Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity

Biochemistry and Cell Biology

Volumn 80, Issue 1, 2002, Pages 65-74

  Strøm, Morten B ^a   Erik Haug, Bengt ^a   Rekdal, Øystein ^a   Skar, Merete L ^a   Stensen, Wenche ^a   Svendsen, John S ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Antimicrobial peptides; Lactoferricin; Non encoded aromatic amino acids; Tryptophan

Indexed keywords

AMINO ACIDS; MICROBIOLOGY; PROTEINS;

ANTIMICROBIAL ACTIVITY;

BIOCHEMISTRY;

ALANINE; AROMATIC AMINO ACID; LACTOFERRICIN; NORLEUCINE; PEPTIDE; TRYPTOPHAN;

ANALYTIC METHOD; ANTIMICROBIAL ACTIVITY; CATTLE; CONFERENCE PAPER; CONTROLLED STUDY; MICELLE; NONHUMAN; PARAMETER; PHYSICAL CHEMISTRY; PROTEIN STRUCTURE; SPECIES DIFFERENCE; SWINE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; HUMANS; LACTOFERRIN; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

BOS TAURUS; BOVINAE; CAPRA; MURINAE; SUIDAE; SUS SCROFA;

EID: 0038064554     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o01-236     Document Type: Conference Paper

References (32)

1. Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin
2. Identification of the bactericidal domain of lactoferrin
3. Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin
4. Role of iron in bacterial infection
5. Preliminary observations on lactoferrin secretion in human vaginal mucus: Variation during the menstrual cycle, evidence of hormonal regulation, and implications for infection with Neisseria gonorrhoeae
6. Folding proteins into membranes
7. The role of tryptophan in the antibacterial activity of a 15-residue bovine lactoferricin peptide
8. Bulky aromatic amino acids increase the antibacterial activity of 15-residue bovine lactoferricin derivatives
9. Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA
10. Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin
11. Anchoring of tryptophan and tyrosine analogs at the hydrocarbon-polar boundary in model membrane vesicles: Parallax analysis of fluorescence quenching induced by nitroxide-labeled phospholipids
12. Structure-biological activity relationships of 11-residue highly basic peptide segment of bovine lactoferrin
13. Antibiotic activity of pentadecapeptides modelled from amino acid descriptors
14. Characterization of the goat lactoferrin cDNA: Assignment of the relevant locus to bovine U12 synteny group
15. Nucleotide and primary amino acid sequence of porcine lactoferrin
16. An iron-binding protein common to many external secretions
17. Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions
18. Construction and synthesis of lactoferricin derivatives with enhanced antibacterial activity
19. The structure of the antimicrobial active center of lactoferricin B bound to sodium dodecyl sulfate micelles
20. The functions of tryptophan residues in membrane proteins
21. Antibacterial activity of 15-residue lactoferricin derivatives
22. Increased antibacterial activity of 15-residue murine lactoferricin derivatives
23. Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin
24. A review: The active peptide of lactoferrin
25. Lactoferrin: A multifunctional glycoprotein
26. N-Acylated and D enantio-mer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity
27. Experimentally determined hydrophobicity scale for proteins at membrane interfaces
28. Determining the membrane topology of peptides by fluorescence quenching
29. SIMCA: A method for analyzing chemical data in terms of similarity and analogy
30. Multivariate data analysis in chemistry
31. The preference of tryptophan for membrane interfaces