Diabetes Mellitus due to Misfolding of a β-Cell Transcription Factor: Stereospecific Frustration of a Schellman Motif in HNF-1α

Journal of Molecular Biology

Volumn 362, Issue 3, 2006, Pages 414-429

  Narayana, Narendra ^a   Phillips, Nelson B ^a   Hua, Qing xin ^a   Jia, Wenhua ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

energy landscape; gene regulation; protein engineering; protein stability; protein structure

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 1ALPHA;

ARTICLE; ATOMIC PARTICLE; CRYSTAL STRUCTURE; DIABETES MELLITUS; DIMERIZATION; GENE MUTATION; HUMAN; HYDROGEN BOND; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION; WILD TYPE;

EID: 33748125880     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.06.086     Document Type: Article

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