Diabetes-associated mutations in a β-cell transcription factor destabilize an antiparallel "mini-zipper" in a dimerization interface

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 5, 2000, Pages 1999-2004

  Hua, Qing Xin ^a   Zhao, Ming ^b   Narayana, Narendra ^a   Nakagawa, Satoe H ^b   Jia, Wenhua ^a   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Diabetes mellitus; Gene regulation; NMR spectroscopy four helix bundle; Protein structure

Indexed keywords

HOMEODOMAIN PROTEIN; NUCLEAR FACTOR I; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ALPHA HELIX; ARTICLE; DIMERIZATION; GENE MUTATION; MATURITY ONSET DIABETES MELLITUS; METABOLIC REGULATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; THERMODYNAMICS;

AMINO ACID SEQUENCE; DIABETES MELLITUS, TYPE 2; DIMERIZATION; DNA-BINDING PROTEINS; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; HYDROGEN-ION CONCENTRATION; ISLETS OF LANGERHANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PROTEIN STRUCTURE, SECONDARY; TRANSCRIPTION FACTORS;

EID: 0034051661     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.5.1999     Document Type: Article

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