLBENZ[A]ANTHRACENE; GLUTAMINE; GLUTATHIONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; SESAME SEED OIL; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER PREVENTION; CELL SURVIVAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALIA; SESAMUM INDICUM;

EID: 1642513490     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607103027006404     Document Type: Article

References (40)

1. Boelens PG, Nijveldt RJ, Houdijk APJ, et al: Glutamine alimentation in catabolic state. J Nutr 131:2569S-2577S, 2001
2. Klimberg VS, McClellan JL: Glutamine, cancer, and its therapy. Am J Surg 172:418-424, 1996
3. Klimberg VS, Nwokedi E, Hutchins LH, et al: Glutamine facilitates chemotherapy while reducing toxicity. JPEN 16:1606, 1992
4. Farr M, Nwokedi E, Woodliff J, et al: Glutamine enhances immunoregulation of tumor growth. JPEN 18:471-476, 1994
5. Rouse K, Nwokedi E, Woodliff J, et al: Ann Surg 221:420-426, 1995
6. Feng Z, Cao Y, Kornbluth J, et al: Glutamine prevents DMBA-induced breast cancer growth. Surg Forum XLVII:524-526, 1996
7. Datta SR, Brunet A, Greenberg ME: Cellular survival: A play in three Akts. Genes Dev 13:2905-2927, 1999
8. Brunet A, Bonni A, Zigmond MJ, et al: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868, 1999
9. Cardone MH, Roy N, Stennicke HR, et al: Regulation of cell death protease caspase 9 by phosphorylation. Science 282:1318-1321, 1998
10. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1-6, 1994
11. Schofied PN, Engstrom W: Insulin-like growth factors in human cancer. IN The Insulin-like Growth Factors: Structure and Biological Function, Schofield PN (ed). Oxford University Press, New York, 1992, pp 241-257
12. Furstenberger G, Senn H-J: Insulin-like growth factors and cancer. Lancet Oncol 3:298-302, 2002
13. Benito M, Valverde AM, Lorenzo M: IGF-1: A mitogen also involved in differentiation processes in mammalian cells. Int J Biochem Cell Biol 28:499-510, 1996
14. Jones JI, Clemmons DR: Insulin-like growth factors and their binding proteins: Biological actions. Endocr Rev 16:3-34, 1995
15. O'Connor R: Survival factors and apoptosis. Adv Biochem Eng Biotechnol 62:137-166, 1998
16. Turner BC, Haffty BG, Narayanan L, et al: Insulin-like growth factor-1 overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 57:3079-3083, 1997
17. Lee AV, Hilsenbeck SG, Yee D: IGF system components as prognostic markers in breast cancer. Breast Cancer Res 47:295-302, 1998
18. Schnarr B, Strunz K, Ohsam J, et al: Down-regulation of insulin-like growth factor-1 receptor and insulin receptor substrate-1 expression in advanced human breast cancer. Int J Cancer 89:506-513, 2000
19. Johnson AT, Kaufmann, YC, Luo S, et al: Effect of glutamine on glutathione, IGF-1 and TGF-β. J Surg Res 111:222-228, 2003.
20. Petit R, Shinal E, French C: AES-14 facilitates rapid intracellular transport of high levels of L-glutamine in mucosal epithelial cells. Proc ASCO 19:612a, 2000
21. Li M, Liu X, Robinson G, et al. Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc Natl Acad Sci USA 94:3425-3430, 1997
22. Russo J, Russo IH: Biological and molecular basis of mammary carcinogenesis. Lab Invest 57:112-137, 1987
23. Fukunishi R: Studies on tumor induction in rats with 7.12-dimethylbenz(a)antracene, with special references to the morphogenesis and fine-structural changes in the target organs. Acta Pathol Jap 18:51-72, 1968
24. Huggins C, Grant L, Brillantes F: Mammary CA induced by single feeding of polynuclear hydrocarbons and its suppression. Nature 189:204-207, 1961
25. Dipple A, Nebzydoski JA: Evidence for the involvement of a diol-epoxide in the binding of 7,12-dimethylbenz[a]anthracene to DNA cells in culture. Chem Biol Interact 20:17-26, 1978
26. Cao Y, Wang J, Henry-Tillman RS, et al: Effect of 7,12-dimethylbenz[a]anthracene (DMBA) on gut glutathione metabolism. J Surg Res 100:135-140, 2001
27. Fafournoux P, Bruhat A, Jousse C: Amino acid regulation of gene expression. Biochem J 351:1-12, 2000
28. Medina MA: Glutamine and cancer. J Nutr 131:2539S-2542S, 2001
29. Jousse C, Bruhat A, Ferrara M, et al: Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression. Biochem J 334:147-153, 1998
30. Wasa M, Barrie BP, Abcouwer SF, et al: Glutamine as a regulator of DNA and protein biosynthesis in human solid tumor cell lines. Ann Surg 224:189-197, 1996
31. Cai JW, Hughes CS, Shen JW, et al: Induction of heat-shock proteins by glutamine: The "feeding effect." FEBS Lett 288:229-232, 1991
32. Poueymirou WT, Conover JC, Schultz RM: Regulation of mouse preimplantation development: Differential effects of CAB medium and Whitten's medium on rates and patterns of protein synthesis in 2-cell embryos. Biol Reprod 41:317-322, 1989
33. Labow BI, Souba WW: Glutamine. World J Surg 24:1503-1513, 2000
34. Karinch AM, Pan M, Lin C-M, et al: Glutamine metabolism in sepsis and infection. J Nutr 131:2535S-2577S, 2001
35. Abcouwer SF, Schwarz C, Meguid RA: Glutamine deprivation induces the expression of GADD45 and GADD153 primarily by mRNA stabilization. J Biol Chem 274:28645-28651; 1999
36. Larsson A, Anderson M: Glutathione synthetase deficiency and other disorders of the gamma-glutamyl cycle, 8th ed. McGraw Hill, New York, 2001
37. Liu B, Andrieu-Abadie N, Levade T, et al: Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem 273:11313-11320, 1998
38. Liu X, Kim CN, Yang J, et al: Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86:147-157, 1996
39. Singletary KW, Milner JA: DNA binding and adduct formation of 7,12-dimethylbenz[a]anthracene by rat mammary epithelial cell aggregates in vitro. Carcinogenesis 7:95-98, 1986
40. nd Annual Cancer Symposium of the Society of Surgical Oncology, March 4-7, 1999, Orlando, Florida, 2002